The origin of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is the subject of many hypotheses. One of them, proposed by Segreto and Deigin, assumes artificial chimeric construction of SARS‐CoV‐2 from a backbone of RaTG13‐like CoV and receptor binding domain (RBD) of a pangolin MP789‐like CoV, followed by serial cell or animal passage. Here we show that this hypothesis relies on incorrect or weak assumptions, and does not agree with the results of comparative genomics analysis. The genetic divergence between SARS‐CoV‐2 (...) and both its proposed ancestors is too high to have accumulated in a lab, given the timeframe of several years. Furthermore, comparative analysis of S‐protein gene sequences suggests that the RBD of SARS‐CoV‐2 probably represents an ancestral non‐recombinant variant. These and other arguments significantly weaken the hypothesis of a laboratory origin for SARS‐CoV‐2, while the hypothesis of a natural origin is consistent with all available genetic and experimental data. (shrink)

The causative agent of COVID‐19 SARS‐CoV‐2 has led to over 4 million deaths worldwide. Understanding the origin of this coronavirus is important for the prevention of future outbreaks. The dominant point of view that the virus transferred to humans either directly from bats or through an intermediate mammalian host has been challenged by Segreto and Deigin, who claim that the genome of SARS‐CoV‐2 has certain features suggestive of its artificial creation. Following their response to our commentary, here we continue the (...) discussion of the proposed arguments for this hypothesis. We show that neither the existence of a furin cleavage site in SARS‐CoV‐2, nor the presence of specific sequences within the nucleotide insertion encoding that site are evidence for intelligent design. We also explain why existing genetic data, viral diversity and past human history suggest that a natural origin of the virus is the most likely scenario. Genetic evidence suggesting otherwise is yet to be presented. (shrink)

On the 28th of October, 2006, Alexander Vladimirovich Kuznetsov, so is his full name, would have turned 80. Although belated, the editorial board of Logic and Logical Philosophy, we, the editors and contributors of the present issue, and other members of the logic community mark this event with the present issue. Most of those who contributed to it knew Kuznetsov in person and/or were influenced by him or by his ideas, which very often resided in somebody else’s papers or (...) became part of a scientific folklore. But, to be sure, there are even more mathematicians and logicians who have been witnesses to his scientific activity and/or have taken advantage of its results. (shrink)

Classical real-valued probabilities come at a philosophical cost: in many infinite situations, they assign the same probability value—namely, zero—to cases that are impossible as well as to cases that are possible. There are three non-classical approaches to probability that can avoid this drawback: full conditional probabilities, qualitative probabilities and hyperreal probabilities. These approaches have been criticized for failing to preserve intuitive symmetries that can be preserved by the classical probability framework, but there has not been a systematic study of the (...) conditions under which these symmetries can and cannot be preserved. This paper fills that gap by giving complete characterizations under which symmetries understood in a certain “strong” way can be preserved by these non-classical probabilities, as well as by offering some results to make it plausible that the strong notion of symmetry here is the right one. Philosophical implications are briefly discussed, but the main purpose of the paper is to offer technical results to help make further philosophical discussion more sophisticated. (shrink)

In the first chapter of Romans, Paul tells us that the power and deity of God are evident from what he has created. One reading of this is that there is an argument from the content of what has been created. Thus, the Book of Wisdom, which may well have been the source of Paul’s ideas here, says that “from the greatness and beauty of created things their original author, by analogy, is seen” (13:5, NAB). This is a kind of (...) teleological or design argument. But one might also argue instead from general features of the universe, such as the fact that there is a universe at all, or that there are contingent states of affairs, or that there is motion. Alternately, one might argue from something extremely specific, but where the details do not matter, such as the conjunction of all contingent facts. The general strategy of cosmological arguments is to take a grand feature of the world, and then argue, abstracting from much of its specific content, that the best or only possible explanation is a First Cause, an entity that stands at the head of a causal chain leading to the occurrence of the existential feature. Typically, the grand feature is something the opponent will not challenge. Instead, opponents tend to ask: 1. Does the grand feature actually have an explanation? 2. Can there be an explanation not involving a First Cause? 3. Need the First Cause be God? Recent discussion has particularly focused on the first two questions, and I wish to primarily focus on the first question myself in this talk. But first a few words about progress on the second and third question, in reverse order. (shrink)

There is a common misconception that our genomes - all unique, except for those in identical twins - have the upper hand in controlling our destiny. The latest genetic discoveries, however, do not support that view. Although genetic variation does influence differences in various human behaviours to a greater or lesser degree, most of the time this does not undermine our genuine free will. Genetic determinism comes into play only in various medical conditions, notably some psychiatric syndromes. Denis Alexander (...) here demonstrates that we are not slaves to our genes. He shows how a predisposition to behave in certain ways is influenced at a molecular level by particular genes. Yet a far greater influence on our behaviours is our world-views that lie beyond science - and that have an impact on how we think the latest genetic discoveries should, or should not, be applied. Written in an engaging style, Alexander's book offers tools for understanding and assessing the latest genetic discoveries critically. (shrink)

The sense of touch informs us of the physical properties of our surroundings and is a critical aspect of communication. Before touches are perceived, mechanical signals are transmitted quickly and reliably from the skin's surface to mechano‐electrical transduction channels embedded within specialized sensory neurons. We are just beginning to understand how soft tissues participate in force transmission and how they are deformed. Here, we review empirical and theoretical studies of single molecules and molecular ensembles thought to be involved in (...) mechanotransmission and apply the concepts emerging from this work to the sense of touch. We focus on the nematode Caenorhabditis elegans as a well‐studied model for touch sensation in which mechanics can be studied on the molecular, cellular, and systems level. Finally, we conclude that force transmission is an emergent property of macromolecular cellular structures that mutually stabilize one another. (shrink)

Rhythm is key to language acquisition. Across languages, rhythmic features highlight fundamental linguistic elements of the sound stream and structural relations among them. A sensitivity to rhythmic features, which begins in utero, is evident at birth. What is less clear is whether rhythm supports infants' earliest links between language and cognition. Prior evidence has documented that for infants as young as 3 and 4 months, listening to their native language supports the core cognitive capacity of object categorization. This precocious link (...) is initially part of a broader template: listening to a non-native language from the same rhythmic class as and to vocalizations of non-human primates provide English-acquiring infants the same cognitive advantage as does listening to their native language. Here, we implement a machine-learning approach to ask whether there are acoustic properties, available on the surface of these vocalizations, that permit infants' to identify which vocalizations are candidate links to cognition. We provided the model with a robust sample of vocalizations that, from the vantage point of English-acquiring 4-month-olds, either support object categorization or fail to do so. We assess whether supervised ML classification models can distinguish those vocalizations that support cognition from those that do not, and which class of acoustic features best support that classification. Our analysis reveals that principal components derived from rhythm-relevant acoustic features were among the most robust in supporting the classification. Classifications performed using temporal envelope components were also robust. These new findings provide in principle evidence that infants' earliest links between vocalizations and cognition may be subserved by their perceptual sensitivity to rhythmic and spectral elements available on the surface of these vocalizations, and that these may guide infants' identification of candidate links to cognition. (shrink)

Nurse practitioners can ease increased pressure on primary care shortage while providing a cost-effective and high-quality alternative to certain physician services. However, scope-of-practice laws are restrictive and their modification remains a source of controversy. Clearly, there is a need for new thinking around the scope of practice debate. This article conducted a review of literature and laws concerning the nursing scope of practice, as well as the outcomes of nurse-led care coordination models. It also examined different manifestations of the controversy (...) that arises in scope of practice debates. We argue that improved care coordination is necessary to improve outcomes and “bend the cost curve downward.” Allowing nurse practitioners and other providers to practice to the full extent of their licenses will result in improved care coordination. This can be accomplished by expanding nursing and other providers' scopes of practice. But any health care reform strategy, particularly with respect to chronic care management, must also serve to activate the patient herself as the keystone in the coordinated care process. Focusing first on the patient's need for coordinated care may be what is necessary to move beyond the existing impasse between physicians and nurses on scope of practice expansion. (shrink)

I argue that standard functionalism leads to absurd conclusions as to the number of minds that would exist in the universe if persons were duplicated. Rather than yielding the conclusion that making a molecule-by-molecule copy of a material person would result in two persons, it leads to the conclusion that three persons, or perhaps only one person, would result. This is absurd and standard functionalism should be abandoned. Social varieties of functionalism fare no better, though there is an Aristotelian variety (...) of functionalism that accepts irreducible finality that escapes this particular reductio. (shrink)

The Protein Ontology (PRO; http://proconsortium.org) formally defines protein entities and explicitly represents their major forms and interrelations. Protein entities represented in PRO corresponding to single amino acid chains are categorized by level of specificity into family, gene, sequence and modification metaclasses, and there is a separate metaclass for protein complexes. All metaclasses also have organism-specific derivatives. PRO complements established sequence databases such as UniProtKB, and interoperates with other biomedical and biological ontologies such as the Gene Ontology (GO). PRO relates to (...) UniProtKB in that PRO’s organism-specific classes of proteins encoded by a specific gene correspond to entities documented in UniProtKB entries. PRO relates to the GO in that PRO’s representations of organism-specific protein complexes are subclasses of the organism-agnostic protein complex terms in the GO Cellular Component Ontology. The past few years have seen growth and changes to the PRO, as well as new points of access to the data and new applications of PRO in immunology and proteomics. Here we describe some of these developments. (shrink)

© 2019 The Author. Background: The phenomenon of being 'with woman' is fundamental to midwifery as it underpins its philosophy, relationships and practices. There is an identified gap in knowledge around the 'with woman' phenomenon from the perspective of midwives providing care in a variety of contexts. As such, the aim of this study was to explore the experiences of being 'with woman' during labour and birth from the perspective of midwives' working in a model where care is provided by (...) a known midwife. Methods: A descriptive phenomenological design was employed with ten midwives working in a 'known midwife' model who described their experiences of being 'with woman' during labour and birth. The method was informed by Husserlian philosophy which seeks to explore the same phenomenon through rich descriptions by individuals revealing commonalities of the experience. Results: Five themes emerged 1) Building relationships; 2) Woman centred care; 3) Impact on the midwife; 4) Impact on the woman; and 5) Challenges in the Known Midwife model. Midwives emphasised the importance of trusting relationships while being 'with woman', confirming that this relationship extends beyond the woman - midwife relationship to include the woman's support people and family. Being 'with woman' during labour and birth in the context of the relationship facilitates woman-centred care. Being 'with woman' influences midwives, and, it is noted, the women that midwives are working with. Finally, challenges that impact being 'with woman' in the known midwife model are shared by midwives. Conclusions: Findings offer valuable insight into midwives' experiences of being 'with woman' in the context of models that provide care by a known midwife. In this model, the trusting relationship is the conduit for being 'with woman' which influences the midwife, the profession of midwifery, as well as women and their families. Descriptions of challenges to being 'with woman' provide opportunities for professional development and service review. Rich descriptions from the unique voice of midwives, provided insight into the applied practices of being 'with woman' in a known midwife model which adds important knowledge concerning a phenomenon so deeply embedded in the philosophy and practices of the profession of midwifery. (shrink)

Necessary Existence breaks ground on one of the deepest questions anyone ever asks: why is there anything? Pruss and Rasmussen present an original defence of the hypothesis that there is a necessarily existing being capable of providing an ultimate foundation for the existence of all things.

This important philosophical reflection on love and sexuality from a broadly Christian perspective is aimed at philosophers, theologians, and educated Christian readers. Alexander R. Pruss focuses on foundational questions on the nature of romantic love and on controversial questions in sexual ethics on the basis of the fundamental idea that romantic love pursues union of two persons as one body. _One Body_ begins with an account, inspired by St. Thomas Aquinas, of the general nature of love as constituted by (...) components of goodwill, appreciation, and unitiveness. Different forms of love, such as parental, collegial, filial, friendly, fraternal, or romantic, Pruss argues, differ primarily not in terms of goodwill or appreciation but in terms of the kind of union that is sought. Pruss examines romantic love as distinguished from other kinds of love by a focus on a particular kind of union, a deep union as one body achieved through the joint biological striving of the sort involved in reproduction. Taking the account of the union that romantic love seeks as a foundation, the book considers the nature of marriage and applies its account to controversial ethical questions, such as the connection between love, sex, and commitment and the moral issues involving contraception, same-sex activity, and reproductive technology. With philosophical rigor and sophistication, Pruss provides carefully argued answers to controversial questions in Christian sexual ethics. "This is a terrific—really quite extraordinary—work of scholarship. It is quite simply the best work on Christian sexual ethics that I have seen. It will become the text that anyone who ventures into the field will have to grapple with—a kind of touchstone. Moreover, it is filled with arguments with which even secular writers on sexual morality will have to engage and come to terms." —_Robert P. George, Princeton University __ "_One Body_ is an excellent piece of philosophical-theological reflection on the nature of sexuality and marriage. This book has the potential to become a standard go-to text for professors and students working on sex ethics issues, whether in philosophy or theology, both for the richness of its arguments, and the scope of its coverage of cases. " — Christopher Tollefsen, University of South Carolina_ "Alexander Pruss here develops sound and humane answers to the whole range of main questions about human sexual and reproductive choices. His principal argument for the key answers is very different from the one I have articulated over the past fifteen years. But his argumentation is at every point attractively direct, careful, energetic in framing and responding to objections, and admirably attentive to realities and the human goods at stake." —_John Finnis, University of Oxford _. (shrink)

LetXbe a standard Borel space, and letEbe acountableBorel equivalence relation onX, i.e., a Borel equivalence relationEfor which every equivalence class [x]Eis countable. By a result of Feldman-Moore [FM],Eis induced by the orbits of a Borel action of a countable groupGonX.The structure of general countable Borel equivalence relations is very little understood. However, a lot is known for the particularly important subclass consisting of hyperfinite relations. A countable Borel equivalence relation is calledhyperfiniteif it is induced by a Borel ℤ-action, i.e., by (...) the orbits of a single Borel automorphism. Such relations are studied and classified in [DJK]. It is shown in Ornstein-Weiss [OW] and Connes-Feldman-Weiss [CFW] that for every Borel equivalence relationEinduced by a Borel action of a countable amenable groupGonXand for every probability measure μ onX, there is a Borel invariant setY⊆Xwith μ = 1 such thatE↾Y is hyperfinite. Motivated by this result, Weiss [W2] raised the question of whether everyEinduced by a Borel action of a countable amenable group is hyperfinite. Later on Weiss showed that this is true forG= ℤn. However, the problem is still open even for abelianG. Our main purpose here is to provide a weaker affirmative answer for general amenableG. We need a definition first. Given two standard Borel spacesX, Y, auniversally measurableisomorphism betweenXandYis a bijection ƒ:X→Ysuch that both ƒ, ƒ-1are universally measurable. Notice now that to assert that a countable Borel equivalence relation onXis hyperfinite is trivially equivalent to saying that there is a standard Borel spaceYand a hyperfinite Borel equivalence relationFonY, which isBorelisomorphic toE, i.e., there is a Borel bijection ƒ:X→YwithxEy⇔ ƒFƒ. We have the following theorem. (shrink)

Introduction While quizzing during informed consent for research to ensure understanding has become commonplace, it is unclear whether the quizzing itself is problematic for potential participants. In this study, we address this issue in a multinational HIV prevention research trial enrolling injection drug users in China and Thailand. Methods Enrolment procedures included an informed consent comprehension quiz. An informed consent survey followed. Results 525 participants completed the informed consent survey (Heng County, China=255, Xinjiang, China=229, Chiang Mai, Thailand=41). Mean age was (...) 33 and mean educational level was 8 yrs. While quizzing was felt to be a good way to determine if a person understands the nature of clinical trial participation (97%) and participants did not generally find the quiz to be problematic, minorities of respondents felt pressured (6%); anxious (5%); bored (5%); minded (5%); and did not find the questions easy (13%). In multivariate analysis, lower educational level was associated with not minding the quizzing (6–10 yrs vs 0–5 yrs: OR=0.27, p=0.03; more than 11 yrs vs 0–5 yrs: OR=0.18, p=0.03). There were also site differences (Heng County vs Xinjiang) in feeling anxious (OR=0.07; p=<0.01), not minding (OR=0.26; p=0.03), being bored (OR=0.25; p=0.01) and not finding the questions easy (OR=0.10; p=<0.01). Conclusions Quizzing during the informed consent process can be problematic for a minority of participants. These problems may be associated with the setting in which research takes place and educational level. Further research is needed to develop, test and implement alternative methods of ensuring comprehension of informed consent. Trial Registration clinicaltrials.gov number NCT00270257. (shrink)

Perceptual conscious experiences result from non-conscious processes that precede them. We document a new characteristic of the cognitive system: the speed with which visual meaningful stimuli are prioritized to consciousness over competing noise in visual masking paradigms. In ten experiments (N = 399) we find that an individual's non-conscious visual prioritization speed (NVPS) is ubiquitous across a wide variety of stimuli, and generalizes across visual masks, suppression tasks, and time. We also find that variation in NVPS is unique, in that (...) it cannot be explained by variation in general speed, perceptual decision thresholds, short-term visual memory, or three networks of attention (alerting, orienting and executive). Finally, we find that NVPS is correlated with subjective measures of sensitivity, as they are measured by the Highly Sensitive Person scale. We conclude by discussing the implications of variance in NVPS for understanding individual variance in behavior and the neural substrates of consciousness. (shrink)

We outline the Gödel-McKinsey-Tarski Theorem on embedding of Intuitionistic Propositional Logic Int into modal logic S4 and further developments which led to the Generalized Embedding Theorem. The latter in turn opened a full-scale comparative exploration of lattices of the (normal) extensions of modal propositional logic S4, provability logic GL, proof-intuitionistic logic KM, and others, including Int. The present paper is a contribution to this part of the research originated from the Gödel-McKinsey-Tarski Theorem. In particular, we show that the lattice ExtInt (...) of intermediate logics is likely to be the only constructing block with which ExtS4, the lattice of the extensions of S4, can be formed. We, however, advise the reader that our exposition is different from the historical lines along which some of the results discussed below came to light. Part 1, presented here, deals mostly with structural issues of extensions of logics, where algebraic semantics, though underlying this approach, is used merely occasionally. Part 2 will be devoted to algebraic analysis of the Embedding Theorem. (shrink)

In this paper we study generic complexity of undecidable problems. It turns out that some classical undecidable problems are, in fact, strongly undecidable, i.e., they are undecidable on every strongly generic subset of inputs. For instance, the classical Halting Problem is strongly undecidable. Moreover, we prove and analog of the Rice theorem for strongly undecidable problems, which provides plenty of examples of strongly undecidable problems. Then we show that there are natural super-undecidable problems. i.e., problem which are undecidable on every (...) generic (not only strongly generic) subset of inputs. In particular, there are finitely presented semigroups with super-undecidable word problem. To construct strongly- and super-undecidable problems we introducea method of generic amplification (an analog of the amplification in complexity theory). Finally, we construct absolutely undecidable problems, which stay undecidable on every non-negligible set of inputs. Their construction rests on generic immune sets. (shrink)

Alexander Vladimirovich Kuznetsov, also known to the second generation of Soviet logicians as Sasha Kuznetsov, was born in Moscow on the 28 th of October, 1926. He lived a short yet fruitful life and died of cancer 1 in Chişinău, Moldova, on the 24 th of July, 1984.

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Grounding Human Rights in a Pluralist World by Grace Y. Kao, and: Christianity and Human Rights: An Introduction ed. by John Witte, Frank S. AlexanderZachary R. CaloGrounding Human Rights in a Pluralist World Grace Y. Kao Washington, DC: Georgetown University Press, 2011. 239pp. $28.45Christianity and Human Rights: An Introduction Edited By John Witte and Frank S. Alexander New York: Cambridge University Press, 2010. 390pp. $29.38Grace Kao’s Grounding (...) Human Rights in a Pluralistic World and Christianity and Human Rights, edited by John Witte and Frank Alexander, both contribute to the growing and sophisticated literature addressing the relationship between religious traditions and human rights. Kao’s book opens by asking whether “the very idea of human rights [must] be premised upon a religious or metaphysical idea in order to be conceptually intelligible, sufficiently protected, or practically stable over time” (4). Kao proposes that this question has generally been answered in one of two ways: a “maximalist” response that identifies religion as a necessary foundation for human rights, and a “minimalist” response that rejects this turn to religion. A significant portion of the book is devoted to assessing representatives of these two approaches. Chapter 2 includes a discussion of maximalist thinkers Michael Perry, Max Stackhouse, Hans Küng, and Nicholas Wolterstorff. Chapters 3 through 5 consider different forms of minimalism, including that found in the work of John Rawls and Martha Nussbaum.Kao’s organization of the debate into maximalism and minimalism imposes a useful typology over a diverse range of thought while also establishing interesting points of contact and contestation among various thinkers. At the same time, because the analysis occurs at a rather high level of abstraction, it will be most useful to those already familiar with the texts and thinkers discussed. This is not a text for those seeking a summary introduction. Those less familiar will still profit from the book, but perhaps more from the opening and closing chapters than those discussed here. [End Page 187]Following the discussion of maximalism and minimalism, the final chapter of Kao’s book presents a model for moving beyond the “extremes” of these two dominant approaches (8). At its most basic, human rights, Kao argues, must be grounded in a nonreligious moral realism. This “straddling” of the “minimalist-maximalist divide” is, in certain respects, a creative and bold proposal for reshaping debate about religion and human rights. It defends the universality of human rights as being necessarily grounded in objective values but does not narrowly locate these values in religious sources. Yet, while offering some intriguing insights, the themes of this final chapter never quite come together to form a comprehensive theory. Kao’s proposal is more a selective appropriation of insights from others than a totalizing alternative.Because Kao does not fully develop her model, it is difficult to assess the particular rights claims that follow from its premises. This is evident, for instance, in Kao’s discussion of the so-called marginal cases, where it remains unclear what specific principles and methods have been employed to develop normative positions (160–61). This disconnect between theory and application limits the book’s ability to have an impact on core disputes within human rights. The most significant fault lines within the contemporary human rights debate involve the content and expanse of human rights more than their theoretical grounding, and human rights language often serves as a way to legitimize preferred political goods. Kao not only needs to defend her approach to grounding human rights but also to establish how this particular grounding informs the norms of human rights.Witte and Alexander’s edited volume, Christianity and Human Rights, addresses the relationship between religion and human rights from a quite different perspective. Whereas Kao critically assesses religion’s role as a foundation for human rights, the essays in Witte and Alexander’s book largely explore the meaning of human rights from within a Christian framework. The book does not entirely bypass questions about the warranting role of religion as such, but its concern is not to justify the role of Christianity within human rights but to develop “the budding new human rights hermeneutic of... (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Vice and Naturalistic OntologyChristopher R. Williams (bio)Keywordscausality, criminality, determinism, medical model, positivismThese questions have been posed: Is vice (encompassing criminal and other wrongful conduct) best regarded as “sick” behavior, “immoral” behavior, or some other type altogether? Are we to understand vice in natural-medical terms, or are we better served by utilizing a moral framework? Is criminality reducible to and best categorized as a metaphysical type the essential features of (...) which are neurological or otherwise biological in nature? Or, perhaps, is criminality closer to a (non-natural) sociological type, the essential features of which can be understood only through reference to social norms and cultural conventions? These are torturously involved philosophical and theoretical questions that have given rise to an equally torturous volume of literature. Without pretending to do justice to these questions or their corresponding literature, several key considerations that must be inserted into and accounted for within the discursive pursuit of these inquiries are worth noting.Where a naturalistic ontology is employed within the study of vice, we reduce the intricacies of deviant behavioral phenomena to what we presume to be their underlying medical/biological properties. It is worth remembering that behavior itself cannot rightfully be said to be “sick”; rather, what we mean to say is that the behavior in question—in our case, various forms of “vice”—is symptomatic of some underlying illness or medical/biological condition. The presumed underlying sickness and the behavior itself are distinct, ontologically linked only through their theorized relationship to one another. This, then, is a key assumption of the medical approach to vice and its ontological classification as a natural-medical kind: that there exists a relationship between the behavior (a symptom) and the underlying illness or medical condition, and that the relationship is of the causal kind. Vice, it is suggested, is a change in state that is caused by (or, at the very least, is a direct consequence of) sickness or illness. Second, to legitimate such attributions, the illness supplying the requisite causal force must be identifiable and its causal connection to the behavior must be or be capable of being sufficiently explicated. In other words, once we have identified the relevant medical/biological properties and the behavior to which they stand in causal relatedness, we must be prepared to characterize this dynamic—we must be able to show exactly how and why such and such a condition gives rise to such and such a behavior.Problematically, causation itself is and has always been a contentious metaphysical specimen. Hume (1955) reminded us of the troubling reality [End Page 39] that we cannot ever “see” one thing cause or necessitate another. We are left, rather, to merely presume the existence of causal relationships between things. How is it, exactly, that disorder in neurodevelopment can necessitate certain behavioral outcomes? Even if we can “see” (in the empirical sense) the disorder and equally “see” the behavior, we cannot of course witness the precise causal action of the former upon the latter. Even if we are content inferring causal action in such cases, we still need to demonstrate the basic conditions of causality. To show that Condition X is causally related Behavior Y, we need to show that they are regularly associated with one another, that Condition X temporally preceded Behavior Y and, most challengingly, that no other conditions or factors have an intervening (e.g., additive, synergistic) influence. Hypothetically, if we were to posit a causal relationship between schizotypal personality traits and violent behavior, we would need to establish: (1) that schizotypal traits and violent behavior regularly coexist; (2) that those traits presented before the manifestation of the violent behavior; and (3) that no other factors (biological, psychological, and/or sociological) contributed in any meaningful way to those manifestations. We would thus need to systematically rule out family dynamics, income, education, intelligence, substance use, and so forth, as contributing factors. If, in turn, we were to determine that the presence of schizotypal traits alone is not sufficient—even if a necessary condition—to produce violent behavior but, rather, that those traits act in concert with other variables to produce the behavior, then we would not truly be... (shrink)

One of the problems that Bayesian regularity, the thesis that all contingent propositions should be given probabilities strictly between zero and one, faces is the possibility of random processes that randomly and uniformly choose a number between zero and one. According to classical probability theory, the probability that such a process picks a particular number in the range is zero, but of course any number in the range can indeed be picked. There is a solution to this particular problem on (...) the books: a measure that assigns the same infinitesimal probability to each number between zero and one. I will show that such a measure, while mathematically interesting, is pathological for use in confirmation theory, for the same reason that a measure that assigns an infinitesimal probability to each possible outcome in a countably infinite lottery is pathological. The pathology is that one can force someone to assign a probability within an infinitesimal of one to an unlikely event. (shrink)

Cantor proved that no set has a bijection between itself and its power set. This is widely taken to have shown that there infinitely many sizes of infinite sets. The argument depends on the princip...

The free-will defence holds that the value of significant free will is so great that God is justified in creating significantly free creatures even if there is a risk or certainty that these creatures will sin. A difficulty for the FWD, developed carefully by Quentin Smith, is that God is unable to do evil, and yet surely lacks no genuinely valuable kind of freedom. Smith argues that the kind of freedom that God has can be had by creatures, without a (...) risk of creatures doing evil. I shall show that Smith's argument fails – the case of God is disanalogous to the case of creatures precisely because creatures are creatures. (shrink)

Plantinga’s Free Will Defense is an argument that, possibly, God cannot actualize a world containing significant creaturely free will and no wrongdoings. I will argue that if standard Molinism is true, there is a pair of worlds w1 and w2 each of which contains a significantly free creature who never chooses wrongly, and that are such that, necessarily, at least one of these worlds is a world that God can actualize.

Consider the following three-step dialectics. (1) Even if God (consistently) commanded torture of the innocent, it would still be wrong. Therefore Divine Command Metaethics (DCM) is false. (2) No: for it is impossible for God to command torture of the innocent. (3) Even if it is impossible, there is a non-trivially true per impossibile counterfactual that even if God (consistently) com­manded torture of the innocent, it would still be wrong, and this counterfac­tual is incompatible with DCM. I shall argue that (...) the last step of this dialectics is flawed because it would rule out every substantive metaethical theory. (shrink)

It is often loosely said that Ramsey The foundations of mathematics and other logical essays, Routledge and Kegan Paul, Abingdon, pp 156–198, 1931) and de Finetti Studies in subjective probability, Kreiger Publishing, Huntington, 1937) proved that if your credences are inconsistent, then you will be willing to accept a Dutch Book, a wager portfolio that is sure to result in a loss. Of course, their theorems are true, but the claim about acceptance of Dutch Books assumes a particular method of (...) calculating expected utilities given the inconsistent credences. I will argue that there are better ways of calculating expected utilities given a potentially inconsistent credence assignment, and that for a large class of credences—a class that includes many inconsistent examples—these ways are immune to Dutch Books and single-shot domination failures. The crucial move is to replace Finite Additivity with Monotonicity, then \\le P\)) and then calculate expected utilities for positive U via the formula \\, dy\). This shows that Dutch Book arguments for probabilism, the thesis that one’s credences should be consistent, do not establish their conclusion. Finally, I will consider a modified argument based on multi-step domination failure that does better, but nonetheless is not as compelling as the Dutch Book arguments appeared to be. (shrink)

A number of philosophers have attempted to solve the problem of null-probability possible events in Bayesian epistemology by proposing that there are infinitesimal probabilities. Hájek and Easwaran have argued that because there is no way to specify a particular hyperreal extension of the real numbers, solutions to the regularity problem involving infinitesimals, or at least hyperreal infinitesimals, involve an unsatisfactory ineffability or arbitrariness. The arguments depend on the alleged impossibility of picking out a particular hyperreal extension of the real numbers (...) and/or of a particular value within such an extension due to the use of the Axiom of Choice. However, it is false that the Axiom of Choice precludes a specification of a hyperreal extension—such an extension can indeed be specified. Moreover, for all we know, it is possible to explicitly specify particular infinitesimals within such an extension. Nonetheless, I prove that because any regular probability measure that has infinitesimal values can be replaced by one that has all the same intuitive features but other infinitesimal values, the heart of the arbitrariness objection remains. (shrink)

Always connect—that is the imperative of today’s media. But what about those moments when media cease to function properly, when messages go beyond the sender and receiver to become excluded from the world of communication itself—those messages that state: “There will be no more messages”? In this book, Alexander R. Galloway, Eugene Thacker, and McKenzie Wark turn our usual understanding of media and mediation on its head by arguing that these moments reveal the ways the impossibility of communication is (...) integral to communication itself—instances they call excommunication. In three linked essays, _Excommunication_ pursues this elusive topic by looking at mediation in the face of banishment, exclusion, and heresy, and by contemplating the possibilities of communication with the great beyond. First, Galloway proposes an original theory of mediation based on classical literature and philosophy, using Hermes, Iris, and the Furies to map out three of the most prevalent modes of mediation today—mediation as exchange, as illumination, and as network. Then, Thacker goes boldly beyond Galloway’s classification scheme by examining the concept of excommunication through the secret link between the modern horror genre and medieval mysticism. Charting a trajectory of examples from H. P. Lovecraft to Meister Eckhart, Thacker explores those instances when one communicates or connects with the inaccessible, dubbing such modes of mediation “haunted” or “weird” to underscore their inaccessibility. Finally, Wark evokes the poetics of the infuriated swarm as a queer politics of heresy that deviates from both media theory and the traditional left. He posits a critical theory that celebrates heresy and that is distinct from those that now venerate Saint Paul. Reexamining commonplace definitions of media, mediation, and communication, _Excommunication_ offers a glimpse into the realm of the nonhuman to find a theory of mediation adequate to our present condition. (shrink)

Electronegativity, described by Linus Pauling described as “The power of an atom in a molecule to attract electrons to itself” (Pauling in The nature of the chemical bond, 3rd edn, Cornell University Press, Ithaca, p 88, 1960), is used to predict bond polarity. There are dozens of methods for empirically quantifying electronegativity including: the original thermochemical technique (Pauling in J Am Chem Soc 54:3570–3582, 1932), numerical averaging of the ionisation potential and electron affinity (Mulliken in J Chem Phys 2:782–784, 1934), (...) effective nuclear charge and covalent radius analysis (Sanderson in J Chem Phys 23:2467, 1955) and the averaged successive ionisation energies of an element’s valence electrons (Martynov and Batsanov in Zhurnal Neorganicheskoi Khimii 5:3171–3175, 1980), etc. Indeed, there are such strong correlations between numerous atomic parameters—physical and chemical—that the term “electronegativity” integrates them into a single dimensionless number between 0.78 and 4.00 that can be used to predict/describe/model much of an element’s physical character and chemical behaviour. The design of the common and popular medium form of the periodic table is in large part determined by four quantum numbers and four associated rules. However, adding electronegativity completes the construction so that it displays the multi-parameter periodic law operating in two dimensions, down the groups and across the periods, with minimal ambiguity. (shrink)

Scoring rules measure the accuracy or epistemic utility of a credence assignment. A significant literature uses plausible conditions on scoring rules on finite sample spaces to argue for both probabilism—the doctrine that credences ought to satisfy the axioms of probabilism—and for the optimality of Bayesian update as a response to evidence. I prove a number of formal results regarding scoring rules on infinite sample spaces that impact the extension of these arguments to infinite sample spaces. A common condition in the (...) arguments for probabilism and Bayesian update is strict propriety: that according to each probabilistic credence, the expected accuracy of any other credence is worse. Much of the discussion needs to divide depending on whether we require finite or countable additivity of our probabilities. I show that in a number of natural infinite finitely additive cases, there simply do not exist strictly proper scoring rules, and the prospects for arguments for probabilism and Bayesian update are limited. In many natural infinite countably additive cases, on the other hand, there do exist strictly proper scoring rules that are continuous on the probabilities, and which support arguments for Bayesian update, but which do not support arguments for probabilism. There may be more hope for accuracy-based arguments if we drop the assumption that scores are extended-real-valued. I sketch a framework for scoring rules whose values are nets of extended reals, and show the existence of a strictly proper net-valued scoring rules in all infinite cases, both for f.a. and c.a. probabilities. These can be used in an argument for Bayesian update, but it is not at present known what is to be said about probabilism in this case. (shrink)

Consider the regularity thesis that each possible event has non-zero probability. Hájek challenges this in two ways: there can be nonmeasurable events that have no probability at all and on a large enough sample space, some probabilities will have to be zero. But arguments for the existence of nonmeasurable events depend on the axiom of choice. We shall show that the existence of anything like regular probabilities is by itself enough to imply a weak version of AC sufficient to prove (...) the Banach–Tarski Paradox on the decomposition of a ball into two equally sized balls, and hence to show the existence of nonmeasurable events. This provides a powerful argument against unrestricted orthodox Bayesianism that works even without AC. A corollary of our formal result is that if every partial order extends to a total preorder while maintaining strict comparisons, then the Banach–Tarski Paradox holds. This yields an argument that incommensurability cannot be avoided in ambitious versions of decision theory. (shrink)

Sceptical theism claims that we have vast ignorance about the realm of value and the connections, causal and modal, between goods and bads. This ignorance makes it reasonable for a theist to say that God has reasons beyond our ken for allowing the horrendous evils we observe. But if so, then does this not lead to moral paralysis when we need to prevent evils ourselves? For, for aught that we know, there are reasons beyond our ken for us to allow (...) the evils, and so we should not prevent them. This paralysis argument, however, shall be argued to rest on a confusion between probabilities and expected utilities. A connection between this paralysis argument and Lenman's1 discussion of the butterfly effect and chaos will be drawn, and the solution offered will apply in both cases. (shrink)

In his article ‘A Cavalry Unit in the Army of Antigonus Monophthalmus: Asthippoi’, N. G. L. Hammond argues that the reading of the manuscript R at Diodorus 19. 29. 2 should be retained and that we should read ⋯π⋯ π⋯σι δ⋯ το⋯ς τε ⋯σθ⋯ππους ⋯νομαζομ⋯νους κα⋯ τοὺς ⋯κ τ⋯ν ἄνω κατοικο⋯ντων ⋯κτακοσιο⋯ς. The readings of F and its copy X, ⋯νθ⋯ππους, and the commonly accepted conjecture of Wesseling ⋯μɸ⋯ππους, should both be abandoned. Hammond's arguments for retaining this reading are that (...) between the variant readings of R and F, R ‘is the more often correct’ ; ⋯σθ⋯ππους, the reading of R, is preferable to F's ⋯νθ⋯ππους on the principle of ‘lectio difficilior’; the ‘difficulty’ of his lectio difficilior is made less by the arguments presented by A. B. Bosworth, 245 ff.), for the restoration at several places in the text of Arrian's Anabasis the word ⋯σθ⋯ταιροι, in place of the editorial emendation of πεζ⋯ταιροι. ‘For just as asthetairoi meant an élite group of Macedonian infantrymen,’ says Hammond, ‘so asthippoi should mean an élite group of Macedonian cavalrymen.’ He then proceeds to examine the passage and its context in an attempt to find confirmation of this proposition and comes to the conclusion that Diodorus' text says that there were 800 cavalrymen, broken into two groups, the asthippoi and ‘the men from the up-country settlers’; these, though having different names, had a close relationship to each other, as is shown by their being brigaded together. Following his derivation of asthetairoi as meaning ‘townsmen-companions’, i.e. companions recruited from the towns of Upper Macedonia, he argues that asthippoi were cavalry recruited from the towns of Upper Macedonia and that τοὺς ⋯κ τ⋯ν ἄνω κατοικο⋯ντων means ‘the sons of settlers in up-country Macedonia’. These 800, says Hammond, were both among Antigonus' best troops and ‘were Macedonians from Europe’. We thus appear, on Hammond's interpretation, to have here a group of 800 Macedonian élite cavalrymen, all of whom were recruited in Upper Macedonia's townships, but of whom some were chosen to be the cavalry-equivalent of the élite ‘townsmen-companions’ by their title of ‘townsmen-cavalry’, whilst the others, similarly recruited – but perhaps of a younger generation? – had no particular distinguishing title beyond ‘sons of settlers in up-country Macedonia’.Now, while it would be exciting to be able to add another one, possibly two Macedonian cavalry units to the Macedonian army of Philip, Alexander and the Successors, there are several aspects of Hammond's arguments that, it seems to me, are less than convincing. Thus, whilst it seems beyond reasonable doubt that ⋯σθ⋯ταιροι should be retained in the text of Arrian, appearing, as it does, six times, this is not an argument that ⋯σθ⋯ππους should be read in Diodorus' text. Both it and F's reading of ⋯νθ⋯ππους are hapax legomena and it is possible that both readings are wrong. But even if we retain ⋯σθ⋯ππους as the correct reading, Hammond's explanation of its meaning is open to objection on several counts. (shrink)

Digital and analog: What do these terms mean today? The use and meaning of such terms change through time. The analog, in particular, seems to go through various phases of popularity and disuse, its appeal pegged most frequently to nostalgic longings for nontechnical or romantic modes of art and culture. The definition of the digital vacillates as well, its precise definition often eclipsed by a kind of fever-pitched industrial bonanza around the latest technologies and the latest commercial ventures. One common (...) response to the question of the digital is to make reference to things like Twitter, Playstation, or computers in general. Here one might be correct, but only coincidentally, for the basic order of digitality (the digitality of digitality) has not yet been demonstrated through mere denotation. And the second question—the question of the analog—is harder still, with responses often also consisting of mere denotations of things: sound waves, the phonograph needle, magnetic tape, a sundial. At least denotation itself is analogical. This article will aim to define the analog explicitly and argue, perhaps counterintuitively, that the golden age of analog thinking was not a few decades past, prior to the wide-spread adoption of the computer. In fact, the fields of structuralism and poststructuralism that emerged in the middle to late twentieth century, concurrent with the deployment of the digital computer, were characteristically digital, what with their focus on the symbolic order and logical economies. If anything, the golden age of analog is happening today, all around us, as evidenced by the proliferation of characteristically analog concerns: sensation, materiality, experience, affect, ethics, and aesthetics. (shrink)

The free-will defence (FWD) holds that the value of significant free will is so great that God is justified in creating significantly free creatures even if there is a risk or certainty that these creatures will sin. A difficulty for the FWD, developed carefully by Quentin Smith, is that God is unable to do evil, and yet surely lacks no genuinely valuable kind of freedom. Smith argues that the kind of freedom that God has can be had by creatures, without (...) a risk of creatures doing evil. I shall show that Smith's argument fails – the case of God is disanalogous to the case of creatures precisely because creatures are creatures. (shrink)

Could it be that Deleuze's most lasting legacy will lie in his ‘Postscript on Control Societies’, a mere 2,300-word essay from 1990? While he discussed computers and new media infrequently, Deleuze admittedly made contributions to the contemporary discourse on computing, cybernetics and networks, particularly in his late work. From the concepts of the rhizome and the virtual, to his occasional interjections on the digital versus the analogue, there is a case to be made that the late Deleuze has not only (...) influenced today's discourse on new media but also proposes an original set of arguments about society and politics at the turn of the new millennium. Focusing on the ‘Postscript on Control Societies’ and a handful of texts that surround it, we will reconstruct an image of what it means to live in the information age. This will have consequences for how we define the digital and the analogue, what the computer means, and ultimately provide some insight into one of the more elusive terms in all of Deleuze, the superfold. (shrink)

A nested mode ontology allows one to make sense of apparently contradictory Christological claims such as that Christ knows everything and there are some things Christ does not know.

There is an important sense in which one can be sure without being certain, i.e., without assigning unit probability. I will offer an explication of this sense of sureness, connecting it with the level of credence that a rational agent would need to have to be confident that she won’t ever lose her confidence. A simple formal result then gives us an explicit formula connecting the threshold α for credence needed for confidence with the threshold needed for being sure: one (...) needs 1−(1−α) to be sure. I then suggest that stepping between α and 1−(1−α) gives a procedure that generates an interesting hierarchy of credential thresholds. (shrink)

Patrick Toner has argued that eternalism, the doctrine that all times are ontologically on par, conflicts with the Catholic view of judgment as based on the state of the soul at death. For, he holds, it is arbitrary that judgment should be based on what happened at some particular time, unless, as presentism holds, that time is the only that really exists. I shall argue that his argument fails because the eternalist can say that judgment is simultaneous with the state (...) of soul that is being judged, and there is nothing arbitrary about judging something at t on the basis of its state at the same time t. (shrink)

The strict dominance principle that a wager always paying better than another is rationally preferable is one of the least controversial principles in decision theory. I shall show that (given the Axiom of Choice) there is a contradiction between strict dominance and plausible isomorphism or symmetry conditions, by showing how in several natural cases one can construct isomorphic wagers one of which strictly dominates the other. In particular, I will show that there is a pair of wagers on the outcomes (...) of a uniform spinner which differ simply in where the zero degrees point of the spinner is defined to be but where one wager dominates the other. I shall also argue that someone who accepts Williamson’s famous argument that the probability of an infinite sequence of heads is zero should accept the symmetry conditions, and thus has reason to weaken the strict dominance principle, and I shall propose a restriction of the principle to “implementable” wagers. Our main result also has implications for social choice principles. (shrink)

Louis Pojman has argued that Christian faith does not entail belief, or even assigning a probability of 1/2 to the claims of Christianity. However, this conclusion fails in many cases because of its ethical consequences. A Christian is committed by his faith to acting in accordance with Christian teaching. However, there are circumstances when it is morally impermissible to act in accordance to beliefs to which one assigns epistemic probability smaller than 1/2, namely when the action is prohibited by ethical (...) claims that one takes to be more probable. It is argued that in most cases such considerations preclude a person who assigns a probability of less 1/2 from being both committed both to Christianity and to the moral life. Matters are particularly clear in the paradigmatic faith-action of Abraham’s sacrifice of Isaac: this action would clearly be immoral if Abraham assigned a probability less than 1/2, or in fact any probability not very close to 1, to the existence of God. A moral version of Pascal’s wager is also discussed. (shrink)

The behavioral sciences have flourished by studying how traditional and/or rational behavior has been governed throughout most of human history by relatively well-informed individual and social learning. In the online age, however, social phenomena can occur with unprecedented scale and unpredictability, and individuals have access to social connections never before possible. Similarly, behavioral scientists now have access to “big data” sets – those from Twitter and Facebook, for example – that did not exist a few years ago. Studies of human (...) dynamics based on these data sets are novel and exciting but, if not placed in context, can foster the misconception that mass-scale online behavior is all we need to understand, for example, how humans make decisions. To overcome that misconception, we draw on the field of discrete-choice theory to create a multiscale comparative “map” that, like a principal-components representation, captures the essence of decision making along two axes: aneast–westdimension that represents the degree to which an agent makes a decision independently versus one that is socially influenced, and anorth–south dimensionthat represents the degree to which there is transparency in the payoffs and risks associated with the decisions agents make. We divide the map into quadrants, each of which features a signature behavioral pattern. When taken together, the map and its signatures provide an easily understood empirical framework for evaluating how modern collective behavior may be changing in the digital age, including whether behavior is becoming more individualistic, as people seek out exactly what they want, or more social, as people become more inextricably linked, even “herdlike,” in their decision making. We believe the map will lead to many new testable hypotheses concerning human behavior as well as to similar applications throughout the social sciences. (shrink)

Here we review concepts related to an ensemble description of G-protein-coupled receptors. The ensemble is characterized by both inactive and active states, whose equilibrium populations and exchange rates depend sensitively on ligand, environment, and allosteric factors. This review focuses on the adenosine A2 receptor, a prototypical class A GPCR. 19F Nuclear Magnetic Resonance studies show that apo A2AR is characterized by a broad ensemble of conformers, spanning inactive to active states, and resembling states defined earlier for rhodopsin. In keeping with (...) ideas associated with a conformational selection mechanism, addition of agonist serves to allosterically restrict the overall degrees of freedom at the G protein binding interface and bias both states and functional dynamics to facilitate G protein binding and subsequent activation. While the ligand does not necessarily “induce” activation, it does bias sampling of states, increase the cooperativity of the activation process and thus, the lifetimes of functional activation intermediates, while restricting conformational dynamics to that needed for activation. GPCRs represent a ubiquitous class of transmembrane receptors, responsible for cell signaling and cell homeostasis. Their activation gives rise to conformational changes that allow the receptor to engage downstream partners. Activation can be thought of in terms of a free energy landscape associated with distinct conformers, responsible for the process. Here, the action of ligands is seen to alter this landscape by enabling transitions between key intermediates. (shrink)

Bayesian epistemology has struggled with the problem of regularity: how to deal with events that in classical probability have zero probability. While the cases most discussed in the literature, such as infinite sequences of coin tosses or continuous spinners, do not actually come up in scientific practice, there are cases that do come up in science. I shall argue that these cases can be resolved without leaving the realm of classical probability, by choosing a probability measure that preserves “enough” regularity. (...) This approach also provides a resolution to the McGrew, McGrew and Vestrum normalization problem for the fine-tuning argument. (shrink)

“We are always already thrown into concrete factual circumstances, facing possibilities that we need to come to grips with. By choosing some we exclude others, thus making them no longer possible. What we are thrown into is the past and present, and the possibilities loom ahead of us, though we may try to turn our back on them. The future is the home of the possibilities while the present and past define the circumstances in which we make our choices, circumstances (...) we can no longer affect.” Or so we might say, and there is something right about this way of talking. Our basic conception of ourselves as agents is radically temporally asymmetric. And so we adopt asymmetric metaphors for time: we talk of time having a direction, as flowing from the future, through the present, to the past, closing possibilities that once were open; or perhaps we think of time as a measure of our own movement from the past to the future. Such metaphors are of very limited value. To think of time as having a direction spatializes time; to think of time as flowing or of ourselves as moving in time is to invite the question of how fast it is flowing or how fast we are moving (at one second per second, perhaps, one might quip, thereby inviting the question of why it cannot flow at two seconds per second instead).             Although the metaphors are flawed, we need to come to grips with an inextricable asymmetry between past and future in them. As agents, we deliberate about the future, while the past we can only bewail or rejoice over. We know the future not only through theoretical knowledge, but also through the intentional knowledge that the agent has of the effects she intends to produce. We think a life that started in years of sorrow but ended in great joy is preferable to one that started with a great joy and ended in years of sorrow.. (shrink)

SpinozaÂ’s God is a being with infinite attributes, each of which expresses infinite essence. Does this mean that God has infinitely many attributes, each of which expresses infinite essence, or does God simply have attributes, each of which is infinite and expresses infinite essence? SpinozaÂ’s argumentation in Letter 9 and the Scholium to Prop. I.10 clearly indicates that it is not just each individual attribute that is infinite, but there are in some sense infinitely many of them. This would seem (...) to settle the issue, except that Spinoza never talks of more than two attributes, Extension.. (shrink)

          The production of a number of vaccines involves the use of cell-lines originally derived from fetuses directly aborted in the 1960s and 1970s. Such cell-lines, indeed sometimes the very same ones, are important to on-going research, including at Catholic institutions. The cells currently used are removed by a number of decades and by a significant number of cellular generations from the original cells. Moreover, the original cells extracted from the bodies (...) of the aborted fetuses were transformed to produce the cell lines, since otherwise they would be incapable of the kind of culturing that is required.           It is generally acknowledged by ethicists, including many Catholic ones generally considered to be orthodox, and by the U.S. bishops, that the use of the cell-lines in connection with the production of vaccines is morally permissible. It does not appear that there is a relevant qualitative difference between the use of the cell-lines in vaccines and in research. One might argue that there is certainty of benefit from a vaccine while the benefits of research are uncertain. However, in any given case of the administration of a vaccine to an individual, it is far from certain that such administration will be of benefit to that individual. After all, the individual might never come in contact with someone infected with the disease in question, particularly if the disease is now uncommon in the individual’s locale. Yet, it is morally certain that some of the administrations of the vaccine will be beneficial. This is parallel to the fact that while any one research project might not be beneficial, the history of biomedical research makes it extremely probable, indeed morally certain, that some project involving the use of such cell-lines will be beneficial. There may, of course, be quantitative difference between the cases—the probabilities and benefits may not be equal—but the difference does not seem to be a qualitative one. Therefore, if one accepts the use of the cell-lines in vaccines, one should accept the use in research in at least some conceivable and perhaps actual circumstances.           The main argument I am interested in in favor of the use of the cell-lines proceeds by first granting that the initial abortion and extraction of cells from the deceased fetus was morally gravely illicit. However, the connection between the currently used derived cells and the abortion and original derivation is sufficiently remote that the use becomes licit. Not all fruit of a poisoned tree is poisoned: it can be morally.... (shrink)