Individual and institutional conflict of interests in biomedical research have becomes matters of increasing concern in recent years. In the United States, the growth in relationships — sponsored research agreements, consultancies, memberships on boards, licensing agreements, and equity ownership — between for-profit corporations and research universities and their scientists has made the problem of conflicts, particularly financial conflicts, more acute. Conflicts can interfere with or compromise important principles and obligations of researchers and their institutions, e.g., adherence to accepted research norms, (...) duty of care to patients, and open exchange of information. Disclosure is a key component of a successful conflict policy. Commitments which conflict with a faculty member's primary obligations to teaching, research, administrative responsibilities, or patient care also need attention. Institutional conflict of interests present different problems, some of which are discussed in an analysis of an actual problem posed by two proposed clinical trials. (shrink)

Disclosure of financial interests in scientific research is the centerpiece of the new conflict of interest regulations issued by the U.S. Public Health Service and the National Science Foundation that became effective October 1, 1995. Several scientific journals have also established financial disclosure requirements for contributors. This paper measures the frequency of selected financial interests held among authors of certain types of scientific publications and assesses disclosure practices of authors. We examined 1105 university authors (first and last cited) from Massachusetts (...) institutions whose 789 articles, published in 1992, appeared in 14 scientific and medical journals. (shrink)

Editors’ Note: As a matter of policy, the editors believe that publishing several reviews of selected texts is a valuable exercise which will enable a cross-section of views to be aired.Copies of this report can be obtained from the Nuffield Council on Bioethics, 28 Bedford Square, London WC1B 3EG, U.K.. The report publishes the recommendation of a Working Party set up in January 1995. Following a wide public consultation, the Working Party prepared its report on xenotransplantation which has been endorsed (...) by the Nuffield Council on Bioethics. (shrink)

Editors’ Note: As a matter of policy, the editors believe that publishing several reviews of selected texts is a valuable exercise which will enable a cross-section of views to be aired.Copies of this report can be obtained from the Nuffield Council on Bioethics, 28 Bedford Square, London WC1B 3EG, U.K. . The report publishes the recommendation of a Working Party set up in January 1995. Following a wide public consultation, the Working Party prepared its report on xenotransplantation which has been (...) endorsed by the Nuffield Council on Bioethics. (shrink)