Investigating the relative severity of emotion recognition deficit across different clinical and high-risk populations has potential implications not only for the prevention, diagnosis and treatment of these diseases, but also for our understanding of the neurobiological mechanisms of emotion perception itself. We reanalyzed data from 4 studies in which we examined facial expression and gender recognition using the same tasks and stimuli. We used a standardized and bias-corrected measure of effect size (Cohen’s D) to assess the extent of impairments in (...) frontotemporal dementia (FTD), Parkinson’s disease treated by L-DOPA (PD-ON) or not (PD-OFF), amnestic Mild Cognitive Impairment (aMCI), Alzheimer’s disease at mild dementia stage (AD), major depressive disorder (MDD), remitted schizophrenia (SCZ-rem), first-episode schizophrenia before (SCZ-OFF) and after (SCZ-ON) medication, as well as unaffected siblings of partients with schizophrenia (SIB). Analyses revealed a pattern of differential impairment of emotion (but not gender) recognition, consistent with the extent of impairment of the fronto-temporal neural networks involved in the processing of faces and facial expressions. Our transnosographic approach combining clinical and high-risk populations with the impact of medication brings new information on the trajectory of impaired emotion perception in neuropsychiatric conditions, and on the neural networks and neurotransmitter systems subserving emotion perception. (shrink)
Depue & Morrone-Strupinsky's (D&M-S's) model of affiliation meets the criteria advanced for the definition of behavior systems and endophenotypes. We argue that its application in psychiatry could be useful for identifying a biological pathophysiology common to a variety of conditions that are currently classified in very different categories of psychiatric nosography, including autism, schizoid personality, primary psychopathy, and dismissing attachment.
This volume collects essays by philosophers and scholars working at the interface of Western philosophy and Buddhist Studies. Many have distinguished scholarly records in Western philosophy, with expertise in analytic philosophy and logic, as well as deep interest in Buddhist philosophy. Others have distinguished scholarly records in Buddhist Studies with strong interests in analytic philosophy and logic. All are committed to the enterprise of cross-cultural philosophy and to bringing the insights and techniques of each tradition to bear in order to (...) illuminate problems and ideas of the other. These essays address a broad range of topics in the philosophy of mind, philosophy of language, logic, epistemology, and metaphysics, and demonstrate the fecundity of the interaction between the Buddhist and Western philosophical and logical traditions. (shrink)
The paradox which characterizes the modern states system is that the dual structure of sovereignty and justice through which the system was originally conceived is no more, yet the system is still with us. Justice was redefined in the 19th century as a mere derivation of state sovereignty, a process reducing the focus of the system to sovereignty alone and thus dispossessing the system of a principle to mediate between the sovereign will and the international community. It is argued in (...) this essay that the lack of a mediating principle may signify violence as inherent in the system, subsequently making intervention and terrorism facets of the established order rather than anomalies. Relying greatly on recent critical international legal studies, the article asks if the strategies suggested by lawyers such as AnthonyD'Amato and Rosalyn Higgins to cope with the paradox, coupled with the contemporary universal human rights arguments, signal a move towards restoring the historical focus of the system. (shrink)
1. Introduction: Machiavelli's method and his interpreters, by A. Parel.--2. Machiavelli's humanism of action, by N. Wood.--3. Machiavelli's thoughts on the psyche and society, by D. Germino.--4. Success and knowledge in Machiavelli, by A. Kontos.--5. Necessity in the beginnings of cities, by H. Mansfield.--6. The concept of fortuna in Machiavelli, by T. Flanagan.--7. In search of Machiavellian virtu, by J. Plamenatz.--8. Machiavelli minore, by A. Parel.--9. The relevance of Machiavelli to contemporary world politics, by A. D'Amato.
Questions regarding what exists are central to various forms of Buddhist philosophy, as they are to many traditions of philosophy. Interestingly, there is perhaps a clearer consensus in Buddhist thought regarding what does not exist than there may be regarding precisely what does exist, at least insofar as the doctrine of anātman (no self, absence of self) is taken to be a fundamental Buddhist doctrine. It may be noted that many forms of Mahāyāna Buddhist philosophy in particular are considered to (...) offer a quite austere ontology—a rather ‘empty’ account of what exists. Continuing in this vein of ontological austerity, here I will attempt to lay out a relatively novel approach to Buddhist ontology, viz. Buddhist fictionalism. (shrink)