Search results for 'TERATOCARCINOMA CELLS' (try it on Scholar)

999 found
Sort by:
  1. Anna M. Wobus (2010). The Janus Face of Pluripotent Stem Cells – Connection Between Pluripotency and Tumourigenicity. Bioessays 32 (11):993-1002.score: 78.0
    Direct download (4 more)  
     
    My bibliography  
     
    Export citation  
  2. A. M. Soto & C. Sonnenschein (2006). Emergentism by Default: A View From the Bench. [REVIEW] Synthese 151 (3):361-376.score: 60.0
    For the last 50 years the dominant stance in experimental biology has been reductionism in general, and genetic reductionism in particular. Philosophers were the first to realize that the belief that the Mendelian genes were reduced to DNA molecules was questionable. Soon, experimental data confirmed these misgivings. The optimism of molecular biologists, fueled by early success in tackling relatively simple problems has now been tempered by the difficulties encountered when applying the same simple ideas to complex problems. We analyze three (...)
    Direct download (8 more)  
     
    My bibliography  
     
    Export citation  
  3. Melinda Cooper (2009). Regenerative Pathologies: Stem Cells, Teratomas and Theories of Cancer. [REVIEW] Medicine Studies 1 (1):55-66.score: 60.0
    What is now familiarly referred to as the ‘embryonic stem (ES) cell’ is a recent biological category whose origins lie in research into benign and malignant teratomas carried out in the 1950s, 60s and 70s. In these studies, the question of the normal or pathological character of the ES cell was a matter of considerable debate and indeed the term ES cell was often used interchangeably with that of the embryonal carcinoma (EC) cell. This article argues that the indecisiveness of (...)
    Direct download (3 more)  
     
    My bibliography  
     
    Export citation  
  4. Ronald K. F. Fung & Ian H. Kerridge (2013). Uncertain Translation, Uncertain Benefit and Uncertain Risk: Ethical Challenges Facing First-in-Human Trials of Induced Pluripotent Stem (Ips) Cells. Bioethics 27 (2):89-96.score: 24.0
    The discovery of induced pluripotent stem (iPS) cells in 2006 was heralded as a major breakthrough in stem cell research. Since then, progress in iPS cell technology has paved the way towards clinical application, particularly cell replacement therapy, which has refueled debate on the ethics of stem cell research. However, much of the discourse has focused on questions of moral status and potentiality, overlooking the ethical issues which are introduced by the clinical testing of iPS cell replacement therapy. First-in-human (...)
    Direct download (6 more)  
     
    My bibliography  
     
    Export citation  
  5. David B. Resnik (2002). The Commercialization of Human Stem Cells: Ethical and Policy Issues. [REVIEW] Health Care Analysis 10 (2):127-154.score: 24.0
    The first stage of the human embryonic stem(ES) cell research debate revolved aroundfundamental questions, such as whether theresearch should be done at all, what types ofresearch may be done, who should do theresearch, and how the research should befunded. Now that some of these questions arebeing answered, we are beginning to see thenext stage of the debate: the battle forproperty rights relating to human ES cells. The reason why property rights will be a keyissue in this debate is simple (...)
    Direct download (6 more)  
     
    My bibliography  
     
    Export citation  
  6. Bartlomiej Swiatczak & Maria Rescigno (2012). How the Interplay Between Antigen Presenting Cells and Microbiota Tunes Host Immune Responses in the Gut. Seminars in Immunology 24 (1):43-49.score: 24.0
    Coordination of immune responses in the gut is a complex task. In order to fight pathogens and maintain a defined population of commensal microbes, the mucosal immune system has to coordinate information from the external (luminal) and internal (abluminal) environment and respond accordingly. Dendritic cells (DCs) are crucial cell types involved in this process as they integrate these signals and direct immunogenic or tolerogenic responses. Here, we review how various functions of DCs depend on microbial stimuli and how these (...)
    Translate to English
    | Direct download  
     
    My bibliography  
     
    Export citation  
  7. William Bechtel (forthcoming). Investigating Neural Representations: The Tale of Place Cells. Synthese:1-35.score: 24.0
    While neuroscientists often characterize brain activity as representational, many philosophers have construed these accounts as just theorists’ glosses on the mechanism. Moreover, philosophical discussions commonly focus on finished accounts of explanation, not research in progress. I adopt a different perspective, considering how characterizations of neural activity as representational contributes to the development of mechanistic accounts, guiding the investigations neuroscientists pursue as they work from an initial proposal to a more detailed understanding of a mechanism. I develop one illustrative example involving (...)
    No categories
    Direct download (2 more)  
     
    My bibliography  
     
    Export citation  
  8. Catherine Waldby, Ian Kerridge & Loane Skene (2012). Multidisciplinary Perspectives on the Donation of Stem Cells and Reproductive Tissue. Journal of Bioethical Inquiry 9 (1):15-17.score: 24.0
    Multidisciplinary Perspectives on the Donation of Stem Cells and Reproductive Tissue Content Type Journal Article Category Symposium Pages 15-17 DOI 10.1007/s11673-011-9351-x Authors Catherine Waldby, School of Social and Political Sciences, University of Sydney, Sydney, Australia Ian Kerridge, Centre for Values, Ethics and the Law in Medicine, Medical Foundation Building (K25), University of Sydney, Sydney, NSW 2006, Australia Loane Skene, Faculty of Law and Faculty of Medicine, Dentistry and Health Studies, University of Melbourne, Melbourne, VA, Australia Journal Journal of Bioethical (...)
    Direct download (6 more)  
     
    My bibliography  
     
    Export citation  
  9. Melinda Bonnie Fagan (2010). Stems and Standards: Social Interaction in the Search for Blood Stem Cells. Journal of the History of Biology 43 (1):67 - 109.score: 24.0
    This essay examines the role of social interactions in the search for blood stem cells, in a recent episode of biomedical research. Linked to mid-20th century cell biology, genetics and radiation research, the search for blood stem cells coalesced in the 1960s and took a developmental turn in the late 1980s, with significant ramifications for immunology, stem cell and cancer biology. Like much contemporary biomedical research, this line of inquiry exhibits a complex social structure and includes several prominent (...)
    Direct download (5 more)  
     
    My bibliography  
     
    Export citation  
  10. H. F. Jelinek, R. M. Cesar & J. J. G. Leandro (2003). Exploring Wavelet Transforms for Morphological Differentiation Between Functionally Different Cat Retinal Ganglion Cells. Brain and Mind 4 (1):67-90.score: 24.0
    Cognition or higher brain activity is sometimes seen as a phenomenon greater than the sum of its parts. This viewpoint however is largely dependent on the state of the art of experimental techniques that endeavor to characterize morphology and its association to function. Retinal ganglion cells are readily accessible for this work and we discuss recent advances in computational techniques in identifying novel parameters that describe structural attributes possibly associated with specific function. These parameters are based on calculating wavelet (...)
    Direct download (8 more)  
     
    My bibliography  
     
    Export citation  
  11. Ioana Iancu & Delia Cristina Balaban (2009). Romanian Media Coverage on Bioethics. The Issue of Stem Cells. Journal for the Study of Religions and Ideologies 8 (22):24.score: 24.0
    In the last decades, scientific developments are largely discussed and debated mainly at the media level. Based on the agenda setting model, the importance of a certain theme is given by the frequency of its appearances in mass-media. Within this context, this paper focuses on the issue of stem cells and its media coverage in Romania. Using content analysis of the most read national newspapers, the research aims to emphasize two relevant aspects: the stem cells issue is only (...)
    No categories
    Direct download (7 more)  
     
    My bibliography  
     
    Export citation  
  12. Karen Lebacqz (2012). Stumbling on Status: Abortion, Stem Cells, and Faulty Reasoning. [REVIEW] Theoretical Medicine and Bioethics 33 (1):75-82.score: 24.0
    Common arguments from the abortion debate have set the stage for the debate on stem cell research. Unfortunately, those arguments demonstrate flawed reasoning—jumping to unfounded conclusions, using value laden language rather than careful argument, and ignoring morally relevant aspects of the situation. The influence of flawed abortion arguments on the stem cell debate results in failures of moral reasoning and in lack of attention to important morally relevant differences between abortion and human embryonic stem cells. Among those differences are (...)
    No categories
    Direct download (2 more)  
     
    My bibliography  
     
    Export citation  
  13. Robert S. Molday & Yi-Te Hsu (1995). The cGMP-Gated Channel of Photoreceptor Cells: Its Structural Properties and Role in Phototransduction. Behavioral and Brain Sciences 18 (3):441-451.score: 24.0
    The cyclic GMP-gated channel responds to changes in free intracellular cGMP, and as a result, it plays a central role in the phototransduction process in rod and cone photoreceptor cells. Recent biochemical, immunochemical, and molecular biology studies indicate that this channel consists of a complex of two distinct subunits and one or more associated proteins. Primary structural analysis indicates that the a and (3 subunits contain a cGMP-binding domain, an even number of membrane-spanning segments, a voltage sensor motif and (...)
    Direct download (4 more)  
     
    My bibliography  
     
    Export citation  
  14. Asim Roy (2013). An Extension of the Localist Representation Theory: Grandmother Cells Are Also Widely Used in the Brain. Frontiers in Psychology 4.score: 24.0
    An extension of the localist representation theory: grandmother cells are also widely used in the brain.
    Direct download (4 more)  
     
    My bibliography  
     
    Export citation  
  15. Nicolae Ovidiu Grad, Ionel Ciprian Pop & Ion Aurel Mironiuc (2012). Stem Cells Therapy and Research. Benefits and Ethical Challences. Journal for the Study of Religions and Ideologies 11 (32):190-205.score: 22.0
    The research on stem cell-based therapies has greatly expanded in recent years. Our text attempts to seek those religious and ethical challenges that stem cell therapy and research bring into debate. Our thesis is that bioethics can defend its principle without a religious background. We will develop our argumentation on three major points: firstly, a comparison between secular ethics and religious views will clarify why stem cell therapy and research are important from a scientific point of view, addressing the very (...)
    No categories
    Direct download (7 more)  
     
    My bibliography  
     
    Export citation  
  16. Agata Sagan & Peter Singer (2007). The Moral Status of Stem Cells. Metaphilosophy 38 (2-3):264–284.score: 21.0
    No categories
    Direct download (6 more)  
     
    My bibliography  
     
    Export citation  
  17. Godfrey B. Tangwa (2007). Moral Status of Embryonic Stem Cells: Perspective of an African Villager. Bioethics 21 (8):449–457.score: 21.0
  18. Peter Walde (2010). Building Artificial Cells and Protocell Models: Experimental Approaches with Lipid Vesicles. Bioessays 32 (4):296-303.score: 21.0
    Direct download (5 more)  
     
    My bibliography  
     
    Export citation  
  19. Anna‐Marei Boehm, Philip Rosenstiel & Thomas Cg Bosch (2013). Stem Cells and Aging From a Quasi‐Immortal Point of View. Bioessays 35 (11):994-1003.score: 21.0
    Direct download (4 more)  
     
    My bibliography  
     
    Export citation  
  20. Thomas C. G. Bosch (2009). Hydra and the Evolution of Stem Cells. Bioessays 31 (4):478-486.score: 21.0
  21. Sean Vincent Murphy & Anthony Atala (2013). Organ Engineering – Combining Stem Cells, Biomaterials, and Bioreactors to Produce Bioengineered Organs for Transplantation. Bioessays 35 (3):163-172.score: 21.0
    Direct download (3 more)  
     
    My bibliography  
     
    Export citation  
  22. Earl Prinsloo, Mokgadi M. Setati, Victoria M. Longshaw & Gregory L. Blatch (2009). Chaperoning Stem Cells: A Role for Heat Shock Proteins in the Modulation of Stem Cell Self‐Renewal and Differentiation? Bioessays 31 (4):370-377.score: 21.0
    Direct download (4 more)  
     
    My bibliography  
     
    Export citation  
  23. Michael D. Green, Sarah Xl Huang & Hans‐Willem Snoeck (2013). Stem Cells of the Respiratory System: From Identification to Differentiation Into Functional Epithelium. Bioessays 35 (3):261-270.score: 21.0
    Direct download (3 more)  
     
    My bibliography  
     
    Export citation  
  24. Lucie Laplane (2011). Stem Cells and the Temporal Boundaries of Development: Toward a Species-Dependent View. Biological Theory 6 (1):48-58.score: 21.0
    Direct download (5 more)  
     
    My bibliography  
     
    Export citation  
  25. Fidel‐Nicolás Lolo, Sergio Casas Tintó & Eduardo Moreno (2013). How Winner Cells Cause the Demise of Loser Cells. Bioessays 35 (4):348-353.score: 21.0
    Direct download (6 more)  
     
    My bibliography  
     
    Export citation  
  26. Yves Maury, Morgane Gauthier, Marc Peschanski & Cécile Martinat (2012). Human Pluripotent Stem Cells for Disease Modelling and Drug Screening. Bioessays 34 (1):61-71.score: 21.0
    No categories
    Direct download (6 more)  
     
    My bibliography  
     
    Export citation  
  27. Tobias Schatton, Natasha Y. Frank & Markus H. Frank (2009). Identification and Targeting of Cancer Stem Cells. Bioessays 31 (10):1038-1049.score: 21.0
  28. C. Florian Bentzinger, Yu Xin Wang, Julia von Maltzahn & Michael A. Rudnicki (2013). The Emerging Biology of Muscle Stem Cells: Implications for Cell‐Based Therapies. Bioessays 35 (3):231-241.score: 21.0
    Direct download (4 more)  
     
    My bibliography  
     
    Export citation  
  29. Xosé R. Bustelo (2012). Intratumoral Stages of Metastatic Cells: A Synthesis of Ontogeny, Rho/Rac GTPases, Epithelial‐Mesenchymal Transitions, and More. Bioessays 34 (9):748-759.score: 21.0
    Direct download (5 more)  
     
    My bibliography  
     
    Export citation  
  30. Trevor A. Graham, Noor Jawad & Nicholas A. Wright (2010). Spindles Losing Their Bearings: Does Disruption of Orientation in Stem Cells Predict the Onset of Cancer? Bioessays 32 (6):468-472.score: 21.0
    No categories
    Direct download (3 more)  
     
    My bibliography  
     
    Export citation  
  31. Eric A. Gustafson & Gary M. Wessel (2010). Vasa Genes: Emerging Roles in the Germ Line and in Multipotent Cells. Bioessays 32 (7):626-637.score: 21.0
    Direct download (4 more)  
     
    My bibliography  
     
    Export citation  
  32. Samer Mi Hussein, Judith Elbaz & Andras A. Nagy (2013). Genome Damage in Induced Pluripotent Stem Cells: Assessing the Mechanisms and Their Consequences. Bioessays 35 (3):152-162.score: 21.0
    Direct download (3 more)  
     
    My bibliography  
     
    Export citation  
  33. Theo Mantamadiotis, Nikos Papalexis & Sebastian Dworkin (2012). CREB Signalling in Neural Stem/Progenitor Cells: Recent Developments and the Implications for Brain Tumour Biology. Bioessays 34 (4):293-300.score: 21.0
  34. Dong‐Bo Ou, Hong‐Juan Lang, Rui Chen, Xiong‐Tao Liu & Qiang‐Sun Zheng (2009). Using Embryonic Stem Cells to Form a Biological Pacemaker Via Tissue Engineering Technology. Bioessays 31 (2):246-252.score: 21.0
    Direct download (4 more)  
     
    My bibliography  
     
    Export citation  
  35. Guangjin Pan, Tao Wang, Hongjie Yao & Duanqing Pei (2012). Somatic Cell Reprogramming for Regenerative Medicine: SCNT Vs. iPS Cells. Bioessays 34 (6):472-476.score: 21.0
    Direct download (4 more)  
     
    My bibliography  
     
    Export citation  
  36. Divya Rajamohan, Elena Matsa, Spandan Kalra, James Crutchley, Asha Patel, Vinoj George & Chris Denning (2013). Current Status of Drug Screening and Disease Modelling in Human Pluripotent Stem Cells. Bioessays 35 (3):281-298.score: 21.0
    Direct download (6 more)  
     
    My bibliography  
     
    Export citation  
  37. Renée Roodbeen & Jan C. M. van Hest (2009). Synthetic Cells and Organelles: Compartmentalization Strategies. Bioessays 31 (12):1299-1308.score: 21.0
    Direct download (4 more)  
     
    My bibliography  
     
    Export citation  
  38. Mircea Steriade (1978). Cortical Long-Axoned Cells and Putative Interneurons During the Sleep-Waking Cycle. Behavioral and Brain Sciences 1 (3):465.score: 21.0
    Direct download (2 more)  
     
    My bibliography  
     
    Export citation  
  39. Jonathan C. W. Edwards (2005). Is Consciousness Only a Property of Individual Cells? Journal of Consciousness Studies 12 (4-5):60-76.score: 20.0
    We perceive colour, shape, sound and touch 'bound together' in a single experience. The following arguments about this binding phenomenon are raised: (1) The individual signals passing from neurone to neurone are not bound together, whether as elements of information or physically. (2) Within a single cell, binding in terms of bringing together of information is potentially feasible. A physical substrate may also be available. (3) It is therefore proposed that a bound conscious experience must be a property of an (...)
    Direct download (2 more)  
     
    My bibliography  
     
    Export citation  
  40. Demetrio Neri (2011). The Race Toward 'Ethically Universally Acceptable' Human Pluripotent (Embryonic-Like) Stem Cells: Only a Problem of Sources? Bioethics 25 (5):260-266.score: 20.0
    Over the past few years, several proposals aimed at procuring human pluripotent (embryonic-like) stem cells without involving the destruction of a human embryo have been proposed and widely discussed. This article focuses on a basic aspect of the debate, namely the plausibility of one or more of these new proposals being able to meet the ethical requirements that those who regard the human embryo as sacred have tried to impose on stem cells research in the last ten years. (...)
    Direct download (6 more)  
     
    My bibliography  
     
    Export citation  
  41. Simon Andrews (2010). Definable Open Sets As Finite Unions of Definable Open Cells. Notre Dame Journal of Formal Logic 51 (2):247-251.score: 20.0
    We introduce CE- cell decomposition , a modified version of the usual o-minimal cell decomposition. We show that if an o-minimal structure $\mathcal{R}$ admits CE-cell decomposition then any definable open set in $\mathcal{R}$ may be expressed as a finite union of definable open cells. The dense linear ordering and linear o-minimal expansions of ordered abelian groups are examples of such structures.
    Direct download (3 more)  
     
    My bibliography  
     
    Export citation  
  42. Andrew Reynolds (2008). Amoebae as Exemplary Cells: The Protean Nature of an Elementary Organism. [REVIEW] Journal of the History of Biology 41 (2):307 - 337.score: 20.0
    In the nineteenth century protozoology and early cell biology intersected through the nexus of Darwin's theory of evolution. As single-celled organisms, amoebae offered an attractive focus of study for researchers seeking evolutionary relationships between the cells of humans and other animals, and their primitive appearance made them a favourite model for the ancient ancestor of all living things. Their resemblance to human and other metazoan cells made them popular objects of study among morphologists, physiologists, and even those investigating (...)
    Direct download (4 more)  
     
    My bibliography  
     
    Export citation  
  43. Susan M. Millard & Nicholas M. Fisk (2013). Mesenchymal Stem Cells for Systemic Therapy: Shotgun Approach or Magic Bullets? Bioessays 35 (3):173-182.score: 20.0
    Given their heterogeneity and lack of defining markers, it is surprising that multipotent mesenchymal stem/stromal cells (MSCs) have attracted so much translational attention, especially as increasing evidence points to their predominant effect being not by donor differentiation but via paracrine mediators and exosomes. Achieving long-term MSC donor chimerism for treatment of chronic disease remains a challenge, requiring enhanced MSC homing/engraftment properties and manipulation of niches to direct MSC behaviour. Meanwhile advances in nanoparticle technology are furthering the development of MSCs (...)
    Direct download (4 more)  
     
    My bibliography  
     
    Export citation  
  44. Pierre-Luc Germain (2012). Cancer Cells and Adaptive Explanations. Biology and Philosophy 27 (6):785-810.score: 18.0
    The aim of this paper is to assess the relevance of somatic evolution by natural selection to our understanding of cancer development. I do so in two steps. In the first part of the paper, I ask to what extent cancer cells meet the formal requirements for evolution by natural selection, relying on Godfrey-Smith’s (2009) framework of Darwinian populations. I argue that although they meet the minimal requirements for natural selection, cancer cells are not paradigmatic Darwinian populations. In (...)
    Direct download (4 more)  
     
    My bibliography  
     
    Export citation  
  45. Michael J. Denton, Govindasamy Kumaramanickavel & Michael Legge (2013). Cells as Irreducible Wholes: The Failure of Mechanism and the Possibility of an Organicist Revival. Biology and Philosophy 28 (1):31-52.score: 18.0
    According to vitalism, living organisms differ from machines and all other inanimate objects by being endowed with an indwelling immaterial directive agency, ‘vital force,’ or entelechy . While support for vitalism fell away in the late nineteenth century many biologists in the early twentieth century embraced a non vitalist philosophy variously termed organicism/holism/emergentism which aimed at replacing the actions of an immaterial spirit with what was seen as an equivalent but perfectly natural agency—the emergent autonomous activity of the whole organism. (...)
    Direct download (5 more)  
     
    My bibliography  
     
    Export citation  
  46. Robert Streiffer (2005). At the Edge of Humanity: Human Stem Cells, Chimeras, and Moral Status. Kennedy Institute of Ethics Journal 15 (4):347-370.score: 18.0
    : Experiments involving the transplantation of human stem cells and their derivatives into early fetal or embryonic nonhuman animals raise novel ethical issues due to their possible implications for enhancing the moral status of the chimeric individual. Although status-enhancing research is not necessarily objectionable from the perspective of the chimeric individual, there are grounds for objecting to it in the conditions in which it is likely to occur. Translating this ethical conclusion into a policy recommendation, however, is complicated by (...)
    Direct download (5 more)  
     
    My bibliography  
     
    Export citation  
  47. Gonzalo Munevar (2008). A Distributive Explanation of “Grandmother” Cells. Proceedings of the Xxii World Congress of Philosophy 34:25-31.score: 18.0
    The existence of “grandmother” cells clashes with the model of the brain as a distributive system and is implausible because such neurons would have powers of representation across visuals angles and contexts. Nevertheless, Kreiman, Koch and others have offered experimental evidence that such neurons do exist. I agree that neurons may indeed fire when the subject looks at a variety of pictures, drawings, etc. of one particular person. I argue, however, that such a “grandmother” cell is nothing but the (...)
    No categories
    Direct download (3 more)  
     
    My bibliography  
     
    Export citation  
  48. Jane Maienschein (2002). Stem Cell Research: A Target Article Collection Part II - What's in a Name: Embryos, Clones, and Stem Cells. American Journal of Bioethics 2 (1):12 – 19.score: 18.0
    In 2001, the U.S. House of Representatives passed the "Human Cloning Prohibition Act" and President Bush announced his decision to allow only limited research on existing stem cell lines but not on "embryos." In contrast, the U.K. has explicitly authorized "therapeutic cloning." Much more will be said about bioethical, legal, and social implications, but subtleties of the science and careful definitions of terms have received much less consideration. Legislators and reporters struggle to discuss "cloning," "pluripotency," "stem cells," and "embryos," (...)
    Direct download (4 more)  
     
    My bibliography  
     
    Export citation  
  49. Thomas V. Cunningham (2013). Skepticism About the “Convertibility” of Induced Pluripotent Stem Cells. American Journal of Bioethics 13 (1):40-42.score: 18.0
    No abstract available. First paragraph: In this issue’s target article, Stier and Schoene-Siefert purport to ‘depotentialize’ the argument from potentiality based on their claim that any human cell may be “converted” into a morally significant entity, and consequently, the argument from potentiality finally succumbs to a reductio ad absurdum. I aim to convey two reasons for skepticism about the innocuousness of the notion of cell convertibility, and hence, the cogency of their argument.
    Direct download (4 more)  
     
    My bibliography  
     
    Export citation  
  50. Stanford Goldman (1973). The Mechanics of Individuality in Nature. II. Barriers, Cells, and Individuality. Foundations of Physics 3 (2):203-228.score: 18.0
    The cell theory of Schleiden and Schwann is generalized to the effect that throughout the natural world, in physics, biology, and sociopsychology, there is a widespread phenomenon of the existence of organized cells, whose organization is usually protected by barriers. These barriers exist not only in space, but in time and even in other domains. These barriers typically not only protect the organization within the cell from external disturbance, but they actively participate in reducing the internal disorganization. It appears (...)
    Direct download (3 more)  
     
    My bibliography  
     
    Export citation  
1 — 50 / 999