David Bourget (Western Ontario)
David Chalmers (ANU, NYU)
Rafael De Clercq
Ezio Di Nucci
Jonathan Jenkins Ichikawa
Jack Alan Reynolds
Learn more about PhilPapers
Acta Biotheoretica 41 (1-2):75-83 (1993)
Control of DNA supercoiling by the free-energy of hydrolysis of ATP that involves gene expression is analyzed in terms of three levels of unconnected metabolic pathways. These are synthesis and breakdown of topoisomerase mRNAs, synthesis and breakdown of topoisomerase proteins and supercoiling and relaxation of DNA. The so-called square-matrix method previously developed for the control of metabolic pathways, is extended to deal with this hierarchical control system. It turns out that also in this case, the matrix of control coefficients is equal to the inverse of the so-called elasticity matrix, which contains all relevant elasticity coefficients as well as information about the structure and connectedness of the pathways involved. For a simpler case of a hierarchy of two systems, we demonstrate that the explicit matrix inversion method may be replaced by an implicit method in which the regulatory effects that run through the other level are described by an additional elasticy coefficient which may then be treated as if local.
|Keywords||No keywords specified (fix it)|
|Categories||categorize this paper)|
Setup an account with your affiliations in order to access resources via your University's proxy server
Configure custom proxy (use this if your affiliation does not provide a proxy)
|Through your library|
References found in this work BETA
Daniel Kahn & Hans V. Westerhoff (1993). The Regulatory Strength: How to Be Precise About Regulation and Homeostasis. Acta Biotheoretica 41 (1-2):85-96.
Citations of this work BETA
F. J. Bruggeman, H. V. Westerhoff & F. C. Boogerd (2002). Biocomplexity: A Pluralist Research Strategy is Necessary for a Mechanistic Explanation of the "Live" State. Philosophical Psychology 15 (4):411 – 440.
Similar books and articles
B. Raïs, C. Chassagnole & J. -P. Mazat (1995). Control of Threonine Pathway in E. Coli. Application to Biotechnologies. Acta Biotheoretica 43 (4):285-297.
Dominique de Vienne, Bruno Bost, Julie Fiévet & Christine Dillmann (2001). Optimisation of Enzyme Concentrations for Unbranched Reaction Chains: The Concept of Combined Response Coefficient. Acta Biotheoretica 49 (4):341-350.
Andy Clark (2005). The Twisted Matrix: Dream, Simulation, or Hybrid? In C. Grau (ed.), Philosophical Essays on the Matrix. Oxford University Press New York
Degeng Wang (2005). “Molecular Gene”: Interpretation in the Right Context. [REVIEW] Biology and Philosophy 20 (2-3):453-464.
Peter A. Bibby & Geoffrey Underwood (1999). Volitional Control in the Learning of Artificial Grammars. Behavioral and Brain Sciences 22 (5):757-758.
Valérie Gaveau & Michel Desmurget (2004). Do Movement Planning and Control Represent Independent Modules? Behavioral and Brain Sciences 27 (1):35-36.
Bernard Korzeniewski & Jean-Pierre Mazat (1996). Theoretical Studies on Control of Oxidative Phosphorylation in Muscle Mitochondria at Different Energy Demands and Oxygen Concentrations. Acta Biotheoretica 44 (3-4):263-269.
Badr Raïs & Jean-Pierre Mazat (1995). Controle de la Chaine de Biosynthese de la Threonine Cheze. Coli. Acta Biotheoretica 43 (1-2):143-153.
Added to index2009-01-28
Total downloads8 ( #409,941 of 1,934,701 )
Recent downloads (6 months)2 ( #269,464 of 1,934,701 )
How can I increase my downloads?