Search results for 'MICE' (try it on Scholar)

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Profile: Keren Mice (Independent researcher)
  1.  24
    Monika Piotrowska (2013). From Humanized Mice to Human Disease: Guiding Extrapolation From Model to Target. Biology and Philosophy 28 (3):439-455.
    Extrapolation from a well-understood base population to a less-understood target population can fail if the base and target populations are not sufficiently similar. Differences between laboratory mice and humans, for example, can hinder extrapolation in medical research. Mice that carry a partial or complete human physiological system, known as humanized mice, are supposed to make extrapolation more reliable by simulating a variety of human diseases. But what justifies our belief that these mice are similar enough to (...)
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  2.  6
    Soraya de Chadarevian (2006). Mice and the Reactor: The “Genetics Experiment” in 1950s Britain. [REVIEW] Journal of the History of Biology 39 (4):707-735.
    The postwar investments by several governments into the development of atomic energy for military and peaceful uses fuelled the fears not only of the exposure to acute doses of radiation as could be expected from nuclear accidents or atomic warfare but also of the long-term effects of low-dose exposure to radiation. Following similar studies pursued under the aegis of the Manhattan Project in the United States, the “genetics experiment” discussed by scientists and government officials in Britain soon after the war, (...)
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  3.  57
    Matthew C. Haug (2007). Of Mice and Metaphysics: Natural Selection and Realized Population‐Level Properties. Philosophy of Science 74 (4):431-451.
    In this paper, I answer a fundamental question facing any view according to which natural selection is a population‐level causal process—namely, how is the causal process of natural selection related to, yet not preempted by, causal processes that occur at the level of individual organisms? Without an answer to this grounding question, the population‐level causal view appears unstable—collapsing into either an individual‐level causal interpretation or the claim that selection is a purely formal, statistical phenomenon. I argue that a causal account (...)
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  4.  13
    Ronald Jensen, Ernest Schimmerling, Ralf Schindler & John Steel (2009). Stacking Mice. Journal of Symbolic Logic 74 (1):315-335.
    We show that either of the following hypotheses imply that there is an inner model with a proper class of strong cardinals and a proper class of Woodin cardinals. 1) There is a countably closed cardinal k ≥ N₃ such that □k and □(k) fail. 2) There is a cardinal k such that k is weakly compact in the generic extension by Col(k, k⁺). Of special interest is 1) with k = N₃ since it follows from PFA by theorems of (...)
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  5.  59
    Peter Vallentyne (2005). Of Mice and Men: Equality and Animals. [REVIEW] Journal of Ethics 9 (3-4):403 - 433.
    Can material Egalitarianism (requiring, for example, the significant promotion of fortune) include animals in the domain of the equality requirement? The problem can be illustrated as follows: If equality of wellbeing is what matters, and normal mice are included in this egalitarian requirement, then normal mice have a much stronger claim to resources than almost any human. This is because normal mice have a much stronger claim to resources than almost any human. This is because their wellbeing (...)
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  6. Paul Bloom (1998). Different Structures for Concepts of Individuals, Stuffs, and Real Kinds: One Mama, More Milk, and Many Mice. Behavioral and Brain Sciences 21 (1):66-67.
    Although our concepts of “Mama,” “milk,” and “mice” have much in common, the suggestion that they are identical in structure in the mind of the prelinguistic child is mistaken. Even infants think about objects as different from substances and appreciate the distinction between kinds (e.g., mice) and individuals (e.g., Mama). Such cognitive capacities exist in other animals as well, and have important adaptive consequences.
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  7. Peter Medawar (1996). The Strange Case of the Spotted Mice and Other Classic Essays on Science. Monograph Collection (Matt - Pseudo).
    Sir Peter Medawar was not only a Nobel prize-winning immunologist but also a wonderful writer about science and scientists. Described by the Washington Post as a `genuinely brilliant popularizer' of science, his essays are remarkable for their clarity and wit. This entertaining selection presents the very best of his writing with a new Foreword by Stephen Jay Gould, one of his greatest admirers. The wide range of subjects include Howard Florey and penicillin, J. B. S. Haldane, whom he describes as (...)
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  8.  22
    F. Barbara Orlans (2000). The Injustice of Excluding Laboratory Rats, Mice, and Birds From the Animal Welfare Act. Kennedy Institute of Ethics Journal 10 (3):229-238.
    : A major shortcoming of the Animal Welfare Act is its exclusion of the species most-used in experimentation-rats, mice, and birds. Considerations of justice dictate that extension of the law to these three species is the morally right thing to do. A brief history of how these species came to be excluded from the laws protecting laboratory animals is also provided, as well as discussion of the implications and significance of expanding the law.
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  9.  21
    Piers J. Hale (2010). Of Mice and Men: Evolution and the Socialist Utopia. William Morris, H.G. Wells, and George Bernard Shaw. [REVIEW] Journal of the History of Biology 43 (1):17 - 66.
    During the British socialist revival of the 1880s competing theories of evolution were central to disagreements about strategy for social change. In News from Nowhere (1891), William Morris had portrayed socialism as the result of Lamarckian processes, and imagined a non-Malthusian future. H.G. Wells, an enthusiastic admirer of Morris in the early days of the movement, became disillusioned as a result of the Malthusianism he learnt from Huxley and his subsequent rejection of Lamarckism in light of Weismann's experiments on (...). This brought him into conflict with his fellow Fabian, George Bernard Shaw, who rejected neo-Darwinism in favour of a Lamarckian conception of change he called "creative evolution.". (shrink)
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  10.  33
    Camilla Flodin (2011). Of Mice and Men: Adorno on Art and the Suffering of Animals. Estetika 48 (2):139-156.
    Theodor W. Adorno’s criticism of human beings’ domination of nature is a familiar topic to Adorno scholars. Its connection to the central relationship between art and nature in his aesthetics has, however, been less analysed. In the following paper, I claim that Adorno’s discussion of art’s truth content (Wahrheitsgehalt) is to be understood as art’s ability to give voice to nature (both human and non-human) since it has been subjugated by the growth of civilization. I focus on repressed non-human nature (...)
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  11.  14
    Farmer Schlutzenberg (2012). Homogeneously Suslin Sets in Tame Mice. Journal of Symbolic Logic 77 (4):1122-1146.
    This paper studies homogeneously Suslin (hom) sets of reals in tame mice. The following results are established: In 0 ¶ the hom sets are precisely the [Symbol] sets. In M n every hom set is correctly [Symbol] and (δ + 1)-universally Baire where ä is the least Woodin. In M u every hom set is <λ-hom, where λ is the supremum of the Woodins.
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  12.  6
    Zhengui Xia & Daniel R. Storm (1995). Evidence That the Type I Adenylyl Cyclase May Be Important for Neuroplasticity: Mutant Mice Deficient in the Gene for Type I Adenylyl Cyclase Show Altered Behavior and LTP. Behavioral and Brain Sciences 18 (3):498-500.
    The regulatory properties of the neurospecific, type I adenylyl cyclase and its distribution within brain have suggested that this enzyme may be important for neuroplasticity. To address this issue, the murine, Ca2+ -stimulated adenylyl cyclase (type I), was inactivated by targeted mutagenesis. Ca2+ -stimulated adenylyl cyclase activity was reduced 40% to 60% in the hippocampus, neocortex, and cerebellum. Long term potentiation in the CA1 region of the hippocampus from mutants was perturbed relative to controls. Both the initial slope and maxim (...)
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  13.  2
    Scott R. Granter, Aaron Bernstein & Richard S. Ostfeld (2014). Of Mice and Men: Lyme Disease and Biodiversity. Perspectives in Biology and Medicine 57 (2):198-207.
    If you consult a medical textbook to learn about the pathogenesis of Lyme disease, you will find a standard narrative. You will learn the disease is caused by the spirochete Borrelia burgdorferi, which is transmitted to people by blacklegged ticks . You will also learn that the natural reservoir for spirochetes in the Northeast is the white-footed mouse , and also likely be told that white-tailed deer are the primary host for gravid female ticks. And that is pretty much the (...)
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  14.  2
    Lara Huber & Lara K. Keuck (2013). Mutant Mice: Experimental Organisms as Materialised Models in Biomedicine. Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 44 (3):385-391.
    Animal models have received particular attention as key examples of material models. In this paper, we argue that the specificities of establishing animal models—acknowledging their status as living beings and as epistemological tools—necessitate a more complex account of animal models as materialised models. This becomes particularly evident in animal-based models of diseases that only occur in humans: in these cases, the representational relation between animal model and human patient needs to be generated and validated. The first part of this paper (...)
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  15.  1
    D. K. Lahiri, D. Chen, B. Maloney, H. W. Holloway, Q. S. Yu, T. Utsuki, T. Giordano, K. Sambamurti & N. H. Greig (2007). The Experimental Alzheimer's Disease Drug Posiphen [-Phenserine] Lowers Amyloid-Beta Peptide Levels in Cell Culture and Mice. J Pharmacol Exp Ther 320:386-96.
    Major characteristics of Alzheimer's disease are synaptic loss, cholinergic dysfunction, and abnormal protein depositions in the brain. The amyloid beta-peptide , a proteolytic fragment of amyloid beta precursor protein , aggregates to form neuritic plaques and has a causative role in AD. A present focus of AD research is to develop safe Abeta-lowering drugs. A selective acetylcholinesterase inhibitor, phenserine, in current human trials lowers both APP and Abeta. Phenserine is dose-limited in animals by its cholinergic actions; its cholinergically inactive enantiomer, (...)
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  16.  2
    Daniel W. Cunningham (1998). The Fine Structure of Real Mice. Journal of Symbolic Logic 63 (3):937-994.
    Before one can construct scales of minimal complexity in the Real Core Model, K(R), one needs to develop the fine-structure theory of K(R). In this paper, the fine structure theory of mice, first introduced by Dodd and Jensen, is generalized to that of real mice. A relative criterion for mouse iterability is presented together with two theorems concerning the definability of this criterion. The proof of the first theorem requires only fine structure; whereas, the second theorem applies to (...)
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  17. R. Dosunmu, J. Wu, L. Adwan, B. Maloney, M. R. Basha, C. A. McPherson, G. J. Harry, D. C. Rice, N. H. Zawia & D. K. Lahiri (2009). Lifespan Profiles of Alzheimer's Disease-Associated Genes and Products in Monkeys and Mice. J Alzheimers Dis 18:211-30.
    Alzheimer's disease is characterized by plaques of amyloid-beta peptide, cleaved from amyloid-beta protein precursor . Our hypothesis is that lifespan profiles of AD-associated mRNA and protein levels in monkeys would differ from mice and that differential lifespan expression profiles would be useful to understand human AD pathogenesis. We compared profiles of AbetaPP mRNA, AbetaPP protein, and Abeta levels in rodents and primates. We also tracked a transcriptional regulator of the AbetaPP gene, specificity protein 1 , and the beta amyloid (...)
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  18.  21
    Bernard E. Rollin (2007). Of Mice and Men. American Journal of Bioethics 7 (5):55 – 57.
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  19. Catharine A. MacKinnon (2004). Of Mice and Men: A Feminist Fragment on Animal Rights. In Cass R. Sunstein & Martha Craven Nussbaum (eds.), Animal Rights: Current Debates and New Directions. Oxford University Press 263--76.
     
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  20. Austen Clark (1993). Mice, Shrews, and Misrepresentation. Journal of Philosophy 60 (6):290-310.
  21.  9
    Lynda Birke (2003). Who—or What—Are the Rats (and Mice) in the Laboratory. Society and Animals 11 (3):207-224.
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  22.  22
    Helena Pedersen (2012). Undercover Education: Mice, Mimesis, and Parasites in the Teaching Machine. Studies in Philosophy and Education 31 (4):365-386.
    What happens to education when the potential it helps realizing in the individual works against the formal purposes of the curriculum? What happens when education becomes a vehicle for its own subversion? As a subject-forming state apparatus working on ideological speciesism, formal education is engaged in both human and animal stratification in service of the capitalist knowledge economy. This seemingly stable condition is however insecured by the animal rights activist as undercover learner and—worker, who enters education and research laboratories under (...)
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  23.  18
    James R. Griesemer & Elihu M. Gerson (2006). Of Mice and Men and Low Unit Cost. Studies in History and Philosophy of Science Part C 37 (2):363-372.
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  24.  7
    Laurie Zoloth, Leilah Backhus & Teresa Woodruff (2008). Waiting to Be Born: The Ethical Implications of the Generation of “Nuborn” and “Nuage” Mice From Pre-Pubertal Ovarian Tissue. American Journal of Bioethics 8 (6):21 – 29.
    Oncofertility is one of the 9 NIH Roadmap Initiatives, federal grants intended to explore previously intractable questions, and it describes a new field that exists in the liminal space between cancer treatment and its sequelae, IVF clinics and their yearning, and basic research in cell growth, biomaterials, and reproductive science and its tempting promises. Cancer diagnoses, which were once thought universally fatal, now often entail management of a chronic disease. Yet the therapies are rigorous, must start immediately, and in many (...)
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  25.  33
    Giles Pearson (2006). 'Does the Fearless Phobic Really Fear the Squeak of Mice “Too Much”?'. Ancient Philosophy 26 (1):81-91.
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  26.  14
    Cynthia B. Cohen (2003). Creating Human-Nonhuman Chimeras: Of Mice and Men. American Journal of Bioethics 3 (3):3 – 5.
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  27.  4
    Sergio Sismondo (1997). Deflationary Metaphysics and the Construction of Laboratory Mice. Metaphilosophy 28 (3):219-232.
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  28.  7
    Nicholas Kolodiy, Gary M. Brosvic, Stacey Bailey, Kevin Hawley, David Pak & Stephanie Ostrich (1993). Water and NaCl Consumption in Long-Evans Rats and Egyptian Spiny Mice. Bulletin of the Psychonomic Society 31 (4):261-264.
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  29.  6
    Jane L. Hurst & Robert J. Beynon (2004). Scent Wars: The Chemobiology of Competitive Signalling in Mice. Bioessays 26 (12):1288-1298.
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  30.  6
    Ernest Schimmerling (2001). The Abc's of Mice. Bulletin of Symbolic Logic 7 (4):485-503.
  31.  12
    Randolph M. Feezell (1984). Of Mice and Men. Modern Schoolman 61 (4):259-265.
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  32.  3
    Detlev Arendt & Katharina Nübler‐Jung (1996). Common Ground Plans in Early Brain Development in Mice and Flies. Bioessays 18 (3):255-259.
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  33.  40
    Jeff Foss (1991). On Saving the Phenomena and the Mice: A Reply to Bourgeois Concerning Van Fraassen's Image of Science. Philosophy of Science 58 (2):278-287.
    In the fusillade he lets fly against Foss (1984), Bourgeois (1987) sometimes hits a live target. I admit that I went beyond the letter of van Fraassen's The Scientific Image (1980), making inferences and drawing conclusions which are often absurd. I maintain, however, that the absurdities must be charged to van Fraassen's account. While I cannot redress every errant shot of Bourgeois, his essay reveals the need for further discussion of the concepts of the phenomena and the observables as used (...)
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  34.  12
    Masahiro Ohsawa, Anna Carlsson, Megumi Asato, Takayuki Koizumi, Yuki Nakanishi, Rebecca Fransson, Anja Sandström, Mathias Hallberg, Fred Nyberg & Junzo Kamei (2011). The Dipeptide Phe-Phe Amide Attenuates Signs of Hyperalgesia, Allodynia and Nociception in Diabetic Mice Using a Mechanism Involving the Sigma Receptor System. Substance 1:7.
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  35. Lynda Birke (2008). Who-Orwhat-Arethe Rats (and Mice) in the Laboratory? In Susan J. Armstrong & Richard George Botzler (eds.), The Animal Ethics Reader. Routledge 326.
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  36.  11
    Corrinne G. Lobe & Andras Nagy (1998). Conditional Genome Alteration in Mice. Bioessays 20 (3):200-208.
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  37.  2
    Leslie R. Meek & Ernest D. Kemble (1990). Effects of Eltoprazine Hydrochloride on Maternal Behavior in Mice. Bulletin of the Psychonomic Society 28 (6):563-564.
  38.  9
    Nicholas Kolodiy, Gary M. Brosvic, David Pak & Sheryl Loeffler (1993). Taste Preference Behavior in Long-Evans Rats and Egyptian Spiny Mice. Bulletin of the Psychonomic Society 31 (4):307-310.
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  39.  8
    Colleen M. Garbe & Ernest D. Kemble (1993). Effects of Novel Odor Exposure on Maternal Aggression in Mice. Bulletin of the Psychonomic Society 31 (6):571-573.
  40.  11
    Karen A. Rader (1999). Of Mice, Medicine, and Genetics: C. C. Little's Creation of the Inbred Laboratory Mouse, 1909–1918. Studies in History and Philosophy of Science Part C 30 (3):319-343.
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  41.  2
    Payam Moula & Per Sandin (2015). Of Mice and Men: European Precautionary Standards Challenged by Uncertainty. Journal of Agricultural and Environmental Ethics 28 (5):867-883.
    For several years, the official European method for deciding whether or not shellfish were fit for human consumption was the mouse bioassay, which was eventually replaced by chemical testing. In this paper, we examine the process of this change, looking at how devices of social, technical, and organisational risk management were re-negotiated locally, nationally, and across the continent. We also show how the political decision to replace a precautionary standard with a management-vigilance device was the result of various dynamics. These (...)
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  42. Q. Feng & R. Jensen (2004). Supercomplete Extenders and Type 1 Mice: Part I. Annals of Pure and Applied Logic 128 (1-3):1-73.
    We study type 1 premice equipped with supercomplete extenders. In this paper, we show that such premice are normally iterable and all normal iteration trees of type 1 premice has a unique cofinal branch. We give a construction of an KC type model using supercomplete type 1 extenders.
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  43.  7
    Colleen M. Garbe, Ernest D. Kemble & Pia C. Strunk (1993). Effects of Chlordiazepoxide on Odor-Induced Risk Assessment Behaviors in Mice. Bulletin of the Psychonomic Society 31 (4):314-316.
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  44.  7
    Z. Michael Nagy (1993). Development of Homeothermy in Infant C3H Mice. Bulletin of the Psychonomic Society 31 (3):221-224.
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  45.  7
    Z. Michael Nagy & Daniel J. Martin (1993). Hypothermia-Induced Retrograde Amnesia in Young and Adult Swiss Mice. Bulletin of the Psychonomic Society 31 (3):225-228.
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  46.  7
    T. L. S. Sprigge (1986). Of Mice, Models and Men. Environmental Ethics 8 (1):83-87.
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  47.  1
    Karen Estep, Thomas Poole, Charles W. Radcliffe, Barbara O’Connell & David Chiszar (1981). Distance Traveled by Mice After Envenomation by a Rattlesnake. Bulletin of the Psychonomic Society 18 (3):108-110.
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  48.  11
    Charles Bieberich & George Scangos (1986). Transgenic Mice in the Study of Immunology. Bioessays 4 (6):245-248.
  49.  1
    Richard B. Harris (1996). Approaches to Conserving Vulnerable Wildlife in China: Does the Colour of Cat Matter - If It Catches Mice? Environmental Values 5 (4):303-334.
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  50.  7
    Anthony Cooper (1974). Effects of Accessory Olfactory Bulb Lesions on the Sexual Behavior of Male Mice. Bulletin of the Psychonomic Society 4 (4):419-420.
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