Background South Africa is likely to be the first country in the world to host an adolescent HIV vaccine trial. Adolescents may be enrolled in late 2007. In the development and review of adolescent HIV vaccine trial protocols there are many complexities to consider, and much work to be done if these important trials are to become a reality. Discussion This article sets out essential requirements for the lawful conduct of adolescent research in South Africa including compliance with consent requirements, (...) child protection laws, and processes for the ethical and regulatory approval of research. Summary This article outlines likely complexities for researchers and research ethics committees, including determining that trial interventions meet current risk standards for child research. Explicit recommendations are made for role-players in other jurisdictions who may also be planning such trials. This article concludes with concrete steps for implementing these important trials in South Africa and other jurisdictions, including planning for consent processes; delineating privacy rights; compiling information necessary for ethics committees to assess risks to child participants; training trial site staff to recognize when disclosures trig mandatory reporting response; networking among relevant ethics commitees; and lobbying the National Regulatory Authority for guidance. (shrink)
The demand for science trainees to have appropriate responsible conduct of research instruction continues to increase the attention shown by federal agencies and graduate school programs to the development of effective ethics curriculums. However, it is important to consider that the main learning environment for science graduate students and post-doctoral research fellows is within a laboratory setting. Here we discuss an internal laboratory program of weekly 15-minute ethics discussions implemented and used over the last 3 years in addition to the (...) graduate school’s program of scientific integrity training. During this time, the environment and culture within our laboratory has changed to place greater emphasis on the ethical implications of our own research and the research we evaluate. We still struggle with how to accurately assess this behavioral change; although, we present preliminary survey results on the evaluation and impact of this style of curriculum for ethics instruction in our laboratory. (shrink)
This paper develops the outlines of a pragmatic, adaptive management-based approach toward the control of invasive nonnative species (INS) through a case study of Kings Bay/Crystal River, a large artesian springs ecosystem that is one of Florida’s most important habitats for endangered West Indian manatees ( Trichechus manatus ). Building upon recent critiques of invasion biology, principles of adaptive management, and our own interview and participant–observer research, we argue that this case study represents an example in which rigid application of (...) invasion biology’s a␣priori imperative to minimize INS has produced counterproductive results from both an ecological and social standpoint. As such, we recommend that INS control in Kings Bay should be relaxed in conjunction with an overall program of adaptive ecosystem management that includes meaningful participation and input from non-institutional stakeholders. However, we also note that adaptive management and INS control are by no means mutually exclusive, in Kings Bay or elsewhere. Instead, we suggest that adaptive management offers a means by which INS control efforts can emerge from—and be evaluated through—ongoing scientific research and participatory dialogue about the condition of specific places, rather than non-contextual assumptions about the harmfulness of INS as a general class. (shrink)
The resercher Ann Talbot presents in this book one of the more complex and in-depth studies ever written about the influence of travel literature on the work of the British philospher John Locke (1632-1704). At the end of the 18th century the study of travel literature was an alternative to academic studies. The philosopher John Locke recommended with enthousiasm these books as a way to comprehend human understanding. Several members of the Royal Society like John Harris (1966-1719) affirmed that the (...) learning that could be obtained through these books was different from the one that provided the educative system of that time. Travel literature could make see the source of the ignorance of the ancients; it stressed the curiosities and extraordinary facts and led to a revision of beliefs and scientific theories of the ancient world. Besides the account of a broad diversity of sujects contributed to the creation of matters of fact, and this was important in order to put rational limits to the descriptions of the world that were commonly accepted. (shrink)
In what follows, I analyze Ralph Strode's treatise on obligations. I have used a hitherto unpublished edition of the text (based on 14 manuscripts) made by Prof. E.J. Ashworth. I first give a brief description of Strode's text, which is all the more necessary given that it is not available to the average reader; I also offer a reconstruction of the rules proposed by Strode, following the style of reconstruction used in my analysis of Burley's and Swyneshed's (...) rules elsewhere—that is, essentially based on the idea that obligationes can be viewed as logical games. In the second part, I address Strode's explicit arguments contra Swyneshed. In the third part, I discuss Strode's epistemic and pragmatic approach to obligationes. (shrink)
Jo Ann Boydston, 2 July 1924 - 25 January 2011Jo Ann Boydston enjoyed a distinguished career as general editor of the Collected Works of John Dewey and director of the Center for Dewey Studies at Southern Illinois University Carbondale. Born in Poteau, Oklahoma of Choctaw Indian heritage, she graduated summa cum laude from Oklahoma State University in 1944. She received an M.A. from Oklahoma State (1947), a Ph.D. from Columbia University (1950), and honorary doctorates from Indiana University (1994) and Southern (...) Illinois University (2004).In 1961, Boydston joined the staff of a modest research project at Southern Illinois University called "Co-operative Research on Dewey Publications" as assistant to project .. (shrink)
This book constitutes the refereed proceedings of the 14th International Conference on Theory and Applications of Satisfiability Testing, SAT 2011, held in Ann Arbor, MI, USA in June 2011.The 25 revised full papers presented together with ...