David Bourget (Western Ontario)
David Chalmers (ANU, NYU)
Rafael De Clercq
Ezio Di Nucci
Jack Alan Reynolds
Learn more about PhilPapers
Acta Biotheoretica 28 (4):239-282 (1979)
The general inorganic nature of traditional selection theory (based on differential growth between any two systems) is pointed out, wherefrom it follows that this theory cannot provide explanations for the characteristics of organic evolution. Specific biophysical aspects enter with the complexity of macro-molecules: vital physical conditions for the perpetuation of the system, irrevocable extinction (= death) and random change leading to novelty, are the result of complexity per se. Further biophysical properties are a direct function of the pathway along which random mutation in nucleic acids is converted into continuous protein — (specifically enzyme) — function, from there into organismic phenotype with fitness components which may, or may not, correspond to identifiable structural units in DNA. The general machine-like properties of enzymes, in that there is no additive relationship between structural (amino acid) composition and functional output, is discussed in more detail. The continuous growth functions of molecular concentrations, directed by enzyme turnover, determine simple laws of growth and morphogenesis in the organic hierarchy and thus of phenotype. Thus, the combined effect of DNA-structure and of environmental parameters (temperature, pressure, pH, etc.) on protein function determines ultimately the actual phenotype and hence, quality and intensity of genotypic selection.
|Keywords||No keywords specified (fix it)|
|Categories||categorize this paper)|
Setup an account with your affiliations in order to access resources via your University's proxy server
Configure custom proxy (use this if your affiliation does not provide a proxy)
|Through your library|
References found in this work BETA
No references found.
Citations of this work BETA
No citations found.
Similar books and articles
L.den Dries & A. J. Wilkie (2003). The Laws of Integer Divisibility, and Solution Sets of Linear Divisibility Conditions. Journal of Symbolic Logic 68 (2):503 - 526.
Henry Byerly (1986). Fitness as a Function. PSA: Proceedings of the Biennial Meeting of the Philosophy of Science Association 1986:494 - 501.
Karen Pittel & Lucas Bretschger, Sectoral Heterogeneity, Resource Depletion, and Directed Technical Change: Theory and Policy.
Ulrich E. Stegmann (2004). The Arbitrariness of the Genetic Code. Biology and Philosophy 19 (2):205-222.
Alejandro Balbín & Eugenio Andrade (2004). Protein Folding and Evolution Are Driven by the Maxwell Demon Activity of Proteins. Acta Biotheoretica 52 (3):173-200.
William C. Wimsatt (1980). The Units of Selection and the Structure of the Multi-Level Genome. PSA: Proceedings of the Biennial Meeting of the Philosophy of Science Association 1980:122 - 183.
Jing Huang & Feng Shi (2005). Support Vector Machines for Predicting Apoptosis Proteins Types. Acta Biotheoretica 53 (1):39-47.
Martin Carrier & Patrick Finzer (2006). Explanatory Loops and the Limits of Genetic Reductionism. International Studies in the Philosophy of Science 20 (3):267 – 283.
Paul Erbrich (1985). On the Probability of the Emergence of a Protein with a Particular Function. Acta Biotheoretica 34 (1):53-80.
Added to index2009-01-28
Total downloads8 ( #389,432 of 1,796,356 )
Recent downloads (6 months)2 ( #347,915 of 1,796,356 )
How can I increase my downloads?