Alternative Definitions of Epistasis: Dependence and Interaction

Trends in Ecology and Evolution 16 (9):498-504 (2001)
Abstract
Although epistasis is at the center of the Fisher-Wright debate, biologists not involved in the controversy are often unaware that there are actually two different formal definitions of epistasis. We compare concepts of genetic independence in the two theoretical traditions of evolutionary genetics, population genetics and quantitative genetics, and show how independence of gene action (represented by the multiplicative model of population genetics) can be different from the absence of gene interaction (represented by the linear additive model of quantitative genetics). The two formulations converge with weak selection but not with strong selection or, for multiple loci, when the aggregated interaction terms are not negligible. As a result of the different formulations of gene interaction, the presence or absence of linkage disequilibrium,/D/, does not necessarily indicate the presence or absence of fitness epistasis. Indeed, linkage disequilibrium is generated in ‘additive’ models in quantitative genetics whenever two (or more) loci experience simultaneous selection. As a research strategy, it is often practical, for theoretical or experimental reasons, to minimize gene interaction by assuming independence of gene action in regard to fitness, or by assuming linear additive effects of multiple loci on a phenotype. However, minimizing the role of epistasis in theoretical investigations hinders our understanding of the origins of diversity and the evolution of complex phenotypes.
Keywords No keywords specified (fix it)
Categories (categorize this paper)
Options
 Save to my reading list
Follow the author(s)
My bibliography
Export citation
Find it on Scholar
Edit this record
Mark as duplicate
Revision history Request removal from index Translate to english
 
Download options
PhilPapers Archive Michael J. Wade, Alternative Definitions of Epistasis: Dependence and Interaction
External links
Setup an account with your affiliations in order to access resources via your University's proxy server
Configure custom proxy (use this if your affiliation does not provide a proxy)
Through your library
References found in this work BETA

No references found.

Citations of this work BETA

No citations found.

Similar books and articles
Paul E. Griffiths & Karola Stotz (2006). Genes in the Postgenomic Era. Theoretical Medicine and Bioethics 27 (6):499-521.
Thomas Fogle (1990). Are Genes Units of Inheritance? Biology and Philosophy 5 (3):349-371.
Peter Godfrey-Smith (1992). Additivity and the Units of Selection. PSA: Proceedings of the Biennial Meeting of the Philosophy of Science Association 1992:315 - 328.
Analytics

Monthly downloads

Added to index

2011-07-04

Total downloads

116 ( #8,857 of 1,102,452 )

Recent downloads (6 months)

38 ( #2,453 of 1,102,452 )

How can I increase my downloads?

My notes
Sign in to use this feature


Discussion
Start a new thread
Order:
There  are no threads in this forum
Nothing in this forum yet.