Intervention, Causal Reasoning, and the Neurobiology of Mental Disorders: Pharmacological Drugs as Experimental Instruments

In psychiatry, pharmacological drugs play an important experimental role in attempts to identify the neurobiological causes of mental disorders. Besides being developed in applied contexts as potential treatments for patients with mental disorders, pharmacological drugs play a crucial role in research contexts as experimental instruments that facilitate the formulation and revision of neurobiological theories of psychopathology. This paper examines the various epistemic functions that pharmacological drugs serve in the discovery, refinement, testing, and elaboration of neurobiological theories of mental disorders. I articulate this thesis with reference to the history of antipsychotic drugs and the evolution of the dopamine hypothesis of schizophrenia in the second half of the twentieth century. I argue that interventions with psychiatric patients through the medium of antipsychotic drugs provide researchers with information and evidence about the neurobiological causes of schizophrenia. This analysis highlights the importance of pharmacological drugs as research tools in the generation of psychiatric knowledge and the dynamic relationship between practical and theoretical contexts in psychiatry.
Keywords psychiatry  pharmacology  neurobiology  dopamine hypothesis of schizophrenia  intevention  causal reasoning
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DOI 10.1016/j.shpsc.2012.01.003
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References found in this work BETA
Stuart Glennan (2002). Rethinking Mechanistic Explanation. Proceedings of the Philosophy of Science Association 2002 (3):S342-353.

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Jacob Stegenga (forthcoming). Effectiveness of Medical Interventions. Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences.

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