Search results for 'phage genetics' (try it on Scholar)

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  1. Jane Maienschein (2007). Frederic Lawrence Holmes.Reconceiving the Gene: Seymour Benzer’s Adventures in Phage Genetics. Edited by William C. Summers. Xiv + 334 Pp., Figs., Index. New Haven, Conn.: Yale University Press, 2006. $50. [REVIEW] Isis 98 (1):212-213.
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  2. Jane Maienschein (2007). Reconceiving the Gene: Seymour Benzer’s Adventures in Phage Genetics. [REVIEW] Isis: A Journal of the History of Science 98:212-213.
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  3.  7
    U. Deichmann (2008). Different Methods and Metaphysics in Early Molecular Genetics - A Case of Disparity of Research? History and Philosophy of the Life Sciences 30 (1):53-78.
    The encounter between two fundamentally different approaches in seminal research in molecular biology-the problems, aims, methods and metaphysics - is delineated and analyzed. They are exemplified by the microbiologist Oswald T. Avery who, in line with the reductionist mechanistic metaphysics of Jacques Loeb, attempted to explain basic life phenomena through chemistry; and the theoretical physicist Max Delbrück who, influenced by Bohr’s antimechanistic views, preferred to explain these phenomena without chemistry. Avery’s and Delbrück’s most important studies took place concurrently. Thus analysis (...)
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    Sally Ramage (2016). Genetics Crime and Justice, Edward Elgar 2015. Current Criminal Law 9 (3):2-29.
    The UK government decided to introduce Income Tax in 1799. Later, tax avoidance schemes involved creation of Deeds of Convenant. It is a fact that crime is increasing but the number of people committing crime is not increasing because many crimes are repeated crimes committed by persons with habitual criminal behaviour, ie hard-core criminals. -/- For more than half a century now, there has been scientific evidence that genetics plays a key role in the origins of criminal behaviour. There (...)
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  5. Massimo Pigliucci (2006). Genetic Variance–Covariance Matrices: A Critique of the Evolutionary Quantitative Genetics Research Program. Biology and Philosophy 21 (1):1-23.
    This paper outlines a critique of the use of the genetic variance–covariance matrix (G), one of the central concepts in the modern study of natural selection and evolution. Specifically, I argue that for both conceptual and empirical reasons, studies of G cannot be used to elucidate so-called constraints on natural selection, nor can they be employed to detect or to measure past selection in natural populations – contrary to what assumed by most practicing biologists. I suggest that the search for (...)
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  6. Sahotra Sarkar (1998). Genetics and Reductionism. Monograph Collection (Matt - Pseudo).
    With the advent of the Human Genome Project there have been many claims for the genetic origins of complex human behavior including insanity, criminality, and intelligence. But what does it really mean to call something 'genetic'? This is the fundamental question that Sahotra Sarkar's book addresses. The author analyses the nature of reductionism in classical and molecular genetics. He shows that there are two radically different kinds of reductionist explanation: genetic reduction and physical reduction . This important book clarifies (...)
     
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  7. Bert Leuridan (2007). Supervenience: Its Logic and its Inferential Role in Classical Genetics. Logique Et Analyse 198:147-171.
    Supervenience is mostly conceived of as a purely philosophical concept. Nevertheless, I will argue, it played an important and very fruitful inferential role in classical genetics. Gregor Mendel assumed that phenotypic traits supervene on underlying factors, and this assumption allowed him to successfully predict and explain the phenotypical regularities he had experimentally discovered. Therefore it is interesting to explicate how we reason about supervenience relations. I will tackle the following two questions. Firstly, can a reliable method (a logic) be (...)
     
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  8.  12
    Richard M. Burian (2005). The Epistemology of Development, Evolution, and Genetics: Selected Essays. Cambridge University Press.
    The essays in this collection examine developments in three fundamental biological disciplines--embryology, evolutionary biology, and genetics--in conflict with each other for much of the twentieth century. They consider key methodological problems and the difficulty of overcoming them. Richard Burian interweaves historical appreciation of the settings within which scientists work, substantial knowledge of the biological problems at stake and the methodological and philosophical issues faced in integrating biological knowledge drawn from disparate sources.
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  9.  11
    Audra J. Wolfe (2012). The Cold War Context of the Golden Jubilee, Or, Why We Think of Mendel as the Father of Genetics. Journal of the History of Biology 45 (3):389 - 414.
    In September 1950, the Genetics Society of America (GSA) dedicated its annual meeting to a "Golden Jubilee of Genetics" that celebrated the 50th anniversary of the rediscovery of Mendel's work. This program, originally intended as a small ceremony attached to the coattails of the American Institute of Biological Sciences (AIBS) meeting, turned into a publicity juggernaut that generated coverage on Mendel and the accomplishments of Western genetics in countless newspapers and radio broadcasts. The Golden Jubilee merits historical (...)
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  10. Thomas Pradeu (forthcoming). Toolbox Murders: Putting Genes in Their Epigenetic and Ecological Contexts: A Review of Griffiths and Stotz, Genetics and Philosophy: An Introduction. [REVIEW] Biology and Philosophy.
    Griffiths and Stotz’s Genetics and Philosophy: An Introduction offers a very good overview of scientific and philosophical issues raised by present-day genetics. Examining, in particular, the questions of how a “gene” should be defined and what a gene does from a causal point of view, the authors explore the different domains of the life sciences in which genetics has come to play a decisive role, from Mendelian genetics to molecular genetics, behavioural genetics, and evolution. (...)
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  11.  11
    Alexander Powell, Maureen A. O'Malley, Staffan Mueller-Wille, Jane Calvert & John Dupré (2007). Disciplinary Baptisms: A Comparison of the Naming Stories of Genetics, Molecular Biology, Genomics and Systems Biology. History and Philosophy of the Life Sciences 29 (1):5-32.
    Understanding how scientific activities use naming stories to achieve disciplinary status is important not only for insight into the past, but for evaluating current claims that new disciplines are emerging. In order to gain a historical understanding of how new disciplines develop in relation to these baptismal narratives, we compare two recently formed disciplines, systems biology and genomics, with two earlier related life sciences, genetics and molecular biology. These four disciplines span the twentieth century, a period in which the (...)
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  12.  29
    Evan Charney (2012). Behavior Genetics and Postgenomics. Behavioral and Brain Sciences 35 (5):331-358.
    The science of genetics is undergoing a paradigm shift. Recent discoveries, including the activity of retrotransposons, the extent of copy number variations, somatic and chromosomal mosaicism, and the nature of the epigenome as a regulator of DNA expressivity, are challenging a series of dogmas concerning the nature of the genome and the relationship between genotype and phenotype. According to three widely held dogmas, DNA is the unchanging template of heredity, is identical in all the cells and tissues of the (...)
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  13.  28
    Keekok Lee (2003). Philosophy and Revolutions in Genetics: Deep Science and Deep Technology. Palgrave Macmillan.
    The last century saw two great revolutions in genetics the development of classic Mendelian theory and the discovery and investigation of DNA. Each fundamental scientific discovery in turn generated its own distinctive technology. These two case studies, examined in this text, enable the author to conduct a philosophical exploration of the relationship between fundamental scientific discoveries on the one hand, and the technologies that spring from them on the other. As such it is also an exercise in the philosophy (...)
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  14.  8
    Heather Widdows (2011). Localized Past, Globalized Future: Towards an Effective Bioethical Framework Using Examples From Population Genetics and Medical Tourism. Bioethics 25 (2):83-91.
    This paper suggests that many of the pressing dilemmas of bioethics are global and structural in nature. Accordingly, global ethical frameworks are required which recognize the ethically significant factors of all global actors. To this end, ethical frameworks must recognize the rights and interests of both individuals and groups (and the interrelation of these). The paper suggests that the current dominant bioethical framework is inadequate to this task as it is over-individualist and therefore unable to give significant weight to the (...)
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  15.  5
    Soraya de Chadarevian (2006). Mice and the Reactor: The “Genetics Experiment” in 1950s Britain. [REVIEW] Journal of the History of Biology 39 (4):707-735.
    The postwar investments by several governments into the development of atomic energy for military and peaceful uses fuelled the fears not only of the exposure to acute doses of radiation as could be expected from nuclear accidents or atomic warfare but also of the long-term effects of low-dose exposure to radiation. Following similar studies pursued under the aegis of the Manhattan Project in the United States, the “genetics experiment” discussed by scientists and government officials in Britain soon after the (...)
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  16.  28
    Christophe Bonneuil (2006). Mendelism, Plant Breeding and Experimental Cultures: Agriculture and the Development of Genetics in France. [REVIEW] Journal of the History of Biology 39 (2):281 - 308.
    The article reevaluates the reception of Mendelism in France, and more generally considers the complex relationship between Mendelism and plant breeding in the first half on the 20th century. It shows on the one side that agricultural research and higher education institutions have played a key role in the development and institutionalization of genetics in France, whereas university biologists remained reluctant to accept this approach on heredity. But on the other side, plant breeders, and agricultural researchers, despite an interest (...)
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  17.  47
    Roberta L. Millstein (2013). Exploring the Status of Population Genetics: The Role of Ecology. Biological Theory 7 (4):346-357.
    The status of population genetics has become hotly debated among biologists and philosophers of biology. Many seem to view population genetics as relatively unchanged since the Modern Synthesis and have argued that subjects such as development were left out of the Synthesis. Some have called for an extended evolutionary synthesis or for recognizing the insignificance of population genetics. Yet others such as Michael Lynch have defended population genetics, declaring "nothing in evolution makes sense except in the (...)
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  18.  10
    Hans-Jörg Rheinberger (2000). Ephestia: The Experimental Design of Alfred Kühn's Physiological Developmental Genetics. [REVIEW] Journal of the History of Biology 33 (3):535-576.
    Much of the early history of developmental and physiological genetics in Germany remains to be written. Together with Carl Correns and Richard Goldschmidt, Alfred Kühn occupies a special place in this history. Trained as a zoologist in Freiburg im Breisgau, he set out to integrate physiology, development and genetics in a particular experimental system based on the flour moth Ephestia kühniella Zeller. This paper is meant to reconstruct the crucial steps in the experimental pathway that led Kühn and (...)
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  19.  7
    Dan Dediu & Morten H. Christiansen (2016). Language Evolution: Constraints and Opportunities From Modern Genetics. Topics in Cognitive Science 8 (2):361-370.
    Our understanding of language, its origins and subsequent evolution, is shaped not only by data and theories from the language sciences, but also fundamentally by the biological sciences. Recent developments in genetics and evolutionary theory offer both very strong constraints on what scenarios of language evolution are possible and probable, but also offer exciting opportunities for understanding otherwise puzzling phenomena. Due to the intrinsic breathtaking rate of advancement in these fields, and the complexity, subtlety, and sometimes apparent non-intuitiveness of (...)
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  20.  26
    Eline M. Bunnik, Antina Jong, Niels Nijsingh & Guido M. W. R. Wert (2013). The New Genetics and Informed Consent: Differentiating Choice to Preserve Autonomy. Bioethics 27 (6):348-355.
    The advent of new genetic and genomic technologies may cause friction with the principle of respect for autonomy and demands a rethinking of traditional interpretations of the concept of informed consent. Technologies such as whole-genome sequencing and micro-array based analysis enable genome-wide testing for many heterogeneous abnormalities and predispositions simultaneously. This may challenge the feasibility of providing adequate pre-test information and achieving autonomous decision-making. At a symposium held at the 11th World Congress of Bioethics in June 2012 (Rotterdam), organized by (...)
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  21.  9
    Melinda Gormley (2009). Scientific Discrimination and the Activist Scientist: L. C. Dunn and the Professionalization of Genetics and Human Genetics in the United States. [REVIEW] Journal of the History of Biology 42 (1):33 - 72.
    During the 1920s and 1930s geneticist L. C. Dunn of Columbia University cautioned Americans against endorsing eugenic policies and called attention to eugenicists' less than rigorous practices. Then, from the mid-1940s to early 1950s he attacked scientific racism and Nazi Rassenhygiene by co-authoring Heredity, Race and Society with Theodosius Dobzhansky and collaborating with members of UNESCO (United Nations Educational, Scientific, and Cultural Organization) on their international campaign against racism. Even though shaking the foundations of scientific discrimination was Dunn's primary concern (...)
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  22. Massimo Pigliucci & Carl D. Schlichting (1997). On the Limits of Quantitative Genetics for the Study of Phenotypic Evolution. Acta Biotheoretica 45 (2):143-160.
    During the last two decades the role of quantitative genetics in evolutionary theory has expanded considerably. Quantitative genetic-based models addressing long term phenotypic evolution, evolution in multiple environments (phenotypic plasticity) and evolution of ontogenies (developmental trajectories) have been proposed. Yet, the mathematical foundations of quantitative genetics were laid with a very different set of problems in mind (mostly the prediction of short term responses to artificial selection), and at a time in which any details of the genetic machinery (...)
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  23.  22
    Marion Vorms (2013). Theorizing and Representational Practices in Classical Genetics. Biological Theory 7 (4):311-324.
    In this paper, I wish to challenge theory-biased approaches to scientific knowledge, by arguing for a study of theorizing, as a cognitive activity, rather than of theories, as abstract structures independent from the agents’ understanding of them. Such a study implies taking into account scientists’ reasoning processes, and their representational practices. Here, I analyze the representational practices of geneticists in the 1910s, as a means of shedding light on the content of classical genetics. Most philosophical accounts of classical (...) fail to distinguish between the purely genetic, or Mendelian level, and the cytological one. I distinguish between them by characterizing them in terms of their respective associated representational practices. I then present how the two levels were articulated within Morgan’s theory of crossing-over, and I describe the representational technique of linkage mapping, which embodies the “merging” of the Mendelian and cytological levels. I propose an analysis of the mapping scheme, as a means of enlightening the conceptual articulation of Mendelian and cytological hypotheses within classical genetics. Finally, I present the respective views of three opponents to Morgan in the 1910s, who had a different understanding of the articulation of cytology and Mendelism, and entertained different views concerning the role and proper interpretation of maps. I propose to consider these diverging perspectives as instantiating what I call different “versions” of classical genetics. (shrink)
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  24.  89
    Walter Glannon (2001). Genes and Future People: Philosophical Issues in Human Genetics. Westview Press.
    Advances in genetic technology in general and medical genetics in particular will enable us to intervene in the process of human biological development which extends from zygotes and embryos to people. This will allow us to control to a great extent the identities and the length and quality of the lives of people who already exist, as well as those we bring into existence in the near and distant future. Genes and Future People explores two general philosophical questions, one (...)
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  25.  5
    U. Deichmann (2004). Early Responses to Avery Et Al.'S Paper on DNA as Hereditary Material. Historical Studies in the Physical and Biological Sciences 34 (2):207-232.
    Avery’s et al. ’s 1944 paper provides the first direct evidence of DNA having gene-like properties and marks the beginning of a new phase in early molecular genetics (with a strong focus on chemistry and DNA). The study of its reception shows that on the whole, Avery’s results were immediately appreciated and motivated new research on transformation, the chemical nature of DNA’s biological specificity and bacteria genetics. It shows, too, that initial problems of transferring transformation to other systems (...)
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  26.  8
    Mairi Levitt & Neil Manson (2007). My Genes Made Me Do It? The Implications of Behavioural Genetics for Responsibility and Blame. Health Care Analysis 15 (1):33-40.
    The idea of individual responsibility for action is central to our conception of what it is to be a person. Behavioural genetic research may seem to call into question the idea of individual responsibility with possible implications for the criminal justice system. These implications will depend on the understandings of the various agencies and professional groups involved in responding to violent and anti-social behaviour, and, the result of negotiations between them over resulting practice. The paper considers two kinds of approaches (...)
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  27.  9
    Marsha L. Richmond (2007). Muriel Wheldale Onslow and Early Biochemical Genetics. Journal of the History of Biology 40 (3):389 - 426.
    Muriel Wheldale, a distinguished graduate of Newnham College, Cambridge, was a member of William Bateson's school of genetics at Cambridge University from 1903. Her investigation of flower color inheritance in snapdragons (Antirrhinum), a topic of particular interest to botanists, contributed to establishing Mendelism as a powerful new tool in studying heredity. Her understanding of the genetics of pigment formation led her to do cutting-edge work in biochemistry, culminating in the publication of her landmark work, The Anthocyanin Pigments of (...)
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  28.  2
    Barbara A. Kimmelman (2006). Mr. Blakeslee Builds His Dream House: Agricultural Institutions, Genetics, and Careers 1900-1915. [REVIEW] Journal of the History of Biology 39 (2):241 - 280.
    Between 1907 and 1915 Albert Francis Blakeslee transformed both himself and the Connecticut Agricultural College at Storrs into things neither had been at the beginning of the century. Using the varied commitments of the agricultural college and experiment station at which he worked as resources with which to build his career, Blakeslee began as a botanist and instructor in botany and ended as a geneticist and teacher of genetics. Moreover, he left behind at Storrs a legacy of genetic research (...)
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  29.  30
    Peter Gildenhuys (2011). Righteous Modeling: The Competence of Classical Population Genetics. [REVIEW] Biology and Philosophy 26 (6):813-835.
    In a recent article, “Wayward Modeling: Population Genetics and Natural Selection,” Bruce Glymour claims that population genetics is burdened by serious predictive and explanatory inadequacies and that the theory itself is to blame. Because Glymour overlooks a variety of formal modeling techniques in population genetics, his arguments do not quite undermine a major scientific theory. However, his arguments are extremely valuable as they provide definitive proof that those who would deploy classical population genetics over natural systems (...)
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  30.  91
    Yuri I. Arshavsky (2003). When Did Mozart Become a Mozart? Neurophysiological Insight Into Behavioral Genetics. Brain and Mind 4 (3):327-339.
    The prevailing concept in modern cognitive neuroscience is that cognitive functions are performed predominantly at the network level, whereas the role of individual neurons is unlikely to extend beyond forming the simple basic elements of these networks. Within this conceptual framework, individuals of outstanding cognitive abilities appear as a result of a favorable configuration of the microarchitecture of the cognitive-implicated networks, whose final formation in ontogenesis may occur in a relatively random way. Here I suggest an alternative concept, which is (...)
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  31.  7
    Jérôme Pierrel (2012). An RNA Phage Lab: MS2 in Walter Fiers' Laboratory of Molecular Biology in Ghent, From Genetic Code to Gene and Genome, 1963-1976. [REVIEW] Journal of the History of Biology 45 (1):109 - 138.
    The importance of viruses as model organisms is well-established in molecular biology and Max Delbrück's phage group set standards in the DNA phage field. In this paper, I argue that RNA phages, discovered in the 1960s, were also instrumental in the making of molecular biology. As part of experimental systems, RNA phages stood for messenger RNA (mRNA), genes and genome. RNA was thought to mediate information transfers between DNA and proteins. Furthermore, RNA was more manageable at the bench (...)
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  32.  26
    John Sadler (2011). Psychiatric Molecular Genetics and the Ethics of Social Promises. Journal of Bioethical Inquiry 8 (1):27-34.
    A recent literature review of commentaries and ‘state of the art’ articles from researchers in psychiatric genetics (PMG) offers a consensus about progress in the science of genetics, disappointments in the discovery of new and effective treatments, and a general optimism about the future of the field. I argue that optimism for the field of psychiatric molecular genetics (PMG) is overwrought, and consider progress in the field in reference to a sample estimate of US National Institute of (...)
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  33.  20
    Emanuele Serrelli (2016). Evolutionary Genetics and Cultural Traits in a 'Body of Theory' Perspective. In Fabrizio Panebianco & Emanuele Serrelli (eds.), Understanding cultural traits. A multidisciplinary perspective on cultural diversity. Springer 179-199.
    The chapter explains why evolutionary genetics – a mathematical body of theory developed since the 1910s – eventually got to deal with culture: the frequency dynamics of genes like “the lactase gene” in populations cannot be correctly modeled without including social transmission. While the body of theory requires specific justifications, for example meticulous legitimations of describing culture in terms of traits, the body of theory is an immensely valuable scientific instrument, not only for its modeling power but also for (...)
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  34. Glenn McGee (2000). The Perfect Baby: Parenthood in the New World of Cloning and Genetics. Rowman & Littlefield Publishers.
    The Perfect Baby is the most popular introduction to ethical issues in genetics. This new edition has been updated to discuss and debate advances in high tech reproduction, genetic testing, gene therapy, human cloning, and stem cell research. It includes a new epilogue by cloning pioneer Ian Wilmut and Glenn McGee.
     
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  35.  21
    Michael R. Dietrich & Brandi H. Tambasco (2007). Beyond the Boss and the Boys: Women and the Division of Labor in Drosophila Genetics in the United States, 1934-1970. [REVIEW] Journal of the History of Biology 40 (3):509 - 528.
    The vast network of Drosophila geneticists spawned by Thomas Hunt Morgan's fly room in the early 20th century has justifiably received a significant amount of scholarly attention. However, most accounts of the history of Drosophila genetics focus heavily on the "boss and the boys," rather than the many other laboratory groups which also included large numbers of women. Using demographic information extracted from the Drosophila Information Service directories from 1934 to 1970, we offer a profile of the gendered division (...)
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  36.  16
    Roberta Bivins (2000). Sex Cells: Gender and the Language of Bacterial Genetics. [REVIEW] Journal of the History of Biology 33 (1):113 - 139.
    Between 1946 and 1960, a new phenomenon emerged in the field of bacteriology. "Bacterial sex," as it was called, revolutionized the study of genetics, largely by making available a whole new class of cheap, fast-growing, and easily manipulated organisms. But what was "bacterial sex?" How could single-celled organisms have "sex" or even be sexually differentiated? The technical language used in the scientific press -- the public and inalienable face of 20th century science -- to describe this apparently neuter organism (...)
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  37.  14
    Henk A. M. J. ten Have (2001). Genetics and Culture: The Geneticization Thesis. Medicine, Health Care and Philosophy 4 (3):295-304.
    The concept of ‘geneticization’ has been introduced in the scholarly literature to describe the various interlocking and imperceptible mechanisms of interaction between medicine, genetics, society and culture. It is argued that Western culture currently is deeply involved in a process of geneticization. This process implies a redefinition of individuals in terms of DNA codes, a new language to describe and interpret human life and behavior in a genomic vocabulary of codes, blueprints, traits, dispositions, genetic mapping, and a gentechnological approach (...)
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  38.  3
    Susana Pinar (2002). The Emergence of Modern Genetics in Spain and the Effects of the Spanish Civil War (1936-1939) on Its Development. Journal of the History of Biology 35 (1):111 - 148.
    The aim of this paper is to show how modern genetics reached Spain through the Junta para la Ampliación de Estudios e Investigaciones Científicas (JAE) during the decade of 1920s, the role played by key persons, and the level of development this discipline achieved from its different points of inception and under the conditions of financial scarcity and political turmoil that prevailed during the Spanish Civil War (1936-1939). In addition, the effect of the war on the continuity of the (...)
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  39.  16
    H. A. E. Zwart (forthcoming). From Playfulness and Self-Centredness Via Grand Expectations to Normalisation: A Psychoanalytical Rereading of the History of Molecular Genetics. [REVIEW] Medicine, Health Care and Philosophy:1-14.
    In this paper, I will reread the history of molecular genetics from a psychoanalytical angle, analysing it as a case history. Building on the developmental theories of Freud and his followers, I will distinguish four stages, namely: (1) oedipal childhood, notably the epoch of model building (1943–1953); (2) the latency period, with a focus on the development of basic skills (1953–1989); (3) adolescence, exemplified by the Human Genome Project, with its fierce conflicts, great expectations and grandiose claims (1989–2003) and (...)
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  40.  55
    Wolfgang Balzer & Pablo Lorenzano (2000). The Logical Structure of Classical Genetics. Journal for General Philosophy of Science / Zeitschrift für Allgemeine Wissenschaftstheorie 31 (2):243-266.
    We present a reconstruction of so-called classical, formal or Mendelian genetics using a notation which we believe is more legible than that of earlier accounts, and lends itself easily to computer implementation, for instance in PROLOG. By drawing from, and emending, earlier work of Balzer and Dawe (1986,1997), the present account presents the three most important lines of development of classical genetics: the so-called Mendel's laws, linkage genetics and gene mapping, in the form of a theory-net. This (...)
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  41.  1
    Bob Simpson (2007). On Parrots and Thorns: Sri Lankan Perspective on Genetics, Science and Personhood. [REVIEW] Health Care Analysis 15 (1):41-49.
    This paper addresses the issue of how the scientific discourse of genetics is expressed in local idioms. The examples used are taken from fieldwork conducted in Sri Lanka and relate principally to Sinhala Buddhist attempts to socialise `big science.' The paper explores idioms of both nature and nurture in local imagery and narratives and draws attention to the rhetorical dimensions of genetic discourses when used in context. The article concludes with a preliminary attempt to identify the ways in which (...)
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  42.  27
    Peter Gildenhuys (2013). Classical Population Genetics and the Semantic Approach to Scientific Theories. Synthese 190 (2):273-291.
    In what follows, I argue that the semantic approach to scientific theories fails as a means to present the Wright—Fisher formalism (WFF) of population genetics. I offer an account of what population geneticist understand insofar as they understand the WFF, a variation on Lloyd's view that population genetics can be understood as a family of models of mid-level generality.
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  43.  5
    Pablo Lorenzano (2014). What is the Status of the Hardy-Weinberg Law Within Population Genetics? Vienna Circle Institute Yearbook 17:159-172.
    The aim of this paper is to further develop van Fraassen’s diagnosis, expanding a previous analysis of the fundamental law of classical genetics and the status of the so-called ‘Mendel’s laws’.6 According to this diagnosis the Hardy-Weinberg law: 1) cannot be considered as axiom (or fundamental law) for classical population genetics, since it is a law that describes an equilibrium that 2) holds only under certain special conditions, and 3) only determines a subclass of models, 4) whose generalized (...)
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  44.  11
    LeRoy Walters (2012). Genetics and Bioethics: How Our Thinking has Changed Since 1969. Theoretical Medicine and Bioethics 33 (1):83-95.
    In 1969, the field of human genetics was in its infancy. Amniocentesis was a new technique for prenatal diagnosis, and a newborn genetic screening program had been established in one state. There were also concerns about the potential hazards of genetic engineering. A research group at the Hastings Center and Paul Ramsey pioneered in the discussion of genetics and bioethics. Two principal techniques have emerged as being of enduring importance: human gene transfer research and genetic testing and screening. (...)
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  45.  22
    Willem de Winter (1997). The Beanbag Genetics Controversy: Towards a Synthesis of Opposing Views of Natural Selection. [REVIEW] Biology and Philosophy 12 (2):149-184.
    The beanbag genetics controversy can be traced from the dispute between Fisher and Wright, through Mayr''s influential promotion of the issue, to the contemporary units of selection debate. It centers on the claim that genic models of natural selection break down in the face of epistatic interactions among genes during phenotypic development. This claim is explored from both a conceptual and a quantitative point of view, and is shown to be defective on both counts.Firstly, an analysis of the controversy''s (...)
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  46.  23
    Michele Loi (2012). Introduction: Genetics and Justice. Ethical Perspectives 19 (1):1-10.
    Introduction to the Ethical Perspectives Theme Issue (19/1) on Genetics and Justice, with contributions by Greg Bognar, David Hunter, Michele Loi, Oliver Feeney, Vilhjálmur Arnason, Durnin et al.
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  47.  11
    Rogeer Hoedemaekers & Henk ten Have (1999). The Concept of Abnormality in Medical Genetics. Theoretical Medicine and Bioethics 20 (6):537-561.
    This paper explores usage of the concept ofabnormality in medical genetics and proposesdirectives for more careful usage of this concept.The conceptual difficulties are first explored, thena model is developed to assess actual usage, followedby analysis of a sample of genetic textbooks andgenetics literature. It appears that fact andvaluation are often intermingled, that referencestandards used to define 'genetic abnormalities' areoften not clear and that the concept of abnormality isoften used independent of the degree of certainty withwhich the altered genetype develops (...)
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  48.  2
    Marilyn E. Coors (2003). A Foucauldian Foray Into the New Genetics. Journal of Medical Humanities 24 (3-4):279-289.
    A Foucauldian assessment of the common presumption that genetic information is potent and thus oppressive demonstrates that the concern may be misplaced. Foucault's concept of “technologies of self” reveals that genetic power originates not only from the potency of genetic information but from the penchant of individuals to victimize themselves in the name of optimal health, enhanced intelligence, perfect babies, or would-be immortality. Rather than seeking liberation from the power of the new genetics, Foucault's reinterpretation of the ancient understanding (...)
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  49.  7
    Charbel N. El-Hani, Ana Maria R. de Alameida, Gilberto C. Bomfim, Leyla M. Joaquim, João Carlos M. Magalhães, Lia M. N. Meyer, Maiana A. Pitombo & Vanessa C. dos Santos (2014). The Contribution of History and Philosophy to the Problem of Hybrid Views About Genes in Genetics Teaching. In Michael R. Matthews (ed.), International Handbook of Research in History, Philosophy and Science Teaching. Springer 469-520.
    Currently there are persistent doubts about the meaning and contributions of the gene concept, mostly related to its interpretation as a stretch of DNA encoding a single functional product, i.e., the classical molecular gene concept. There is, however, much conceptual variation around genes, leading to important difficulties in genetics teaching. We investigated whether and how conceptual variation related to the gene concept and gene function models is present in school science and what potential problems it may bring to (...) teaching and learning. Here, we report results on how ideas about genes and gene function are treated in textbooks and appear in students’ views and, also, about a teaching strategy for improving higher education students’ understanding of scientific models and conceptual variation around genes and their functions. (shrink)
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    Aaron Panofsky (2011). Field Analysis and Interdisciplinary Science: Scientific Capital Exchange in Behavior Genetics. Minerva 49 (3):295-316.
    This paper uses Pierre Bourdieu’s field theory to develop tools for analyzing interdisciplinary scientific fields. Interdisciplinary fields are scientific spaces where no single form of scientific capital has a monopoly and therefore multiple forms of scientific capital constitute the structures and stakes of scientific competition. Scientists compete to accumulate and define forms of scientific capital and also to set the rates of exchange between them. The paper illustrates this framework by applying it to the interdisciplinary field of behavior genetics. (...)
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