This article examines a series of Schelling-like models of residential segregation, in which agents prefer to be in the minority. We demonstrate that as long as agents care about the characteristics of their wider community, they tend to end up in a segregated state. We then investigate the process that causes this and conclude that the result hinges on the similarity of informational states among agents of the same type. This is quite different from Schelling-like behavior and suggests that segregation (...) is an instance of macrobehavior that can arise from a wide variety of micromotives. (shrink)

Biologists frequently draw on ideas and terminology from engineering. Evolutionary systems biology—with its circuits, switches, and signal processing—is no exception. In parallel with the frequent links drawn between biology and engineering, there is ongoing criticism against this cross-fertilization, using the argument that over-simplistic metaphors from engineering are likely to mislead us as engineering is fundamentally different from biology. In this article, we clarify and reconfigure the link between biology and engineering, presenting it in a more favorable light. We do so (...) by, first, arguing that critics operate with a narrow and incorrect notion of how engineering actually works, and of what the reliance on ideas from engineering entails. Second, we diagnose and diffuse one significant source of concern about appeals to engineering, namely that they are inherently and problematically metaphorical. We suggest that there is plenty of fertile ground left for a continued, healthy relationship between engineering and biology. (shrink)

Taking his critique of totalitarianizing conceptions of community as a starting point, this text examines Jean-Luc Nancy's work of an ‘ontology of plural singular being’ for its political implications. It argues that while at first this ontology seems to advocate a negative or an anti-politics only, it can also be read as a ‘theory of communicative praxis’ that suggests a certain ethos – in the form of a certain use of symbols (which is expressed only inaptly by the word ‘style’) (...) that would render the ontological plurality of singulars perceptible and practically effective. Finally, some recent texts by Nancy even sidestep the ontology of being-with and face the question of what politics, faced with demands of justice, could be and what a democratic politics could provide. Both of these aspects in Nancy's work, however, still remain to be spelled out more politically. (shrink)

Historically, one of the most controversial aspects of Darwinian evolution has been the prominent role that randomness and random change play in it. Most biologists agree that mutations in DNA have random effects on fitness. However, fitness is a highly simplified scalar representation of an enormously complex phenotype. Challenges to Darwinian thinking have focused on such complex phenotypes. Whether mutations affect such complex phenotypes randomly is ill understood. Here I discuss three very different classes of well-studied molecular phenotypes in which (...) mutations cause nonrandom changes, based on our current knowledge. What is more, this nonrandomness facilitates evolutionary adaptation. Thus, living beings may translate DNA change into nonrandom phenotypic change that facilitates Darwinian evolution. (shrink)

Systems involving many interacting variables are at the heart of the natural and social sciences. Causal language is pervasive in the analysis of such systems, especially when insight into their behavior is translated into policy decisions. This is exemplified by economics, but to an increasing extent also by biology, due to the advent of sophisticated tools to identify the genetic basis of many diseases. It is argued here that a regularity notion of causality can only be meaningfully defined for systems (...) with linear interactions among their variables. For the vastly more important class of nonlinear systems, no such notion is likely to exist. This thesis is developed with examples of dynamical systems taken mostly from mathematical biology. It is discussed with particular reference to the problem of causal inference in complex genetic systems, systems for which often only statistical characterizations exist. (shrink)

Mutational robustness facilitates evolutionary innovations. Gene duplications are unique kinds of mutations, in that they generally increase such robustness. The frequent association of gene duplications in regulatory networks with evolutionary innovation is thus a special case of a general mechanism linking innovation to robustness. The potential power of this mechanism to promote evolutionary innovations on large time scales is illustrated here with several examples. These include the role of gene duplications in the vertebrate radiation, flowering plant evolution and heart development, (...) which encompass some of the most striking innovations in the evolution of life. BioEssays 30:367–373, 2008. © 2008 Wiley Periodicals, Inc. (shrink)

Obwohl Claude Lefort auaerhalb Frankreichs nur Eingeweihten bekannt sein durfte, war er einer der einflussreichsten politischen Theoretiker fur den franzosischen Diskurs seit dem Zweiten Weltkrieg. Nach dem Krieg hatte er in diversen Projekten an der Etablierung einer franzosischen kritischen Linken pragend mitgewirkt, die sich gegen die partei- und Sowjetunionstreue Linie Sartres durchzusetzen hatte. So entwickelte er ein Verstandnis des kommunistischen Totalitarismus, das dann gleichsam eine Kontrastfolie fur seine Demokratie- und Menschenrechtstheorie abgeben konnte. In allen diesen Aspekten lassen sich wesentliche Entwicklungen (...) auch der internationalen politiktheoretischen Debatten auf seine Diskussionsbeitrage zuruckfuhren. Am bekanntesten ist sicherlich seine These von der Verortung des Kerns der Demokratie in einer streitbaren Zivilgesellschaft, welche sich der staatlichen Kontrolle ebenso entzieht, wie sie die Besetzung des "leeren Ortes der Macht" durch die politischen Akteure verhindert. Der Band rekonstruiert die Demokratie- und Politiktheorie Leforts und bettet jene bekannte These in vielfaltige und sehr viel weiter reichende theoretische Kontexte ein. In der Arbeit mit den Ideen Leforts konnen die Beitrager daruber hinaus zeigen, dass Leforts Theorie auch fur aktuelle Phanomene und Debatten (wie z.B. die Occupy!-Bewegung, die Debatte um den Populismus und diejenige um die Konstitutionalisierung des Volkerrechts) nach wie vor von groaer Originalitat und ungeminderter Bedeutung ist. (shrink)

Es scheint mir fruchtbar, bestimmte theologisch-anthropologische Grundkonzeption des Alten Testaments im Rahmen des Imperfektibilitäts-Diskurses zu beschreiben. Ausgangspunkt für die besonders an Gen 6,5 (im Kontext von Gen 6-8) anknüpfende Position der „Unfähigkeit des Menschen zur Vervollkommnung“: Alle Reflexionen geschehen in Gen 6,5ff. nur von Gott her und auf das Verhältnis Mensch-Gott hin; es gibt keine individuell/kollektive Unterscheidung bei dieser Problematik, sowohl der einzelne Mensch wie auch die Menschheit sind imperfektibel. Das Konzept ist offen für einen Inklusionsansatz, der vom Differenzprinzip her (...) denkt, verfolgt selbst aber eine andere, theologische, Zielrichtung und führt den Lesenden die Angewiesenheit des Menschen auf Gottes Gnade sowie ihre Zusage vor Augen. (shrink)

In discussing the works of 16th-century theorists Francisco de Vitoria and Alberico Gentili, this article examines how two different conceptions of a global legal community affect the legal character of the international order and the obligatory force of international law. For Vitoria the legal bindingness of ius gentium necessarily presupposes an integrated character of the global commonwealth that leads him to as it were ascribe legal personality to the global community as a whole. But then its legal status and its (...) consequences have to be clarified. For Gentili on the other hand, sovereign states in their plurality are the pinnacle of the legal order(s). His model of a globally valid ius gentium then oscillates between being analogous to private law, depending on individual acceptance by states and being natural law, appearing in a certain sense as a form rather of morality than of law. (shrink)

Recombination is often considered a disruptive force for well‐adapted phenotypes, but recent evidence suggests that this cost of recombination can be small. A key benefit of recombination is that it can help create proteins and regulatory circuits with novel and useful phenotypes more efficiently than point mutation. Its effectiveness stems from the large‐scale reorganization of genotypes that it causes, which can help explore far‐flung regions in genotype space. Recent work on complex phenotypes in model gene regulatory circuits and proteins shows (...) that the disruptive effects of recombination can be very mild compared to the effects of mutation. Recombination thus can have great benefits at a modest cost, but we do not understand the reasons well. A better understanding might shed light on the evolution of recombination and help improve evolutionary strategies in biochemical engineering. (shrink)