Search results for 'IN-VIVO' (try it on Scholar)

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  1.  1
    Pio Garcia (2015). Computer Simulations and Experiments: In Vivo–in Vitro Conditions in Biochemistry. Foundations of Chemistry 17 (1):49-65.
    Scientific practices have been changed by the increasing use of computer simulations. A central question for philosophers is how to characterize computer simulations. In this paper, we address this question by analyzing simulations in biochemistry. We propose that simulations have been used in biochemistry long before computers arrived. Simulation can be described as a surrogate relationship between models. Moreover, a simulative aspect is implicit in the classical dichotomy between in vivo–in vitro conditions. Based on a discussion about how to characterize (...)
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  2.  8
    Joel Chan & Christian Schunn (2015). The Impact of Analogies on Creative Concept Generation: Lessons From an In Vivo Study in Engineering Design. Cognitive Science 39 (1):126-155.
    Research on innovation often highlights analogies from sources outside the current problem domain as a major source of novel concepts; however, the mechanisms underlying this relationship are not well understood. We analyzed the temporal interplay between far analogy use and creative concept generation in a professional design team's brainstorming conversations, investigating the hypothesis that far analogies lead directly to very novel concepts via large steps in conceptual spaces . Surprisingly, we found that concepts were more similar to their preceding concepts (...)
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  3. Marcel Weber (2014). Experimental Modeling in Biology: In Vivo Representation and Stand-Ins As Modeling Strategies. Philosophy of Science 81 (5):756-769.
    Experimental modeling in biology involves the use of living organisms (not necessarily so-called "model organisms") in order to model or simulate biological processes. I argue here that experimental modeling is a bona fide form of scientific modeling that plays an epistemic role that is distinct from that of ordinary biological experiments. What distinguishes them from ordinary experiments is that they use what I call "in vivo representations" where one kind of causal process is used to stand in for a physically (...)
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  4.  31
    Nikos Logothetis, In Vivo Brain Connectivity: Optimization of Manganese Enhanced MRI for Neuronal Tract Tracing.
    manganese (Mn2+) enhanced MRI (MEMRI) to study neuronal connectivity in vivo opens the possibility to these studies. However, several drawbacks exist that challenge its applicability. High Mn2+ concentrations produce cytotoxic effects that can perturb the circuits under study. In the other hand, the MR signal is..
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  5.  9
    Melissa A. Maurer-Jones & Christy L. Haynes (2012). Toward Correlation in In Vivo and In Vitro Nanotoxicology Studies. Journal of Law, Medicine & Ethics 40 (4):795-801.
    Nanomaterials have the promise of revolutionizing current treatment and diagnosis of diseases, which has led to 33 nanotherapeutics drugs currently on the market and many more in various stages of clinical trials. With an increasing number of products available and in development, along with the unique, emergent properties of the nanoparticle therapeutics themselves, regulatory agencies are now faced with decisions regarding the regulation of such novel technologies. Regulatory guidance, particularly in pre-clinical stages, has the potential to facilitate quick and safe (...)
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  6.  17
    Roger Strand, Ragnar Fjelland & Torgeir Flatmark (1996). In Vivo Interpretation of in Vitro Effect Studies with a Detailed Analysis of the Method of in Vitro Transcription in Isolated Cell Nuclei. Acta Biotheoretica 44 (1):1-21.
    In vitro experimental approaches are of central importance to contemporary molecular and cellular biology and toxicology. However, the scientific value or impact of in vitro results depends on their relevance in vivo. In vitro effect studies address inobservable in vivo phenomena through experiments on analogous in vitro phenomena. We present a theoretical basis developed to evaluate the in vivo relevance of in vitro effect studies. As a case study, the procedure for measuring specific gene transcription in isolated cell nuclei (nuclear (...)
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  7. Roger Strand (forthcoming). Fra in vitro til in vivo. Norsk Filosofisk Tidsskrift.
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  8.  43
    Ullica Segerstrale (1986). Colleagues in Conflict: An 'in Vivo' Analysis of the Sociobiology Controversy. [REVIEW] Biology and Philosophy 1 (1):53-87.
    Edward O. Wilson's forays into human sociobiology have been the target of persistent, vehement attack by his Harvard colleague in evolutionary biology, Richard C. Lewontin. Through examination of existing documents in the case, together with in-depth personal interviews of Wilson, Lewontin, and other biologists, the reasons for Wilson's stance and Lewontin's criticisms are uncovered. It is argued that the dispute is not primarily personally or politically motivated, but involves a conflict between long-term scientific-cum-moral agendas, with the reductionist program as a (...)
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  9.  19
    Kevin Dunbar & Isabelle Blanchette (2001). The in Vivo/in Vitro Approach to Cognition: The Case of Analogy. Trends in Cognitive Sciences 5 (8):334-339.
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  10.  11
    Stephen F. Bush (2011). Toward in Vivo Nanoscale Communication Networks: Utilizing an Active Network Architecture. Frontiers of Computer Science in China 5 (1):1--9.
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  11.  16
    Sarah Buss (2014). Experiments In Vivo, In Vitro, and In Cathedra. Ethics 124 (4):860-881.
    In the context of a largely exploratory inquiry, I warn against oversimplifying the relationships among intuitions, emotions, principle-governed reasoning, and responsiveness to reasons. I point out that one cannot determine the normative status of some fact without determining whether a case can be made for this status. But I also note that, though reason is thus autonomous, every episode of reasoning depends causally on the way things nonnormatively are, and this makes it possible for any reasoner to challenge even her (...)
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  12.  18
    Yair Neuman (2012). Ja immunologiczne: tworzenie znaczenia in vivo. Avant: Trends in Interdisciplinary Studies 3 (1).
    [Przekład] Ja immunologiczne jest naszym zreifikowanym opisem procesów, dzięki którym układ odpornościowy utrzymuje wyodrębnioną tożsamość organizmu i siebie samego. Jest to proces interpretacyjny, i żeby badać go w sposób naukowo konstruktywny, powinniśmy połączyć długoletnią hermeneutyczną tradycję pytania o naturę interpretacji ze współczesnym rozumieniem układu odpornościowego, pojawiającymi się technologiami badawczymi oraz zaawansowanymi narzędziami obliczeniowymi analizującymi dane sensoryczne.
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  13. Kevin Dunbar (1999). The Scientist in Vivo: How Scientists Think and Reason in the Laboratory. In L. Magnani, N. J. Nersessian & P. Thagard (eds.), Model-Based Reasoning in Scientific Discovery. Kluwer/Plenum 89--98.
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  14.  14
    A. M. Perault-Staub, P. Tracqui & J. F. Staub (1992). Modelling of in Vivo Calcium Metabolism. I. Optimal Cooperation Between Constant and Rhythmic Behaviours. Acta Biotheoretica 40 (2-3):95-102.
    The relevance of nonlinear dynamics to calcium metabolism led us to reevaluate the role of Ca-regulating hormones in Ca homeostasis. We suggest that, firstly, the main Ca metabolic functions in rat-bone and gut - are organized as dynamic entities able to generate various temporal expressions, including self-oscillating patterns and, secondly, Ca homeostasis results from interaction between both metabolic and hormonal oscillators. Following this schema, a major role for the hormonal system, with its circadian pattern, could be to act directly on (...)
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  15.  13
    P. Tracqui, J. F. Staub & A. M. Perault-Staub (1992). Modelling of in Vivo Calcium Metabolism. II. Minimal Structure or Maximum Dynamic Diversity: The Interplay of Biological Constraints. Acta Biotheoretica 40 (2-3):103-111.
    The temporal behaviour of the nonlinear compartmental model we have developed for rat calcium metabolism is discussed with respect to the theoretical properties of the self-oscillating autocatalytic subunit around which the model is constructed. Depending on the approximations made, this subunit is described by a minimal two-variable model, SU2, or by a three-variable one, SU3. The diversity of the theoretical dynamic behaviours possible with SU2 is greatly increased with SU3. But the identification of SU3 parameter values in three different experimental (...)
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  16. Roland A. Coulson (1983). Relationship Between Fluid Flow and O2 Demand in Tissues in Vivo and in Vitro. Perspectives in Biology and Medicine 27 (1):121-126.
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  17. Clifford W. Curney (1963). Effect of Radiation on the Mouse Stem Cell Compartment in Vivo. Perspectives in Biology and Medicine 6 (2):233-245.
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  18. Jeong-Won Jeong, Vijay N. Tiwari, Michael E. Behen, Harry T. Chugani & Diane C. Chugani (2014). In Vivo Detection of Reduced Purkinje Cell Fibers with Diffusion MRI Tractography in Children with Autistic Spectrum Disorders. Frontiers in Human Neuroscience 8.
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  19.  13
    Jeanette Kennett (2012). Living With One's Choices Moral Reasoning In Vitro and In Vivo. In Robyn Langdon & Catriona Mackenzie (eds.), Emotions, Imagination, and Moral Reasoning. Psychology Press 257.
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  20.  8
    Lauren Kegley (2010). In-vivo testing of vertically aligned nanowire implantable titanium electrodes in the rattus norvegicus hippocampus. Inquiry 11.
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  21.  1
    Hannes Schmidt & Fritz G. Rathjen (2010). Signalling Mechanisms Regulating Axonal Branching in Vivo. Bioessays 32 (11):977-985.
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  22.  5
    Sylvain Marcellini, Juan Pablo Henriquez & Ariana Bertin (2012). Control of Osteogenesis by the Canonical Wnt and BMP Pathways in Vivo. Bioessays 34 (11):953-962.
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  23.  9
    Søren S. L. Andersen & Torsten Wittmann (2002). Toward Reconstitution of in Vivo Microtubule Dynamics in Vitro. Bioessays 24 (4):305-307.
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  24.  5
    H. M. Lieberstein (1965). Determination of the Tension-Stretch Relation for a Point in the Aorta From Measurement in Vivo of Pressure at Three Equally Spaced Points. Acta Biotheoretica 17 (2):49-94.
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  25. Steve Kellmeyer (2007). Embryo Adoption: A Form of In Vivo Organ Donation? The National Catholic Bioethics Quarterly 7 (2):263-270.
     
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  26. Xose R. Bustelo, Vincent Sauzeau & Inmaculada M. Berenjeno (2007). GTP‐Binding Proteins of the Rho/Rac Family: Regulation, Effectors and Functions in Vivo. Bioessays 29 (4):356-370.
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  27.  7
    Karen Dawson (1988). Segmentation and a Oral Status in Vivo and in Vitro: A Scientific Perspective. Bioethics 2 (1):1–14.
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  28.  2
    Peter Dröge (1994). Protein Tracking‐Induced Supercoiling of DNA: A Tool to Regulate DNA Transactions in Vivo? Bioessays 16 (2):91-99.
  29.  2
    Jonathan B. L. Bard (1990). Traction and the Formation of Mesenchymal Condensations in Vivo. Bioessays 12 (8):389-395.
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  30.  1
    James E. Haber (1995). In Vivo Biochemistry: Physical Monitoring of Recombination Induced by Site‐Specific Endonucleases. Bioessays 17 (7):609-620.
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  31.  2
    Ian C. MacDonald, Alan C. Groom & Ann F. Chambers (2002). Cancer Spread and Micrometastasis Development: Quantitative Approaches for in Vivo Models. Bioessays 24 (10):885-893.
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  32.  2
    Peter E. Nielsen (1989). In Vivo Footprinting: Studies of Protein–DNA Interactions in Gene Regulation. Bioessays 11 (5):152-155.
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  33.  2
    Paul Siegel & Richard Warren (2013). The Effect of Very Brief Exposure on Experienced Fear After in Vivo Exposure. Cognition and Emotion 27 (6):1013-1022.
  34.  1
    Toshiya Teraishi & Kenji Miura (2009). Toward an in Situ Phospho‐Protein Atlas: Phospho‐and Site‐Specific Antibody‐Based Spatio‐Temporally Systematized Detection of Phosphorylated Proteins in Vivo. Bioessays 31 (8):831-842.
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  35.  1
    Jeffrey Boone Miller, Elizabeth A. Everitt, Timothy H. Smith, Nancy E. Block & Janice A. Dominov (1993). Cellular and Molecular Diversity in Skeletal Muscle Development: News From in Vitro and in Vivo. Bioessays 15 (3):191-196.
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  36.  3
    H. J. J. Leenen (1986). The Legal Status of the Embryo in Vivo and in Vitro: Research on and the Medical Treatment of Embryos. Journal of Law, Medicine & Ethics 14 (3-4):129-132.
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  37.  1
    Dirk‐Henner Lankenau & Gregory B. Gloor (1998). In Vivo Gap Repair in Drosophila: A One‐Way Street with Many Destinations. Bioessays 20 (4):317-327.
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  38.  1
    Irving L. Weissman (1986). Lymphocyte Homing Receptors and the Immune Response in Vivo. Bioessays 5 (3):112-116.
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  39.  1
    Hiromi Fujiwara & Toshiyuki Hamaoka (1986). The Cellular and Molecular Basis of the Lyt‐1+2− T Cell‐Mediated Tumor‐Eradicating Mechanism in Vivo. Bioessays 4 (1):19-23.
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  40. Tudor M. Baetu, Ann-Sophie Barwich, Daniel Brooks, Sébastien Dutreuil & Pierre-Luc Germain (2013). Model Thinking in the Life Sciences: Complexity in the Making: Second European Advanced Seminar in the Philosophy of the Life Sciences,“In Vivo, Ex Vivo, in Vitro, in Silico: Models in the Life Sciences” Hermance, Switzerland, 10–14 September 2012.(Meeting Report). [REVIEW] Biological Theory 8 (1):121 - 124.
     
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  41. E. W. Kraegen, J. A. Sowden, M. B. Halstead, Pw Clark, Kj Rodnick, Dj Chisholm & De James (1994). Glucose Transporters and in Vivo Glucose Uptake in Skeletal and Cardiac Muscle: Fasting, Insulin Cells. Bioessays 16:753-759.
     
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  42. H. J. J. Leenen (1986). 4. The Legal Status of the Embryo in Vivo and in Vitro: Research on and the Medical Treatment of Embryos. Journal of Law, Medicine and Ethics 14 (3-4):129-132.
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  43. F. MAÑAS, Cidm Gonzalez, A. Weyers, L. Ugnia, Ovando H. García & I. Larripa (2007). Evaluación de genotoxicidad in vivo mediante el ensayo cometa y de micronúcleos en ratones tratados con glifosato. Theoria 15:53-60.
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  44. Benedikt Römer, Alexander Sartorius, Dragos Inta, Barbara Vollmayr & Peter Gass (2008). Imaging New Neurons in Vivo: A Pioneering Tool to Study the Cellular Biology of Depression? Bioessays 30 (9):806-810.
  45.  2
    Ubaldo Casotto (2012). L’Uomo Vivo in Chesterton. The Chesterton Review in Italiano 2 (1):111-119.
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  46.  1
    Elisa Magrì (2015). L’auto-riferimento del corpo vivo Sull’abitudine in Hegel e Merleau-Ponty. In Elisa Magrì Danilo Manca (ed.), Hegel e la fenomenologia trascendentale. Edizioni ETS 81-100.
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  47. G. Soranzo (1958). Tre elogi poco noti di Lorenzo il Magnifico, uno a lui vivo, due in morte. Rinascimento 9:203-316.
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  48.  2
    Piotr Grzegorz Nowak (forthcoming). The Moral Evaluation of Living Organ Donation and Trade in Human Organs in Light of Kant's Ethics. Diametros 46:30-54.
    In the article I justify the acceptability of ex vivo transplantation and I provide the ethical evaluation of trafficking in human organs from the Kantian perspective. Firstly, I refer to passages of Kant's works, where he explicitly states that depriving oneself of one’s body parts for other purposes than self-preservation is not permitted. I explain that the negative ethical evaluation of the disposal of the body parts was given various justifications by Kant. Subsequently, I provide partial criticism of this justification, (...)
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  49. Andoni Ibarra & Thomas Mormann (2006). Scientific Theories as Intervening Representations. Theoria 55 (1):21 - 38.
    In this paper some classical representational ideas of Hertz and Duhem are used to show how the dichotomy between representation and intervention can be overcome. More precisely, scientific theories are reconstruected as complex networks of intervening representations (or representational interventions). The formal apparatus developed is applied to elucidate various theoretical and prctical aspects of the in vivo/in vitro problem of biochemistry. Moreover, adjoint situations (Galois connections) are used to eplain the relation between empirical facts and theoretical laws in a new (...)
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  50.  5
    Susan Bell Trickett & J. Gregory Trafton (2007). “What If…”: The Use of Conceptual Simulations in Scientific Reasoning. Cognitive Science 31 (5):843-875.
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