Search results for 'TARGETED MUTATION' (try it on Scholar)

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  1. Iñigo Martincorena & Nicholas M. Luscombe (2013). Non‐Random Mutation: The Evolution of Targeted Hypermutation and Hypomutation. Bioessays 35 (2):123-130.score: 168.0
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  2. John Bickle (2006). Reducing Mind to Molecular Pathways: Explicating the Reductionism Implicit in Current Cellular and Molecular Neuroscience. [REVIEW] Synthese 151 (3):411-434.score: 60.0
    As opposed to the dismissive attitude toward reductionism that is popular in current philosophy of mind, a “ruthless reductionism” is alive and thriving in “molecular and cellular cognition”—a field of research within cellular and molecular neuroscience, the current mainstream of the discipline. Basic experimental practices and emerging results from this field imply that two common assertions by philosophers and cognitive scientists are false: (1) that we do not know much about how the brain works, and (2) that lower-level neuroscience cannot (...)
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  3. J. H. Van Hateren (forthcoming). Intrinsic Estimates of Fitness Affect the Causal Structure of Evolutionary Change. Biology and Philosophy:1-18.score: 24.0
    The causal structure of Darwinian evolution by natural selection is investigated. Its basic scheme is reproduction resulting from a feedback loop driven by internal and external causes. Causation internal to the loop connects genotype, development, phenotype, and fitness, with environmental constraints on the latter preventing runaway reproduction. External causes driving the core loop are environmental change and genetic change . This basic causal structure is complicated by modern additions such as control of mutation rate, niche construction, interactions between evolution (...)
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  4. David L. Vaux (2011). Response to “The Tissue Organization Field Theory of Cancer: A Testable Replacement for the Somatic Mutation Theory” DOI: 10.1002/Bies. 201100025. [REVIEW] Bioessays 33 (9):660-661.score: 21.0
  5. Christel Kamp, Claus O. Wilke, Christoph Adami & Stefan Bornholdt (2002). Viral Evolution Under the Pressure of an Adaptive Immune System: Optimal Mutation Rates for Viral Escape. Complexity 8 (2):28-33.score: 21.0
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  6. Susan M. Rosenberg, Chandan Shee, Ryan L. Frisch & P. J. Hastings (2012). Stress‐Induced Mutation Via DNA Breaks in Escherichia Coli: A Molecular Mechanism with Implications for Evolution and Medicine. Bioessays 34 (10):885-892.score: 21.0
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  7. David L. Vaux (2011). In Defense of the Somatic Mutation Theory of Cancer. Bioessays 33 (5):341-343.score: 21.0
  8. William Amos (2010). Heterozygosity and Mutation Rate: Evidence for an Interaction and its Implications. Bioessays 32 (1):82-90.score: 21.0
  9. Koodali T. Nishant, Nadia D. Singh & Eric Alani (2009). Genomic Mutation Rates: What High‐Throughput Methods Can Tell Us. Bioessays 31 (9):912-920.score: 21.0
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  10. Melissa A. Wilson Sayres & Kateryna D. Makova (2011). Genome Analyses Substantiate Male Mutation Bias in Many Species. Bioessays 33 (12):938-945.score: 21.0
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  11. Ted Honderich, Targeted Killing.score: 18.0
    This paper by Prof. Daniel Statman, moral philosopher at the University of Haifa in Israel and author of the books Moral Dilemmas and Religion and Morality , offers a philosophical defense for such targeted killings or assassinations as those by Israel of Palestinians. The paper argues that if one accepts the moral legitimacy of the large-scale killing of combatants in conventional (what may come to be called 'old-fashioned') wars, one cannot object -- on moral grounds -- to the (...) killing of terrorists in what are called wars against terror. If one rejects this legitimacy, one must object to all killing in war, targeted and non-targeted alike, and thus not support the view, which is criticized here, that targeted killings are particularly disturbing from a moral point of view. (shrink)
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  12. Edward L. Felton & Ronald R. Sims (2005). Teaching Business Ethics: Targeted Outputs. [REVIEW] Journal of Business Ethics 60 (4):377 - 391.score: 18.0
    Business ethics is once again a hot topic as examples of improper business practices that violate commonly accepted ethical norms are brought to our attention. With the increasing number of scandals business schools find themselves on the defensive in explaining what they are doing to help respond to the call to teach ‘‘more’’ business ethics. This paper focuses on two issues germane to business ethics teaching efforts: the ‘‘targeted output’’ goals of teaching business ethics and when in the curriculum (...)
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  13. David M. Buss (2006). The Evolutionary Genetics of Personality: Does Mutation Load Signal Relationship Load? Behavioral and Brain Sciences 29 (4):409-409.score: 18.0
    The mutation-selection hypothesis may extend to understanding normal personality variation. Traits such as emotional stability, agreeableness, and conscientiousness figure strongly in mate selection and show evidence of non-additive genetic variance. They are linked with reproductively relevant outcomes, including longevity, resource acquisition, and mating success. Evolved difference-detection adaptations may function to spurn individuals whose high mutation load signals a burdensome relationship load. (Published Online November 9 2006).
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  14. Jerome C. Wakefield (2006). High Mental Disorder Rates Are Based on Invalid Measures: Questions About the Claimed Ubiquity of Mutation-Induced Dysfunction. Behavioral and Brain Sciences 29 (4):424-426.score: 18.0
    Three reservations about Keller & Miller's (K&M's) argument are explored: Serious validity problems afflict epidemiological criteria discriminating disorders from non-disorders, so high rates may be misleading. Normal variation need not be mild disorder, contrary to a possible interpretation of K&M's article. And, rather than mutation-selection balance, true disorders may result from unselected combinations of normal variants over many loci. (Published Online November 9 2006).
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  15. Claire Finkelstein, Jens David Ohlin & Andrew Altman (eds.) (2012). Targeted Killings: Law and Morality in an Asymmetrical World. OUP Oxford.score: 18.0
    The war on terror is remaking conventional warfare. The protracted battle against a non-state organization, the demise of the confinement of hostilities to an identifiable battlefield, the extensive involvement of civilian combatants, and the development of new and more precise military technologies have all conspired to require a rethinking of the law and morality of war. Just war theory, as traditionally articulated, seems ill-suited to justify many of the practices of the war on terror. The raid against Osama Bin Laden's (...)
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  16. Katerina Hadjimatheou (2014). The Relative Moral Risks of Untargeted and Targeted Surveillance. Ethical Theory and Moral Practice 17 (2):187-207.score: 18.0
    Is surveillance that is targeted towards specific individuals easier to justify than surveillance that targets broad categories of people? Untargeted surveillance is routinely accused of treating innocent people as suspects in ways that are unfair and of failing to pursue security effectively. I argue that in a wide range of cases untargeted surveillance treats people less like suspects than more targeted alternatives. I also argue that it often deters unwanted behaviour more effectively than targeted alternatives, including profiling. (...)
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  17. George N. Reeke (1997). Constructivism: Can Directed Mutation Improve on Classical Neural Selection? Behavioral and Brain Sciences 20 (4):574-575.score: 18.0
    Quartz & Sejnowski (Q&S) find flaws in standard theories of neural selection, which they propose to repair by introducing Lamarckian mechanisms for anatomical refinement that are analogous to directed mutation in evolution. The reversal of cause and effect that these mechanisms require is no more plausible in an explanation of cognition than it is in an explanation of evolution.
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  18. A. Tahan & M. Monajjemi (2011). Solvent Dielectric Effect and Side Chain Mutation on the Structural Stability of Burkholderia Cepacia Lipase Active Site: A Quantum Mechanical/Molecular Mechanics Study. Acta Biotheoretica 59 (3):291-312.score: 18.0
    Quantum mechanical and molecular dynamics methods were used to analyze the structure and stability of neutral and zwitterionic configurations of the extracted active site sequence from a Burkholderia cepacia lipase, histidyl-seryl-glutamin (His86-Ser87-Gln88) and its mutated form, histidyl-cysteyl-glutamin (His86-Cys87-Gln88) in vacuum and different solvents. The effects of solvent dielectric constant, explicit and implicit water molecules and side chain mutation on the structure and stability of this sequence in both neutral and zwitterionic forms are represented. The quantum mechanics computations represent that (...)
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  19. Mary Malucchi (2011). A Novel “Planetary Man”: From the Philosophical Paradigm of Modernity to Contemporary Anthropological Mutation: The Perspective of Ernesto Balducci. World Futures 67 (8):519 - 530.score: 18.0
    Italian priest, essayist, and intellectual of the twentieth century, Ernesto Balducci identified the crucial turning points of the new millennium by advancing original perspectives capable of opening unusual future scenarios. Sensitive to emergences of society (pollution, wars, ecological collapse), he retraces the causes in the more general ?crisis of modernity,? proposing a new paideia and a new model of thought. He theorizes the construction of a novel planetary horizon that presupposes not only the building of new organizational structures, but also (...)
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  20. Daniel Nettle (2006). Reconciling the Mutation-Selection Balance Model with the Schizotypy-Creativity Connection. Behavioral and Brain Sciences 29 (4):418-418.score: 18.0
    Keller & Miller (K&M) make a persuasive case for the role of mutation-selection balance in the persistence of such disorders as schizophrenia. However, there is evidence relating illness liability to creativity, which seems to imply balancing selection. I argue for a hybrid position, where schizotypal personality traits can have fitness advantages or disadvantages, with mutational load and neurodevelopmental conditions determining which outcome is observed. (Published Online November 9 2006).
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  21. Garland E. Allen (1969). Hugo De Vries and the Reception of the "Mutation Theory". Journal of the History of Biology 2 (1):55 - 87.score: 18.0
    De Vries' mutation theory has not stood the test of time. The supposed mutations of Oenothera were in reality complex recombination phenomena, ultimately explicable in Mendelian terms, while instances of large-scale mutations were found wanting in other species. By 1915 the mutation theory had begun to lose its grip on the biological community; by de Vries' death in 1935 it was almost completely abandoned. Yet, as we have seen, during the first decade of the present century it achieved (...)
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  22. Mark Bedau, Adaptation of Mutation Rates in a Simple Model of Evolution.score: 18.0
    We have studied the adaptation of mutation rates in a simple model of evolution. The model consists of a two-dimensional world with a periodically replenished resource and a uctuating population of evolving agents whose survival and reproduction are an implicit a function of their success at nding resources and their internal metabolism. Earlier work suggested that mutation rate is a control parameter that governs a transition between two qualitatively di erent kinds of complex adaptive systems, and that the (...)
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  23. Rafael Caballero (2002). Policy Schemes and Targeted Technologies in an Extensive Cereal–Sheep Farming System. Agriculture and Human Values 19 (1):63-74.score: 18.0
    Many commentators and experts arguethat extensive agricultural systems across theEuropean Union (EU) should be supported toreach the two main functions of the EuropeanModel of Agriculture (EMA): lively economicsystems and environmental awareness. We arguethat the main current policy instrument of theEMA, the CAP (Common Agricultural Policy),should be targeted to take advantage ofexisting regional diversity in social realitiesand agricultural structures. Community-basedresearch work has been carried out throughoutthe 1990s in the cereal–sheep farming system ofCastile-La Mancha (south-central Spain), wherea system of land-use operates (...)
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  24. Anurag Mishra & Josef Pfeuffer, Targeted Contrast Agents for MR Imaging.score: 18.0
    Smart MR contrast agents exhibit modulation of their relaxivity by specific physiological or biochemical trigger-events, while targeted MR contrast agents are envisioned to deliver the large gadolinium chelates into the target tissue. In an effort to develop novel smart and targeted MR contrast agents, the series of the DO3A based multifunctional chelating agents with the variable length of the side chain has been synthesized. They serve as valuable multipurpose precursors for contrast agents based on gadolinium chelates in the (...)
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  25. Hans Joachim Poethke (1988). Sex Ratio Polymorphism: The Impact of Mutation and Drift on Evolution. Acta Biotheoretica 37 (2).score: 18.0
    This paper addresses the question, which sex ratio will evolve in a population that is subject to mutation and drift. The problem is analyzed using a simulation model as well as analytical methods. A detailed simulation model for the evolution of a population's allele distribution shows that for the sex ratio game a wide spectrum of different population states may evolve from on the one hand a monomorphic state with one predominant allele and with all other alleles suppressed by (...)
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  26. Bernadette Bensaude Vincent & Sacha Loeve (2014). Metaphors in Nanomedicine: The Case of Targeted Drug Delivery. NanoEthics 8 (1):1-17.score: 18.0
    The promises of nanotechnology have been framed by a variety of metaphors, that not only channel the attention of the public, orient the questions asked by researchers, and convey epistemic choices closely linked to ethical preferences. In particular, the image of the ‘therapeutic missile’ commonly used to present targeted drug delivery devices emphasizes precision, control, surveillance and efficiency. Such values are highly praised in the current context of crisis of pharmaceutical innovation where military metaphors foster a general mobilization of (...)
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  27. Ana M. Soto & Carlos Sonnenschein (2011). The Tissue Organization Field Theory of Cancer: A Testable Replacement for the Somatic Mutation Theory. Bioessays 33 (5):332-340.score: 17.0
  28. Carlos Sonnenschein & Ana M. Soto (2011). Response to “In Defense of the Somatic Mutation Theory of Cancer” DOI: 10.1002/Bies. 201100022. Bioessays 33 (9):657-659.score: 17.0
  29. Aysen Bakir & Scott J. Vitell (2010). The Ethics of Food Advertising Targeted Toward Children: Parental Viewpoint. [REVIEW] Journal of Business Ethics 91 (2):299 - 311.score: 16.0
    The children’s market has become significantly more important to marketers in recent years. They have been spending increasing amounts on advertising, particularly of food and beverages, to reach this segment. At the same time, there is a critical debate among parents, government agencies, and industry experts as to the ethics of food advertising practices aimed toward children. The␣present study examines parents’ ethical views of food advertising targeting children. Findings indicate that parents’ beliefs concerning at least some dimensions of moral intensity (...)
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  30. Michael L. Gross (2006). Assassination and Targeted Killing: Law Enforcement, Execution or Self-Defence? Journal of Applied Philosophy 23 (3):323–335.score: 15.0
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  31. Ernest B. Hook (1997). The Exclusion of Minor Malformations in the Study of Mutation in the Offspring of Survivors of Atomic Bombs: Methodological, Not Sociopolitical, Rationale. [REVIEW] Journal of the History of Biology 30 (2):239 - 242.score: 15.0
  32. Steven R. David (2003). Israel's Policy of Targeted Killing. Ethics and International Affairs 17 (1):111–126.score: 15.0
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  33. Francesca Merlin (2010). Evolutionary Chance Mutation: A Defense of the Modern Synthesis' Consensus View. Philosophy and Theory in Biology 2 (20130604).score: 15.0
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  34. F. D'Eaubonne (1999). Feminism—Ecology: Revolution or Mutation? Ethics and the Environment 4 (2):175-177.score: 15.0
  35. Henry C. Theriault (2010). Genocidal Mutation and the Challenge of Definition. Metaphilosophy 41 (4):481-524.score: 15.0
    Abstract: The optimum definition of the term "genocide" has been hotly contested almost since the term was coined. Definitional boundaries determine which acts are covered and excluded and thus to a great extent which cases will benefit from international attention, intervention, prosecution, and reparation. The extensive legal, political, and scholarly discussions prior to this article have typically (1) assumed "genocide" to be a fixed social object and attempted to define it as precisely as possible or (2) assumed the need for (...)
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  36. Megan Braun & Daniel R. Brunstetter (2014). Rethinking the Criterion for Assessing Cia-Targeted Killings: Drones, Proportionality and Jus Ad Vim. Journal of Military Ethics 12 (4):304-324.score: 15.0
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  37. Eugene D. Weinberg (2007). Survival Advantage of the Hemochromatosis C282Y Mutation. Perspectives in Biology and Medicine 51 (1):98-102.score: 15.0
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  38. Gerd Sommerhoff (1990). Life, Brain, and Consciousness: New Perceptions Through Targeted Systems Analysis. Distributors for the U.S. And Canada, Elsevier Science Pub. Co..score: 15.0
    In this volume the author tackles this problem in a rigorous analysis which begins with the general dynamics of living systems and leads the reader step-by-step ...
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  39. Yvonne Terlingen (2010). The United States and the Un's Targeted Sanctions of Suspected Terrorists: What Role for Human Rights? Ethics and International Affairs 24 (2):131-142.score: 15.0
  40. Maurice Clavelin (2004). Le copernicianisme et la mutation de la philosophie naturelle. Revue de Métaphysique et de Morale 3 (3):353-370.score: 15.0
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  41. Oscar Vilarroya (2005). A Categorial Mutation. Behavioral and Brain Sciences 28 (4):508-509.score: 15.0
    The proposal of Steels & Belpaeme (S&B) is on the right track to solve the nativist/empiricist/culturalist controversy. However, their nativist model of colour categorization does not correspond to a proper genetic model. Colour perception is the outcome of a complex process of development. A direct correspondence between genes and colour categories cannot be the right approach to the problem.
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  42. Jean-François Nordmann (2012). De la transmission des savoirs à la formation des compétences : une hypothèse sur l'École et son besoin actuel de mutation. Rue Descartes 1 (1):66-87.score: 15.0
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  43. S. Buetow (2005). High Need Patients Receiving Targeted Entitlements: What Responsibilities Do They Have in Primary Health Care? Journal of Medical Ethics 31 (5):304-306.score: 15.0
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  44. Campbell McPherson (2000). From Grand Policy to Targeted Destruction: Consumers as Victims of EU Satellite Television Policy. [REVIEW] Journal of Business Ethics 25 (2):129 - 141.score: 15.0
    In July 1997 the European Commission proposed a "Directive on the Legal protection of Service based on, or consisting of Conditional Access" (to various electronic systems).This paper considers the proposed Directive within the context of the European Union's failure to develop and maintain a coherent policy relating to satellite television broadcasts direct to the individual's home (DTH) within the nascent Single European Market (SEM), and the consequences of that policy failure for "ordinary" consumers who are highly unlikely to have a (...)
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  45. Jacques Pontier (1973). Théorie de la Cible: Un Modèle Markovien Pour l'Évolution Génétique d'Une Mutation Latente. Acta Biotheoretica 22 (3).score: 15.0
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  46. Norman K. Swazo (2013). Engaging the Normative Question in the H5N1 Avian Influenza Mutation Experiments. Philosophy, Ethics, and Humanities in Medicine 8 (1):12.score: 15.0
    In recent time there has been ample discussion concerning censorship of research conducted in two labs involved in avian influenza virus research. Much of the debate has centered on the question whether the methods and results should reach to open disclosure given the “dual use” nature of this research which can be used for nefarious purposes.
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  47. Lynn Helena Caporale (2000). Mutation is Modulated: Implications for Evolution. Bioessays 22 (4):388-395.score: 15.0
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  48. Hugo de Vries (1917). The Origin of the Mutation Theory. The Monist 27 (3):403-410.score: 15.0
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  49. Douglas Zook (2002). Symbiogenesis as a Partner of Mutation. Perspectives in Biology and Medicine 45 (2):287-291.score: 15.0
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  50. Steven A. Frank & Martin A. Nowak (2004). Problems of Somatic Mutation and Cancer. Bioessays 26 (3):291-299.score: 15.0
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