In this paper I defend epistemic circularity by arguing that the “No Self-Support” principle (NSS) is false. This principle, ultimately due to Fumerton ( 1995 ), states that one cannot acquire a justified belief in the reliability of a source of belief by trusting that very source. I argue that NSS has the skeptical consequence that the trustworthiness of all of our sources ultimately depends upon the trustworthiness of certain fundamental sources – sources that we cannot justifiably believe to be (...) reliable. This is a problem, I claim, because if the trustworthiness of all of our sources depends upon sources that we should not believe to be reliable, then a reflective individual should not trust any of his sources at all. The hidden cost of rejecting epistemic circularity is thus the unacceptable skeptical thesis that reflective individuals like you and I have no justified beliefs whatsoever. (shrink)

Limit cycles, because they are constituted of a periodic succession of states (discrete or continuous) constitute a good manner to store information. From any points of the state space reached after a perturbation or stimulation of the cognitive system storing this information, one can aim to join through a more or less long return trajectory a precise neighbourhood of the asymptotic trajectory at a specific moment (or a specific place) on the limit cycle, i.e. where the information of interest stands. (...) We propose that the isochronal fibration, initially imagined and described by A. T. Winfree may be an excellent way to connect directly those two locations. Each isochron is indeed the set of points in temporal phase with one single point of the attractor. The characterisation of the isochronal fibration of various dynamical systems is not easy and until now has principally only been done numerically but not analytically. By integrating the homogeneous solutions of the dynamical system we can solve this fibration in the case of the well known anharmonic pendulum. Other isochronal fibration on classical examples such as the van der Pol system and the non-symmetrical PFK limit cycle are obtained numerically and we also provide the first numerical study on 3-dimentional systems like the anharmonic pendulum with a linear relaxation on its third variable and the Lorenz attractor. The empirical approach seems us useful for dealing with the isochronal fibration which could constitute a powerful tool for understanding and controlling the dynamics of biological or biological-inspired systems. (shrink)

At the beginning of this special issue of Acta Biotheoretica carrying the above title, we present a brief overview on currently important topics that have been brought up during the last “European Conference on Mathematical and Theoretical Biology” in Edinburgh. After emphasizing the need for a “synthetic biology” also from the side of theory, model building and analysis, we survey most plenary talks of this Conference and a selected series of eigth review articles, which are mainly related to corresponding minisymposia, (...) reflecting the current state of the art and the lively discussion within this interdisciplinary field. (shrink)

When we perceive the external world, our brain has to deal with the incompleteness and uncertainty associated with sensory inputs, memory and prior knowledge. In theoretical neuroscience probabilistic approaches have received a growing interest recently, as they account for the ability to reason with incomplete knowledge and to efficiently describe perceptive and behavioral tasks. How can the probability distributions that need to be estimated in these models be represented and processed in the brain, in particular at the single cell level? (...) We consider the basic function carried out by photoreceptor cells which consists in detecting the presence or absence of light. We give a system-level understanding of the process of phototransduction based on a bayesian formalism: we show that the process of phototransduction is equivalent to a temporal probabilistic inference in a Hidden Markov Model (HMM), for estimating the presence or absence of light. Thus, the biochemical mechanisms of phototransduction underlie the estimation of the current state probability distribution of the presence of light. A classical descriptive model describes the interactions between the different molecular messengers, ions, enzymes and channel proteins occurring within the photoreceptor by a set of nonlinear coupled differential equations. In contrast, the probabilistic HMM model is described by a discrete recurrence equation. It appears that the binary HMM has a general solution in the case of constant input. This allows a detailed analysis of the dynamics of the system. The biochemical system and the HMM behave similarly under steady-state conditions. Consequently a formal equivalence can be found between the biochemical system and the HMM. Numerical simulations further extend the results to the dynamic case and to noisy input. All in all, we have derived a probabilistic model equivalent to a classical descriptive model of phototransduction, which has the additional advantage of assigning a function to phototransduction. The example of phototransduction shows how simple biochemical interactions underlie simple probabilistic inferences. (shrink)

Multi-level discrete models of genetic networks, or the more general piecewise affine differential models, provide qualitative information on the dynamics of the system, based on a small number of parameters (such as synthesis and degradation rates). Boolean models also provide qualitative information, but are based simply on the structure of interconnections. To explore the relationship between the two formalisms, a piecewise affine differential model and a Boolean model are compared, for the carbon starvation response network in E. coli . The (...) asymptotic dynamics of both models are shown to be quite similar. This study suggests new tools for analysis and reduction of biological networks. (shrink)

Ischemic stroke involves numerous and complex pathophysiological mechanisms including blood flow reduction, ionic exchanges, spreading depressions and cell death through necrosis or apoptosis. We used a mathematical model based on these phenomena to study the influences of intensity and duration of ischemia on the final size of the infarcted area. This model relies on a set of ordinary and partial differential equations. After a sensibility study, the model was used to carry out in silico experiments in various ischemic conditions. The (...) simulation results show that the proportion of apoptotic cells increases when the intensity of ischemia decreases, which contributes to the model validation. The simulation results also show that the influence of ischemia duration on the infarct size is more complicated. They suggest that reperfusion is beneficial when performed in the early stroke but may be either inefficacious or even deleterious when performed later after the stroke onset. This aggravation could be explained by the depolarisation waves which might continue to spread ischemic damage and by the speeding up of the apoptotic process leading to cell death. The effect of reperfusion on cell death through these two phenomena needs to be further studied in order to develop new therapeutic strategies for stroke patients. (shrink)

Secretion is a fundamental cellular process involving the regulated release of intracellular products from cells. Physiological functions such as neurotransmission, or the release of hormones and digestive enzymes, are all governed by cell secretion. Anomalies in the processes involved in secretion contribute to the development and progression of diseases such as diabetes and other hormonal disorders. To unravel the mechanisms that govern such diseases, it is essential to understand how hormones, growth factors and neurotransmitters are synthesized and processed, and how (...) their signals are recognized, amplified and transmitted by intracellular signaling pathways in the target cells. Here, we discuss diverse aspects of the detailed mechanisms involved in secretion based on mathematical models. The models range from stochastic ones describing the trafficking of secretory vesicles to deterministic ones investigating the regulation of cellular processes that underlie hormonal secretion. In all cases, the models are closely related to experimental results and suggest theoretical predictions for the secretion mechanisms. (shrink)

We study the SIS and SIRI epidemic models discussing different approaches to compute the thresholds that determine the appearance of an epidemic disease. The stochastic SIS model is a well known mathematical model, studied in several contexts. Here, we present recursively derivations of the dynamic equations for all the moments and we derive the stationary states of the state variables using the moment closure method. We observe that the steady states give a good approximation of the quasi-stationary states of the (...) SIS model. We present the relation between the SIS stochastic model and the contact process introducing creation and annihilation operators. For the spatial stochastic epidemic reinfection model SIRI, where susceptibles S can become infected I, then recover and remain only partial immune against reinfection R, we present the phase transition lines using the mean field and the pair approximation for the moments. We use a scaling argument that allow us to determine analytically an explicit formula for the phase transition lines in pair approximation. (shrink)

This paper presents a theory of reasoning with evidence in order to determine the facts in a criminal case. The focus is on the process of proof, in which the facts of the case are determined, rather than on related legal issues, such as the admissibility of evidence. In the literature, two approaches to reasoning with evidence can be distinguished, one argument-based and one story-based. In an argument-based approach to reasoning with evidence, the reasons for and against the occurrence of (...) an event, e.g., based on witness testimony, are central. In a story-based approach, evidence is evaluated and interpreted from the perspective of the factual stories as they may have occurred in a case, e.g., as they are defended by the prosecution. In this paper, we argue that both arguments and narratives are relevant and useful in the reasoning with and interpretation of evidence. Therefore, a hybrid approach is proposed and formally developed, doing justice to both the argument-based and the narrative-based perspective. By the formalization of the theory and the associated graphical representations, our proposal is the basis for the design of software developed as a tool to make sense of the evidence in complex cases. (shrink)

I characterize the main approaches to the moral consideration of children developed in the light of the argument from 'marginal' cases, and develop a more adequate strategy that provides guidance about the moral responsibilities adults have towards children. The first approach discounts the significance of children's potential and makes obligations to all children indirect, dependent upon interests others may have in children being treated well. The next approaches agree that the potential of children is morally considerable, but disagree as to (...) whether and why children with intellectual disabilities are morally considerable. These approaches explore the moral significance of intellectual capacities, species membership, the capacity for welfare, and the interests of others. I argue that relationships characterized by reciprocity of care are morally valuable, that both the potential to be in such relationships and the actuality of being in them are morally valuable, and that many children with significant intellectual disabilities have this potential. (shrink)

In this study, we aim to investigate how multinational corporations (MNCs) balance ethical pressures from both the home and host countries. Drawing on theories from institutional theory, international business, and business ethics, we build a theoretical framework to explain the ethical behavior of MNCs. We apply the institutional logic concept to examine how MNCs with established logics and principles that have grown in the home country respond to local ethical expectations in the host country. We differentiate the core values from (...) the peripheral components of a MNC’s institutional logic and propose that a MNC will pursue distinctive ethical strategies under different scenarios and choose the “right” configuration of core values and peripheral components that align with institutional environment in host countries. (shrink)

In a recent paper, Peter Singer suggests that some interesting new findings in experimental moral psychology support what he has contended all along—namely that intuitions should play little or no role in adequate justifications of normative ethical positions. Not only this but, according to Singer, these findings point to a central flaw in the method (or epistemological theory) of reflective equilibrium used by many contemporary moral philosophers. In this paper, we try to defend reflective equilibrium from Singer’s attack and, in (...) part, we do this by discussing Singer’s own favoured moral methodology as outlined in his Practical Ethics . Although basing ethics solely on (certain kinds of) intuitions certainly is problematic, we argue, basing it solely on ‘reason’ gives rise to similar problems. The best solution would arguably be one which could strike a balance between the two—but, we suggest, this is precisely what reflective equilibrium is all about. (shrink)

G. A. Cohen’s Rescuing Justice and Equality proposes that both concepts need rescuing from the work of John Rawls. Especially, it is concerned with Rawls’ famous second principle of justice according to which social primary goods should be distributed equally unless an unequal distribution is to the benefit of the worst off. The question is why this would ever be necessary if all parties are just. Cohen and I agree that Rawls cannot really justify inequalities on the basis given. But (...) he also thinks equality is the correct analysis of justice, though he provides no actual direct arguments for this. He does, however, provide a striking analytical argument claiming that fundamental principles of justice must be fact insensitive, and that Rawls’s view of justice violates this requirement. I argue that the requirement is itself misconceived and that principles of justice cannot possibly be fact insensitive in the sense developed by Cohen. Few philosophers share this view of Cohen’s—which I argue is due to several conceptual mistakes. With these ironed out, the contractarian view, broadly speaking, is seen to be plausible and powerful. Meanwhile Cohen appears to embrace intuitionism, a stance that cannot possibly be acceptable in social philosophy. In the end, Cohen is successful in arguing that Rawls cannot have what he wants, but neither is Cohen successful in claiming that justice is equality. (shrink)

We first discuss Michael Dummett’s philosophy of mathematics and Robert Brandom’s philosophy of language to demonstrate that inferentialism entails the falsity of Church’s Thesis and, as a consequence, the Computational Theory of Mind. This amounts to an entirely novel critique of mechanism in the philosophy of mind, one we show to have tremendous advantages over the traditional Lucas-Penrose argument.

“Van den Belt recently examined the notion that synthetic biology and the creation of ‘artificial’ organisms are examples of scientists ‘playing God’. Here I respond to some of the issues he raises, including some of his comments on my previous discussions of the value of the term ‘life’ as a scientific concept.”.

Whether nanotechnology is ethically unique and “nanoethics” should be treated as a field in its own right remain important, contested issues. This essay seeks to contribute to the debates on these issues by exploring several foundational questions about the relationship of ethics and nanotechnology. Ethical issues related to nanotechnology exist and adoption of a defeasible presumption that such issues amount to old ethical wine in new technological bottles appears justified. Such issues are not engendered solely by intrinsic features of the (...) nanotechnology field, but also by contingent features of the social contexts in which work in the field unfolds. The sets of factors that engender ethical issues related to nanotechnology are combinations of social-contextual and technical elements. While there do not appear to be any qualitatively new nanotechnology-related ethical issues, nanotechnology is different, ethically, from other fields of technical inquiry in at least two ways. To avoid diluting ethical concern about nanotechnology and revival of the noxious notions of autonomous technology and technological determinism, thinking, writing, and speaking about ‘nanoethics’ should yield to thinking, writing, and speaking about ‘ethical issues related to nanotechnology in society.’ Finally, nanotechnology practitioners should become familiar with the ethical dimension of their work. (shrink)

In this paper I defend the view that a zygote is a human from the fission objection that is widely thought to be decisive against the view. I do so, drawing upon a recent discussion of this issue by John Burgess, by explaining in detail the metaphysical position the proponent of the view should adopt in order to rebut the objection.

How can an incomplete and uncertain model of the environment be used to perceive, infer, decide and act efficiently? This is the challenge that both living and artificial cognitive systems have to face. Symbolic logic is, by its nature, unable to deal with this question. The subjectivist approach to probability is an extension to logic that is designed specifically to face this challenge. In this paper, we review a number of frequently encountered cognitive issues and cast them into a common (...) Bayesian formalism. The concepts we review are ambiguities, fusion, multimodality, conflicts, modularity, hierarchies and loops. First, each of these concepts is introduced briefly using some examples from the neuroscience, psychophysics or robotics literature. Then, the concept is formalized using a template Bayesian model. The assumptions and common features of these models, as well as their major differences, are outlined and discussed. (shrink)

Cancer is a complex disease, necessitating research on many different levels; at the subcellular level to identify genes, proteins and signaling pathways associated with the disease; at the cellular level to identify, for example, cell-cell adhesion and communication mechanisms; at the tissue level to investigate disruption of homeostasis and interaction with the tissue of origin or settlement of metastasis; and finally at the systems level to explore its global impact, e.g. through the mechanism of cachexia. Mathematical models have been proposed (...) to identify key mechanisms that underlie dynamics and events at every scale of interest, and increasing effort is now being paid to multi-scale models that bridge the different scales. With more biological data becoming available and with increased interdisciplinary efforts, theoretical models are rendering suitable tools to predict the origin and course of the disease. The ultimate aims of cancer models, however, are to enlighten our concept of the carcinogenesis process and to assist in the designing of treatment protocols that can reduce mortality and improve patient quality of life. Conventional treatment of cancer is surgery combined with radiotherapy or chemotherapy for localized tumors or systemic treatment of advanced cancers, respectively. Although radiation is widely used as treatment, most scheduling is based on empirical knowledge and less on the predictions of sophisticated growth dynamical models of treatment response. Part of the failure to translate modeling research to the clinic may stem from language barriers, exacerbated by often esoteric model renderings with inaccessible parameterization. Here we discuss some ideas for combining tractable dynamical tumor growth models with radiation response models using biologically accessible parameters to provide a more intuitive and exploitable framework for understanding the complexity of radiotherapy treatment and failure. (shrink)

Dusky groupers ( Epinephelus marginatus ) are characterized by a complex sex allocation strategies and overexploitation of bigger individuals. We developed an individual based model to investigate the long-term effects of density dependence on grouper population dynamics and to analyze the variabilities of extinction probabilities as a result of interacting mortalities at different life stages. We conduct several simulations with different forms of sex allocation functions and different combinations of mortality rates. The model was parametrized using data on dusky grouper (...) populations from the literature. The most important insights produced by this simulation study are that density dependence of sex allocation is an evolutionarily stable strategy, increases the population biomass, mitigates the effect of the removal of large male and indicates a need for protection of females and flexible stages. (shrink)

Optimal foraging theory has been criticized for underestimating patch exploitation time. However, proper modeling of costs not only answers these criticisms, but it also explains apparently irrational behaviors like the sunk-cost effect. When a forager is sure to experience high initial costs repeatedly, the forager should devote more time to exploitation than searching in order to minimize the accumulation of said costs. Thus, increased recognition or reconnaissance costs lead to increased exploitation times in order to reduce the frequency of future (...) costs, and this result can be used to explain paradoxical human preference for higher costs. In fact, this result also provides an explanation for how continuing a very costly task indefinitely provides the optimal long-term rate of gain; the entry cost of each new task is so great that the forager avoids ever returning to search. In general, apparently irrational decisions may be optimal when considering the lifetime of a forager within a larger system. (shrink)

Toxic plants have been used for years in agriculture to control major crop pests. However, the continuous exposure of targeted pests to toxins dramatically increases the rate of resistance evolution (Gassman et al. in Annu Rev Entomol 54:147–163, 2009a ; Tabashnik et al. Nat Biotechnol 26:199–202, 2008 ). To prevent or delay resistance, non toxic host plants can be used as refuges. Our study considers spatial and temporal refuges that are respectively implemented concurrently or alternatively a toxic crop. A conceptual (...) model based on impulsive differential equations is proposed to describe the dynamics of the susceptible and resistant pest populations over time. The mathematical study enlightens threshold values of the proportion of the spatial refuge and key parameters that should help to understand evolution of pest resistance to toxic crop. (shrink)

In this work, we compare two global approaches which are usually considered as completely unconnected one with the other. The former is Thom’s topology and the latter is Jung’s psychology. More precisely, it seemed to us interesting to adapt some morphologies of Thom’s catastrophe theory to some Jung’s notions. Thus, we showed that the swallowtail, which is one of these morphologies, was able to describe geometrically the structural organisation of the psyche according to Jung, with its collective unconscious, personal unconscious (...) and conscious. Moreover, we have correlated this morphology with Jung’s evolutive processes like individualisation and individuation. These comparisons incited us to think that some morphologies of Thom’s catastrophe theory are the geometrical dealing of Jung’s archetypes. (shrink)

Libertarianism and the shareholder model of corporate responsibility have long been thought of as natural bedfellows. In a recent contribution to the Journal of Business Ethics , Brian Schaefer goes so far as to suggest that a proponent of shareholder theory cannot coherently and consistently embrace any moral position other than philosophical libertarianism. The view that managers have a fiduciary obligation to advance the interests of shareholders exclusively is depicted as fundamentally incompatible with the acknowledgement of natural positive duties – (...) duties to aid others that have not been acquired by some prior commitment or transaction. I argue that Schaefer is mistaken. Positive duties are incompatible with the shareholder model only if we must contribute to their fulfilment in the corporate context; only if we have some reason to think that it is not possible or not permissible to discharge these obligations entirely in our private lives or through our various other roles and capacities. But we have no good reason to accept this. I argue that individuals are presumptively free to decide how and when to discharge their positive duties, and that buying shares does not cause this presumption to lapse. Hence a non-libertarian moral theory can be held without incoherence by a proponent of the shareholder model. (shrink)

In this article I reply to comments made by Agustin Vicente and Giridhari Lal Pandit on Science and the Pursuit of Wisdom (McHenry 2009 ). I criticize analytic philosophy, go on to expound the argument for the need for a revolution in academic inquiry so that the basic aim becomes wisdom and not just knowledge, defend aim-oriented empiricism, outline my solution to the human world/physical universe problem, and defend the thesis that free will is compatible with physicalism.

The standard economic theory of choice is extended to accommodate a particular form of akratic choice. The empirical content of the new theory is fully characterized. A characterization of revealed akratic choice, in terms of observable choice only, is also provided. These results are consistent with the viewpoint that akrasia is a concept that can be empirically substantiated.

Nietzsche's model of eternal return triggers a drama of affirmation, the overcoming of a simple miming of our ancestors in favour of an active participation in the counter-actualisation of hidden potentials in recurrent events. Based on a close study of Zarathustra's struggle to free himself from a suffocating nihilism, the paper focuses on the revelatory caesura that ushers in what Deleuze calls the third synthesis of time, a time of ‘doing’ rather than reflection.

Critical responses to Wide Sargasso Sea have seized upon Rhys's novel as an exemplary model of writing back. Looking beyond the actual repetitions which recall Brontë’s text, I explore Rhys's novel as an expression of virtual difference and becomings that exemplify Deleuze's three syntheses of time. Elaborating the processes of becoming that Deleuze's third synthesis depicts, Antoinette's fate emerges not as a violence against an original identity. Rather, what the reader witnesses is a series of becomings or masks, some of (...) which are validated, some of which are not, and it is in the rejection of certain masks, forcing Antoinette to become-Bertha, that the greatest violence lies. (shrink)

The popularity of Deleuze and Guattari is an undeniable precedent in current theoretical exchanges, and it could be stated without much contention that one's theoretical positioning must at some point deal with the salient conceptual offerings of Deleuze and Guattari, especially their double-opus, Anti-Oedipus and A Thousand Plateaus wherein a wealth of critique abounds. However, the significant trends concerning Deleuze and Guattari ‘scholarship’ may be jeopardised by the (ab)use of certain conceptual themes and methods in their work that are distorted (...) and employed by big business looking to secure their legacies of power by means of a control mechanism that looks to subjugate an entire world by means of (to borrow a term from Mihai Spariosu) ‘globalitarianism’. Our aim here will be to use McDonald's Corporation as an example of how the theoretical offerings of Deleuze and Guattari have been indirectly and hastily deployed for corporate ends, how these attempts are counter-Deleuzian, and to answer at least one of Žižek's criticisms against Deleuze. (shrink)

Baumgarten's Enlightenment Aesthetica provides an important philosophical analogon to Deleuze's alignment of the ‘logic of sense’ and the ‘logic of sensation’. By linking serious reason with its ‘other’, frivolous feeling, the book greatly influenced Herder and the Romantic movement. Baumgarten called aesthetics ‘logic's younger sister’. Like Deleuze he propagates nothing less than the ‘becoming-girl’ of philosophy.

Metamorphosis is a sudden change, a ‘becoming-other’ in life or in philosophical perspective. A revelatory event initiates in a double manner the move from Heidegger's futile search for a transcendental IT that delivers perceptible beings to the confident positing of Deleuze's transcendental empiricism, suffused with the IF of incorporeal sense. In the process Deleuze dramatically enacts his personal connection between sense (Sinn) and being (Sein).

This essay suggests an approach to the reading of Deleuze and Guattari's A Thousand Plateaus, grasped as a philosophical event that is as directly pragmatic as it is abstract and speculative. A series of key Deleuzo-Guattarian concepts (in particular, multiplicity, minority and double becoming) are staged from the angle of philosophy's relation to its disciplinary outside. These concepts are then transferred to the relation between the authors' philosophical lineage and the new cultural outside into which the Chinese translation will propel (...) their thought. Emphasis is placed on the writing – and reading – of philosophy as a creative act of collective import and ethical force. (shrink)

In this paper I argue that Deleuze's ‘thinking with’ Whitehead gives access to a range of novel conceptual resources that offer a route out of phenomenology and back to life, a movement beyond intentionality and back to things ‘in their free and wild state’. I lay out four conceptual and methodological markers (there are many more) – creativity, event, prehension, empiricism – that characterise Deleuze's metaphysics and provide a guide for showing how these develop through a sustained becoming with Whitehead. (...) I conclude by looking at Deleuze and Guattari's use of the term most famously associated with Whitehead: the concept of ‘process’. (shrink)

Deleuze and Whitehead are both centrally concerned with the problem of how to reconcile the emergence of the New with the evident continuity and uniformity of the world through time. They resolve this problem through the logic of what Deleuze calls ‘double causality’, and Whitehead the difference between efficient and final causes. For both thinkers, linear cause-and-effect coexists with a vital capacity for desire and decision, guaranteeing that the future is not just a function of the past. The role of (...) desire and decision can be seen in recent developments in biology. (shrink)

It is argued in this paper that recent work on immanence and transcendence in Whitehead scholarship, notably by Basile and Nobo, provides helpful guidelines and ideas for work on problems regarding immanence in Deleuze's philosophy. By following arguments on theism and naturalism in the reception of Whitehead, it argues that Deleuze's philosophy depends on reciprocal relations between that actual and the virtual such that they cannot be considered as separate without also being incomplete. It is then shown that Deleuze's philosophy (...) allows for metaphysical terms such as ‘pure’ without having to concede a separate and self-sufficient pure realm. (shrink)

The essay consists of three parts: the first argues that Deleuze's moral philosophy in The Logic of Sense provides an ethical model of counter-actualisation; the second shows how three different practices of art therapy offer a means to effect this counter-actualisation and thereby demonstrate the restorative power of art; the third explores how such a power might form part of what Guattari calls the ‘ethico-aesthetic paradigm’ (Guattari 1995).

This paper inquires into the nexus between the Deleuzian critical-clinical hypothesis and its literary instantiation in Beckett, with a focus on How It Is (1964) and Worstward Ho (1983b). I propose to read the interruptions in style symptomatically, and stuttering language in Beckett as liminal expression, thus tracing the flows and breaks of desire which Deleuze theorises in the sense of a symptomatological unconscious. The schizoid style as liminal expression exemplified in Beckett's work will be read as marking transit stages (...) in the process of becoming which invites taking it as a proper language of the body without organs. (shrink)

In 1886, Nietzsche wrote: ‘I am still waiting for a philosophical doctor in the extraordinary sense of the term’: a doctor who pursues not truth, but an exceptional kind of health. Nietzsche's will to health, his theory of drive organisation, and his insistence that the philosopher put himself at risk, all work together in his overall project, which consists of taking up the very role of the highly revalued physician for whom he is waiting. Deleuze and Guattari engage this same (...) task of a revalued doctoring in the Capitalisme et Schizophrénie books, attacking the disease of oedipality and providing instructions for the deorganisation of the organism as self-cure. Offering tips on this radical treatment, they employ the figure of the hypochondriac to show how it can fail. Both Nietzsche and Deleuze and Guattari perform a revaluation of health as a condition of chronic critique, a condition that wraps itself around illness to keep itself critical. (shrink)

This article offers two commentaries on two of Félix Guattari's essays from Chaosmosis: ‘The New Aesthetic Paradigm’ and ‘Schizoanalytic Metamodelisation’. The first commentary attends specifically to how Guattari figures the infinite/finite relation in relation to what he calls the three Assemblages (pre-, extant, and post-capitalism) and then even more specifically to the mechanics of this relation – or folding – within the third ‘processual’ Assemblage or new aesthetic paradigm of the essay's title. The second commentary looks at what Guattari has (...) to say about this paradigm in relation to subjectivity, that is, the schizoanalytic programme or practice of metamodelling. Here the focus is on the turn to asignifying semiotics – but also the importance of signifying material and indeed the actual material scene of encounter – in any programme for the production of subjectivity (it is here also that the symptom makes its appearance). (shrink)

This article explores the contemporary ‘symptomatic’ position of radically excluded social groups through a critical engagement with the work of Žižek, Deleuze and Guattari. It begins with a presentation and critique of Žižek's theorisation, arguing that while he correctly perceives the symptomatic status of certain social groups and issues, his approach is insufficiently radical because of its reliance on inappropriate structuralist assumptions and metaphysical negativity. It then compares this theory to Deleuze and Guattari's theory of minoritarianism, viewed as a similar (...) attempt to engage with the symptomatic effects of exclusion. A political trajectory is derived from Deleuze and Guattari's theory which reconceives the politics of the excluded in terms of emancipatory lines of flight rather than gestures of identification. The article then explores social movements arising from the growing phenomenon of global exclusion in neoliberalism, looking at examples such as Somalia and Bolivia, and proposing autonomy and networked approaches to social life as responses to exclusion which reconfigure social space in affirmative ways. (shrink)

If the dominant ethico-philosophical thinking of responsibility in the West is founded upon, or tied to a certain figure of death, it is because this ethical notion of responsibility is also a certain econo-onto-thanatology. Here the notion of the gift to the other is always already inscribed within a certain economic equivalence of value, or an economic determination of temporality as the geometric figure of the circle, or a certain economy of the experiences of abandonment and mourning, through which the (...) event-character of the gift, its excess and its infinite surplus is economised, reduced, repressed, or even annulled. Reading Jacques Derrida's deconstruction of this econo-onto-thanatology, and relating him to Schelling, Heidegger, Levinas and Kierkegaard, this article attempts to reveal this very complex relationship of the ethical notion of responsibility and the gift with death, in order to think anew – in the spirit of Derrida – a responsibility in relation to mourning and abandonment, and in relation to a death that does not figure in any figuration of self-figuration and self-presence, but – to speak with Maurice Blanchot – as interminable, incessant worklessness, as endless ruination and abandonment of itself. This impossible aporia of the notion of responsibility is itself a dis-figuring of death, which is also an aporia of an instant which escapes, in its event character, the geometric figure of time as circle. (shrink)

‘The Final “Thank You”’ uses the work of Jacques Derrida and Friedrich Nietzsche to think the occasion of the 1995 rugby World Cup, hosted by the newly democratic South Africa. This paper deploys Nietzsche's Zarathustra to critique how a figure such as Nelson Mandela is understood as a ‘Superman’ or an ‘Overhuman’ in the moment of political transition. The philosophical focus of the paper, however, turns on the ‘thank yous’ exchanged by the white South African rugby captain, François Pienaar, and (...) the black president at the event of the Springbok victory. It is the value, and the proximity and negation, of the ‘thank yous’ – the relation of one to the other – that constitutes the core of the article.1. (shrink)

A poem encrypts, though not predictably, the effects it may have when at some future moment, in another context, it happens to be read and inscribed in a new situation, in ‘an interpretation that transforms the very thing it interprets’, as Jacques Derrida puts it in Specters of Marx. In Wallace Stevens's ‘The Man on the Dump’ (1942), we are told: ‘The dump is full/Of images’. The poem's movement is itself a complex temporal to and fro that aims to repudiate (...) and even annihilate these images. This renunciation leaves the man on the dump ‘The Latest Freed Man’, as the title of another Stevens poem puts it. Like Walter Benjamin's Angel of History, he has his back toward history and has rejected its images in ‘disgust’ in order to face toward a future that will, he hopes, be purified of ideology. Yet Stevens knows that more such images will come and will need in their turn to be rejected and junked, in an endless task of purification. In a now impossibly outdated way, Stevens nevertheless wanted the poet – that is, himself, the man on the dump – to be the begetter of a new ideology, or a new fiction that would, in a powerful speech act, replace all those outworn images on the dump. In the context of potentially catastrophic climate change (as the result of something like a global auto-immune disorder), the second part of the essay complements this commentary on the poem with a free reading; a performative reading, reading as work or as oeuvre that does something with words, for which Jacques Derrida calls. This reading sees Stevens's text as somehow the proleptic foretelling of a present situation. Such future chiming is also, it is argued, a sign to sign relation, an anticipatory allegory or prophecy, or, perhaps, a miniature apocalypse in the etymological sense of an enigmatic unveiling of what has not yet happened. (shrink)

In the interview conducted with Giovanna Borradori, after the attack on the World Trade Centre, in September 2001, Jacques Derrida is pressed to specify connections between his own thinking, Heidegger's deployment of the term ‘event’, and the use of the term ‘event’ to pick out the unprecedented character of that attack. Derrida intimates that the attack is, perhaps, not as unprecedented, not the ‘wholly other’ which it has been framed as being. His reading of that event is to move it (...) from a naive status, as ‘wholly other’, to a philosophically inflected thinking of the political, in the mode of the ‘wholly otherwise’, that is, in a sense to be made out here, whereby politics takes precedence over physics, as the originator of the basic components to be thought, and whereby the future takes precedence over the past, as the site at which what is arrives. The principal aim of this article is to consider how to think this counter-factual ontology, in the mode of a future anteriority. The article will set out Heidegger's move from affirming a fundamental ontology, of Dasein, to an ontology in parentheses (vom Ereignis) but will show how both of these are objectionable, on different counts, to Derrida and to Levinas. Derrida explores the options of supplementing an inadmissible thetic stance, with respect to the future, and therefore with respect to what there is, by developing the notion of the prosthetic, that which stands in for the impossible, timelessly asserted thesis. Levinas invents a new mode of phenomenology which opens a route into this ‘wholly otherwise’. These two strands of enquiry contribute to an analysis displacing these versions of ontology, in favour of a reformulation of political ontology. A subsidiary aim is to clarify Derrida's reservations with respect to the Heideggerian notion of the event. These reservations about Heidegger's usage throw light on his reluctance to deploy the term, within an analysis of the destruction of the World Trade Centre. (shrink)

This article inquires into a paradoxical position held by the concept of ‘nature’ in Derrida's thought. While a pivotal part of his project of deconstruction is devoted to a critique of the metaphysical privileging of nature over its others (technics, culture, and so on), the same project also aims at dismantling the hierarchical binary opposition of man/animal. Insofar as the term ‘animal’ or ‘animality’ to a large extent overlaps with nature, these two strands of his thought appear to stand in (...) a significant tension with each other. I explore this conceptual tension by re-examining Derrida's early critique of the notion of nature – specifically in his reading of Rousseau – in conjunction with his later engagement with the question of animality. As my reading shows, deviating from his early approach, his later work indicates the way in which animal others (and, by extension, all living and non-living others) are indeed constituted by supplementarity and yet, in their irreplaceable singularity, exceed the very structure of supplementarity. This opens up a new way of conceiving nature, no longer as originary presence nor simply as an effect of supplementary play, but in terms of the aporetic relation between supplementarity and what may be termed ‘the unsupplementable’. (shrink)

In this paper, I argue that we need to re-address the issue of freedom as it relates to democracy and critical practice. My argument is drawn out of Derrida's deconstructive reading of Jean-Luc Nancy's The Experience of Freedom which proposes freedom in ontological terms as an experience of indeterminate openness that must be thought prior to any freedom of the self. I show how Derrida's reading of Nancy's text is itself a re-enactment of the freedom that Derrida finds wanting in (...) Nancy's text, but which, by that very fact, affirms the power of critique in its capacity to think freely. The urgency of the thought of freedom is not something that can be avoided, but is itself the fact of critique in its thinking of democracy as a possibility, as something that might come about, as distinct from an already accomplished idea. To think in this way is, I argue, a matter of virtue, that is, of being free, as the virtue of critique and its capacity to act decisively, thereby bringing something forth by risking what it already is, in the absolute possibility of it not being. (shrink)

This essay considers the ‘limit’ in Derrida's work from the early consideration of linearisation in ‘Ousia and Grammē’ to the conception of limit as aporia in Aporias. Developing Derrida's tripartite definition of the limit via a reading of Being and Time as closure, border and demarcation, the essay then considers the earlier presentation of limit in Heidegger as temporal primordiality. Developing the metaphysics of line as presentation of presence in terms of Aristotle's aporetics of time as line, the circle is (...) then considered as representing the closed field of presence and its definition via the negation of being's other. This leads to Derrida's early, foundational definition of the law of metaphysics as submission-subtraction, and his proposal of the trace as an alternate way of thinking spatially about being, nonbeing and difference. The second half of the essay then proposes a series of alternative ways of thinking geometrically to those of the traditional metaphysics of point-line-circle topography. Thus topology is proposed as an alternate means of thinking field enclosure, similarity and difference. The figures of the double torus and mathematical limit are proposed as a potential alternative geometry for Western thought. Finally the essay concludes on the apotropaic logic of the problem which echoes that of the trace and is developed in contradistinction to the aporia. Proposing the edge as an interim state between the metaphysics of the line and the deconstructive impossibilities of the aporia, it suggests that the limits of metaphysics are to be found not merely in the apotropaic law of submission-subtraction, but also across alternate geometries which facilitate the bringing together of the two central elements of the totality of Derrida's thinking the limit: différance and singularity. (shrink)

This article recalls Derrida's reading of Levinasian ethics as a discourse of the other, particularly in ‘Violence and Metaphysics’, in order to re-elaborate Derrida's own account of the other's heterogeneity, notably in light of critiques of deconstruction's thinking of difference, alterity, and the unconditional. At stake here is the precise meaning of what may be termed wholly other; or, better still, the specific nature of the arguments about the question of the other from among Derrida's earlier texts, which must be (...) recalled amidst any appeal to absolute alterity, especially of the kind frequently found in Derrida commentary today. The article suggests that, in the process of Derrida reading Levinas, the radical alterity of the other is sustained in ‘Violence and Metaphysics’ principally in terms of the legitimacy (or ‘discipline’) of a question that arises only on the hither side of a phenomenology of the other – a phenomenology that emerges, nonetheless, as its unacknowledged ground. Thus, in contrast to Levinasian thought (and yet also in deeper affinity with what we might term, for Derrida, its still obscured originality), deconstruction's discourse of the other opens onto the wholly other not simply as the ‘beyond’ or the ‘outside’ of phenomenology's limits, but only at the point where the phenomenological gives way in something like a double sense. (shrink)

Miranda Fricker's important study of epistemic injustice is focussed primarily on testimonial injustice and hermeneutic injustice. It explores how agents' capacities to make assertions and provide testimony can be impaired in ways that can involve forms of distinctively epistemic injustice. My paper identifies a wider range of forms of epistemic injustice that do not all involve the ability to make assertions or offer testimony. The paper considers some examples of some other ways in which injustice can prevent someone from participating (...) in inquiry. (shrink)

In this paper I discuss Plato's conception of expertise as a part of the Platonic theory of a good, successful life (eudaimonia). In various Platonic dialogues, Socrates argues that the good life requires a certain kind of knowledge that guides all our good, beneficial actions: the “knowledge of the good and bad”, which is to be acquired by “questioning ourselves and examining our and others’ beliefs”. This knowledge encompasses the particular knowledge of how to recognize experts in a given technical (...) domain. The central element in Socrates’ account of an expert is what I call the truth-and-caring criterion: an expert has to make seeking the truth and avoiding (avoidable) error her supreme epistemic goal and she has to make caring for common goods the supreme goal of practising her expertise. (shrink)

The standard interpretation of Hume on testimony takes him to be a reductionist; justification of beliefs from testimony ultimately depends on one's own first-person experience. Yet Hume's main discussions of testimony in the Treatise and first Enquiry suggest a social account. Hume appeals to shared experience and develops norms of belief from testimony that are not reductionist. It is argued that the reductionist interpretation rests on an overly narrow view of Hume's theory of ideas. By attending to such mechanisms of (...) the imagination as abstraction and fictions, it is shown that Hume's theory of ideas does not forestall a non-reductionist social epistemology. (shrink)

It has been argued that Hume's account of testimony is seriously inadequate: an autonomous knower of the sort Hume defends cannot, through simple inductive methods, justify accepting another's testimony as true. This conclusion is no doubt correct. But Hume does not defend the idea of an autonomous knower, nor does he defend relying upon simple inductive methods. An examination of Hume's critique of Descartes’ method of doubt shows him as a defender of what might be called the responsible knower, and (...) reveals the sophistication of the inductive methods he wishes to defend. It is shown that Hume can and does use these methods to justify accepting the testimony of others. (shrink)

I describe two concepts of epistemic injustice. The first of these concepts is explained through a critique of Alvin Goldman's veritistic social epistemology. The second is closely based on Miranda Fricker's concept of epistemic injustice. I argue that there is a tension between these two forms of epistemic injustice and tentatively suggest some ways of resolving the tension.

This paper examines several recent positions on the nature of testimony and argues that all are unsatisfactory. The first section argues against narrow, broad, and moderate views. The second section argues against Jennifer Lackey's recent analysis of testimony. Her position is supposed to avoid the problems of the prior accounts, but still suffers from two problems. After discussing those problems, this paper offers and defends an alternative analysis of testimony.

In this paper I respond to three commentaries on Epistemic Injustice: Power and the Ethics of Knowing. In response to Alcoff, I primarily defend my conception of how an individual hearer might develop virtues of epistemic justice. I do this partly by drawing on empirical social psychological evidence supporting the possibility of reflective self-regulation for prejudice in our judgements. I also emphasize the fact that individual virtue is only part of the solution – structural mechanisms also have an essential role (...) in combating epistemic injustice. My response to Goldberg principally concerns my perceptual account of the epistemology of testimony, which I defend as being both well-motivated and best categorized as a species of non-inferentialism. I also explain its relation to the reductionism/non-reductionism contrast, and defend my resistance to casting it as any kind of default view. In response to Hookway, I contrast discriminatory with distributive forms of epistemic injustice, and defend the basic taxonomy I present in the book, which casts testimonial and hermeneutical injustice as the two fundamental discriminatory forms of epistemic injustice. (shrink)

Miranda Fricker's Epistemic Injustice is a wide-ranging and important book on a much-neglected topic: the injustice involved in cases in which distrust arises out of prejudice. Fricker has some important things to say about this sort of injustice: its nature, how it arises, what sustains it, and the unhappy outcomes associated with it for the victim and the society in which it takes place. In the course of developing this account, Fricker also develops an account of the epistemology of testimony. (...) Focusing my attention on that account, my central claims are two. First, at least some of Fricker's arguments against existing (inferentialist and non-inferentialist) views in the epistemology of testimony are less than fully persuasive, and the (non-inferentialist) view she ends up endorsing is not all that different from the views she criticizes. Second, her reasons for harboring doubts regarding the role of a principle of default entitlement within a non-inferentialist account are not persuasive. Neither of these claims affects the overall argument Fricker is trying to run. Rather, they suggest that Fricker may have picked more fights than she needed to in the epistemology of testimony. If so, we have reason to detach Fricker's important work on epistemic injustice from some of the details of the story she tells regarding the epistemology of testimony. (shrink)

This paper explores the significant strengths of Fricker's account, and then develops the following questions. Can volitional epistemic practice correct for non-volitional prejudices? How can we address the structural causes of credibility-deflation? Are the motivations behind identity prejudice mostly other-directed or self-directed? And does Fricker aim for neutrality vis-à-vis identity, in which case her account conflicts with standpoint theory?

Throughout his career Hutcheson praised the achievements of the pagan moral philosophers of classical antiquity, the Stoics in particular. In recent secondary literature his moral theory has been characterized as a synthesis of Christianity and Stoicism. Yet Hutcheson's attitude towards the ancient heathen moralists was more complex and ambivalent than this idea of ‘Christian Stoicism’ suggests. According to Hutcheson, pagans who did not believe in Christ and who had never even heard of him were capable of virtue, and even, he (...) asserted controversially, of salvation. Yet Hutcheson did not think that the virtue of pagans, let alone their salvation, was a result of their moral philosophical theories. Hutcheson's applause for pagan philosophy as an intellectual achievement did not indicate a commitment to it, but was based on a detached and cautious evaluation that involved significant reservations concerning the truth and usefulness of pagan ethical thought. (shrink)

This article provides a re-evaluation of David Hume's intensive reading of the classics at an important moment of his literary and intellectual career. It sets out to reconstruct the extent and depth of this reading as well as the uses – scholarly, philosophical and polemical – to which Hume put the information he had gathered in the course of it. The article contends that Hume read the classics against the grain to collect data on a wide range of cultural information (...) which he could utilise for a number of literary and philosophical projects he was engaged in during the early 1750s. This reading soon came to pervade almost all aspects of Hume's literary activities of that period and resulted in what is here described as a fragmentary history of classical antiquity. As a result Hume's reading of the classics emerges from this article as both more extensive and more significant than has so far been acknowledged. (shrink)

Adam Smith's ethics have long been thought to be much closer to the Stoic school than to any other school of the ancient world. Recent scholarship however has focused on the fact that Smith also appears to be quite close to Aristotle. I shall attend to Smith's deployment of a version of the doctrine of the mean, shall show that it is quite close to Aristotle's, shall demonstrate that in its detailed application it is seriously at odds with Stoic teaching (...) on the passions, and particularly with their teachings on anger, and shall conclude that on a central issue of ethics Smith is a good deal closer to Aristotelian than to Stoic thinking. (shrink)

The Cambridge Platonists were a group of religious thinkers who attended and taught at Cambridge from the 1640s until the 1660s. The four most important of them were Benjamin Whichcote, John Smith, Ralph Cudworth, and Henry More. The most prominent sentimentalist moral philosophers of the Scottish Enlightenment – Hutcheson, Hume, and Adam Smith – knew of the works of the Cambridge Platonists. But the Scottish sentimentalists typically referred to the Cambridge Platonists only briefly and in passing. The surface of Hutcheson, (...) Hume, and Smith's texts can give the impression that the Cambridge Platonists were fairly distant intellectual relatives of the Scottish sentimentalists – great great-uncles, perhaps, and uncles of a decidedly foreign ilk. But this surface appearance is deceiving. There were deeply significant philosophical connections between the Cambridge Platonists and the Scottish sentimentalists, even if the Scottish sentimentalists themselves did not always make it perfectly explicit. (shrink)

Without questioning Hutcheson's general affinities with the Stoics, this article focuses on two important differences in moral psychology that show the limits of the appropriation of Stoicism in Hutcheson's ethics of benevolence. First, Hutcheson's distinction between calm affections and violent passions does not fully match with the Stoic distinction between constantiæ and perturbationes, since the emotion of sorrow remains in Hutcheson's table of the calm affections. As far as sorrow as a public affection is concerned, this first point is tied (...) to a second point, which Hutcheson highlights himself: His conception of virtue as benevolence and the general importance of the public affections seem to be in conflict with a Stoic conception of virtue as an internal good, since the happiness of others, which is the object of both Hutchesonian benevolence and the public sense, is external for the Stoics. (shrink)

We briefly overview some of the historical landmarks on the path leading to the reduction of the number of logical connectives in classical logic. Relying on the duality inherent in Boolean algebras, we introduce a new operator ( Nallor ) that is the dual of Schönfinkel’s operator. We outline the proof that this operator by itself is sufficient to define all the connectives and operators of classical first-order logic ( Fol ). Having scrutinized the proof, we pinpoint the theorems of (...) Fol that are needed in the proof. Using the insights gained from the proof, we show that there are four binary operators that each can serve as the only undefined logical constant for Fol . Finally, we show that from every n -ary connective that yields a functionally complete singleton set of connectives two Schönfinkel-type operators are definable, and all the latter are so definable. (shrink)

Internal sets and the Boolean algebras of the collection of the internal sets are of central importance in non-standard analysis. Boolean algebras are the algebraization of propositional logic while the logic applied in non-standard analysis (in non-standard stochastics) is the first order or the higher order logic (type theory). We present here a first order logic algebraization for the collection of internal sets rather than the Boolean one. Further, we define an unusual probability on this algebraization.

In this paper, we propose an extension of free pregroups with lower bounds on sets of pregroup elements. Pregroup grammars based on such pregroups provide a kind of an algebraic counterpart to universal quantification over type-variables. In particular, we show how our pregroup extensions can be used for pregroup grammars expressing natural-language coordination and extraction.

In the following we show that general property S considered by Cowen [1], Cowen and Kolany in [3] and earlier by Cowen in [2] and Kolany in [4] as hypergraph satisfiability, can be constructively reduced to (3, 2) · SAT , that is to satisfiability of (at most) triples with two-element forbidden sets. This is an analogue of the“classical” result on the reduction of SAT to 3 · SAT.

After defining, for each many-sorted signature Σ = (S, Σ), the category Ter ( Σ ), of generalized terms for Σ (which is the dual of the Kleisli category for , the monad in Set S determined by the adjunction from Set S to Alg ( Σ ), the category of Σ -algebras), we assign, to a signature morphism d from Σ to Λ , the functor from Ter ( Σ ) to Ter ( Λ ). Once defined the mappings (...) that assign, respectively, to a many-sorted signature the corresponding category of generalized terms and to a signature morphism the functor between the associated categories of generalized terms, we state that both mappings are actually the components of a pseudo-functor Ter from Sig to the 2-category Cat . Next we prove that there is a functor Tr Σ , of realization of generalized terms as term operations, from Alg ( Σ ) × Ter ( Σ ) to Set , that simultaneously formalizes the procedure of realization of generalized terms and its naturalness (by taking into account the variation of the algebras through the homomorphisms between them). We remark that from this fact we will get the invariance of the relation of satisfaction under signature change. Moreover, we prove that, for each signature morphism d from Σ to Λ , there exists a natural isomorphism θ d from the functor to the functor , both from the category Alg ( Λ ) × Ter ( Σ ) to the category Set , where d * is the value at d of the arrow mapping of a contravariant functor Alg from Sig to Cat , that shows the invariant character of the procedure of realization of generalized terms under signature change. Finally, we construct the many-sorted term institution by combining adequately the above components (and, in a derived way, the many-sorted specification institution), but for a strict generalization of the standard notion of institution. (shrink)

A first-order theory has the Independence Property provided implies for some i whenever are formulae of a suitable type and ( Q ) is any quantifier sequence. Variants of this property have been noticed for some time in logic programming and in linear programming.