Search results for 'LATE-PHASE' (try it on Scholar)

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  1. Thomas C. Jones (2005). A Call to Restructure the Drug Development Process: Government Over-Regulation and Non-Innovative Late Stage (Phase III) Clinical Trials Are Major Obstacles to Advances in Health Care. Science and Engineering Ethics 11 (4):575-587.score: 45.0
    The history of drug/vaccine development has included major advances guided primarily by risk/benefit analyses concerning the innovative agent, not by evidence-based clinical trials (Phase I–IV). Because the approval for new drugs is hindered under the present process, the system requires restructuring. The Phase I/II study period should be more flexible, using the “environment of knowledge” about the new agent, plus risk/benefit assessments. Phase III, as presently constructed, does not add new adverse events data, it provides a narrower profile of drug (...)
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  2. Arnim von Stechow, Times as Degrees: Früh(Er) 'Early(Er)' , Spät(Er) 'Late(R)', and Phase Adverbs.score: 36.0
    There is a rich literature about the temporal conjunctions before/after, but at the time I gave the talk that underlies this paper I was not aware of any analysis of the temporal comparatives früher/später ‘earlier/later’, which may be used to express similar states of affairs, but are constructed differently.2 Recently I got acquainted with the del Prete’s thesis about It. prima/dopo, which analyses prima as a comparative and dopo as a preposition.3 This is the only paper known to me that (...)
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  3. John Bickle (2006). Reducing Mind to Molecular Pathways: Explicating the Reductionism Implicit in Current Cellular and Molecular Neuroscience. [REVIEW] Synthese 151 (3):411-434.score: 30.0
    As opposed to the dismissive attitude toward reductionism that is popular in current philosophy of mind, a “ruthless reductionism” is alive and thriving in “molecular and cellular cognition”—a field of research within cellular and molecular neuroscience, the current mainstream of the discipline. Basic experimental practices and emerging results from this field imply that two common assertions by philosophers and cognitive scientists are false: (1) that we do not know much about how the brain works, and (2) that lower-level neuroscience cannot (...)
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  4. Jody Stanley, Jason Forte, Patrick Cavanagh & Olivia Carter (2011). Onset Rivalry: The Initial Dominance Phase is Independent of Ongoing Perceptual Alternations. Frontiers in Human Neuroscience 5.score: 22.0
    Binocular rivalry has been used to study a wide range of visual processes, from the integration of low-level features to the selection of signals that reach awareness. However, many of these studies do not distinguish between early and late phases of rivalry. There is clear evidence that the ‘onset’ stage of rivalry is characterized by stable, yet idiosyncratic biases that are independent of the subsequent alternations and perceptual biases experienced during sustained rivalry. Low-level stimulus features have robust effects in the (...)
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  5. James Lindesay (2007). Consequences of a Cosmological Phase Transition at the TeV Scale. Foundations of Physics 37 (4-5):491-531.score: 21.0
    A finite vacuum energy density implies the existence of a UV scale for gravitational modes. This gives a phenomenological scale to the dynamical equations governing the cosmological expansion that must satisfy constraints consistent with quantum measurability and spatial flatness. Examination of these constraints for the observed dark energy density establishes a time interval from the transition to the present, suggesting major modifications from the thermal equations of state far from Planck density scales. The assumption that a phase transition initiates the (...)
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  6. Timothy H. Boyer (2008). Comment on Experiments Related to the Aharonov–Bohm Phase Shift. Foundations of Physics 38 (6):498-505.score: 18.0
    Recent experiments undertaken by Caprez, Barwick, and Batelaan should clarify the connections between classical and quantum theories in connection with the Aharonov–Bohm phase shift. It is pointed out that resistive aspects for the solenoid current carriers play a role in the classical but not the quantum analysis for the phase shift. The observed absence of a classical lag effect for a macroscopic solenoid does not yet rule out the possibility of a lag explanation of the observed phase shift for a (...)
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  7. G. Matteucci, D. Iencinella & C. Beeli (2003). The Aharonov–Bohm Phase Shift and Boyer's Critical Considerations: New Experimental Result but Still an Open Subject? Foundations of Physics 33 (4):577-590.score: 18.0
    The main experiments concerning the Aharonov–Bohm phase shifts, seen in an electron interference pattern, and their Boyer semiclassical explanations are reviewed. A new experiment is also presented which emphasizes the subtleties involved in the interpretations of the magnetic Aharonov–Bohm phase shift as a result of a non-dispersive or dispersive effect.
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  8. Augusto Garuccio (2004). Interferometry with Phase Conjugate Mirrors and Measure of One-Way Velocity of Light. Foundations of Physics 34 (12):1983-1992.score: 18.0
    A Michelson interferometer with a phase-conjugate mirror (PCM) is described and discussed. The behavior of phase conjugate mirrors is discussed and the result of an experiment with a Michelson interferometer with a phase-conjugate mirror is described and commented. This interferometer has been proposed to be used to test the intrinsic non-locality of quantum mechanics. In this paper a new experimental setup to study the one-way velocity of light is proposed, which uses this new interesting device.
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  9. Geert Munnichs (2004). Whom to Trust? Public Concerns, Late Modern Risks, and Expert Trustworthiness. Journal of Agricultural and Environmental Ethics 17 (2):113-130.score: 18.0
    This article discusses the conditions under which the use of expert knowledge may provide an adequate response to public concerns about high-tech, late modern risks. Scientific risk estimation has more than once led to expert controversies. When these controversies occur, the public at large – as a media audience – faces a paradoxical situation: on the one hand it must rely on the expertise of scientists as represented in the mass media, but on the other it is confused by competing (...)
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  10. James A. Anderson & Jonathan Kimmelman (2014). Are Phase 1 Trials Therapeutic? Risk, Ethics, and Division of Labor. Bioethics 28 (3):138-146.score: 18.0
    Despite their crucial role in the translation of pre-clinical research into new clinical applications, phase 1 trials involving patients continue to prompt ethical debate. At the heart of the controversy is the question of whether risks of administering experimental drugs are therapeutically justified. We suggest that prior attempts to address this question have been muddled, in part because it cannot be answered adequately without first attending to the way labor is divided in managing risk in clinical trials. In what follows, (...)
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  11. Stefan Dragulinescu (2012). The Problem of Processes and Transitions: Are Diseases Phase Kinds? [REVIEW] Medicine, Health Care and Philosophy 15 (1):79-89.score: 18.0
    In this paper I discuss a central objection against diseases being natural kinds—namely, that diseases are processes or transitions and hence they should not be conceptualized in the ‘substantish’ framework of natural kinds. I indicate that the objection hinges on conceiving disease kinds as phase kinds, in contrast to the non-phase, natural kinds of the exact sciences. I focus on somatic diseases and argue, via a representative comparison, that if disease kinds are phase kinds, then exact science kinds are phase (...)
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  12. Carlos Castro (2010). On Nonlinear Quantum Mechanics, Noncommutative Phase Spaces, Fractal-Scale Calculus and Vacuum Energy. Foundations of Physics 40 (11):1712-1730.score: 18.0
    A (to our knowledge) novel Generalized Nonlinear Schrödinger equation based on the modifications of Nottale-Cresson’s fractal-scale calculus and resulting from the noncommutativity of the phase space coordinates is explicitly derived. The modifications to the ground state energy of a harmonic oscillator yields the observed value of the vacuum energy density. In the concluding remarks we discuss how nonlinear and nonlocal QM wave equations arise naturally from this fractal-scale calculus formalism which may have a key role in the final formulation of (...)
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  13. Sam Werner (2012). Observation of Berry's Geometric Phase by Neutron Interferometry. Foundations of Physics 42 (1):122-139.score: 18.0
    On the 25th anniversary of Berry’s historic papers on the geometric phase, I discuss here our neutron interferometry experiment in which this phase is clearly separated from the dynamical phase. The connection of this experiment to the observation of the sign reversal of the wave function of a fermion during a 2π precession in a magnetic field by three groups independently in 1975 is discussed.
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  14. Marnie Hughes-Warrington (2012). The Ethics of Internationalisation in Higher Education: Hospitality, Self-Presence and 'Being Late'. Educational Philosophy and Theory 44 (3):312-322.score: 18.0
    While the concept of internationalization plays a key role in contemporary discussions on the activities and outcomes sought by universities, it is commonly argued that it is poorly understood or realised in practice. This has led some to argue that more work is needed to define the dimensions of the concept, or even to plot out stages of its achievement. This paper aims not to provide a definition of internationalisation for those working in higher education. On the contrary, it seeks (...)
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  15. Gilles Dutilh, Eric-Jan Wagenmakers, Ingmar Visser & Han L. J. van der Maas (2011). A Phase Transition Model for the Speed-Accuracy Trade-Off in Response Time Experiments. Cognitive Science 35 (2):211-250.score: 18.0
    Most models of response time (RT) in elementary cognitive tasks implicitly assume that the speed-accuracy trade-off is continuous: When payoffs or instructions gradually increase the level of speed stress, people are assumed to gradually sacrifice response accuracy in exchange for gradual increases in response speed. This trade-off presumably operates over the entire range from accurate but slow responding to fast but chance-level responding (i.e., guessing). In this article, we challenge the assumption of continuity and propose a phase transition model for (...)
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  16. Norihiro Kamide (2006). Phase Semantics and Petri Net Interpretation for Resource-Sensitive Strong Negation. Journal of Logic, Language and Information 15 (4):371-401.score: 18.0
    Wansing’s extended intuitionistic linear logic with strong negation, called WILL, is regarded as a resource-conscious refinment of Nelson’s constructive logics with strong negation. In this paper, (1) the completeness theorem with respect to phase semantics is proved for WILL using a method that simultaneously derives the cut-elimination theorem, (2) a simple correspondence between the class of Petri nets with inhibitor arcs and a fragment of WILL is obtained using a Kripke semantics, (3) a cut-free sequent calculus for WILL, called twist (...)
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  17. Gilad Gour (2002). The Quantum Phase Problem: Steps Toward a Resolution. [REVIEW] Foundations of Physics 32 (6):907-926.score: 18.0
    Defining the observable φ canonically conjugate to the number observable N has long been an open problem in quantum theory. The problem stems from the fact that N is bounded from below. In a previous work we have shown how to define the absolute phase observable Φ≡|φ| by suitably restricting the Hilbert space of x and p like variables. Here we show that also from the classical point of view, there is no rigorous definition for the phase even though it's (...)
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  18. Enzo Brunetti, Pedro E. Maldonado & Francisco Aboitiz (2013). Phase Synchronization of Delta and Theta Oscillations Increase During the Detection of Relevant Lexical Information. Frontiers in Psychology 4.score: 18.0
    During monitoring of the discourse, the detection of the relevance of incoming lexical information could be critical for its incorporation to update mental representations in memory. Because, in these situations, the relevance for lexical information is defined by abstract rules that are maintained in memory, results critical to understand how an abstract level of knowledge maintained in mind mediates the detection of the lower-level semantic information. In the present study, we propose that neuronal oscillations participate in the detection of relevant (...)
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  19. Francesco De Martini, Fabio Sciarrino, Nicolò Spagnolo & Chiara Vitelli (2011). Generation of Highly Resilient to Decoherence Macroscopic Quantum Superpositions Via Phase-Covariant Quantum Cloning. Foundations of Physics 41 (3):492-508.score: 18.0
    In this paper we analyze the resilience to decoherence of the Macroscopic Quantum Superpositions (MQS) generated by optimal phase-covariant quantum cloning according to two coherence criteria, both based on the concept of Bures distance in Hilbert spaces. We show that all MQS generated by this system are characterized by a high resilience to decoherence processes. This analysis is supported by the results of recent MQS experiments of N=3.5×104 particles.
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  20. Gabriel Troc (2010). Fredric Jameson, Postmodernism or the Cultural Logic of Late Capitalism. Journal for the Study of Religions and Ideologies 2 (4):197-205.score: 18.0
    Fredric Jameson, Postmodernism or the Cultural Logic of Late Capitalism Duke University Press, 1991.
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  21. Rosemarie Dlc Bernabe, Ghislaine Jmw van Thiel, Jan Am Raaijmakers & Johannes Jm van Delden (2014). The Fiduciary Obligation of the Physician-Researcher in Phase IV Trials. BMC Medical Ethics 15 (1):11.score: 18.0
    BackgroundIn this manuscript, we argue that within the context of phase IV, physician-researchers retain their fiduciary obligation to treat the patient-participants.DiscussionWe first clarify why the perspective that research ethics ought to be differentiated from clinical ethics is not applicable in phase IV, and therefore, why therapeutic orientation is most convivial in this phase. Next, assuming that ethics guidelines may be representative of common morality, we show that ethics guidelines see physician-researchers primarily as physicians and only secondarily as researchers. We then (...)
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  22. Jèssica Jaques Pi (2013). Kant's Aesthetic Reading of Aristotle's "Philia": Disinterestedness and the Mood of the Late Enlightenment. Revista de Filosofía (Madrid) 37 (2):55-68.score: 18.0
    This article roots Kant’s concept of disinterestedness, as he uses it in the Critique of Judgment, in Aristotle’s notion of philia by establishing a path from ethics to aesthetics and back. In this way, the third Critique turns out to be one of the main sources for a new ideal of humanity: the ideal suitable for late Enlightenment. This article argues that Kant reaches this fruitful use of disinterestedness by giving to Aristotle’s concept of philia an aesthetic turn.
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  23. Robert T. Knight Bradley Voytek, Ryan T. Canolty, Avgusta Shestyuk, Nathan E. Crone, Josef Parvizi (2010). Shifts in Gamma Phase–Amplitude Coupling Frequency From Theta to Alpha Over Posterior Cortex During Visual Tasks. Frontiers in Human Neuroscience 4.score: 18.0
    The phase of ongoing theta (4-8 Hz) and alpha (8-12 Hz) electrophysiological oscillations is coupled to high gamma (80-150 Hz) amplitude, which suggests that low frequency oscillations modulate local cortical activity. While this phase-amplitude coupling (PAC) has been demonstrated in a variety of tasks and cortical regions, it has not been shown whether task demands differentially affect the regional distribution of the preferred low-frequency coupling to high gamma. To address this issue we investigated multiple-rhythm theta/alpha phase to high gamma amplitude (...)
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  24. André Knops Jan Willem Koten, Jr, Jan Lonnemann, Klaus Willmes (2011). Micro and Macro Pattern Analyses of fMRI Data Support Both Early and Late Interaction of Numerical and Spatial Information. Frontiers in Human Neuroscience 5.score: 18.0
    Numbers and space are two semantic primitives that interact with each other. Both recruit brain regions along the dorsal pathway, notably parietal cortex. This makes parietal cortex a candidate for the origin of numerical spatial interaction. The underlying cognitive architecture of the interaction is still under scrutiny. Two classes of explanations can be distinguished. The early interaction approach assumes that numerical and spatial information are integrated into a single representation at a semantic level. A second approach postulates independent semantic representations. (...)
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  25. Christina Matta (2010). Spontaneous Generation and Disease Causation: Anton de Bary's Experiments with Phytophthora Infestans and Late Blight of Potato. [REVIEW] Journal of the History of Biology 43 (3):459 - 491.score: 18.0
    Anton de Bary is best known for his elucidation of the life cycle of Phytopthora infestans, the causal organism of late blight of potato and the crop losses that caused famine in nineteenth-century Europe. But while practitioner histories often claim this accomplishment as a founding moment of modern plant pathology, closer examination of de Bary's experiments and his published work suggest that his primary motiviation for pursing this research was based in developmental biology, not agriculture. De Bary shied away from (...)
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  26. M. J. Rave (2008). Interpreting Quantum Interference Using a Berry's Phase-Like Quantity. Foundations of Physics 38 (12):1073-1081.score: 18.0
    We show that quantum interference can be interpreted in terms of a phase invariant quantity, not unlike the Berry’s phase. Under this interpretation, closed loops in time become fundamental quantum entities, and all quantum states become periodic. Decoherence is then seen to occur naturally as a consequence. This formalism, although counterintuitive, provides another useful way of assigning meaning to quantum probabilities and quasi-probabilities.
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  27. J. Matias Palva Satu Palva (2011). Functional Roles of Alpha-Band Phase Synchronization in Local and Large-Scale Cortical Networks. Frontiers in Psychology 2:204-204.score: 18.0
    Alpha-frequency band (8-14 Hz) oscillations are among the most salient phenomena in human electroencephalography (EEG) recordings and yet their functional roles have remained unclear. Much of research on alpha oscillations in human EEG has focused on peri-stimulus amplitude dynamics, which phenomenologically support an idea of alpha oscillations being negatively correlated with local cortical excitability and having a role in the suppression of task-irrelevant neuronal processing. This kind of an inhibitory role for alpha oscillations is also supported by several functional magnetic (...)
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  28. Anita Strezova (2013). Overview on Iconophile and Iconoclastic Attitudes Toward Images in Early Christianity and Late Antiquity. Journal for the Study of Religions and Ideologies 12 (36):228-258.score: 18.0
    This study offers an overview of the opposing attitudes towards the image worship in the Early Christianity and the Late Antiquity. It shows that a dichotomy between creation and veneration of images on one side and iconoclastic tendencies on the other side persisted in the Christian tradition throughout the first seven centuries. While the representations of holy figures and holy events increased in number throughout theByzantine Empire, they led to a puritanical reaction by those who saw the practice of image (...)
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  29. J. D. M. Vianna, M. C. B. Fernandes & A. E. Santana (2005). Galilean-Covariant Clifford Algebras in the Phase-Space Representation. Foundations of Physics 35 (1):109-129.score: 18.0
    We apply the Galilean covariant formulation of quantum dynamics to derive the phase-space representation of the Pauli–Schrödinger equation for the density matrix of spin-1/2 particles in the presence of an electromagnetic field. The Liouville operator for the particle with spin follows from using the Wigner–Moyal transformation and a suitable Clifford algebra constructed on the phase space of a (4 + 1)-dimensional space–time with Galilean geometry. Connections with the algebraic formalism of thermofield dynamics are also investigated.
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  30. P. Watson & A. J. Bracken (2014). Quantum Phase Space From Schwinger's Measurement Algebra. Foundations of Physics 44 (7):762-780.score: 18.0
    Schwinger’s algebra of microscopic measurement, with the associated complex field of transformation functions, is shown to provide the foundation for a discrete quantum phase space of known type, equipped with a Wigner function and a star product. Discrete position and momentum variables label points in the phase space, each taking \(N\) distinct values, where \(N\) is any chosen prime number. Because of the direct physical interpretation of the measurement symbols, the phase space structure is thereby related to definite experimental configurations.
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  31. Frederic Gilbert, Alexander R. Harris & Robert M. I. Kapsa (2012). Efficacy Testing as a Primary Purpose of Phase 1 Clinical Trials: Is It Applicable to First-in-Human Bionics and Optogenetics Trials? AJOB Neuroscience 3 (2):20-22.score: 18.0
    In her article, Pascale Hess raises the issue of whether her proposed model may be extrapolated and applied to clinical research fields other than stem cell-based interventions in the brain (SCBI-B) (Hess 2012). Broadly summarized, Hess’s model suggests prioritizing efficacy over safety in phase 1 trials involving irreversible interventions in the brain, when clinical criteria meet the appropriate population suffering from “degenerative brain diseases” (Hess 2012). Although there is a need to reconsider the traditional phase 1 model, especially with respect (...)
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  32. Scott Y. H. Kim, Robert G. Holloway, Samuel Frank, Renee Wilson & Karl Kieburtz (2008). Trust in Early Phase Research: Therapeutic Optimism and Protective Pessimism. [REVIEW] Medicine, Health Care and Philosophy 11 (4):393-401.score: 18.0
    Bioethicists have long been concerned that seriously ill patients entering early phase (‘phase I’) treatment trials are motivated by therapeutic benefit even though the likelihood of benefit is low. In spite of these concerns, consent forms for phase I studies involving seriously ill patients generally employ indeterminate benefit statements rather than unambiguous statements of unlikely benefit. This seeming mismatch between attitudes and actions suggests a need to better understand research ethics committee members’ attitudes toward communication of potential benefits and risks (...)
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  33. Miriam Kos, Danielle Van den Brink & Peter Hagoort (2012). Individual Variation in the Late Positive Complex to Semantic Anomalies. Frontiers in Psychology 3.score: 18.0
    It is well-known that, within ERP paradigms of sentence processing, semantically anomalous words elicit N400 effects. Less clear, however, is what happens after the N400. In some cases N400 effects are followed by Late Positive Complexes (LPC), whereas in other cases such effects are lacking. We investigated several factors which could affect the LPC, such as contextual constraint, inter-individual variation and working memory. Seventy-two participants read sentences containing a semantic manipulation (Whipped cream tastes sweet/anxious and creamy). Neither contextual constraint nor (...)
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  34. Kai J. Miller, Dora Hermes, Christopher J. Honey, Mohit Sharma, Rajesh P. N. Rao, Marcel Den Nijs, Eberhard E. Fetz, Terrence J. Sejnowski, Adam O. Hebb, Jeffrey G. Ojemann, Scott Makeig & Eric C. Leuthardt (2010). Dynamic Modulation of Local Population Activity by Rhythm Phase in Human Occipital Cortex During a Visual Search Task. Frontiers in Human Neuroscience 4:197.score: 18.0
    Brain rhythms are more than just passive phenomena in visual cortex. For the first time, we show that the physiology underlying brain rhythms actively suppresses and releases cortical areas on a second-to-second basis during visual processing. Furthermore, their influence is specific at the scale of individual gyri. We quantified the interaction between broadband spectral change and brain rhythms on a second-to-second basis in electrocorticographic (ECoG) measurement of brain surface potentials in five human subjects during a visual search task. Comparison of (...)
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  35. Sander Nieuwenhuis Stephen B. R. E. Brown, Henk van Steenbergen, Guido P. H. Band, Mischa de Rover (2012). Functional Significance of the Emotion-Related Late Positive Potential. Frontiers in Human Neuroscience 6.score: 18.0
    The late positive potential (LPP) is an event-related potential component over visual cortical areas that is modulated by the emotional intensity of a stimulus. However, the functional significance of this neural modulation remains elusive. We conducted two experiments in which we studied the relation between LPP amplitude, subsequent perceptual sensitivity to a non-emotional stimulus (Experiment 1) and visual cortical excitability, as reflected by P1/N1 components evoked by this stimulus (Experiment 2). During the LPP modulation elicited by unpleasant stimuli, perceptual sensitivity (...)
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  36. Joydeep Bhattacharya Susanne Reiterer, Ernesto Pereda (2011). On a Possible Relationship Between Linguistic Expertise and EEG Gamma Band Phase Synchrony. Frontiers in Psychology 2.score: 18.0
    Recent research has shown that extensive training in and exposure to a second language can modify the language organization in the brain by causing both structural and functional changes. However it is not yet known how these changes are manifested by the dynamic brain oscillations and synchronization patterns subserving the language networks. In search for synchronization correlates of proficiency and expertise in second language acquisition, multivariate EEG signals were recorded from 44 high and low proficiency bilinguals during processing of natural (...)
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  37. Paul H. E. Tiesinga & Terrence J. Sejnowski (2010). Mechanisms for Phase Shifting in Cortical Networks and Their Role in Communication Through Coherence. Frontiers in Human Neuroscience 4.score: 18.0
    In the primate visual cortex, the phase of spikes relative to oscillations in the local field potential (LFP) in the gamma frequency range (30-80Hz) can be shifted by stimulus features such as orientation and thus the phase may carry information about stimulus identity. According to the principle of communication through coherence (CTC), the relative LFP phase between the LFPs in the sending and receiving circuits affects the effectiveness of the transmission. CTC predicts that phase shifting can be used for stimulus (...)
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  38. Peter Heil Benedikt Zoefel (2013). Detection of Near-Threshold Sounds is Independent of EEG Phase in Common Frequency Bands. Frontiers in Psychology 4.score: 18.0
    Low-frequency oscillations in the electroencephalogram (EEG) are thought to reflect periodic excitability changes of large neural networks. Consistent with this notion, detection probability of near-threshold somatosensory, visual, and auditory targets has been reported to co-vary with the phase of oscillations in the EEG. In audition, entrainment of δ-oscillations to the periodic occurrence of sounds has been suggested to function as a mechanism of attentional selection. Here, we examine in humans whether the detection of brief near-threshold sounds in quiet depends on (...)
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  39. Stephen Bre Brown, Henk van Steenbergen, Guido Ph Band, Mischa de Rover & Sander Nieuwenhuis (2012). Functional Significance of the Emotion-Related Late Positive Potential. Frontiers in Human Neuroscience 6:33-33.score: 18.0
    The late positive potential (LPP) is an event-related potential component over visual cortical areas that is modulated by the emotional intensity of a stimulus. However, the functional significance of this neural modulation remains elusive. We conducted two experiments in which we studied the relation between LPP amplitude, subsequent perceptual sensitivity to a non-emotional stimulus (Experiment 1) and visual cortical excitability, as reflected by P1/N1 components evoked by this stimulus (Experiment 2). During the LPP modulation elicited by unpleasant stimuli, perceptual sensitivity (...)
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  40. Stefan Dürschmid, Tino Zaehle, Klaus Kopitzki, Jürgen Voges, Friedhelm Carl Schmitt, Hans-Jochen Heinze, Robert T. Knight & Hermann Hinrichs (2013). Phase-Amplitude Cross-Frequency Coupling in the Human Nucleus Accumbens Tracks Action Monitoring During Cognitive Control. Frontiers in Human Neuroscience 7.score: 18.0
    The Nucleus Accumbens (NAcc) is an important structure for the transfer of information between cortical and subcortical structures, especially the prefrontal cortex and the hippocampus. However, the mechanism that allows the NAcc to achieve this integration is not well understood. Phase-amplitude cross-frequency coupling (PAC) of oscillations in different frequency bands has been proposed as an effective mechanism to form functional networks to optimize transfer and integration of information. Here we assess PAC between theta and high gamma oscillations as a potential (...)
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  41. S. Murray & P. J. Bex (2009). Perceived Blur in Naturally Contoured Images Depends on Phase. Frontiers in Psychology 1:185-185.score: 18.0
    Perceived blur is an important measure of image quality and clinical visual function. The magnitude of image blur varies across space and time under natural viewing conditions owing to changes in pupil size and accommodation. Blur is frequently studied in the laboratory with a variety of digital filters, without comparing how the choice of filter affects blur perception. We examine the perception of image blur in synthetic images composed of contours whose orientation and curvature spatial properties matched those of natural (...)
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  42. Vincenzo Romei Nienke Hoogenboom (2010). Probing Different Time-Scales of Oscillatory Fluctuations in Visual Awareness: From Behavior to Phase. Frontiers in Human Neuroscience 4.score: 18.0
    Probing Different Time-Scales of Oscillatory Fluctuations in Visual Awareness: From Behavior to Phase.
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  43. Douglas McLelland Rufin VanRullen (2013). What Goes Up Must Come Down: EEG Phase Modulates Auditory Perception in Both Directions. Frontiers in Psychology 4.score: 18.0
    What goes up must come down: EEG phase modulates auditory perception in both directions.
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  44. Julien Dubois R. VanRullen, N. A. Busch, J. Drewes (2011). Ongoing EEG Phase as a Trial-by-Trial Predictor of Perceptual and Attentional Variability. Frontiers in Psychology 2.score: 18.0
    Even in well-controlled laboratory environments, apparently identical repetitions of an experimental trial can give rise to highly variable perceptual outcomes and behavioral responses. This variability is generally discarded as a reflection of intrinsic noise in neuronal systems. However, part of this variability may be accounted for by trial-by-trial fluctuations of the phase of ongoing oscillations at the moment of stimulus presentation. For example, the phase of an electro-encephalogram (EEG) oscillation reflecting the rapid waxing and waning of sustained attention can predict (...)
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  45. Hermann Ackermann Susanne Maria Reiterer, Xiaochen Hu, Michael Erb, Giuseppina Rota, Davide Nardo, Wolfgang Grodd, Susanne Winkler (2011). Individual Differences in Audio-Vocal Speech Imitation Aptitude in Late Bilinguals: Functional Neuro-Imaging and Brain Morphology. Frontiers in Psychology 2.score: 18.0
    An unanswered question in adult language learning or late bi- and multilingualism is why individuals show marked differences in their ability to imitate foreign accents. While recent research acknowledges that more adults than previously assumed can still acquire a “native” foreign accent, very little is known about the neuro-cognitive correlates of this special ability. We investigated 140 German speaking individuals displaying varying degrees of “mimicking” capacity, based on natural language text, sentence and word imitations either in their second language English (...)
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  46. Michael N. Marsh (2010). Out-of-Body and Near-Death Experiences: Brain-State Phenomena or Glimpses of Immortality? OUP Oxford.score: 15.0
    Personalised accounts of out-of-body (OBE) and near-death (NDE) experiences are frequently interpreted as offering evidence for immortality and an afterlife. Since most OBE/NDE follow severe curtailments of cerebral circulation with loss of consciousness, the agonal brain supposedly permits 'mind', 'soul' or 'consciousness' to escape neural control and provide glimpses of the afterlife. -/- Michael Marsh critically analyses the work of five key writers who support this so-called "dying brain" hypothesis. He firmly disagrees with such otherworldly 'mystical' or 'psychical' interpretations, ably (...)
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  47. Jonathan Kimmelman (2007). Clinical Trials and Scid Row: The Ethics of Phase 1 Trials in the Developing World. Developing World Bioethics 7 (3):128–135.score: 15.0
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  48. K. P. Weinfurt, Daniel P. Sulmasy, Kevin A. Schulman & Neal J. Meropol (2003). Patient Expectations of Benefit From Phase I Clinical Trials: Linguistic Considerations in Diagnosing a Therapeutic Misconception. Theoretical Medicine and Bioethics 24 (4):329-344.score: 15.0
    The ethical treatment of cancer patientsparticipating in clinical trials requiresthat patients are well-informed about thepotential benefits and risks associated withparticipation. When patients enrolled in phaseI clinical trials report that their chance ofbenefit is very high, this is often taken as evidence of a failure of the informed consent process. We argue, however, that some simple themes from the philosophy of language may make such a conclusion less certain. First, the patient may (...)
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  49. Ben Goertzel (1993). Phase Transitions in Associative Memory Networks. Minds and Machines 3 (3):313-317.score: 15.0
    Ideas from random graph theory are used to give an heuristic argument that associative memory structure depends discontinuously on pattern recognition ability. This argument suggests that there may be a certain minimal size for intelligent systems.
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  50. R. D. Pentz, R. D. Harvey, M. White, Z. L. Farmer, O. Dashevskaya, Z. Chen, C. Lewis, T. K. Owonikoko & F. R. Khuri (2011). Research Biopsies in Phase I Studies: Views and Perspectives of Participants and Investigators. Irb 34 (2):1-8.score: 15.0
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