Search results for '*Animal Models' (try it on Scholar)

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  1. C. Degeling & J. Johnson (2013). Evaluating Animal Models: Some Taxonomic Worries. Journal of Medicine and Philosophy 38 (2):91-106.score: 40.0
    The seminal 1993 article by LaFollette and Shanks “Animal Models in Biomedical Research: Some Epistemological Worries” introduced an influential taxonomy into the debate about the value of animal experimentation. The distinction they made between hypothetical and causal analog models served to highlight a concern regarding extrapolating results obtained in animal models to human subjects, which endures today. Although their taxonomy has made a significant contribution to the field, we maintain that it is flawed, and instead, we offer (...)
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  2. Niall Shanks, Ray Greek & Jean Greek (2009). Are Animal Models Predictive for Humans? Philosophy, Ethics, and Humanities in Medicine 4 (1):2.score: 40.0
    It is one of the central aims of the philosophy of science to elucidate the meanings of scientific terms and also to think critically about their application. The focus of this essay is the scientific term predict and whether there is credible evidence that animal models, especially in toxicology and pathophysiology, can be used to predict human outcomes. Whether animals can be used to predict human response to drugs and other chemicals is apparently a contentious issue. However, when one (...)
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  3. Thomas H. J. Burne, Darryl W. Eyles & John J. McGrath (2008). Animal Models May Help Fractionate Shared and Discrete Pathways Underpinning Schizophrenia and Autism. Behavioral and Brain Sciences 31 (3):264-265.score: 40.0
    Crespi & Badcock (C&B) present an appealing and parsimonious synthesis arguing that schizophrenia and autism are differentially regulated by maternal versus paternal genomic imprinting, respectively. We argue that animal models related to schizophrenia and autism provide a useful platform to explore the mechanisms outlined by C&B. We also note that schizophrenia and autism share certain risk factors such as advanced paternal age. Apart from genomic imprinting, copy number variants related to advanced paternal age may also contribute to the differential (...)
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  4. Cory Wright, Animal Models of Depression in Neuropsychopharmacology Qua Feyerabendian Philosophy of Science.score: 40.0
    The neuropsychopharmacological methods and theories used to investigate the nature of depression have been viewed as suspect for a variety of philosophical and scientific reasons. Much of this criticism aims to demonstrate that biochemical- and neurological-based theories of this mental illness are defective, due in part because the methods used in their service are consistently invalidated, failing to induce depression in pre-clinical animal models. Neuropsychopharmacologists have been able to stave off such criticism by showing that their methods are context (...)
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  5. Kathy Steece-Collier (1995). Neural Grafting in Human Disease Versus Animal Models: Cautionary Notes. Behavioral and Brain Sciences 18 (1):71-72.score: 40.0
    Over the past two decades, research on neural transplantation in animal models of neurodegeneration has provided provocative in sights into the therapeutic use of grafted tissue for various neurological diseases. Although great strides have been made and functional benefits gained in these animal models, much information is still needed with regard to transplantation in human patients. Several factors are unique to human disease, for example, age of the recipient, duration of disease, and drug interaction with grafted cells; these (...)
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  6. L. Wolpert (2009). Review of "Animal Models in the Light of Evolution" by Niall Shanks, Ph.D., and C. Ray Greek, M.D. [REVIEW] Philosophy, Ethics, and Humanities in Medicine 5 (1):12-12.score: 40.0
    Animal Models in the Light of Evolution provides persuasive evidence that animal models should be used with great caution when applying the results to human diseases. Mice and other model animals are both similar and different, in their biology, to humans.
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  7. Barbara Webb (2001). Can Robots Make Good Models of Biological Behaviour? Behavioral and Brain Sciences 24 (6):1033-1050.score: 36.0
    How should biological behaviour be modelled? A relatively new approach is to investigate problems in neuroethology by building physical robot models of biological sensorimotor systems. The explication and justification of this approach are here placed within a framework for describing and comparing models in the behavioural and biological sciences. First, simulation models – the representation of a hypothesis about a target system – are distinguished from several other relationships also termed “modelling” in discussions of scientific explanation. Seven (...)
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  8. Daniel Steel & Megan Delehanty, Models and Mechanisms: On the Methodology of Animal Extrapolation.score: 34.0
    Any account of extrapolation from animal models to humans must confront two basic challenges: explain how extrapolation can be justified even when there are causally relevant differences between model and target, and explain how the suitability of a model can be established given only limited information about the target. We argue that existing approaches to extrapolation—either in terms of capacities or mechanisms—do not adequately address these challenges. However, we propose a further elaboration of the mechanisms approach that provides a (...)
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  9. Nikos Logothetis, Myocardial and Cerebral Perfusion Studies in Animal Models.score: 32.0
    In-vivo phenotyping of genetically engineered mouse models for amyotrophic lateral sclerosis is established by combining BT-MRI and CASL G. Vanhoutte1, E. Storkebaum2, P. Carmeliet2, A. Van der Linden1.
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  10. Ray Greek & Niall Shanks (2011). Complex Systems, Evolution, and Animal Models. Studies in History and Philosophy of Science Part C 42 (4):542-544.score: 30.0
  11. Cameron Shelley (2010). Why Test Animals to Treat Humans? On the Validity of Animal Models. Studies in History and Philosophy of Science Part C 41 (3):292-299.score: 30.0
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  12. Rebecca D. Burwell & Howard Eichenbaum (1999). What's New in Animal Models of Amnesia? Behavioral and Brain Sciences 22 (3):446-447.score: 30.0
    In general, we endorse Aggleton & Brown's thesis that the neuroanatomy of amnesia comprises two functionally distinct systems, but we are disappointed in the lack of detail regarding the critical functional contribution of the hippocampus. We also take issue with the characterization of the cortical areas surrounding the hippocampus, particularly the decreased emphasis on the cortical input to the hippocampus.
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  13. Kenneth F. Schaffner (2001). Extrapolation From Animal Models. In MachamerPeter (ed.), Theory and Method in the Neurosciences. 200.score: 30.0
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  14. Peter N. Steinmetz & Stephen I. Helms Tillery (1994). Animal Models: Some Empirical Worries. Public Affairs Quarterly 8 (3):287-298.score: 30.0
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  15. Ray Greek & Jean Greek (2002). Animal Models of Human Disease in Light of Darwin and DNA. Human Rights Review 4 (1):74-85.score: 30.0
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  16. David Lubinski & Travis Thompson (1993). Animal Models: Nature Made Us, but Was the Mold Broken? Behavioral and Brain Sciences 16 (4):664.score: 30.0
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  17. Nazneen Aziz (1995). Animal Models of Polycystic Kidney Disease. Bioessays 17 (8):703-712.score: 30.0
  18. Disale C. (2008). Anti-Amnesic Potentials of a Novel Phytochemical Formulation PZA-3 in Animal Models Relevant to Alzheimer's Disease. Frontiers in Human Neuroscience 2.score: 30.0
  19. Hugh LaFollette & Niall Shanks (1993). Animal Models in Biomedical Research: Some Epistemological Worries. Public Affairs Quarterly 7 (2):113-130.score: 30.0
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  20. No Authorship Indicated (1999). Review of Animal Models of Human Psychology: Critique of Science, Ethics, and Policy. [REVIEW] Journal of Theoretical and Philosophical Psychology 19 (2):227-228.score: 30.0
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  21. Cameron Shelley (2006). Analogical Reasoning with Animal Models in Biomedical Research. In L. Magnani (ed.), Model-Based Reasoning in Science and Engineering. College Publications. 203--213.score: 30.0
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  22. Imke Tammen (2012). Animal Models for Human Disease–Reflections From an Animal Researcher's Perspective. Between the Species 15 (1):3.score: 30.0
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  23. Scott M. Williams, Jonathan L. Haines & Jason H. Moore (2004). The Use of Animal Models in the Study of Complex Disease: All Else is Never Equal or Why Do so Many Human Studies Fail to Replicate Animal Findings? Bioessays 26 (2):170-179.score: 30.0
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  24. S. Ahlenius (1991). The" Clever Hans" Phenomenon in Animal Models of Schizophrenia, or Homology as an Important Factor in Comparing Behavioral Functions Across Species. Perspectives in Biology and Medicine 34 (2):219.score: 30.0
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  25. Ranjita Betarbet, Todd B. Sherer & J. Timothy Greenamyre (2002). Animal Models of Parkinson's Disease. Bioessays 24 (4):308-318.score: 30.0
  26. R. Betabert, T. B. Sherer & J. T. Greenamyre (2002). Animal Models of Parkinson's Diseases. Bioessays 24:308-318.score: 30.0
     
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  27. Stephanie Brewer & Trevor Williams (2004). Finally, a Sense of Closure? Animal Models of Human Ventral Body Wall Defects. Bioessays 26 (12):1307-1321.score: 30.0
  28. Xos� R. Bustelo (2002). Understanding Rho/Rac Biology in T-Cells Using Animal Models. Bioessays 24 (7):602-612.score: 30.0
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  29. Xavier Cousin, Uwe Str�hle & Arnaud Chatonnet (2005). Are There Non-Catalytic Functions of Acetylcholinesterases? Lessons From Mutant Animal Models. Bioessays 27 (2):189-200.score: 30.0
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  30. Jonathon D. Crystal (2012). Validating Animal Models of Metacognition. In Michael Beran, Johannes Brandl, Josef Perner & Joëlle Proust (eds.), The Foundations of Metacognition. Oxford University Press. 36.score: 30.0
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  31. Edwin E. Gantt (2000). Animal Models of Human Psychology: Critique of Science, Ethics, and Policy. Journal of Theoretical and Philosophical Psychology 19 (2):227-228.score: 30.0
     
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  32. David Ingle (1980). Animal Models for Lateralized Sex Differences. Behavioral and Brain Sciences 3 (2):240.score: 30.0
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  33. Charles L. Jobe (1968). Selection and Development of Animal Models of Myocardial Infarction. In. In Peter Koestenbaum (ed.), Proceedings. [San Jose? Calif.. 101.score: 30.0
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  34. P. J. Langlais (1992). Role of Diencephalic Lesions and Thiamine Deficiency in Korsakoff's Amnesia: Insights From Animal Models. In L. R. Squire & N. Butters (eds.), Neuropsychology of Memory. Guilford Press. 440--450.score: 30.0
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  35. A. David Milner (1987). Animal Models for the Syndrome of Spatial Neglect. In M. Jeannerod (ed.), Neurophysiological and Neuropsychological Aspects of Spatial Neglect. Elsevier Science Ltd. 259--288.score: 30.0
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  36. Gairdner Moment (1982). Aging in Mammals Mammalian Models for Research on Aging The Committee on Animal Models for Research on Aging, Division of Biological Sciences, Assembly of Biological Sciences. Bioscience 32 (3):209-209.score: 30.0
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  37. Richard G. M. Morris (2002). Episodic-Like Memory in Animals: Psychological Criteria, Neural Mechanisms and the Value of Episodic-Like Tasks to Investigate Animal Models of Neurodegenerative Disease. In Alan Baddeley, John Aggleton & Martin Conway (eds.), Episodic Memory: New Directions in Research. Oup Oxford.score: 30.0
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  38. Patricia Murphy (2010). Genetically Based Animal Models of Attention Deficit Hyperactivity Disorder. Journal of Mind and Behavior 31 (3):179.score: 30.0
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  39. Eugene Nattie (2009). Sudden Infant Death Syndrome and Serotonin: Animal Models. Bioessays 31 (2):130-133.score: 30.0
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  40. James Lindemann Nelson (1989). Animal Models in'Exemplary'Medical Research: Diabetes as a Case Study. Between the Species 5 (4):4.score: 30.0
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  41. S. Plous (1993). Animal Models of Human Communication. Behavioral and Brain Sciences 16 (4):660.score: 30.0
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  42. B. Ranjita, B. S. Todd & J. T. Greenamyre (2002). Animal Models of Parkinson's Disease. Bioessays 24:308-18.score: 30.0
     
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  43. A. E. Renold (1985). Planned Integration of International Visiting Fellows and Scientists: Enhancement of Morale, Productivity, and Impact in a Laboratory Concerned with Human Diabetes and its Animal Models. Perspectives in Biology and Medicine 29 (3 Pt 2):S214 - 7.score: 30.0
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  44. Endel Tulving & Hans J. Markowitsch (1994). What Do Animal Models of Memory Model? Behavioral and Brain Sciences 17 (3):498-499.score: 30.0
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  45. Lynn R. Willis & Martin G. Hulsey (1994). Worries About Animal Models in Biomedical Research a Response to Lafollette and Shanks. Public Affairs Quarterly 8 (2):205-218.score: 30.0
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  46. Thomas M. Zollner, Harald Renz, Frederik H. Igney & Khusru Asadullah (2004). Animal Models of T‐Cell‐Mediated Skin Diseases. Bioessays 26 (6):693-696.score: 30.0
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  47. Lucas C. Parra Davide Reato, Asif Rahman, Marom Bikson (2013). Effects of Weak Transcranial Alternating Current Stimulation on Brain Activity—a Review of Known Mechanisms From Animal Studies. Frontiers in Human Neuroscience 7.score: 28.0
    Rhythmic neuronal activity is ubiquitous in the human brain. These rhythms originate from a variety of different network mechanisms, which give rise to a wide-ranging spectrum of oscillation frequencies. In the last few years an increasing number of clinical research studies have explored transcranial alternating current stimulation (tACS) with weak current as a tool for affecting brain function. The premise of these interventions is that tACS will interact with ongoing brain oscillations. However, the exact mechanisms by which weak currents could (...)
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  48. Ruud van den Bos (2000). General Organizational Principles of the Brain as Key to the Study of Animal Consciousness. Psyche 6 (5).score: 26.0
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  49. John G. Taylor (2001). What Do Neuronal Network Models of the Mind Indicate About Animal Consciousness? Animal Welfare Supplement 10:63- 75.score: 26.0
  50. Richard Twine (2010). Animals as Biotechnology: Ethics, Sustainability, and Critical Animal Studies. Earthscan.score: 26.0
    This book concludes by considering whether growing counter calls to reduce our consumption of meat/dairy products in the face of climate change threats are in ...
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