Sleep and synaptic homeostasis

Behavioral and Brain Sciences 28 (1):85-85 (2005)
We propose that sleep is linked to synaptic homeostasis. Specifically, we propose that: (1) Wakefulness is associated with synaptic potentiation in cortical circuits; (2) synaptic potentiation is tied to the homeostatic regulation of slow wave activity; (3) slow wave activity is associated with synaptic downscaling; and (4) synaptic downscaling is tied to several beneficial effects of sleep, including performance enhancement.
Keywords Long-term depression  Synaptic scaling  Learning  Consolidation  Delta sleep  Slow waves  Slow oscillations
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DOI 10.1017/S0140525X05430022
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