Search results for 'TERATOCARCINOMA CELLS' (try it on Scholar)

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  1.  3
    Anna M. Wobus (2010). The Janus Face of Pluripotent Stem Cells – Connection Between Pluripotency and Tumourigenicity. Bioessays 32 (11):993-1002.
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  2.  43
    A. M. Soto & C. Sonnenschein (2006). Emergentism by Default: A View From the Bench. [REVIEW] Synthese 151 (3):361-376.
    For the last 50 years the dominant stance in experimental biology has been reductionism in general, and genetic reductionism in particular. Philosophers were the first to realize that the belief that the Mendelian genes were reduced to DNA molecules was questionable. Soon, experimental data confirmed these misgivings. The optimism of molecular biologists, fueled by early success in tackling relatively simple problems has now been tempered by the difficulties encountered when applying the same simple ideas to complex problems. We analyze three (...)
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  3.  2
    Melinda Cooper (2009). Regenerative Pathologies: Stem Cells, Teratomas and Theories of Cancer. [REVIEW] Medicine Studies 1 (1):55-66.
    What is now familiarly referred to as the ‘embryonic stem (ES) cell’ is a recent biological category whose origins lie in research into benign and malignant teratomas carried out in the 1950s, 60s and 70s. In these studies, the question of the normal or pathological character of the ES cell was a matter of considerable debate and indeed the term ES cell was often used interchangeably with that of the embryonal carcinoma (EC) cell. This article argues that the indecisiveness of (...)
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  4.  66
    William Bechtel (2016). Investigating Neural Representations: The Tale of Place Cells. Synthese 193 (5):1287-1321.
    While neuroscientists often characterize brain activity as representational, many philosophers have construed these accounts as just theorists’ glosses on the mechanism. Moreover, philosophical discussions commonly focus on finished accounts of explanation, not research in progress. I adopt a different perspective, considering how characterizations of neural activity as representational contributes to the development of mechanistic accounts, guiding the investigations neuroscientists pursue as they work from an initial proposal to a more detailed understanding of a mechanism. I develop one illustrative example involving (...)
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  5.  11
    Melinda Bonnie Fagan (2010). Stems and Standards: Social Interaction in the Search for Blood Stem Cells. Journal of the History of Biology 43 (1):67 - 109.
    This essay examines the role of social interactions in the search for blood stem cells, in a recent episode of biomedical research. Linked to mid-20th century cell biology, genetics and radiation research, the search for blood stem cells coalesced in the 1960s and took a developmental turn in the late 1980s, with significant ramifications for immunology, stem cell and cancer biology. Like much contemporary biomedical research, this line of inquiry exhibits a complex social structure and includes several prominent (...)
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  6.  15
    Melinda Bonnie Fagan (2016). Stem Cells and Systems Models: Clashing Views of Explanation. Synthese 193 (3):873-907.
    This paper examines a case of failed interdisciplinary collaboration, between experimental stem cell research and theoretical systems biology. Recently, two groups of theoretical biologists have proposed dynamical systems models as a basis for understanding stem cells and their distinctive capacities. Experimental stem cell biologists, whose work focuses on manipulation of concrete cells, tissues and organisms, have largely ignored these proposals. I argue that ‘failure to communicate’ in this case is rooted in divergent views of explanation: the theoretically-inclined modelers (...)
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  7.  20
    David B. Resnik (2002). The Commercialization of Human Stem Cells: Ethical and Policy Issues. [REVIEW] Health Care Analysis 10 (2):127-154.
    The first stage of the human embryonic stem(ES) cell research debate revolved aroundfundamental questions, such as whether theresearch should be done at all, what types ofresearch may be done, who should do theresearch, and how the research should befunded. Now that some of these questions arebeing answered, we are beginning to see thenext stage of the debate: the battle forproperty rights relating to human ES cells. The reason why property rights will be a keyissue in this debate is simple (...)
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  8.  17
    Ronald K. F. Fung & Ian H. Kerridge (2013). Uncertain Translation, Uncertain Benefit and Uncertain Risk: Ethical Challenges Facing First-in-Human Trials of Induced Pluripotent Stem (Ips) Cells. Bioethics 27 (2):89-96.
    The discovery of induced pluripotent stem (iPS) cells in 2006 was heralded as a major breakthrough in stem cell research. Since then, progress in iPS cell technology has paved the way towards clinical application, particularly cell replacement therapy, which has refueled debate on the ethics of stem cell research. However, much of the discourse has focused on questions of moral status and potentiality, overlooking the ethical issues which are introduced by the clinical testing of iPS cell replacement therapy. First-in-human (...)
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  9.  11
    Bartlomiej Swiatczak & Maria Rescigno (2012). How the Interplay Between Antigen Presenting Cells and Microbiota Tunes Host Immune Responses in the Gut. Seminars in Immunology 24 (1):43-49.
    Coordination of immune responses in the gut is a complex task. In order to fight pathogens and maintain a defined population of commensal microbes, the mucosal immune system has to coordinate information from the external (luminal) and internal (abluminal) environment and respond accordingly. Dendritic cells (DCs) are crucial cell types involved in this process as they integrate these signals and direct immunogenic or tolerogenic responses. Here, we review how various functions of DCs depend on microbial stimuli and how these (...)
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  10.  11
    Yue Liang Zheng (2016). Some Ethical Concerns About Human Induced Pluripotent Stem Cells. Science and Engineering Ethics 22 (5):1277-1284.
    Human induced pluripotent stem cells can be obtained from somatic cells, and their derivation does not require destruction of embryos, thus avoiding ethical problems arising from the destruction of human embryos. This type of stem cell may provide an important tool for stem cell therapy, but it also results in some ethical concerns. It is likely that abnormal reprogramming occurs in the induction of human induced pluripotent stem cells, and that the stem cells generate tumors in (...)
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  11.  5
    Franco Giorgi & Luis Emilio Bruni (2016). Germ Cells Are Made Semiotically Competent During Evolution. Biosemiotics 9 (1):31-49.
    Germ cells are cross-roads of development and evolution. They define the origin of every new generation and, at the same time, represent the biological end-product of any mature organism. Germ cells are endowed with the following capacities: to store a self-descriptive program, to accumulate a protein-synthesizing machinery, and to incorporate enough nourishment to sustain embryonic development. To accomplish this goal, germ cells do not simply unfold a pre-determined program or realize a sole instructive role. On the contrary, (...)
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  12.  20
    Karen Lebacqz (2012). Stumbling on Status: Abortion, Stem Cells, and Faulty Reasoning. [REVIEW] Theoretical Medicine and Bioethics 33 (1):75-82.
    Common arguments from the abortion debate have set the stage for the debate on stem cell research. Unfortunately, those arguments demonstrate flawed reasoning—jumping to unfounded conclusions, using value laden language rather than careful argument, and ignoring morally relevant aspects of the situation. The influence of flawed abortion arguments on the stem cell debate results in failures of moral reasoning and in lack of attention to important morally relevant differences between abortion and human embryonic stem cells. Among those differences are (...)
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  13.  9
    Cheryl Lancaster (2016). The Acid Test for Biological Science: STAP Cells, Trust, and Replication. Science and Engineering Ethics 22 (1):147-167.
    In January 2014, a letter and original research article were published in Nature describing a process whereby somatic mouse cells could be converted into stem cells by subjecting them to stress. These “stimulus-triggered acquisition of pluripotency” cells were shown to be capable of contributing to all cell types of a developing embryo, and extra-embryonic tissues. The lead author of the publications, Haruko Obokata, became an overnight celebrity in Japan, where she was dubbed the new face of Japanese (...)
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  14.  15
    H. F. Jelinek, R. M. Cesar & J. J. G. Leandro (2003). Exploring Wavelet Transforms for Morphological Differentiation Between Functionally Different Cat Retinal Ganglion Cells. Brain and Mind 4 (1):67-90.
    Cognition or higher brain activity is sometimes seen as a phenomenon greater than the sum of its parts. This viewpoint however is largely dependent on the state of the art of experimental techniques that endeavor to characterize morphology and its association to function. Retinal ganglion cells are readily accessible for this work and we discuss recent advances in computational techniques in identifying novel parameters that describe structural attributes possibly associated with specific function. These parameters are based on calculating wavelet (...)
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  15.  9
    Stavros Ioannidis (2014). The Philosophy of Stem Cells. [REVIEW] Metascience 24 (2):285-288.
    Melinda Fagan’s book on the philosophy of stem cell biology is a superb discussion of this exciting field of contemporary science, and the first book-length philosophical treatment of the subject. It contains a detailed and insightful examination of stem cell science, its structure, methods, and challenges.The book does not require any previous knowledge of stem cell biology—all the relevant scientific details and concepts, the central experimental procedures and results, as well as the historical development of the field, are presented in (...)
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  16.  18
    Catherine Waldby, Ian Kerridge & Loane Skene (2012). Multidisciplinary Perspectives on the Donation of Stem Cells and Reproductive Tissue. Journal of Bioethical Inquiry 9 (1):15-17.
    Multidisciplinary Perspectives on the Donation of Stem Cells and Reproductive Tissue Content Type Journal Article Category Symposium Pages 15-17 DOI 10.1007/s11673-011-9351-x Authors Catherine Waldby, School of Social and Political Sciences, University of Sydney, Sydney, Australia Ian Kerridge, Centre for Values, Ethics and the Law in Medicine, Medical Foundation Building (K25), University of Sydney, Sydney, NSW 2006, Australia Loane Skene, Faculty of Law and Faculty of Medicine, Dentistry and Health Studies, University of Melbourne, Melbourne, VA, Australia Journal Journal of Bioethical (...)
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  17.  5
    Robert S. Molday & Yi-Te Hsu (1995). The cGMP-Gated Channel of Photoreceptor Cells: Its Structural Properties and Role in Phototransduction. Behavioral and Brain Sciences 18 (3):441-451.
    The cyclic GMP-gated channel responds to changes in free intracellular cGMP, and as a result, it plays a central role in the phototransduction process in rod and cone photoreceptor cells. Recent biochemical, immunochemical, and molecular biology studies indicate that this channel consists of a complex of two distinct subunits and one or more associated proteins. Primary structural analysis indicates that the a and (3 subunits contain a cGMP-binding domain, an even number of membrane-spanning segments, a voltage sensor motif and (...)
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  18.  3
    Ioana Iancu & Delia Cristina Balaban (2009). Romanian Media Coverage on Bioethics. The Issue of Stem Cells. Journal for the Study of Religions and Ideologies 8 (22):24.
    In the last decades, scientific developments are largely discussed and debated mainly at the media level. Based on the agenda setting model, the importance of a certain theme is given by the frequency of its appearances in mass-media. Within this context, this paper focuses on the issue of stem cells and its media coverage in Romania. Using content analysis of the most read national newspapers, the research aims to emphasize two relevant aspects: the stem cells issue is only (...)
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  19.  70
    Lucie Laplane (2011). Stem Cells and the Temporal Boundaries of Development: Toward a Species-Dependent View. Biological Theory 6 (1):48-58.
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  20. Mircea Steriade (1978). Cortical Long-Axoned Cells and Putative Interneurons During the Sleep-Waking Cycle. Behavioral and Brain Sciences 1 (3):465.
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  21.  15
    Anna‐Marei Boehm, Philip Rosenstiel & Thomas Cg Bosch (2013). Stem Cells and Aging From a Quasi‐Immortal Point of View. Bioessays 35 (11):994-1003.
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  22. Agata Sagan & Peter Singer (2007). The Moral Status of Stem Cells. Metaphilosophy 38 (2-3):264–284.
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  23.  18
    Thomas C. G. Bosch (2009). Hydra and the Evolution of Stem Cells. Bioessays 31 (4):478-486.
  24.  1
    Samer Mi Hussein, Judith Elbaz & Andras A. Nagy (2013). Genome Damage in Induced Pluripotent Stem Cells: Assessing the Mechanisms and Their Consequences. Bioessays 35 (3):152-162.
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  25.  10
    Yves Maury, Morgane Gauthier, Marc Peschanski & Cécile Martinat (2012). Human Pluripotent Stem Cells for Disease Modelling and Drug Screening. Bioessays 34 (1):61-71.
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  26.  2
    Xosé R. Bustelo (2012). Intratumoral Stages of Metastatic Cells: A Synthesis of Ontogeny, Rho/Rac GTPases, Epithelial‐Mesenchymal Transitions, and More. Bioessays 34 (9):748-759.
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  27.  13
    Godfrey B. Tangwa (2007). Moral Status of Embryonic Stem Cells: Perspective of an African Villager. Bioethics 21 (8):449–457.
  28.  16
    Peter Walde (2010). Building Artificial Cells and Protocell Models: Experimental Approaches with Lipid Vesicles. Bioessays 32 (4):296-303.
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  29.  3
    Tobias Schatton, Natasha Y. Frank & Markus H. Frank (2009). Identification and Targeting of Cancer Stem Cells. Bioessays 31 (10):1038-1049.
  30.  2
    Renée Roodbeen & Jan C. M. van Hest (2009). Synthetic Cells and Organelles: Compartmentalization Strategies. Bioessays 31 (12):1299-1308.
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  31.  19
    Fidel‐Nicolás Lolo, Sergio Casas Tintó & Eduardo Moreno (2013). How Winner Cells Cause the Demise of Loser Cells. Bioessays 35 (4):348-353.
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  32.  11
    Divya Rajamohan, Elena Matsa, Spandan Kalra, James Crutchley, Asha Patel, Vinoj George & Chris Denning (2013). Current Status of Drug Screening and Disease Modelling in Human Pluripotent Stem Cells. Bioessays 35 (3):281-298.
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  33.  8
    Earl Prinsloo, Mokgadi M. Setati, Victoria M. Longshaw & Gregory L. Blatch (2009). Chaperoning Stem Cells: A Role for Heat Shock Proteins in the Modulation of Stem Cell Self‐Renewal and Differentiation? Bioessays 31 (4):370-377.
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  34.  10
    Nicolae Ovidiu Grad, Ionel Ciprian Pop & Ion Aurel Mironiuc (2012). Stem Cells Therapy and Research. Benefits and Ethical Challences. Journal for the Study of Religions and Ideologies 11 (32):190-205.
    The research on stem cell-based therapies has greatly expanded in recent years. Our text attempts to seek those religious and ethical challenges that stem cell therapy and research bring into debate. Our thesis is that bioethics can defend its principle without a religious background. We will develop our argumentation on three major points: firstly, a comparison between secular ethics and religious views will clarify why stem cell therapy and research are important from a scientific point of view, addressing the very (...)
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  35.  6
    Sean Vincent Murphy & Anthony Atala (2013). Organ Engineering – Combining Stem Cells, Biomaterials, and Bioreactors to Produce Bioengineered Organs for Transplantation. Bioessays 35 (3):163-172.
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  36.  4
    C. Florian Bentzinger, Yu Xin Wang, Julia von Maltzahn & Michael A. Rudnicki (2013). The Emerging Biology of Muscle Stem Cells: Implications for Cell‐Based Therapies. Bioessays 35 (3):231-241.
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  37.  2
    Guangjin Pan, Tao Wang, Hongjie Yao & Duanqing Pei (2012). Somatic Cell Reprogramming for Regenerative Medicine: SCNT Vs. iPS Cells. Bioessays 34 (6):472-476.
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  38.  2
    Theo Mantamadiotis, Nikos Papalexis & Sebastian Dworkin (2012). CREB Signalling in Neural Stem/Progenitor Cells: Recent Developments and the Implications for Brain Tumour Biology. Bioessays 34 (4):293-300.
  39.  2
    Michael D. Green, Sarah Xl Huang & Hans‐Willem Snoeck (2013). Stem Cells of the Respiratory System: From Identification to Differentiation Into Functional Epithelium. Bioessays 35 (3):261-270.
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  40.  1
    Trevor A. Graham, Noor Jawad & Nicholas A. Wright (2010). Spindles Losing Their Bearings: Does Disruption of Orientation in Stem Cells Predict the Onset of Cancer? Bioessays 32 (6):468-472.
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  41.  1
    Eric A. Gustafson & Gary M. Wessel (2010). Vasa Genes: Emerging Roles in the Germ Line and in Multipotent Cells. Bioessays 32 (7):626-637.
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  42.  1
    Dong‐Bo Ou, Hong‐Juan Lang, Rui Chen, Xiong‐Tao Liu & Qiang‐Sun Zheng (2009). Using Embryonic Stem Cells to Form a Biological Pacemaker Via Tissue Engineering Technology. Bioessays 31 (2):246-252.
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  43.  58
    Robert Streiffer (2005). At the Edge of Humanity: Human Stem Cells, Chimeras, and Moral Status. Kennedy Institute of Ethics Journal 15 (4):347-370.
    : Experiments involving the transplantation of human stem cells and their derivatives into early fetal or embryonic nonhuman animals raise novel ethical issues due to their possible implications for enhancing the moral status of the chimeric individual. Although status-enhancing research is not necessarily objectionable from the perspective of the chimeric individual, there are grounds for objecting to it in the conditions in which it is likely to occur. Translating this ethical conclusion into a policy recommendation, however, is complicated by (...)
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  44. Pierre-Luc Germain (2012). Cancer Cells and Adaptive Explanations. Biology and Philosophy 27 (6):785-810.
    The aim of this paper is to assess the relevance of somatic evolution by natural selection to our understanding of cancer development. I do so in two steps. In the first part of the paper, I ask to what extent cancer cells meet the formal requirements for evolution by natural selection, relying on Godfrey-Smith’s (2009) framework of Darwinian populations. I argue that although they meet the minimal requirements for natural selection, cancer cells are not paradigmatic Darwinian populations. In (...)
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  45.  17
    Mathias Grote (2010). Surfaces of Action: Cells and Membranes in Electrochemistry and the Life Sciences. Studies in History and Philosophy of Science Part C 41 (3):183-193.
    The term ‘cell’, in addition to designating fundamental units of life, has also been applied since the nineteenth century to technical apparatuses such as fuel and galvanic cells. This paper shows that such technologies, based on the electrical effects of chemical reactions taking place in containers, had a far-reaching impact on the concept of the biological cell. My argument revolves around the controversy over oxidative phosphorylation in bioenergetics between 1961 and 1977. In this scientific conflict, a two-level mingling of (...)
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  46.  51
    Michael J. Denton, Govindasamy Kumaramanickavel & Michael Legge (2013). Cells as Irreducible Wholes: The Failure of Mechanism and the Possibility of an Organicist Revival. Biology and Philosophy 28 (1):31-52.
    According to vitalism, living organisms differ from machines and all other inanimate objects by being endowed with an indwelling immaterial directive agency, ‘vital force,’ or entelechy . While support for vitalism fell away in the late nineteenth century many biologists in the early twentieth century embraced a non vitalist philosophy variously termed organicism/holism/emergentism which aimed at replacing the actions of an immaterial spirit with what was seen as an equivalent but perfectly natural agency—the emergent autonomous activity of the whole organism. (...)
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  47.  64
    John Harris (2003). Stem Cells, Sex, and Procreation. Cambridge Quarterly of Healthcare Ethics 12 (4):353-371.
    Sex is not the answer to everything, though young men think it is, but it may be the answer to the intractable debate over the ethics of human embryonic stem cell research. In this paper, I advance one ethical principle that, as yet, has not received the attention its platitudinous character would seem to merit. If found acceptable, this principle would permit the beneficial use of any embryonic or fetal tissue that would, by default, be lost or destroyed. More important, (...)
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  48.  13
    K. Devolder (2005). Creating and Sacrificing Embryos for Stem Cells. Journal of Medical Ethics 31 (6):366-370.
    The compromise position that accepts the use and derivation of stem cells from spare in vitro fertilisation embryos but opposes the creation of embryos for these purposes is a very weak ethical position. This paper argues that whatever the basis is on which defenders of this viewpoint accord intrinsic value to the embryo, once they accept the creation and sacrifice of embryos to benefit infertile people with a child-wish, they do not have a sound moral argument to condemn the (...)
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  49.  5
    Andrew Reynolds (2008). Amoebae as Exemplary Cells: The Protean Nature of an Elementary Organism. [REVIEW] Journal of the History of Biology 41 (2):307 - 337.
    In the nineteenth century protozoology and early cell biology intersected through the nexus of Darwin's theory of evolution. As single-celled organisms, amoebae offered an attractive focus of study for researchers seeking evolutionary relationships between the cells of humans and other animals, and their primitive appearance made them a favourite model for the ancient ancestor of all living things. Their resemblance to human and other metazoan cells made them popular objects of study among morphologists, physiologists, and even those investigating (...)
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  50.  1
    Anette Forss (2012). Cells and the (Imaginary) Patient: The Multistable Practitioner–Technology–Cell Interface in the Cytology Laboratory. [REVIEW] Medicine, Health Care and Philosophy 15 (3):295-308.
    Modern health care is inextricably bound up with technologically mediated knowledge and practice. It is vital to investigate its use and role in different clinical contexts characterized, on one hand, by face to face practitioner and patient encounters (where technology may be conceptualised as hindering therapeutic relations) and, on the other hand, by practitioners’ encounter with bodily parts in laboratories (where conceiving of patients may be thought of as confounding objectivity). To contribute to the latter, I offer an ethnographic analysis (...)
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