The Viral Origins of Telomeres and Telomerases and their Important Role in Eukaryogenesis and Genome Maintenance
David Bourget (Western Ontario)
David Chalmers (ANU, NYU)
Rafael De Clercq
Jack Alan Reynolds
Learn more about PhilPapers
Biosemiotics 1 (2):191-206 (2008)
Whereas telomeres protect terminal ends of linear chromosomes, telomerases identify natural chromosome ends, which differ from broken DNA and replicate telomeres. Although telomeres play a crucial role in the linear chromosome organization of eukaryotic cells, their molecular syntax most probably descended from an ancient retroviral competence. This indicates an early retroviral colonization of large double-stranded DNA viruses, which are putative ancestors of the eukaryotic nucleus. This contribution demonstrates an advantage of the biosemiotic approach towards our evolutionary understanding of telomeres, telomerases, other reverse transcriptases and mobile elements. Their role in genetic/genomic content organization and maintenance is no longer viewed as an object of randomly derived alterations (mutations) but as a highly sophisticated hierarchy of regulatory networks organized and coordinated by natural genome-editing competences of viruses
|Keywords||Telomeres Telomerases Eukaryotic nucleus Persistent viruses|
|Categories||categorize this paper)|
|Through your library||Configure|
Similar books and articles
Alexander E. Vinogradov (2001). Mirrored Genome Size Distributions in Monocot and Dicot Plants. Acta Biotheoretica 49 (1).
Jesse Steinberg (2005). Reply to Allhoff on Telomeres and the Ethics of Cloning. American Journal of Bioethics 5 (1):27-28.
Jane Maienschein (2008). Elizabeth Blackburn and the Story of Telomeres: Deciphering the Ends of DNA (Review). Perspectives in Biology and Medicine 51 (4):655-658.
Ehud Lamm (2010). Genes Versus Genomes: The Role of Genome Organization in Evolution. Dissertation, Tel Aviv University
Jesse R. Steinberg (2005). Response to Fritz Allhoff, "Telomeres and the Ethics of Human Cloning" (AJOB 4:2). American Journal of Bioethics 5 (1):W27-W28.
Richard Sternberg (1996). The Role of Constrained Self-Organization in Genome Structural Evolution. Acta Biotheoretica 44 (2).
Fritz Allhoff (2004). Telomeres and the Ethics of Human Cloning. American Journal of Bioethics 4 (2):29 – 31.
Günther Witzany (2006). Natural Genome-Editing Competences of Viruses. Acta Biotheoretica 54 (4).
A. K. Sharma (1986). Evolution of Cell and Chromosome Structure in Eukaryote. Acta Biotheoretica 35 (1-2).
Arthur B. Cody (2000). Informational Darwinism. Inquiry 43 (2):167 – 179.
Added to index2009-01-28
Total downloads12 ( #104,552 of 1,004,647 )
Recent downloads (6 months)1 ( #64,617 of 1,004,647 )
How can I increase my downloads?