David Bourget (Western Ontario)
David Chalmers (ANU, NYU)
Rafael De Clercq
Jack Alan Reynolds
Learn more about PhilPapers
Journal of Medical Ethics 27 (3):151-156 (2001)
For a few decades, patients with Parkinson's disease have been treated with intracerebral transplantations of fetal mesencephalic tissue. The results of open trials have been variable. Double blind, placebo-controlled studies have recently been started in order to further investigate the efficacy of this new medical technique. In this paper we challenge the need for sham surgery in neurotransplantation research on PD patients. Considerations regarding the research subjects' informed consent, therapeutic misconception, the integrity of the human body, and the assessment of risks and benefits argue against sham surgery for patients with PD. Moreover, there is an alternative, less harmful mode of research that can provide the same or comparable scientific evidence. A plea is made for intrapatient research based on quantitative measurements of the patient's pre- and post-operative condition combined with similar research on a reference group of patients who have received the standard treatment
|Keywords||No keywords specified (fix it)|
|Categories||categorize this paper)|
Setup an account with your affiliations in order to access resources via your University's proxy server
Configure custom proxy (use this if your affiliation does not provide a proxy)
|Through your library|
References found in this work BETA
No references found.
Citations of this work BETA
No citations found.
Similar books and articles
Teresa Swift & Richard Huxtable (2013). The Ethics of Sham Surgery in Parkinson's Disease: Back to the Future? Bioethics 27 (4):175-185.
John C. Fletcher (2003). Sham Neurosurgery in Parkinson's Disease: Ethical at the Time. American Journal of Bioethics 3 (4):54-56.
R. L. Albin (2002). Sham Surgery Controls: Intracerebral Grafting of Fetal Tissue for Parkinson's Disease and Proposed Criteria for Use of Sham Surgery Controls. Journal of Medical Ethics 28 (5):322-325.
Raúl de la Fuente-Fernández & A. Jon Stoessl (2004). The Biochemical Bases of the Placebo Effect. Science and Engineering Ethics 10 (1):143-150.
Nir Lipsman, Rebecca Zener & Mark Bernstein (2009). Personal Identity, Enhancement and Neurosurgery: A Qualitative Study in Applied Neuroethics. Bioethics 23 (6):375-383.
Elisabeth Hildt (2009). Ethical Challenges in Cell-Based Interventions for Neurological Conditions: Some Lessons To Be Learnt From Clinical Transplantation Trials in Patients with Parkinson's Disease. American Journal of Bioethics 9 (5):37-38.
Benjamin Seltzer, Jennifer J. Vasterling, Charles W. Mathias & Angela Brennan (2001). Clinical and Neuropsychological Correlates of Impaired Awareness of Deficits in Alzheimer Disease and Parkinson Disease: A Comparative Study. Neuropsychiatry, Neuropsychology, and Behavioral Neurology 14 (2):122-129.
Bernhard Bogerts (2002). Does Catatonia Have a Specific Brain Biology? Behavioral and Brain Sciences 25 (5):580-581.
den Bosch & M. P. (2005). Structures in Neuropharmacology. Poznan Studies in the Philosophy of the Sciences and the Humanities 84 (1):343-359.
Franklin G. Miller (2004). Sham Surgery: An Ethical Analysis. Science and Engineering Ethics 10 (1):41-48.
Irwin Savodnik (2002). The Disease Status of Catatonia. Behavioral and Brain Sciences 25 (5):590-591.
A. Antonini, R. Benti, R. Notaris, S. Tesei, A. Zecchinelli, G. Sacilotto, N. Meucci, M. Canesi, C. Mariani, G. Pezzoli & P. Gerundini (2003). 123i-Ioflupane/Spect Binding to Striatal Dopamine Transporter (Dat) Uptake in Patients with Parkinson's Disease, Multiple System Atrophy, and Progressive Supranuclear Palsy. Neurological Sciences 24 (3).
Karsten Witt, Jens Kuhn, Lars Timmermann, Mateusz Zurowski & Christiane Woopen (2013). Deep Brain Stimulation and the Search for Identity. Neuroethics 6 (3):499-511.
Walter Glannon (1998). Responsibility, Alcoholism, and Liver Transplantation. Journal of Medicine and Philosophy 23 (1):31 – 49.
Added to index2010-08-24
Total downloads4 ( #289,172 of 1,410,276 )
Recent downloads (6 months)1 ( #177,872 of 1,410,276 )
How can I increase my downloads?