Search results for 'ELEMENT-BINDING PROTEIN' (try it on Scholar)

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  1.  6
    Syed Hasan Arif (2009). A Ca2+‐Binding Protein with Numerous Roles and Uses: Parvalbumin in Molecular Biology and Physiology. Bioessays 31 (4):410-421.
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  2. John Bickle (2006). Reducing Mind to Molecular Pathways: Explicating the Reductionism Implicit in Current Cellular and Molecular Neuroscience. [REVIEW] Synthese 151 (3):411-434.
    As opposed to the dismissive attitude toward reductionism that is popular in current philosophy of mind, a “ruthless reductionism” is alive and thriving in “molecular and cellular cognition”—a field of research within cellular and molecular neuroscience, the current mainstream of the discipline. Basic experimental practices and emerging results from this field imply that two common assertions by philosophers and cognitive scientists are false: (1) that we do not know much about how the brain works, and (2) that lower-level neuroscience cannot (...)
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  3.  4
    James B. Hurley (1995). Recoverin, a Calcium-Binding Protein in Photoreceptors. Behavioral and Brain Sciences 18 (3):497-498.
    Recoverin is a Ca2+-binding protein found primarily in vertebrate photoreceptors. The proposed physiological function of recoverin is based on the finding that recoverin inhibits light-stimulated phosphorylation of rhodopsin. Recoverin interacts with rod outer segment membranes in a Ca2+-dependent manner. This interaction requires N-terminal acylation of recoverin. Four types of fatty acids have been detected on the N-terminus of recoverin, but the functional significance of this heterogeneous acylation is not yet clear.
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  4. D. K. Lahiri, B. Maloney, J. T. Rogers & Y. W. Ge (2013). PuF, an Antimetastatic and Developmental Signaling Protein, Interacts with the Alzheimer's Amyloid-Beta Precursor Protein Via a Tissue-Specific Proximal Regulatory Element. Bmc Genomics 14:68.
    BACKGROUND: Alzheimer's disease is intimately tied to amyloid-beta peptide. Extraneuronal brain plaques consisting primarily of Abeta aggregates are a hallmark of AD. Intraneuronal Abeta subunits are strongly implicated in disease progression. Protein sequence mutations of the Abeta precursor protein account for a small proportion of AD cases, suggesting that regulation of the associated gene may play a more important role in AD etiology. The APP promoter possesses a novel 30 nucleotide sequence, or "proximal regulatory element" , at -76/-47, (...)
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  5.  47
    Michael J. B. Krieger (2005). To B or Not to B: A Pheromone‐Binding Protein Regulates Colony Social Organization in Fire Ants. Bioessays 27 (1):91-99.
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  6. Kimitoshi Kohno, Hiroto Izumi, Takeshi Uchiumi, Megumi Ashizuka & Michihiko Kuwano (2003). The Pleiotropic Functions of the Y‐Box‐Binding Protein, YB‐1. Bioessays 25 (7):691-698.
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  7.  4
    Edward Chu & Carmen J. Allegra (1996). The Role of Thymidylate Synthase as an RNA Binding Protein. Bioessays 18 (3):191-198.
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  8.  5
    Katia Ancelin, Christine Brun & Eric Gilson (1998). Role of the Telomeric DNA‐Binding Protein TRF2 in the Stability of Human Chromosome Ends. Bioessays 20 (11):879-883.
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  9.  1
    David A. Nelles, Mark Y. Fang, Stefan Aigner & Gene W. Yeo (2015). Applications of Cas9 as an RNA-Programmed RNA-Binding Protein. Bioessays 37 (7):732-739.
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  10.  1
    Maureen McLeod (1989). Regulation of Meiosis: From DNA Binding Protein to Protein Kinase. Bioessays 11 (1):9-14.
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  11.  2
    Evelync Friederich, Eric Pringault, Monique Arpin & Daniel Louvard (1990). From the Structure to the Function of Villin, an Actin‐Binding Protein of the Brush Border. Bioessays 12 (9):403-408.
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  12.  1
    Igor F. Zhimulev, Elena S. Belyaeva, Tatiana Yu Vatolina & Sergey A. Demakov (2012). Banding Patterns in Drosophila Melanogaster Polytene Chromosomes Correlate with DNA‐Binding Protein Occupancy. Bioessays 34 (6):498-508.
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  13. Katia Ancelin, Christine Brun & Eric Gilson (1998). Role of the Telomeric DNA-Binding Protein TRF2 in the Stability of Human Chromosome Ends. Bioessays 20 (11):879-883.
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  14. John W. Chase (1984). The Role of E. Coli Single‐Stranded DNA Binding Protein in DNA Metabolism. Bioessays 1 (5):218-222.
  15. Mauro Chinappi, Fabio Cecconi & Carlo Massimo Casciola (2011). Computational Analysis of Maltose Binding Protein Translocation. Philosophical Magazine 91 (13-15):2034-2048.
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  16. Julie Deschênes‐Furry, Nora Perrone‐Bizzozero & Bernard J. Jasmin (2006). The RNA‐Binding Protein HuD: A Regulator of Neuronal Differentiation, Maintenance and Plasticity. Bioessays 28 (8):822-833.
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  17. M. J. Krleger (2004). To H or Not to B: A Pheromone—Binding Protein Re-at Os Colony Social Organization I Nf Ire a Nts. Bioessays 27:9.
     
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  18. Susan P. C. Cole & Roger G. Deeley (1998). Multidrug Resistance Mediated by the ATP‐Binding Cassette Transporter Protein MRP. Bioessays 20 (11):931-940.
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  19.  8
    Ronald E. Hileman, Jonathan R. Fromm, John M. Weiler & Robert J. Linhardt (1998). Glycosaminoglycan‐Protein Interactions: Definition of Consensus Sites in Glycosaminoglycan Binding Proteins. Bioessays 20 (2):156-167.
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  20. Susan Jaken & Peter J. Parker (2000). Protein Kinase C Binding Partners. Bioessays 22 (3):245-254.
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  21.  1
    Ronald E. Hileman, Jonathan R. Fromm, John M. Weiler & Robert J. Linhardt (1998). Glycosaminoglycan-Protein Interactions: Definition of Consensus Sites in Glycosaminoglycan Binding Proteins. Bioessays 20 (2):156-167.
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  22. Susan P. C. Cole & Roger G. Deeley (1998). Multidrug Resistance Mediated by the ATP-Binding Cassette Transporter Protein MRP. Bioessays 20 (11):931-940.
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  23. Martino Mona (2008). Binding Consent or Element of Presumed Consent? Conceptualization and Legal Relevance of Advance Health Care Directives in the Context of Multicultural Bioethics. Ethik in der Medizin 20 (3):248-257.
     
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  24.  14
    John Dempsher (1982). Basic Function in the Nervous System - a Unified Theory. Acta Biotheoretica 31 (3):185-202.
    A new theory for basic function in the nervous system has recently been proposed (Dempsher, J., 1979a, 1979b; 1980, 1981). The major basic themes of the new theory are as follows: (1) There are two fundamental units of structure and function, the fibre or conducting mechanism, and the neurocentre, where nervous system function as we know it takes place. (2) The nerve impulse is regarded as a mathematical event. The mathematics is the result of a prescribed fusion of energy and (...)
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  25. Ken Aizawa, A Reply to Bechtel and Mundale.
    One theme in recent philosophical attention to neuroscience has been that closer, more serious attention to actual neuroscientific research, and its results, challenges the familiar view that psychological properties are multiply realized by neuroscientific properties. Shagrir, (1998), presents a number of diverse reasons to think that diversity in neuroscientifically identified structures and properties does not inevitably lead to multiple realization. Bechtel and Mundale, (1999), argue that neuroscientific practice extending over a century contradicts the consequences of the hypothesis that psychological functions (...)
     
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  26. D. K. Lahiri, Y. W. Ge, J. T. Rogers, K. Sambamurti, N. H. Greig & B. Maloney (2006). Taking Down the Unindicted Co-Conspirators of Amyloid Beta-Peptide-Mediated Neuronal Death: Shared Gene Regulation of BACE1 and APP Genes Interacting with CREB, Fe65 and YY1 Transcription Factors. [REVIEW] Curr Alzheimer Res 3:475-83.
    Major hallmarks of Alzheimer's disease include brain deposition of the amyloid-beta peptide , which is proteolytically cleaved from a large Abeta precursor protein by beta and gamma- secretases. A transmembrane aspartyl protease, beta-APP cleaving enzyme , has been recognized as the beta-secretase. We review the structure and function of the BACE1 protein, and of 4129 bp of the 5'-flanking region sequence of the BACE1 gene and its interaction with various transcription factors involved in cell signaling. The promoter region (...)
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  27.  1
    Melissa Little, Greg Holmes & Patrick Walsh (1999). WT1: What has the Last Decade Told Us? Bioessays 21 (3):191-202.
    When positionally cloned in late 1989, it was anticipated that mutations within the Wilms' tumour suppressor gene (WT1) would prove responsible for this common solid kidney cancer of childhood. Characterisation of the WT1 expression pattern and of the structure of the encoded protein isoforms and their mode of action has now spanned almost a decade. WT1 proteins act as nucleic acid-binding zinc finger-containing transcription factors involved in both transactivation and repression. These activities are facilitated and constrained by interactions with (...)
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  28.  13
    Stuart K. Archer, Charles Claudianos & Hugh D. Campbell (2005). Evolution of the Gelsolin Family of Actin-Binding Proteins as Novel Transcriptional Coactivators. Bioessays 27 (4):388-396.
    The gelsolin gene family encodes a number of higher eukaryotic actin-binding proteins that are thought to function in the cytoplasm by severing, capping, nucleating or bundling actin filaments. Recent evidence, however, suggests that several members of the gelsolin family may have adopted unexpected nuclear functions including a role in regulating transcription. In particular, flightless I, supervillin and gelsolin itself have roles as coactivators for nuclear receptors, despite the fact that their divergence appears to predate the evolutionary appearance of nuclear receptors. (...)
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  29.  4
    Spiros A. Vlahopoulos, Stella Logotheti, Dimitris Mikas, Athina Giarika, Vassilis Gorgoulis & Vassilis Zoumpourlis (2008). The Role of ATF‐2 in Oncogenesis. Bioessays 30 (4):314-327.
    Activating Transcription Factor-2 is a sequence-specific DNA-binding protein that belongs to the bZIP family of proteins and plays diverse roles in the mammalian cells. In response to stress stimuli, it activates a variety of gene targets including cyclin A, cyclin D and c-jun, which are involved in oncogenesis in various tissue types. ATF-2 expression has been correlated with maintenance of a cancer cell phenotype. However, other studies demonstrate an antiproliferative or apoptotic role for ATF-2. In this review, we summarize (...)
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  30.  32
    Phyllis McKay Illari & Jon Williamson (2010). Function and Organization: Comparing the Mechanisms of Protein Synthesis and Natural Selection. Studies in History and Philosophy of Science Part C 41 (3):279-291.
    In this paper, we compare the mechanisms of protein synthesis and natural selection. We identify three core elements of mechanistic explanation: functional individuation, hierarchical nestedness or decomposition, and organization. These are now well understood elements of mechanistic explanation in fields such as protein synthesis, and widely accepted in the mechanisms literature. But Skipper and Millstein have argued that natural selection is neither decomposable nor organized. This would mean that much of the current mechanisms literature does not apply to (...)
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  31.  15
    Alexander Dibrov, Yvonne Myal & Etienne Leygue (2009). Computational Modelling of Protein Interactions: Energy Minimization for the Refinement and Scoring of Association Decoys. Acta Biotheoretica 57 (4):419-428.
    The prediction of proteinprotein interactions based on independently obtained structural information for each interacting partner remains an important challenge in computational chemistry. Procedures where hypothetical interaction models (or decoys) are generated, then ranked using a biochemically relevant scoring function have been garnering interest as an avenue for addressing such challenges. The program PatchDock has been shown to produce reasonable decoys for modeling the association between pig alpha-amylase and the VH-domains of camelide antibody raised against it. We designed a (...)
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  32.  2
    Michael Doyle, Lukas Badertscher, Lukasz Jaskiewicz, Stephan Güttinger, Sabine Jurado, Tabea Hugenschmidt, Ulrike Kutay & Witold Filipowicz, The Double-Stranded RNA Binding Domain of Human Dicer Functions as a Nuclear Localization Signal.
    Dicer is a key player in microRNA (miRNA) and RNA interference (RNAi) pathways, processing miRNA precursors and doublestranded RNA into ~21-nt-long products ultimately triggering sequence-dependent gene silencing. Although processing of substrates in vertebrate cells occurs in the cytoplasm, there is growing evidence suggesting Dicer is also present and functional in the nucleus. To address this possibility, we searched for a nuclear localization signal (NLS) in human Dicer and identified its C-terminal double-stranded RNA binding domain (dsRBD) as harboring NLS activity. We (...)
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  33.  12
    Pierre Pica (1995). Condition C and Epistemic Contexts : A Case Study of Epithets and Anti-Logophoricity Pronouns in French. In Young-Sun Kim, Byung-Choon Lee, Kyoung-Jae Lee, Kyun-Kwon Yang & Jong-Kuri Yoon (eds.), A Festchrift for Dong-Whee Yang. Hankuk Publishing
    Epithets and pronominals 'en' and 'y' in French have a variety of Binding properties that are unexpected on conventional approach to Binding Theory. We argue that the linguistic variety observed cross-linguistically (and perhaps, more surprinsingly, within a single language) - derives from the morphological properties of the anaphoric element - which we claim lack number features. Epithets and pronominal like 'en' and 'y' are predicates modifying null but semantically active nouns, and must theefore refer to the Speaker. These properties, we (...)
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  34. Rafik I. Beekun & Jamal A. Badawi (2005). Balancing Ethical Responsibility Among Multiple Organizational Stakeholders: The Islamic Perspective. [REVIEW] Journal of Business Ethics 60 (2):131 - 145.
    In spite of a renewed interest in the relationship between spirituality and managerial thinking, the literature covering the link between Islam and management has been sparse – especially in the area of ethics. One potential reason may be the cultural diversity of nearly 1.3 billion Muslims globally. Yet, one common element binding Muslim individuals and countries is normative Islam. Using all four sources of this religion’s teachings, we outline the parameters of an Islamic model of normative business ethics. We explain (...)
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  35.  6
    James B. Hurley (1995). Recoverin and Ca2+ in Vertebrate Phototransduction. Behavioral and Brain Sciences 18 (3):425-428.
    Recoverin is a 23 kDa Ca2+binding protein that has been detected primarily in vertebrate photoreceptors. The role of recoverin in phototransduction has been investigated using a variety of biochemical methods. Initial reports suggesting that recoverin regulates photoreceptor guanylyl cyclase have not been confirmed. Instead, recoverin appears to determine the lifetime of lightstimulated phosphodiesterase activity, perhaps by regulating rhodopsin phosphorylation. Retinal recoverin is heterogeneously fatty acylated at its ammo-terminus. The amino-terminal fatty acid appears to be involved in the interaction of (...)
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  36. Shelley D. Copley (2012). Moonlighting is Mainstream: Paradigm Adjustment Required. Bioessays 34 (7):578-588.
    Moonlighting – the performance of more than one function by a single protein – is becoming recognized as a common phenomenon with important implications for systems biology and human health. The different functions of a moonlighting protein may use different regions of the protein structure, or alternative structures that occur due to post-translational modifications and/or differences in binding partners. Often the different functions of moonlighting proteins are used at different times or in different places. The existence of (...)
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  37. Mihnea Capraru, Choosing Short: An Explanation of the Similarities and Dissimilarities in the Distribution Patterns of Binding and Covaluation.
    Covaluation is the generalization of coreference introduced by Tanya Reinhart. Covaluation distributes in patterns that are very similar yet not entirely identical to those of binding. On a widespread view, covaluation and binding distribute similarly because binding is defined in terms of covaluation. Yet on Reinhart's view, binding and covaluation are not related that way: binding pertains to syntax, covaluation does not. Naturally, the widespread view can easily explain the similarities between binding and covaluation, whereas Reinhart can easily explain the (...)
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  38. Christopher J. G. Meacham (2010). Binding and its Consequences. Philosophical Studies 149 (1):49-71.
    In “Bayesianism, Infinite Decisions, and Binding”, Arntzenius et al. (Mind 113:251–283, 2004 ) present cases in which agents who cannot bind themselves are driven by standard decision theory to choose sequences of actions with disastrous consequences. They defend standard decision theory by arguing that if a decision rule leads agents to disaster only when they cannot bind themselves, this should not be taken to be a mark against the decision rule. I show that this claim has surprising implications for a (...)
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  39.  26
    J. Corcoran & John Herring (1971). Notes on a Semantic Analysis of Variable Binding Term Operators. Logique Et Analyse 55:644-657.
    -/- A variable binding term operator (vbto) is a non-logical constant, say v, which combines with a variable y and a formula F containing y free to form a term (vy:F) whose free variables are exact ly those of F, excluding y. -/- Kalish-Montague proposed using vbtos to formalize definite descriptions, set abstracts {x: F}, minimalization in recursive function theory, etc. However, they gave no sematics for vbtos. Hatcher gave a semantics but one that has flaws. We give a correct (...)
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  40.  40
    Darren Natale, Cecilia N. Arighi, Winona C. Barker, Judith A. Blake, Carol J. Bult, Michael Caudy, Harold J. Drabkin, Peter D’Eustachio, Alexei V. Evsikov, Hongzhan Huang, Jules Nchoutmboube, Natalia V. Roberts, Barry Smith, Jian Zhang & Cathy H. Wu (2011). The Protein Ontology: A Structured Representation of Protein Forms and Complexes. Nucleic Acids Research 39 (1):D539-D545.
    The Protein Ontology (PRO) provides a formal, logically-based classification of specific protein classes including structured representations of protein isoforms, variants and modified forms. Initially focused on proteins found in human, mouse and Escherichia coli, PRO now includes representations of protein complexes. The PRO Consortium works in concert with the developers of other biomedical ontologies and protein knowledge bases to provide the ability to formally organize and integrate representations of precise protein forms so as to (...)
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  41.  12
    Alfred Gierer (1963). Function of Aggregated Reticulocyte Ribosomes in Protein Synthesis. J. Mol. Biol 6:148-157.
    Applying mild methods of preparation, part of the ribosomes of rabbit reticulocytes are found in aggregates (later called polyribosomes) of up to six ribosomal units. Upon treatment with RNA-ase, they desintegrate into single ribosomes. The fast-sedimenting aggregates are found to be more active in protein synthesis in terms of incorporation of radioactive amino acids, whereas the single ribosomes are more receptive to stimulation by the artificial messenger RNA poly-U. The findings indicate that the linkage of ribosomes into aggregates is (...)
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  42.  45
    Casey O'Callaghan (2014). Intermodal Binding Awareness. In David J. Bennett & Christopher S. Hill (eds.), Sensory Integration and the Unity of Consciousness. MIT 73-103.
    It is tempting to hold that perceptual experience amounts to a co-conscious collection of visual, auditory, tactual, gustatory, and olfactory episodes. If so, each aspect of perceptual experience on each occasion is associated with a specific modality. This paper, however, concerns a core variety of multimodal perceptual experience. It argues that there is perceptually apparent intermodal feature binding. I present the case for this claim, explain its consequences for theorizing about perceptual experience, and defend it against objections. I maintain that (...)
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  43.  13
    Bruno J. Strasser (2010). Collecting, Comparing, and Computing Sequences: The Making of Margaret O. Dayhoff's "Atlas of Protein Sequence and Structure", 1954–1965. [REVIEW] Journal of the History of Biology 43 (4):623 - 660.
    Collecting, comparing, and computing molecular sequences are among the most prevalent practices in contemporary biological research. They represent a specific way of producing knowledge. This paper explores the historical development of these practices, focusing on the work of Margaret O. Dayhoff, Richard V. Eck, and Robert S. Ledley, who produced the first computer-based collection of protein sequences, published in book format in 1965 as the Atlas of Protein Sequence and Structure. While these practices are generally associated with the (...)
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  44.  13
    Dan Zeman (2015). Relativism and Bound Predicates of Personal Taste: An Answer to Schaffer's Argument From Binding. Dialectica 69 (2):155-183.
    In this paper I put forward and substantiate a possible defensive move on behalf of the relativist about predicates of personal taste that can be used to block a recent contextualist argument raised against the view: the ‘argument from binding’ proposed in Schaffer (). The move consists in adopting Recanati's “variadic functions” apparatus and applying it to predicates of personal taste like ‘tasty’ and experiencer phrases like ‘for John’. I substantiate the account in a basic relativistic framework and reply to (...)
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  45.  15
    François Claveau (2011). Evidential Variety as a Source of Credibility for Causal Inference: Beyond Sharp Designs and Structural Models. Journal of Economic Methodology 18 (3):233-253.
    There is an ongoing debate in economics between the design-based approach and the structural approach. The main locus of contention regards how best to pursue the quest for credible causal inference. Each approach emphasizes one element ? sharp study designs versus structural models ? but these elements have well-known limitations. This paper investigates where a researcher might look for credibility when, for the causal question under study, these limitations are binding. It argues that seeking variety of evidence ? understood specifically (...)
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  46.  9
    Kersten Hall (2011). William Astbury and the Biological Significance of Nucleic Acids, 1938–1951. Studies in History and Philosophy of Science Part C 42 (2):119-128.
    Famously, James Watson credited the discovery of the double-helical structure of DNA in 1953 to an X-ray diffraction photograph taken by Rosalind Franklin. Historians of molecular biology have long puzzled over a remarkably similar photograph taken two years earlier by the physicist and pioneer of protein structure William T. Astbury. They have suggested that Astbury’s failure to capitalize on the photograph to solve DNA’s structure was due either to his being too much of a physicist, with too little interest (...)
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  47.  3
    Jean-Rémy Martin (2013). Experiences of Activity and Causality in Schizophrenia: When Predictive Deficits Lead to a Retrospective Over-Binding. Consciousness and Cognition 22 (4):1361-1374.
    In this paper I discuss an intriguing and relatively little studied symptomatic expression of schizophrenia known as experiences of activity in which patients form the delusion that they can control some external events by the sole means of their mind. I argue that experiences of activity result from patients being prone to aberrantly infer causal relations between unrelated events in a retrospective way owing to widespread predictive deficits. Moreover, I suggest that such deficits may, in addition, lead to an aberrant (...)
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  48.  5
    Piers D. L. Howe & Adam Ferguson (2015). The Identity‐Location Binding Problem. Cognitive Science 39 (7):1622-1645.
    The binding problem is fundamental to visual perception. It is the problem of associating an object's visual properties with itself and not with some other object. The problem is made particular difficult because different properties of an object, such as its color, shape, size, and motion, are often processed independently, sometimes in different cortical areas. The results of these separate analyses have to be combined before the object can be seen as a single coherent entity as opposed to a collection (...)
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  49.  15
    Antti Revonsuo & K. Tarkko (2002). Binding in Dreams: The Bizarreness of Dream Images and the Unity of Consciousness. Journal of Consciousness Studies 9 (7):3-24.
    Binding can be described at three different levels: In neuroscience it refers to the integration of single-cell activities to form functional neural assemblies, especially in response to global stimulus properties; in cognitive science it refers to the integration of distributed modular input processing to form unified representations for memory and action, and in consciousness studies it refers to the unity of phenomenal consciousness . To describe and explain the unity of consciousness, detailed phenomenological descriptions of binding at the phenomenal level (...)
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  50.  46
    Eric LaRock (2007). Disambiguation, Binding, and the Unity of Visual Consciousness. Theory and Psychology 17 (6):747-77.
    Recent findings in neuroscience strongly suggest that an object’s features (e.g., its color, texture, shape, etc.) are represented in separate areas of the visual cortex. Although represented in separate neuronal areas, somehow the feature representations are brought together as a single, unified object of visual consciousness. This raises a question of binding: how do neural activities in separate areas of the visual cortex function to produce a feature-unified object of visual consciousness? Several prominent neuroscientists have adopted neural synchrony and attention-based (...)
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