Online research in philosophy

This article argues that understanding everyday practices in neurobiological labs requires us to take into account a variety of different action positions: self-conscious social actors, technical artifacts, conscious organisms, and organisms being merely alive. In order to understand the interactions among such diverse entities, highly differentiated conceptual tools are required. Drawing on the theory of the German philosopher and sociologist Helmuth Plessner, the paper analyzes experimenters as self-conscious social persons who recognize monkeys as conscious organisms. Integrating Plessner’s ideas into the stock of concepts used in science and technology studies provides richer descriptions of laboratory life. In particular, this theory allows an understanding of a crucial feature of neurobiological brain research: the construction of the brain as the epistemic object of brain research. As such, the brain must be isolated from the acting and interacting organism in a complicated process.

The history of what we call molecular biology today is not just the story of DNA. Molecular biology emerged from and was supported by a multiplicity of widely scattered, differently embedded, and loosely, if at all connected experimental systems for characterizing living beings to the level of biologically relevant macromolecules. By implementing different modes of technical analysis, these systems created a new space of representation in which the central concepts of molecular biology gradually became articulated. The paper describes the establishment of the rat liverin vitro protein synthesis system of Paul Zamecnik and his group a the Collis P. Huntington Memorial Hospital of Harvard University between 1947 and 1952. Insofar as such systems orient the research activity, they may also prove helpful for the orientation of the historian. Experimental systems „have a life of their own.

As the expression itself indicates, ‘point of view’ is in the first place applied to spatial locations for visual observation. I can see a certain group of objects from different positions, or points of view. When seen from certain points, a particular object in the group is hidden behind others, from other points it isn’t. It is still the same group of objects, so in one sense I see the same thing. In another sense, I don’t see the same thing, for I see different parts, sides or aspects of that same group of objects. My visual impression is different as well, unless perfect symmetry of the group makes the difference in perspective phenomenologically unnoticeable.

Exploring central philosophical issues concerning scientific research in modern experimental biology, this book clarifies the strategies, concepts, reasoning, approaches, tools, models and experimental systems deployed by researchers. It also integrates recent developments in historical scholarship, in particular, the New Experimentalism, making this work of interest to philosophers and historians of science as well as to biological researchers.

The issue of scientific realism is discussed in terms of the specific details of the practice of experimental meson and baryon spectroscopy in the field of High-Energy Physics (HEP), during the period from 1966 to 1970. The philosophical positions of I. Hacking, A. Fine, J. Leplin, and N. Rescher that concern scientific realism are presented in such a manner as to allow for the evaluation of their appropriateness in the description of this experimental research field. This philosophical analysis focuses on the empirical adequacy of these four philosophical models that purport to describe the process of acquiring knowledge of the physical world. In this specific case, an experiment performed by the HEP research group at the University of Notre Dame to study the scattering interaction.

Attention to scientific practice offers a novel response to philosophical queries about how conceptual understanding is empirically accountable. The locus of the issue is thereby shifted, from perceptual experience to experimental and fieldwork interactions. More important, conceptual articulation is shown to be not merely ?spontaneous? and intralinguistic, but instead involves a establishing a systematic domain of experimental operations. The importance of experimental practice for conceptual understanding is especially clearly illustrated by cases in which entire domains of scientific investigation were first made accessible to articulated conceptual understanding. We thereby see more clearly how experimental systems themselves, and not merely the theories and models they make possible, have an intentional directedness and ?representational? import.

My paper draws on examples from molecular biology, the details of which I have developed elsewhere (Rheinberger 1992, 1993, 1995, 1997). Here, I can give only a brief outline of my argument. Reduction of complexity is a prerequisite for experimental research. To make sense of the universe of living beings, the modern biologist is bound to divide his world into fragments in which parameters can be defined, quantities measured, qualities identified. Such is the nature of any "experimental system." Ontic complexity has to be reduced in order to make experimental research possible. The complexity of the research object, however, is epistemically retained in the rich context of an experimental landscape, where the eruption of "volcanic systems" can change the scenery dramatically as the result of particular, unprecedented findings.

In 1937, a group of researchers in Nazi Germany began investigating tobacco mosaic virus (TMV) with the hope of using the virus as a model system for understanding gene behavior in higher organisms. They soon developed a creative and interdisciplinary work style and were able to continue their research in the postwar era, when they made significant contributions to the history of molecular biology. This group is significant for two major reasons. First, it provides an example of how researchers were able to produce excellent scientific research in the midst of dictatorship and war. Coupled with the group's ongoing success in postwar Germany, the German TMV investigators provide a dramatic example of how scientific communities deal with adversity as well as rapid political and social change. Second, since the researchers focused heavily (though not exclusively) on TMV, their story allows us to analyze how an experimental system other than phage contributed to the emergence of molecular biology.

I propose a new perspective on the study of scientific revolutions. This is a transformation from an object-only perspective to an ontological perspective that properly treats objects and processes as distinct kinds. I begin my analysis by identifying an object bias in the study of scientific revolutions, where it takes the form of representing scientific revolutions as changes in classification of physical objects. I further explore the origins of this object bias. Findings from developmental psychology indicate that children cannot distinguish processes from objects until the age of 7, but they have already developed a core system of object knowledge as early as 4 months of age. The persistence of this core system is responsible for the object bias among mature adults, i.e., the tendency to apply knowledge of physical objects to temporal processes. In light of the distinction between physical objects and temporal processes, I redraw the picture of the Copernican revolution. Rather than seeing it as a taxonomic shift from a geocentric to a heliocentric cosmology, we should understand it as a transformation from a conceptual system that was built around an object concept to one that was built around a process concept.

This paper makes two contributions to the research on cooperation in experimental social dilemmas. First, we demonstrate an interaction between group size and communication in which the effectiveness of communication in promoting cooperation declines as group size increases. Second, we corroborate some previous research showing the positive effect of communication is due to sincere signaling of cooperative intentions. The experimental data comes from 289 undergraduate student subjects playing public goods games over a computer network. These findings suggest that large group size opens up a niche for the evolution of institutions for collective action.