Extrapolation from a well-understood base population to a less-understood target population can fail if the base and target populations are not sufficiently similar. Differences between laboratory mice and humans, for example, can hinder extrapolation in medical research. Mice that carry a partial or complete human physiological system, known as humanized mice, are supposed to make extrapolation more reliable by simulating a variety of human diseases. But what justifies our belief that these mice are similar enough to (...) their human counterparts to simulate human disease? I argue that, unless three requirements are met in the process of humanizing mice, very little does. My requirements are not meant to provide necessary and sufficient conditions that guarantee a particular outcome. Instead, they serve as a heuristic for guiding scientific judgments involving extrapolation. In developing each requirement, I engage with philosophical issues concerning the nature of model-based science and the mechanistic approach (and its limits) to making generalizations in the life sciences. (shrink)
In this paper, I answer a fundamental question facing any view according to which natural selection is a population‐level causal process—namely, how is the causal process of natural selection related to, yet not preempted by, causal processes that occur at the level of individual organisms? Without an answer to this grounding question, the population‐level causal view appears unstable—collapsing into either an individual‐level causal interpretation or the claim that selection is a purely formal, statistical phenomenon. I argue that a causal account (...) of realization provides an answer to the grounding question. By applying this account of realization to the natural selection of melanism in rock pocket mice, I show how an alternative, formal account of realization, favored by proponents of the statistical interpretation, misses biologically important features. More generally, this paper shows how metaphysical issues about realization normally discussed in the philosophy of mind apply to debates in philosophy of biology. Thus, it is a first step toward fleshing out the oft‐noted similarities between debates in these areas. (shrink)
Can material Egalitarianism (requiring, for example, the significant promotion of fortune) include animals in the domain of the equality requirement? The problem can be illustrated as follows: If equality of wellbeing is what matters, and normal mice are included in this egalitarian requirement, then normal mice have a much stronger claim to resources than almost any human. This is because normal mice have a much stronger claim to resources than almost any human. This is because their wellbeing (...) is much lower than that of normal humans. Thus, equality of wellbeing requires a massive shift of resources away from most humans to mice. This view, however, seems crazy. I explore this problem and propose a solution. (shrink)
Theodor W. Adorno’s criticism of human beings’ domination of nature is a familiar topic to Adorno scholars. Its connection to the central relationship between art and nature in his aesthetics has, however, been less analysed. In the following paper, I claim that Adorno’s discussion of art’s truth content (Wahrheitsgehalt) is to be understood as art’s ability to give voice to nature (both human and non-human) since it has been subjugated by the growth of civilization. I focus on repressed non-human nature (...) and examine Adorno’s interpretation of Eduard Mörike’s poem ‘Mausfallen-Sprüchlein’ (Mousetrap rhyme). By giving voice to the repressed animal, Mörike’s poem manages to point towards the possibility of a changed relationship between mice and men, between nature and humanity, which is necessary in order to achieve reconciliation amongst humans as well. (shrink)
Although our concepts of “Mama,” “milk,” and “mice” have much in common, the suggestion that they are identical in structure in the mind of the prelinguistic child is mistaken. Even infants think about objects as different from substances and appreciate the distinction between kinds (e.g., mice) and individuals (e.g., Mama). Such cognitive capacities exist in other animals as well, and have important adaptive consequences.
: A major shortcoming of the Animal Welfare Act is its exclusion of the species most-used in experimentation-rats, mice, and birds. Considerations of justice dictate that extension of the law to these three species is the morally right thing to do. A brief history of how these species came to be excluded from the laws protecting laboratory animals is also provided, as well as discussion of the implications and significance of expanding the law.
Before one can construct scales of minimal complexity in the Real Core Model, K(R), one needs to develop the fine-structure theory of K(R). In this paper, the fine structure theory of mice, first introduced by Dodd and Jensen, is generalized to that of real mice. A relative criterion for mouse iterability is presented together with two theorems concerning the definability of this criterion. The proof of the first theorem requires only fine structure; whereas, the second theorem applies to (...) real mice satisfying AD and follows from a general definability result obtained by abstracting work of John Steel on L(R). In conclusion, we discuss several consequences of the work presented in this paper relevant to two issues: the complexity of scales in K(R) and the strength of the theory ZF + AD + ¬ DC R. (shrink)
Abstract Surprisingly, little theoretical attention has so far been paid to the ?Comparative Assumption?: the attempt to extrapolate from species to species in psychology (and particularly to the human species). This paper examines the problems and the possibilities inherent in the Comparative Assumption. Perhaps the most important conclusion of the paper is that much more work is needed on this intriguing question.
Oncofertility is one of the 9 NIH Roadmap Initiatives, federal grants intended to explore previously intractable questions, and it describes a new field that exists in the liminal space between cancer treatment and its sequelae, IVF clinics and their yearning, and basic research in cell growth, biomaterials, and reproductive science and its tempting promises. Cancer diagnoses, which were once thought universally fatal, now often entail management of a chronic disease. Yet the therapies are rigorous, must start immediately, and in many (...) cases result in premature failure of the body's reproductive ability. In women, this loss is especially poignant; unlike the routine storage of sperm, which is done in men and boys facing similar treatment decisions, freezing oocytes in anticipation of fertility loss is not possible in most cases, and creating an embryo within days of diagnosis raises significant moral, social and medical challenges. Oncofertility is the study of how to harvest ovarian tissue in women facing cancer to preserve their gametes for future use with IVF, thus allowing the decisions about childbearing to be deferred and reproductive choices to be preserved. The research endeavor uses the capacity of the ovarian follicle to produce eggs in vitro . Developing the human follicle to ovulate successfully outside the body is scientifically difficult and ethically challenging. Infertility is linked to long-standing religious and moral traditions, and is intertwined with deeply contentious social narratives about women, families, illness and birth. Is the research morally permissible? Perhaps imperative if understood as a repair from iatrogenic harms? How are considerations of justice central to the work? How will vulnerable subjects be protected? What are the moral implications of the work for women, children and families? What are the implications for society if women could store ovarian tissue as a way of stopping the biological clock? What are the moral possibilities and challenges if eggs can be produced in large quantities from a stored ovarian tissue? (shrink)
What happens to education when the potential it helps realizing in the individual works against the formal purposes of the curriculum? What happens when education becomes a vehicle for its own subversion? As a subject-forming state apparatus working on ideological speciesism, formal education is engaged in both human and animal stratification in service of the capitalist knowledge economy. This seemingly stable condition is however insecured by the animal rights activist as undercover learner and—worker, who enters education and research laboratories under (...) false premises in order to extract the knowledge necessary to dismantle the logic of animal utility on which the scientific-educational apparatus rests. The present article is based on a semi-structured interview with an undercover worker. It draws on a synthesis of critical education and posthumanist theories to configure knowledge creation and subjectification processes in the “negative spaces” of education. The techne of undercover work includes mnemotechnical and prosthetic devices, calculation of risk, and mimetic labor. The article argues that the agenda of the undercover worker generates a multi-strained mimetic complex that composes a parasitic educational subject-assemblage redirecting scientific knowledge away from the animal stratification logic of the knowledge economy into different viral circuits; different lines of flight. It invites a rearticulation of the formal education state apparatus in more indeterminate directions, provoking scientific-educational knowledge-practices to become a catalytic impulse for their own disintegration. (shrink)
In the fusillade he lets fly against Foss (1984), Bourgeois (1987) sometimes hits a live target. I admit that I went beyond the letter of van Fraassen's The Scientific Image (1980), making inferences and drawing conclusions which are often absurd. I maintain, however, that the absurdities must be charged to van Fraassen's account. While I cannot redress every errant shot of Bourgeois, his essay reveals the need for further discussion of the concepts of the phenomena and the observables as used (...) by van Fraassen. (shrink)
In the animal literature, the concept of dominance usually links status in intermale encounters with differential reproductive success. Mazur & Booth effectively review the human literature correlating testosterone with intermale competition, but more profound questions relating this to male–female dynamics have yet to be addressed in research with humans.
Empathy refers to a whole class or “cluster” of behaviors based in emotional linkage between individuals. The capacity for empathy is not unique to humans, but has evolved in a range of mammals that live in complex social groups. There is good evidence for empathy in primates, pachyderms, cetaceans, social carnivores, and rodents. Because empathy is grounded in the same neurological architecture as other prosocial behaviors such as trust, reciprocity, cooperation, and fairness, it seems likely that a whole suite of (...) interlinked moral behaviors have coevolved in social mammals. This essay explores the concept of empathy, reviews the scientific evidence for empathy in several species of social mammals, and suggests why empathy is adaptive. The paper concludeswith a discussion of what, if anything, the discovery of empathy in other animals suggests for how we treat them and how we think about our own morality. (shrink)
The computational theory of cognition (CTC) holds that the mind is akin to computer software. This article aims to show that CTC is incorrect because it is not able to distinguish the ability to solve a maze from the ability to solve its mirror image. CTC cannot do so because it only individuates brain states up to isomorphism. It is shown that a finer individuation that would distinguish left-handed from right-handed abilities is not compatible with CTC. The view is explored (...) that CTC correctly individuates in an autonomous domain of the mental, leaving discrimination between left and right to some non-cognitive component of psychology such as physiology. I object by showing that the individuation provided by CTC does not properly describe in any domain. An embodied computational taxonomy, rather than software alone, is required for an adequate science of the mind. (shrink)
The expression "artificial animal" denotes a range of different objects from teddy bears to the results of genetic engineering. As a basis for further investigation, this article first of all presents the main interpretations and traces their systematic interconnections. The subsequent sections concentrate on artificial animals in the context of play. The development of material toys is fueled by robotics. It gives toys artificial sense organs, limbs, and cognitive abilities, thus enabling them to act in the real world. The second (...) line of development, closely related to research into Artificial Life, creates virtual beings "living" on computer screens. Themost essential difference between these variants are the sense modalities involved in interaction. Virtual beings can only be seen and heard, whereas material toys can be touched as well. Therefore, the simulation of haptic qualities plays an important role. In order to complete the proposed typology, two further areas are outlined, namely artificial animals outside play and "artificial animals in the medium of flesh" which are alive but designed and created by man. Research on artificial animals belongs to an extended notion of ecosemiotics, as they are part of ecosystems which may themselves be virtual such as the Internet. (shrink)
As opposed to the dismissive attitude toward reductionism that is popular in current philosophy of mind, a “ruthless reductionism” is alive and thriving in “molecular and cellular cognition”—a field of research within cellular and molecular neuroscience, the current mainstream of the discipline. Basic experimental practices and emerging results from this field imply that two common assertions by philosophers and cognitive scientists are false: (1) that we do not know much about how the brain works, and (2) that lower-level neuroscience cannot (...) explain cognition and complex behavior directly. These experimental practices involve intervening directly with molecular components of sub-cellular and gene expression pathways in neurons and then measuring specific behaviors. These behaviors are tracked using tests that are widely accepted by experimental psychologists to study the psychological phenomenon at issue (e.g., memory, attention, and perception). Here I illustrate these practices and their importance for explanation and reduction in current mainstream neuroscience by describing recent work on social recognition memory in mammals. (shrink)
Since intelligent design (ID) advocates claimed the ubiquitous mouse trap as an example of systems that cannot have evolved, mouse trap history is doubly relevant to studying material culture. On the one hand, debunking ID claims about mouse traps and, by implication, also about other irreducibly complex systems has a high educational value. On the other hand, a case study of mouse trap history may contribute insights to the academic discussion about material culture evolution. Michael Behe argued that mouse traps (...) cannot trap mice with any part missing; therefore, they cannot have a precursor with one part less, therefore, cannot have a continuous history, and therefore, cannot have evolved. The patented and seminal precursor of current flat snap traps, however, had one part less, because spring and striker were formed of one wire. Secondly, historical records that reach back into the Bronze Age suggest that its history continued for a very long time. Thirdly, all prerequisites for evolution (variation, transmission, and selection) abound in mouse trap populations. Hence, Behe’s triple-jump conclusion about mouse traps is false each step. There is no, in principle, impossibility for mouse traps to evolve. An evolutionary account of mouse trap history also has academic merits beyond its educational value. Three important conclusions can be drawn: (1) reticulate phylogenies of artifact systems may be resolvable as overlapping, but branching, phylogenies of parts; (2) homologous ideas may be realized by analogous material, that is, phylogenies of information do not necessarily coincide with those of material parts; (3) recombination of parts between different artifact systems increases the cumulative nature of cultural evolution. (shrink)
Emotions often misfire. We sometimes fear innocuous things, such as spiders or mice, and we do so even if we firmly believe that they are innocuous. This is true of all of us, and not only of phobics, who can be considered to suffer from extreme manifestations of a common tendency. We also feel too little or even sometimes no fear at all with respect to very fearsome things, and we do so even if we believe that they are (...) fearsome. Indeed, instead of shunning fearsome things, we might be attracted to them. Emotions that seem more thought-involving, such as shame, guilt or jealousy, can also misfire. You can be ashamed of your big ears even though we can agree that there is nothing shameful in having big ears, and even though you judge that having big ears does not warrant shame. And of course, it is also possible to experience too little or even no shame at all with respect to something that is really shameful. Many of these cases involve a conflict between one’s emotion and one’s evaluative judgement. Emotions that are thus conflicting with judgement can be called ‘recalcitrant emotions’. The question I am interested in is whether or not recalcitrant emotions amount to emotional illusions, that is, whether or not these cases are sufficiently similar to perceptual illusions to justify the claim that they fall under the same general heading. The answer to this depends on what emotions are. For instance, the view that emotions are evaluative judgments makes it difficult to make room for the claim that emotional errors are perceptual illusions. Fearing an innocuous spider would simply amount to making the error of judging that the spider is fearsome while it is in fact innocuous. This might involve an illusion of some sort, but it certainly does not amount to anything like a perceptual illusion. In this chapter, I argue that recalcitrant emotions are a kind of perceptual illusion.. (shrink)
Saying that psychological states are functional states, the functionalist claims more than that psychological states have functions. Rather, functionalism is the theory that psychological states are defined and constituted by their functions. On this view, what it is to be a psychological state of a certain sort just is and consists entirely of having a certain function. Anything that has that function in a suitable system would therefore be that psychological state. If storing information for later use is the essential (...) function of memory, then anything that has that function counts as a memory. Similarly, one might say that anything that traps or kills mice counts as a mouse trap. (shrink)
Every day, in laboratories in countries all around the globe, molecular biologists and their technical assistants manufacture new organisms. Some of these organisms are chimeras, expressing quite different properties in different clusters of their cells – flies or mice, for example, that contain both male and female tissues. Others are designed as factories for the manufacture of specific substances; thus it’s routine to build bacteria with special genetic fragments inserted into them, and to use the organisms so engineered to (...) churn out large quantities of proteins for medical, agricultural, or experimental purposes. This wide-ranging ability to create new forms of life depends on representations of biologically significant molecules, nucleic acids and proteins. The bio-engineers draw on maps that show the arrangement of genes, on reams of printout that identify the sequences of bases in particular regions of DNA, on pictures of molecular structures and on general claims about DNA replication, transcription, and translation. (shrink)
Someday soon (if it hasn't happened in secret already), a human will be cloned, and mankind will embark on a scientific and moral journey whose destination cannot be foretold. In Copycats: The Science and Ethics of Cloning, Arlene Judith Klotzko describes the new world of possibilities that can be glimpsed over the horizon. In a lucid and engaging narrative, she explains that the technology to create clones of living beings already exists, inaugurated in 1996 by Dolly the sheep, the first (...) mammal cloned from a single adult cell. Dolly is the culmination of a long scientific quest to understand the puzzle of our development from one cell into a complex organism--the outcome of a "fantastic experiment" envisioned six decades before her birth. Scientists have since cloned mice, cows, goats, pigs, rabbits and cats. Using the same laboratory tools and techniques, they are trying to grow an embryo, cloned from a single cell of a human being. Their goal is not to make copies of existing people, but to design therapies for currently untreatable diseases and the afflictions of old age. Our fascination with cloning is about much more than science and its extraordinary medical implications. In riveting prose, full of illusions to art, music and the cinema, Klotzko shows why the prospect of human cloning triggers our dearest hopes and especially our darkest fears, forcing us to ponder anew what it means to be human. And what it would be like to have "a clone of your own.". (shrink)
In this paper, I examine an experimental technique, gene targeting, used for establishing genotype/phenotype relationships. Through analyzing a case study, I identify many pitfalls that may lead to false conclusions about these relationships. I argue that some of these pitfalls may seriously affect gene targeting's usefulness for associating phenotypes with genes cataloged by the Human Genome Project. This case also shows the use of gene targeted mice as model systems for studying genotype/phenotype relationships in humans. Moreover, I argue that (...) it reveals the weakness of one attempt to draw conclusions about the biological determination of sexual and aggressive behaviors in humans. (shrink)
The chronologic age classically used in demography is often unable to give useful information about which exact stage in development or aging processes has reached an organism. Hence, we propose here to explain in some applications for what reason the chronologic age fails in explaining totally the observed state of an organism, which leads to propose a new notion, the biological age. This biological age is essentially determined by the number of divisions before the Hayflick’s limit the tissue or mitochondrion (...) in a critical organ (in the sense where its loss causes the death of the whole organism) has already used for its development and adult phases. We give a precise definition of the biological age of an organ based on the Hayflick’s limit of its cells and we introduce a desynchronization index (the cell entropy) for some critical tissues or membranes, which are mainly skin, intestinal endothelium, alveoli epithelium and mitochondrial inner membrane. In these actively metabolising interface tissues or membranes, there is a rapid turnover of cells, of their cytoplasmic constituents such as proteins, and of membrane lipids. The boundaries corresponding to these tissues, cells or membranes have vital functions of interface with the environment (protection, homeothermy, nutrition and respiration) and have a rapid turnover (the total cell renewal time is in mice equal to 3 weeks for the skin, 1.5 day for the intestine, 4 months for the alveolae and 11 days for mitochondrial inner membrane) conditioning their biological age. The biological age of a tissue is made of two major components: (1) first, its embryonic age based on the distance (in number of divisions) between the birth date of its first differentiated cell and the time until it reaches its final boundary at the end of its development and (2) second, its adult age whose complement until its death is just the lapse of time made of the sum of remaining cell cycle durations authorized by its Hayflick’s limit. From this definition, we calculate the global biological lifespan of an organism and revisit notions like demographic survival curves, duration and synchrony of cell cycles, living boundaries from proto-cells to organs, and embryonic and adult phases duration. (shrink)
Sex dimorphism occurs when group means differ by four or more standard deviations. However, the average size of the corpus callosum is greater in males by about one standard deviation in rats, 0.2 standard deviation in humans, and virtually zero in mice. Furthermore, variations in corpus callosum size are related to brain size and are not sex specific.
One winter morning, the two of us—both postdoctoral fellows in medical humanities and bioethics—gathered with a handful of reproductive science graduate students in the lab to watch a demonstration on making alginate beads. Due to their three-dimensional nature, the beads are capable of holding ovarian follicles—the beads act as though they were a small ovary. The scientists in the lab have managed to mature the follicles maintained in the beads into eggs, fertilize these eggs, and produce the birth of live (...)mice. This research was begun in an effort to develop a means of gathering ovarian follicles from young human cancer patients before they commence cancer treatment that may result in their infertility, thus .. (shrink)
The reader may wish to know something of Antoine Arnauld and his times. His life was full of conflict, with the Jesuits, with the king of France and, though he was a zealous Catholic, with the pope.[ Note ] The son of a wealthy lawyer, he never had to work for his living at anything he did not choose to do. As a priest he never seems to have had any pastoral or teaching responsibilities except those he chose to assume. (...) By choice he was an almost full-time controversialist, whose extant writings fill some forty large volumes. Day by day he went into his study, sharpened his pen and attacked someone---or defended someone, or refuted an answer, or answered a pretended refutation, or wrote a Premier Écrit pour la defense de la seconde lettre. His writings are mostly in the style of some of the less well-known works of Hobbes and Locke, or of certain writings Marx and Engels left to the criticism of the mice. (shrink)
Many people involved in the life sciences and related fields and industries routinely cause mice, rats, dogs, cats, primates and other non-human animals to experience pain, suffering, and an early death, harming these animals greatly and not for their own benefit. Harms, however, require moral justification, reasons that pass critical scrutiny. Animal experimenters and dissectors might suspect that strong moral justification has been given for this kind of treatment of animals. I survey some recent attempts to provide such a (...) justification and show that they do not succeed: they provide no rational defense of animal experimentation and related activities. Thus, the need for a rational defense of animal experimentation remains. (shrink)
The so-called "biometric-Mendelian controversy" has received much attention from science studies scholars. This paper focuses on one scientist involved in this debate, Arthur Dukinfield Darbishire, who performed a series of hybridization experiments with mice beginning in 1901. Previous historical work on Darbishire's experiments and his later attempt to reconcile Mendelian and biometric views describe Darbishire as eventually being "converted" to Mendelism. I provide a new analysis of this episode in the context of Darbishire's experimental results, his underlying epistemology, and (...) his influence on the broader debate surrounding the rediscovery and acceptance of Mendelism. I investigate various historiographical issues raised by this episode in order to reflect on the idea of "conversion" to a scientific theory. Darbishire was an influential figure who resisted strong forces compelling him to convert prematurely due to his requirements that the new theory account for particularly important anomalous facts and answer the most pressing questions in the field. (shrink)
Two strains of male mice have bred over fortygenerations, starting with the work of RobertCairns and his colleagues, one strain with ahigh level of intra-species aggression, theother a low level of aggression. Thehigh-aggression mice tend to establishdominance hierarchies and particularly fight inthe presence of female mice. Thelow-aggression mice tend, in groups of theirown, to have a high degree of low-intensity,peaceful social contact, and to be more timidin initiating action than the high-aggressionmice. Biochemical differences have beenobserved between (...) the two strains, and confirmedby the present data: the high-aggression micehave greater dopamine concentrations (in thecaudate nucleus and nucleus accumbens), lowerlevels of the stress hormone corticosterone,and higher levels of testosterone than thelow-aggression mice. The current experimentswere designed to answer questions about theflexibility of adaptive behaviors:specifically, what is the effect of early dailymaternal separation on adult stress response ineach strain? What are the behavioral andhormonal mechanisms by which, as has beenobserved, low-aggression mice achieve adominant status when brought into situationswhere they compete for territory withhigh-aggression mice? Finally, what are thesocial and neurochemical mechanisms by whichhigh-aggression mice can develop low-aggressionbehavior if brought out of isolation and intogroups?Maternal separation was found to lead todecreases in stress levels, as measured bycorticosterone, in the low-aggression but notthe high-aggression, mice – presumably becauseof the surplus of maternal care the pupsreceive on returning to the nest. When alow-aggression mouse became dominant and ahigh-aggression mouse became submissive, theirusual pattern of corticosterone andtestosterone levels was found to be reversed. The change to low-aggression behavior inhigh-aggression mice switching from anisolation condition to a group condition, wasmediated by a decrease in D 1 dopaminereceptor densities.These results, like the ones on which theybuild, argue for substantial developmentalinfluences in expressions of the genesinfluencing aggressive or cooperative behavior. In this approach to evolution, epigenesis istreated not as a set of traits and behaviorspredetermined by the genome, but as a set ofprobabilistic tendencies toward certain traitsand behaviors. (shrink)
Most evidence for the role of regular inflection as a default operation comes from languages that confound the morphological properties of regular and irregular forms with their phonological characteristics. For instance, regular plurals tend to faithfully preserve the base’s phonology (e.g., rat-rats), whereas irregular nouns tend to alter it (e.g., mouse- mice). The distinction between regular and irregular inflection may thus be an epiphenomenon of phonological faithfulness. In Hebrew noun inflection, however, morphological regularity and phonological faithfulness can be distinguished: (...) Nouns whose stems change in the plural may take either a regular or an irregular suffix, and nouns whose stems are preserved in the plural may take either a regular or an irregular suffix. We use this dissociation to examine two hallmarks of default inflection: its lack of dependence on analogies from similar regular nouns, and its application to nonroots such as names. We show that these hallmarks of regularity may be found whether or not the plural form preserves the stem faithfully: People apply the regular suffix to novel nouns that don’t resemble existing nouns, and to names that sound like irregular nouns, regardless of whether the stem is ordinarily preserved in the plural of that family of nouns. Moreover, when they pluralize names (e.g., the Barak-Barakim), they do not apply the stem changes that are found in their homophonous nouns (e.g., barak-brakim “lightning”), replicating an effect found in English and German. These findings show that the distinction between regular and irregular phenomena cannot be reduced to differences in the kinds of phonological changes associated with those phenomena in English. Instead, regularity and irregularity must be distinguished in terms of the kinds of mental computations that effect them: symbolic operations versus memorized idiosyncrasies. A corollary is that complex words are not generally dichotomizable as “regular” or “irregular”; different aspects of a word may be regular or irregular depending on whether they violate the rule for that aspect and hence must be stored in memory.. (shrink)
Velvet revolutions, continued-. The strange toppling of Slobadan Milošević ; "The country summoned me" ; Orange Revolution in Ukraine ; The revolution that wasn't ; 1968 and 1989 ; 1989! ; Velvet Revolution in past and future -- Europe and other headaches. Ghosts in the machine ; Are there moral foundations of European power? ; The twins' new Poland ; Exchange of empires ; Why Britain is in Europe ; Europe's new story ; National anthems ; "O chink, where is (...) thy wall?" ; The perfect EU member -- Islam, terror and freedom. La Alhambra ; Islam in Europe ; The invisible front line ; Against taboos ; Respect? ; Secularism or atheism? ; No if and no buts -- USA! USA!. Mr. President ; 9/11 ; Anti-Europeanism in America ; In defence of the fence ; Zorba the Bush ; Warsaw, Missouri ; Dancing with history ; Liberalism -- Beyond the West. Beauty and the beast in Burma ; Soldiers of the hidden Imam ; East meets West ; The brotherhood against Pharaoh ; Cities of no God ; Beyond race -- Writers and facts. The brown grass of memory ; The Stasi on our minds ; Orwell in our time ; Orwell's list ; Is "British intellectual" an oxymoron? ; "Ich bin ein Berliner" ; The literature of fact -- Envoi. Elephant, feet of clay ; Decivilization ; The mice in the organ. (shrink)
To illustrate dramatically the progress and potential in the field of synthetic biology, one can begin the story with the 2011 winner of the Lasker Clinical Medical Research Award (Youyou 2011). She was an 81-year-old Chinese scientist, Dr. Tu Youyou, who was given an assignment in 1969 by the Chinese government to find a treatment for malaria from among Chinese herbal medicines. She investigated more than 2,000 Chinese herbal preparations, winnowed them down to some 640 possibilities, obtained 380 extracts from (...) about 200 Chinese herbs, and tested them against a mouse model of malaria. She found one extract, of the Artemisia plant, effective in mice, but she could not reproduce the results consistently. So she .. (shrink)
Modest_Witness@Second_Millennium. FemaleMan_Meets_OncoMouse explores the roles of stories, figures, dreams, theories, facts, delusions, advertising, institutions, economic arrangements, publishing practices, scientific advances, and politics in twentieth- century technoscience. The book's title is an e-mail address. With it, Haraway locates herself and her readers in a sprawling net of associations more far-flung than the Internet. The address is not a cozy home. There is no innocent place to stand in the world where the book's author figure, FemaleMan, encounters DuPont's controversial laboratory rodent, OncoMouse. (...) Haraway sees the world of contemporary technoscience as a drama. Information sciences and life sciences are at the center of the dramatic action. Scenes are set in landscapes where maps of human genetic differences are stored in databases, racialized bodies are reconfigured by morphing for photographs in popular magazines, and transgenic mice important to breast cancer research are patented intellectual property. The actors are many, and not all are human. Beginning with the Modest Witness, the key figure in the Science Revolution, Haraway shows us the trouble lurking in race and gender- marked practices for attesting to matters of fact. In later scenes, Haraway explores the kinship relations among the many cyborg creatures produced in the late twentieth-century--in nuclear research, genetic engineering, reproductive technologies, computer-mediated representational practices, and mutations in biological approaches to "race.". (shrink)
Donna Haraway's work has transformed the fields of cyberculture, feminist studies, and the history of science and technology. Her subjects range from animal dioramas in the American Museum of Natural History to research in transgenic mice, from gender in the laboratory to the nature of the cyborg. Trained as an historian of science, she has produced a series of books and essays that have become essential reading in cultural studies, gender studies, and the history of science. The Haraway Reader (...) brings together a generous selection of Donna Haraway's work. Included is her "Manifesto for Cyborgs," in which she famously wrote that she "would rather be a cyborg than a goddess." Other selections are taken from her three major works, Primate Visions, Modest Witness , and Simians, Cyborgs and Women , as well as some of her more recent writing on animals. For readers in cultural studies, feminist theory, science studies, and cyberculture, Donna Haraway is one of our keenest observers of nature, science, and the social world. This volume is the best introduction to her thought. (shrink)
We show that every sufficiently iterable countable mouse has a unique iteration strategy whose associated iteration maps are lexicographically minimal. This enables us to extend the results of [3] on the good behavior of the standard parameter from tame mice to arbitrary mice.
Choosing a compassionate lifestyle that makes you feel good and positively impacts on the environment and on animals has never been easier. In this practical and accessible handbook, loaded with resources for all products that are mentioned, Ingrid Newkirk presents fabulous options that will not only enhance your life, but those of your neighbors, your community, animals, and the earth itself. From comfortable home furnishings, to delicious foods, to fashionable clothing there are a myriad of choices to be made that (...) can have a lasting positive effect on the well-being of animals and the environment, including: - recognizing hidden animal ingredients in cosmetics and household products - raising ecologically aware and animal-friendly kids - creating healthy, environmentally-friendly meals for everyday and special occasions - dressing with style without using leather or other animal products - dealing kindly with mice, insects, and other 'pests' in home or garden - adopting the right animal companion for you - volunteering and investing in eco- and animal-friendly companies - traveling with Eco-consciousness. (shrink)
We set $\mathscr{D} = \langle\mathscr{D}, \leq_L, \tt\#\rangle$ , where D is the set of degrees of nonconstructibility for countable sets of countable ordinals. We show how to define inductively over this structure the degrees of such sets of ordinals in K, the core model, and the next few core models thereafter, i.e. without reference to mice, premice or measurable cardinals.
This work proposes an analysis of the cognitive and motivational components of hope, its basic properties, and the affective dispositions and behaviors it is likely to induce. In our view current treatments of hope do not fully account for its specificity, by making hope overlap with positive expectation or some specification of positive expectation. In contrast, we attempt to highlight the distinctive features of hope, pointing to its differences from positive expectation, as well as from a sense of successful agency, (...) optimism, trust, and faith. Fear and anxiety are also addressed, and the latter is analyzed as a state of mind implying both fear and hope. Finally, the relationship between hope and motivation is explored, and “active” hope is compared with “passive” hope. Some concluding remarks summarize the results of our analysis, and stress the role of hope in fostering the individual’s well-being. (shrink)
Research on whistle-blowing has been hampered by a lack of a sound theoretical base. In this paper, we draw upon existing theories of motivation and power relationships to propose a model of the whistle-blowing process. This model focuses on decisions made by organization members who believe they have evidence of organizational wrongdoing, and the reactions of organization authorities. Based on a review of the sparse empirical literature, we suggest variables that may affect both the members' decisions and the organization's responses.
When successful and ethical managers are alerted to possible organizational wrongdoing, they take corrective action before the problems become crises. However, recent research [e. g., Rynes et al. (2007, Academy of Management Journal 50(5), 987-1008)] indi cates that many organizations fail to implement evidence-based practices (i. e., practices that are consistent with research findings), in many aspects of human resource management. In this paper, we draw from years of research on whistle-blowing by social scientists and legal scholars and offer concrete (...) suggestions to managers who are interested in encouraging internal reporting of problems requiring attention, and to observers of questionable activity who are considering reporting it. We also identify ways that research suggests policy-makers can have a more positive influence. We hope that these suggestions will help foster evidence-based practice regarding whistle-blowing. (shrink)
We argue in favor of the adaptive value of acceptance and that it deserves a definite status within the 'positive paradigm'. Acceptance currently suffers from ambiguous connotations because of its lack of optimistic biases and its similarity to resignation. We endeavor to show that acceptance and resignation are distinct attitudes by exploring their relationships with various phenomena-frustration, disappointment, expectation, positive thinking, replanning, and accuracy. The resulting distinguishing features of acceptance-thriving versus returning to baseline; realistic optimism versus hopelessness; persistence and flexible (...) replanning versus disengagement-are crucial for adaptive coping, and appear to be in keeping with the positive paradigm. (shrink)
Who blows the whistle — a loner or a well-liked team player? Which of them is more likely to lead a successful opposition to perceived organizational wrongdoing? The potential influence of co-worker pressures to conform on whistle-blowing activity or the likely effects of whistle-blowing on the group have not been addressed. This paper presents a preliminary model of whistle-blowing as an act of nonconformity. One implication is that the success of an opposition will depend on the characteristics of the whistle-blower (...) and how the complaint is pursued. Specific hypotheses and general suggestions for future research and practice are offered. (shrink)
This work aims to identify the constituents of forgiveness in terms of the forgiver's beliefs and motivating goals. After addressing the antecedents of forgiveness—a perceived wrong—and distinguishing the notion of mere harm from that of offense, we describe the victim's typical retributive reactions—revenge and resentment—and discuss their advantages and disadvantages. Then we focus on the forgiver's mind-set, pointing to the relationship between forgiveness and acceptance of the wrong, addressing the forgiver's motivating goals, and discussing both their self-interested and altruistic implications. (...) In so doing we also discuss the role of the forgiver's positive feelings towards the offender, arguing that, however important, they are unnecessary to forgiveness. We finally identify two kinds of forgiveness—conditional and unconditional—suggesting that they are grounded on different notions of “worth.”. (shrink)
This study examined experimentally the effect of retaliation strength and accounting students’ level of moral reasoning, on their propensity to blow the whistle (PBW) when faced with a serious wrongdoing. Fifty-one senior accounting students enrolled in an auditing course offered by a large New Zealand university participated in the study. Participants responded to three hypothetical whistle-blowing scenarios and completed an instrument that measured moral reasoning (Welton et al., 1994, Accounting Education . International Journal (Toronto, Ont.) 3 (1), 35–50) on one (...) of two conditions – i.e., strong or weak retaliation for whistle-blowing. Consistent with the results of Arnold and Ponemon (1991, Auditing: A Journal of Practice and Theory 10 , 1–15) this study found that the strength of retaliation and participants’ moral reasoning level positively affected their PBW. Unlike results reported in Arnold and Ponemon (1991, Auditing; A Journal of Practice and Theory 10 , 1–15) a significant interaction effect of moral reasoning level and retaliation on participants’ PBW was not found. However, results showed that a participant’s gender has a significant effect on the relationship between his or her moral reasoning level and PBW. These results support the need to improve ethical awareness through accounting education and to increase protection for whistle-blowing (Miceli 2004, Journal of Management Inquiry 13 , 364–366). Furthermore, many participants found it difficult to take a stand when serious wrongdoing is discovered. Therefore, policymakers must exercise caution when placing heavy reliance on whistle-blowing, especially when whistle-blower protection processes are complex and not easily accessible, and processes to facilitate whistle-blowing may vary substantially between public and private sector organizations (Scholtens, 2003, Review of the operation of the Protected Disclosures Act 2000: Report to the Minister of State Services ). (shrink)
This paper examines deviant managerial behavior, and compares such behavior to the clinical psychological sociopathic model. The scope of a multinational corporate operation can enhance or degrade the quality of life for individuals with more impact than at any previous time in history. Social costs are compared to the results of sociopathic behavior and examined as the result of amoral or immoral behavior. The idea of the sociopathic manager is discussed, and theoretical causes of sociopathic development are examined with bases (...) in behavioral, economic and criminological literature. Future research and recommendations for prevention of sociopathic behavior are advanced. (shrink)
We analyzed data from a survey of employees of a large military base in order to assess possible differences in the whistle-blowingprocess due to type of wrongdoing observed. Employees who observed perceived wrongdoing involving mismanagement, sexual harassment, or unspecified legal violations were significantly more likely to report it than were employees who observed stealing, waste, safety problems, or discrimination. Further, type of wrongdoing was significantly related to reasons given by employees who observed wrongdoing but did not report it, across all (...) forms of wrongdoing. However, the primary reason that observers did not report it was that they thought nothing could be done to rectify the situation. Finally, type of wrongdoing was significantly related to the cost of the wrongdoing, the quality of the evidence about the wrongdoing, and the comprehensiveness of retaliation against the whistle-blower. These findings suggest that type of wrongdoing makes a difference in the whistle-blowing process, and it should be examined in future research. (shrink)
Comparable worth is a controversial compensation strategy. In this paper, research issues that arise when employers perform point-based job evaluations, but deviate from them because of market factors, are discussed. Greater research attention to the actual operation of markets and to the consequences of conflicts in equity perceptions is encouraged.
