Stiff Person Syndrome (SPS) is a rare autoimmune disorder associated with antibodies against glutamic acid decarboxylase (GAD-Ab), the key enzyme in γ -aminobutyric acid synthesis (GABA). In order to investigate the role of cerebral benzodiazepinereceptor binding in SPS, we performed [ 11 C]flumazenil (FMZ) positron emission tomography (PET) in a female patient with SPS compared to nine healthy controls. FMZ is a radioligand to the postsynaptic central (...) benzodiazepine receptor which is co-localized with the GABA-A receptor. In the SPS patient, we found a global reduction of cortical FMZ binding. In addition, distinct local clusters of reduced radiotracer binding were observed. These data provide first in vivo evidence for a reduced postsynaptic GABA-A receptor availability which may reflect the loss of GABAergic neuronal inhibition in SPS. (shrink)
Higher order cognitive processes, including ethical decision making (EDM), are influenced by the experiencing of discrete emotions. Recent research highlights the negative influence one such emotion, anger, has on EDM and its underlying processes. The mechanism, however, by which anger disrupts the EDM has not been investigated. The current study sought to discover whether cognitive appraisals of an emotion-evoking event are the driving mechanisms behind the influence of anger on EDM. One primary (goal obstacle) and one secondary (certainty) appraisal of (...) anger were examined. Study results suggest that appraisals of certainty are the driving mechanism behind the negative relationship between anger and EDM. Certainty appraisals led to less application of EDM-promoting strategies and more unethical social motives. Findings further highlight the value of investigating appraisals of emotional events, given their cognitive nature, for their potential effects on cognitive operations, such as EDM. Future directions and implications are discussed. (shrink)
The Early Modern Subject explores the understanding of self-consciousness and personal identity--two fundamental features of human subjectivity--as it developed in early modern philosophy. Udo Thiel presents a critical evaluation of these features as they were conceived in the seventeenth and eighteenth centuries. He explains the arguments of thinkers such as Descartes, Locke, Leibniz, Wolff, and Hume, as well as their early critics, followers, and other philosophical contemporaries, and situates them within their historical contexts. Interest in the issues of self-consciousness (...) and personal identity is in many ways characteristic and even central to early modern thought, but Thiel argues here that this is an interest that continues to this day, in a form still strongly influenced by the conceptual frameworks of early modern thought. In this book he attempts to broaden the scope of the treatment of these issues considerably, covering more than a hundred years of philosophical debate in France, Britain, and Germany while remaining attentive to the details of the arguments under scrutiny and discussing alternative interpretations in many cases. (shrink)
On 5 May 1957, Leopold Löwenheim passed away in a Berlin hospital following a short but severe illness, unnoticed by the community of mathematical logicians who believed that he had perished in a Nazi concentration camp in or shortly after 1940 (the year of publication in the Journal of Symbolic Logic of his last paper before the end of World War II). The 50th anniversary of his death seems an appropriate date for the posthumous publication of a paper that was (...) supposed to appear in Fundamenta Mathematicae in 1939, the galley proofs of which Löwenheim had already seen and corrected when German troops invaded Poland on 1 September 1939. Löwenheim managed to save the proofs through the War, despite the loss of most of his possessions during the bombing of Berlin in 1943 and 1944. By another lucky chance, a copy of the proofs survived in the present author's possession, when the originals were lost during a flat clearing in Berlin as part of the estate of Johannes Teichert (1904?1994), Löwenheim's step-son, when his widow moved into a nursing-home in May 1999. Later, I will expand these short remarks slightly but seize the present opportunity to resume (and in some places add to) the extant data on Löwenheim's life and writings. (shrink)
Hebb's theory of cell assemblies is a precursor of the neural network approach used as an implicit hypothesis by most contemporary neuroscientists. Applying this model to language representation leads to demanding predictions about the organization of semantic categories. Other implications of a Hebbian approach to language representation, however, may prove problematic with respect to both neurolinguistic concepts and the results of neuroimaging studies.
This study examined the role of key causal analysis strategies in forecasting and ethical decision-making. Undergraduate participants took on the role of the key actor in several ethical problems and were asked to identify and analyze the causes, forecast potential outcomes, and make a decision about each problem. Time pressure and analytic mindset were manipulated while participants worked through these problems. The results indicated that forecast quality was associated with decision ethicality, and the identification of the critical causes of the (...) problem was associated with both higher quality forecasts and higher ethicality of decisions. Neither time pressure nor analytic mindset impacted forecasts or ethicality of decisions. Theoretical and practical implications of these findings are discussed. (shrink)
The current study uses a sensemaking model and thinking strategies identified in earlier research to examine ethical decision making. Using a sample of 163 undergraduates, a low-fidelity simulation approach is used to study the effects personal involvement (in causing the problem and personal involvement in experiencing the outcomes of the problem) could have on the use of cognitive reasoning strategies that have been shown to promote ethical decision making. A mediated model is presented which suggests that environmental factors influence reasoning (...) strategies, reasoning strategies influence sensemaking, and sensemaking in turn influences ethical decision making. Findings were mixed but generally supported the hypothesized model. It is interesting to note that framing the outcomes of ethically charged situations in terms of more global organizational outcomes rather than personal outcomes was found to promote the use of pro-ethical cognitive reasoning strategies. (shrink)
This study examined the role of key causal analysis strategies in forecasting and ethical decision-making. Undergraduate participants took on the role of the key actor in several ethical problems and were asked to identify and analyze the causes, forecast potential outcomes, and make a decision about each problem. Time pressure and analytic mindset were manipulated while participants worked through these problems. The results indicated that forecast quality was associated with decision ethicality, and the identification of the critical causes of the (...) problem was associated with both higher quality forecasts and higher ethicality of decisions. Neither time pressure nor analytic mindset impacted forecasts or ethicality of decisions. Theoretical and practical implications of these findings are discussed. (shrink)
Friedrich Albert Lange (1828?1875) author of a famous History of Materialism and Critique of Its Present Significance(1866, English transi.I?III 1877?79, repr.1925 with introduction by Bertrand Russell), was also interested in the epistemological foundations of formal logic.Part I of his intended two?volume Logische Studienwas published posthumously in 1877 by Hermann Cohen?head?of the Marburg school of neo?Kantianism.Lange, departing from Kant, claims that spatial intuition is the source of the apodeictic character not only of the truths of mathematics, but also of the truths (...) of logic.He aims at showing this by basing validity and invalidity of syllogistic inferences on an interpretation of the standard forms (of proposition in assertoric syllogistic) with the help of the five kinds of possible relations (in fact what is known today as the Gergonne?Euler relations) between extensions of concepts given to us as areas in a plane, i.e.in space.Generality is achieved by considering all possible variations within each type of spatial relation, exhibiting a connection between concept and intuition reminding Lange of the Kantian ?schema?. Lange is well aware of the contemporary English ?algebraic? logic, but he considers its approach as the appropriate one for a logic of content (Inhaltslogik)and not for a logic of extension (Umfangslogik)Lange did not live to enjoy the recognition by some leading logicians (amongst them John Venn, to whose reference in 1881 to Lange?s ?admirable Logische Studien?the present paper owes it title), nor could he respond to the many critics of his proposed foundation of logic.Its radicality as well as its broad reception (and discussion up to at least 1959) seem to entitle Lange?s Logische Studiento an, if modest, place in the history of logic in the 19th century. (shrink)
Case-based instruction is a stable feature of ethics education, however, little is known about the attributes of the cases that make them effective. Emotions are an inherent part of ethical decision-making and one source of information actively stored in case-based knowledge, making them an attribute of cases that likely facilitates case-based learning. Emotions also make cases more realistic, an essential component for effective case-based instruction. The purpose of this study was to investigate the influence of emotional case content, and complementary (...) socio-relational case content, on case-based knowledge acquisition and transfer on future ethical decision-making tasks. Study findings suggest that emotional case content stimulates retention of cases and facilitates transfer of ethical decision-making principles demonstrated in cases. (shrink)
Organizational leaders face environmental challenges and pressures that put them under ethical risk. Navigating this ethical risk is demanding given the dynamics of contemporary organizations. Traditional models of ethical decision-making (EDM) are an inadequate framework for understanding how leaders respond to ethical dilemmas under conditions of uncertainty and equivocality. Sensemaking models more accurately illustrate leader EDM and account for individual, social, and environmental constraints. Using the sensemaking approach as a foundation, previous EDM models are revised and extended to comprise a (...) conceptual model of leader EDM. Moreover, the underlying factors in the model are highlighted—constraints and strategies. Four trainable, compensatory strategies (emotion regulation, self-reflection, forecasting, and information integration) are proposed and described that aid leaders in navigating ethical dilemmas in organizations. Empirical examinations demonstrate that tactical application of the strategies may aid leaders in making sense of complex and ambiguous ethical dilemmas and promote ethical behavior. Compensatory tactics such as these should be central to organizational ethics initiatives at the leader level. (shrink)
This study examined the role of reflection on personal cases for making ethical decisions with regard to new ethical problems. Participants assumed the position of a business manager in a hypothetical organization and solved ethical problems that might be encountered. Prior to making a decision for the business problems, participants reflected on a relevant ethical experience. The findings revealed that application of material garnered from reflection on a personal experience was associated with decisions of higher ethicality. However, whether the case (...) was viewed as positive or negative, and whether the outcomes, processes, or outcomes and processes embedded in the experience were examined, influenced the application of case material to the new problem. As expected, examining positive experiences and the processes involved in those positive experiences resulted in greater application of case material to new problems. Future directions and implications for understanding ethical decision making are discussed. (shrink)
Brouwer's criticism of mathematical proofs making essential use of the tertium non datur had a surprisingly late response in logical circles. Among the diverse reactions in the mid 1920s and early 1930s, it is possible to delimit a coherent body of opinions on these questions: (1) whether Brouwer's denial of the tertium non datur meant only the abandonment of this classical law or, beyond that, the affirmation of its negation; (2) whether one or both of these alternatives were logically inconsistent; (...) and (3) whether Brouwer's line of argument was forced to take resort to the very law it was designed to refute. The controversy centred around a series of articles by Marcel Barzin and Alfred Errera who fought against the intuitionistic critique, missed their victory because of conceptual confusions and fallacious reasoning, but emerged unconvinced from the debate in the late 1930s. The controversy is of interest to the historiography of formal logic since it stimulated the clarification not only of the concepts of formal validity, decidability, many-valued systems of logic and non-classical systems generally, but also of the distinction between object and meta-level, and between a formal system and its semantics. Most important, the debate, by putting pressure on the intuitionistic camp to make their ideas more precise, seems to have given the decisive motivation towards Heyting's answer to this demand by his axiomatization of intuitionistic logic in 1930. (shrink)
A nonfoundationalist reading of Fides et Ratio, both in its negative regard for Enlightenment reasoning and its implicit understanding of the philosophical task of justifying belief, enables an appreciation of the encyclical as a particular kind of post-Enlightenment Roman Catholic stance. A nonfoundationalist perspective, understood as a philosophical position on the justification of belief, can be instructive in the encyclical’s articulation of Credo ut intelligam. Fides et Ratio offers a contextualized understanding of justification in its treatment of universality that can (...) only be recognized, affirmed and confessed within the particularity of faith. (shrink)
Although case-based training is popular for ethics education, little is known about how specific case content influences training effectiveness. Therefore, the effects of (a) codes of ethical conduct and (b) forecasting content were investigated. Results revealed richer cases, including both codes and forecasting content, led to increased knowledge acquisition, greater sensemaking strategy use, and better decision ethicality. With richer cases, a specific pattern emerged. Specifically, content describing codes alone was more effective when combined with short-term forecasts, whereas content embedding codes (...) within context was more effective when combined with long-term forecasts, leading to greater knowledge acquisition and sensemaking strategy use. (shrink)
BackgroundThe Netherlands is one of the few countries where euthanasia is legal under strict conditions. This study investigates whether Dutch newspaper articles use the term ‘euthanasia’ according to the legal definition and determines what arguments for and against euthanasia they contain.MethodsWe did an electronic search of seven Dutch national newspapers between January 2009 and May 2010 and conducted a content analysis.ResultsOf the 284 articles containing the term ‘euthanasia’, 24% referred to practices outside the scope of the law, mostly relating to (...) the forgoing of life-prolonging treatments and assistance in suicide by others than physicians. Of the articles with euthanasia as the main topic, 36% described euthanasia in the context of a terminally ill patient, 24% for older persons, 16% for persons with dementia, and 9% for persons with a psychiatric disorder. The most frequent arguments for euthanasia included the importance of self-determination and the fact that euthanasia contributes to a good death. The most frequent arguments opposing euthanasia were that suffering should instead be alleviated by better care, that providing euthanasia can be disturbing, and that society should protect the vulnerable.ConclusionsOf the newspaper articles, 24% uses the term ‘euthanasia’ for practices that are outside the scope of the euthanasia law. Typically, the more unusual cases are discussed. This might lead to misunderstandings between citizens and physicians. Despite the Dutch legalisation of euthanasia, the debate about its acceptability and boundaries is ongoing and both sides of the debate are clearly represented. (shrink)
The Deutsche Forschungsgemeinschaft (DFG)is supporting a research project entitled ?Case studies towards the establishment of a social history of logic? with a grant, initially for two years. The project is being carried out by a team of five members under the direction of Professor Christian Thiel in the Institut für Philosophie and the Interdisziplinäres Institut für Wissenschaftstheorie und Wissenschaftsgeschichte (IIWW) of the University of Erlangen-Nürnberg.
The anti-metaphysical attitude of the neo-positivist movement is notorious. It is an essential mark of what its members regarded as the scientific world view. The paper focuses on a metaphysical variation of the scientific world view as proposed by Heinrich Scholz and his Münster group, who can be regarded as a peripheral part of the movement. They used formal ontology for legitimizing the use of logical calculi. Scholz's relation to the neo-positivist movement and his contributions to logic and foundations are (...) discussed. His heuristic background can be drawn from a set of six methodological ‘articles of faith’, formulated in 1942 and published here for the first time. I would like to thank Gudrun Mikus (Paderborn) for her assistance in collecting the material, Neil Tennant (Ohio State University, Columbus) for his efforts to improve the paper not only in lingual aspects, and Christian Thiel (Erlangen) and two anonymous referees for their helpful comments. CiteULike Connotea Del.icio.us What's this? (shrink)
A reformulation of our understanding of freedom is required if we are adequately to confront the environmental crisis. Engaging the debate between biocentric ecologists and sociocentric ecologists, I argue that the biocentric effort to ascribe rights (negative liberty) to nature is misbegotten. In turn, I suggest that the sociocentric effort to seek ecological realignment through the extension of human reason (positive liberty) is equally problematic. Martin Heidegger, who rejects both “negative” and “positive” notions of liberty, offers an understanding of human (...) freedom that constitutes an ecologically attuned alternative. (shrink)
An increasing number of genetic tests are available as an early spin-off from human genetic research. Beyond their application in the context of medical diagnosis there are other possible domains of use: e.g. in the testing of individuals asking for life or health insurance. It is claimed that individuals with an increased genetic risk might have to pay higher premiums or, worse, might be unable to obtain insurance coverage at all. The main question discussed in this paper will be whether (...) there is a right to health and/or life insurance coverage without prior genetic testing. The legal regulations of the use of genetic tests in the insurance system are various. While some countries in principle permit the use of (some) genetic tests for the calculation of actuarial risks, others banned genetic tests for non-medical uses; still other countries have not made any explicit provisions up to now. In the face of the attempted harmonisation of legal systems, as well as an increasing commercialisation of the international market for genetic tests, which neglects national borders, providing criteria for a moral evaluation of this issue appears to be a timely and urgent task. The view defended in this paper is that a right to health insurance without genetic testing is legitimised, insofar as health insurance belongs to the provision of elementary requirements, and insofar as the latter is everybody's moral right. On the other hand, it is implausible to postulate a right to life insurance without genetic testing â as long as life insurance is understood to be a part of one's provision of supplementary requirements. (shrink)
Questions concerning moral problems caused by the lifesciences and concerning the adequate methods and instruments to solve these are timely and urgent; especially in the face of intense debates on the acceptability of research on human embryonic stem cells and preimplantation diagnostics, to name only two applications developed from research in the life-sciences. Unfortunately, the constant and accusing demand that life-scientists must behave morally does not give us a clue on how ethics may help in establishing guidelines for moral behaviour. (...) In this heated situation the foundation of ethics-committees seems to be the motto of the day. But instead of functioning as necessary and fruitful scientific advisory boards, these committees run the risk of being misused as a fashionable (and soon forgotten) weapon in the battle for political opinion-leadership. In the following article, the view is defended that ethics is a scientific enterprise and has an important role to play in political decision making on lifesciences issues. Content Type Journal Article Pages 29-31 Authors Felix Thiele, Bad Neuenahr-Ahrweiler GmbH, Wilhelmstrasse 56, D-53474 Bad Neuenahr-Ahrweiler, Germany Journal Human Reproduction & Genetic Ethics Online ISSN 2043-0469 Print ISSN 1028-7825 Journal Volume Volume 8 Journal Issue Volume 8, Number 2 / 2002. (shrink)
Since the cloned sheep Dolly was born, reproductive cloning of humans (i.e. the cloning of complete human individuals) has seemed to be â at least in principle â achievable. The technical possibility of reproductive cloning leaves the question unanswered of whether the actual production of a clone would be morally acceptable. Considering several arguments against reproductive cloning â which claim that the moral status of a cloned individual and its clone respectively renders it morally objectionable to carry out cloning â (...) we defend the thesis that these arguments are not apodictic (i.e. relative to all ends and means of cloning humans) but are only hypothetical (i.e. relative to some ends and means of cloning humans). Although at present we think it is difficult to find a plausible aim of cloning that is not an instrumentalisation of the cloned (and, therefore, morally objectionable), it could, nevertheless, be that in the future there might be ends and means that justify reproductive cloning. We conclude by criticising the apodictic ban on reproductive cloning declared by most international resolutions and much national legislation. (shrink)
In What is Philosophy?, Deleuze and Guattari make the claim that ‘[i]t may be that believing in this world, in this life, becomes our most difficult task, or the task of a mode of existence still to be discovered on our plane of immanence today. This is the empiricist conversion.’ What are we to make of such a calling? The paper explicates why and in what sense this statement is of exemplary significance both for an appropriate understanding of Deleuze's political (...) thought and for a most timely conceptualisation of politics in a world so clearly defined by immanence, and nothing but immanence. I argue that Deleuze's rigorously constructive approach to the world is not beyond politics, as some recent readings have declared (e.g. those of Badiou and Hallward). Rather, we have to appreciate that in Deleuze and Guattari's demand for a ‘belief in this world’ the political intersects with the dimension of the ethical in such a way that our understanding of both is transformed. Only after this ‘empiricist conversion’ can we truly think of a Deleuzian politics that does justice to a plane of immanence ‘immanent only to itself’. (shrink)
The Heart of Judgment explores the nature, historical significance, and contemporary relevance of practical wisdom. Primarily a work in moral and political thought, it also relies extensively on the latest research in cognitive neuroscience to confirm and extend our understanding of the faculty of judgment. Ever since the ancient Greeks first discussed practical wisdom, the faculty of judgment has been an important topic for philosophers and political theorists. It remains one of the virtues most demanded of our public officials. The (...) greater the liberties and responsibilities accorded to citizens in democratic regimes, the more the health and welfare of society rest upon their exercise of good judgment. While giving full credit to the roles played by reason and deliberation in good judgment, the book underlines the central importance of intuition, emotion, and worldly experience. (shrink)
The paper deals with some of the developments in analysis against the background of Hilbert's contributions to the Calculus of Variations. As a starting point the transformation is chosen that took place at the end of the 19th century in the Calculus of Variations, and emphasis is placed on the influence of Dirichlet's principle. The proof of the principle (the resuscitation ) led Hilbert to questions arising in the 19th and 20th problems of his famous Paris address in 1900: theexistence (...) in a generalized sense, and theregularity of solutions of elliptic partial differential equations. By this new concept Hilbert pointed out two very important issues the history of which is closely tied up with the rise of modern analysis. Further on, Hilbert'stheorem of independence of the Calculus of Variations, an important contribution to its formal apparatus as well as to its field theory, is briefly discussed. But even as Hilbert published his first essential results, he was turning his attention to another area of mathematics that differs in an important respect from the Calculus of Variations:integral equations. Hilbert did so because he recognized that in this branch by its flexibility he was coming closer to his goal of an unifying methodological approach to analysis. (shrink)
