David Bourget (Western Ontario)
David Chalmers (ANU, NYU)
Rafael De Clercq
Jack Alan Reynolds
Learn more about PhilPapers
Medical research involving human subjects raises complex ethical, legal and social issues. Investigators sometimes find that their obligations with respect to a research project come into conflict with their obligations to individual patients. The ethical conduct of research rests on 3 guiding principles: respect for persons, beneficience, and justice. Respect for persons underlies the duty to obtain informed consent from study participants. Beneficence demands a favourable balance between the potential benefits and harms of participation. Justice requires that vulnerable people not be exploited and that eligible candidates who may benefit from participation not be excluded without good cause. Studies must be designed in a way that ensures the validity of findings and must address questions of sufficient importance to justify the risks of participation. In any clinical trial there must be genuine uncertainty as to which treatment arm offers the most benefit, and placebo controls should not be used if effective standard therapies exist. Researchers have a responsibility to inform themselves about the ethical, legal and policy standards that govern their activities. When difficulties arise, they should consult the existing literature and seek the advice of experts in research ethics
|Keywords||No keywords specified (fix it)|
|Categories||categorize this paper)|
Setup an account with your affiliations in order to access resources via your University's proxy server
Configure custom proxy (use this if your affiliation does not provide a proxy)
|Through your library||
References found in this work BETA
No references found.
Citations of this work BETA
No citations found.
Similar books and articles
Leslie Meltzer Henry, Undesirable Implications of Disclosing Individual Genetic Results to Research Participants.
David Wendler & Christine Grady (2008). What Should Research Participants Understand to Understand They Are Participants in Research? Bioethics 22 (4):203–208.
Alexander Friedman, Emily Robbins & David Wendler (2012). Which Benefits of Research Participation Count as 'Direct'? Bioethics 26 (2):60-67.
Eric G. Yan & Kerim M. Munir (2004). Regulatory and Ethical Principles in Research Involving Children and Individuals with Developmental Disabilities. Ethics and Behavior 14 (1):31 – 49.
Andrew D. McRae & Charles Weijer, Lessons From Everyday Lives: A Moral Justification for Acute Care Research.
Bridget Pratt & Bebe Loff (2013). A Framework to Link International Clinical Research to the Promotion of Justice in Global Health. Bioethics 27 (3):387-396.
Elyn R. Saks, Dilip V. Jeste, Eric Granholm, Barton W. Palmer & Lawrence Schneiderman (2002). Ethical Issues in Psychosocial Interventions Research Involving Controls. Ethics and Behavior 12 (1):87 – 101.
Charles Weijer & Paul B. Miller (2007). Refuting the Net Risks Test: A Response to Wendler and Miller's "Assessing Research Risks Systematically". Journal of Medical Ethics 33 (8):487-490.
Adil E. Shamoo (2009). Responsible Conduct of Research. Oxford University Press.
Benjamin Sachs (2011). Going From Principles to Rules in Research Ethics. Bioethics 25 (1):9-20.
Roger Stanev (2012). Review of The Oxford Textbook of Clinical Research Ethics, by D. Wendler, C. Grady, R. Crouch, R. Lie, F. Miller, and E. Emanuel. Theoretical Medicine and Bioethics 33 (3):221-226.
Franklin G. Miller & Steven Joffe (2006). Evaluating the Therapeutic Misconception. Kennedy Institute of Ethics Journal 16 (4):353-366.
Ezekiel J. Emanuel (ed.) (2003). Ethical and Regulatory Aspects of Clinical Research: Readings and Commentary. Johns Hopkins University Press.
Tom L. Beauchamp, Bruce Jennings, Eleanor D. Kinney & Robert J. Levine (2002). Pharmaceutical Research Involving the Homeless. Journal of Medicine and Philosophy 27 (5):547 – 564.
Added to index2010-09-08
Total downloads7 ( #304,000 of 1,726,249 )
Recent downloads (6 months)1 ( #369,877 of 1,726,249 )
How can I increase my downloads?