Search results for 'A. L. Bardou' (try it on Scholar)

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  1. R. G. Seigneuric, J.-L. Chassé, P. Auger & A. Bardou (2005). Simulated Interactions Between a Class III Antiarrhythmic Drug and a Figure 8 Reentry. Acta Biotheoretica 53 (4).score: 1350.0
    Ventricular Fibrillation is responsible for a majority of sudden cardiac death, but little is known about how ventricular tachycardia (VT) degenerates into ventricular fibrillation. Several clinical studies focused only on preventing VT with a class III antiarrhythmic drug resulted in many deaths. Our simulations investigate the interactions between an antiarrhythmic drug likely to suppress a VT and a Figure 8 reentry. A parameter AAR is introduced to increase the action potential duration and therefore simulate various Class III drugs. Simulations are (...)
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  2. A. L. Bardou, R. G. Seigneuric, J.-L. Chassé & P. M. Auger (1999). Incidence of Dispersion of Refractoriness and Cellular Coupling Resistance on Cardiac Reentries and Ventricular Fibrillation. Acta Biotheoretica 47 (3-4).score: 960.0
    We used computer simulations to study the possible role of the dispersion of cellular coupling, refractoriness or both, in the mechanisms underlying cardiac arrhythmias. Local ischemia was first assumed to induce cell to cell dispersion of the coupling resistance (Case 1), refractory period (Case 2), or both of them (Case 3). Our numerical experiments based on the van Capelle and Durrer model showed that vortices could not be induced by cell to cell variations. With cellular properties dispersed in a patchy (...)
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  3. P. Auger, R. Cardinal, A. Bril, L. Rochette & A. Bardou (1992). Interpretation of Epicardial Mapping by Means of Computer Simulations: Applications to Calcium, Lidocaine and to BRL 34915. Acta Biotheoretica 40 (2-3).score: 960.0
    The aim of this work was to compare experimental investigations on effects of lidocaine, calcium and, BRL 34915 on reentries to simulated data obtained by use of a model of propagation based on the Huygens' constriction method already described in previous works. Calcium and lidocaine effects are investigated on anisotropic conduction conditions. In both cases, reduction in conduction velocities are observed. In lidocaine case, a refractory area is located along the longitudinal axis. In agreement with experimental electrical mapping, the simulations (...)
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  4. Alain L. Bardou, Pierre M. Auger, Jean-Luc Chasse & Renaud Seigneuric (1997). Theoretical Study of Cardiac Transient Conduction Blocks on Reentries Induction. Applications to Antiarrhythmic Drugs. Acta Biotheoretica 45 (3-4).score: 450.0
    Limitations of antiarrhythmic drugs on cardiac sudden death prevention appeared since the early 80's. The "Cardiac Arrhythmia Suppression Trial"(CAST) showed more recently that mortality was significantly higher inpatients treated with some particular antiarrhythmic drugs than in non-treated patients. In this field, our group recently demonstrated that a bolus of a Class 1B antiarrhythmic drug was able to trigger a ventricular fibrillation due to transient blocks induction. The aim of the present work was to systematically study, by use of the van (...)
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  5. Alain L. Bardou, Pierre M. Auger, Soumeya Achour, Philippe Dumee, Pierre J. Birkui & Marie-Claude Govaere (1995). Effect of Myocardial Infarction and Ischemia on Induction of Cardiac Reentries and Ventricular Fibrillation. Acta Biotheoretica 43 (4).score: 450.0
    The present work is aimed at investigating the effects of myocardial infarction and ischemia on induction of ventricular fibrillation. Electrophysiologic effects of global and local ischemia (variation of the dispersion of refractory periods as well as conduction velocity) on initiation of reentry mechanisms was studied by means of computer simulations based on a cellular automata model of propagation of activation wave through a ventricular surface element. A local area of ischemia where effects of the dispersion of refractory periods are investigated (...)
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