If stem cell-based therapies are developed, we will likely confront a difficult problem of justice: for biological reasons alone, the new therapies might benefit only a limited range of patients. In fact, they might benefit primarily white Americans, thereby exacerbating long-standing differences in health and health care.
We report on the deliberations of an interdisciplinary group of experts in science, law, and philosophy who convened to discuss novel ethical and policy challenges in stem cell research. In this report we discuss the ethical and policy implications of safety concerns in the transition from basic laboratory research to clinical applications of cell-based therapies derived from stem cells. Although many features of this transition from lab to clinic are common to other therapies, three aspects of stem cell biology pose (...) unique challenges. First, tension regarding the use of human embryos may complicate the scientific development of safe and effective cell lines. Second, because human stem cells were not developed in the laboratory until 1998, few safety questions relating to human applications have been addressed in animal research. Third, preclinical and clinical testing of biologic agents, particularly those as inherently complex as mammalian cells, present formidable challenges, such as the need to develop suitable standardized assays and the difficulty of selecting appropriate patient populations for early phase trials. We recommend that scientists, policy makers, and the public discuss these issues responsibly, and further, that a national advisory committee to oversee human trials of cell therapies be established. **NB we did not reccommend a NAC, we think it might be appropriate**. (shrink)
Besides seeing a rabbit or seeing that the rabbit is grayish, do we also sometimes see barely just the particular animal (not as an animal or as anything) or the feature rabbitness or grayness? Such bare, nonverbalizable perception is called "indeterminate perception" (nirvikalpaka pratyakṣa) in Nyāya. Standard Nyāya postulates such pre-predicative bare perception in order to honor the rule that awareness of a qualified entity must be caused by awareness of the qualifier. After connecting this issue with the Western debate (...) concerning the "myth of the given," seven distinct arguments are presented showing that the very notion of such indeterminate perception is epistemically otiose and that the Nyāya theory of perception is better off without it. (shrink)
Some ten years ago an interesting discussion took place in the pages of this journal. It began with an article by Arindam Chakrabarti (2000) whose title betrays its intention: "Against Immaculate Perception: Seven Reasons for Eliminating Nirvikalpaka Perception from Nyāya." There followed a response by Stephen H. Phillips (2001), "There's Nothing Wrong with Raw Perception: A Response to Chakrabarti's Attack on Nyāya's Nirvikalpaka Pratyakṣa," which in turn was commented upon in Chakrabarti's "Reply to Stephen Phillips" (2001).This discussion, as is (...) clear from the titles, concerns the need and even possibility of nirvikalpaka perception. What Chakrabarti tries to do is "to show why we can easily do without .. (shrink)
Witnessing the fate of the various definitions of truth, Donald Davidson has recently called the very drive to define truth a “folly.” Before him, Kant and Frege had given independent arguments why a general definition of truth is impossible. After a quick summary of their arguments, I recount several reasons that Gangeśa gave for not counting truth as a genuine natural universal. I argue that in spite of defining truth as a feature of personal and ephemeral awareness episodes, the Nyāya (...) ya realists such as Gangeśa could maintain that truth is independent of recognition of truth. In the course of my argument, I also show that Roy Perrett’s alleged proof against realism does not succeed. I conclude that realism does not need nonmental atemporal truth-bearers (propositions) which are eternally wholly true (or wholly false), and that knowledge-independence from truths and things can be shown without admitting the existence of unknowable things or truths. (shrink)
Amartya Sen has made deep and lasting contributions to the academic disciplines of economics, philosophy, and the social sciences more broadly. He has engaged in policy dialogue and public debate, advancing the cause of a human development focused policy agenda, and a tolerant and democratic polity. This argumentative Indian has made the case for the poorest of the poor, and for plurality in cultural perspective. It is not surprising that he has won the highest awards, ranging from the Nobel Prize (...) in Economics to the Bharat Ratna, India's highest civilian honor. This public recognition has gone hand in hand with the affection and admiration that Amartya's friends and students hold for him. -/- This volume of essays, written in honor of his 75th birthday by his students and peers, covers the range of contributions that Sen has made to knowledge. They are written by some of the world's leading economists, philosophers and social scientists, and address topics such as ethics, welfare economics, poverty, gender, human development, society and politics. This first volume covers the topics of Ethics, Normative Economics and Welfare; Agency, Aggregation and Social Choice; Poverty, Capabilities and Measurement; and Identity, Collective Action and Public Economics. It is a fitting tribute to Sen's own contributions to the discourse on Ethics, Welfare and Measurement. -/- Contributors include: Sabina Alkire, Paul Anand, Sudhir Anand, Kwame Anthony Appiah, A. B. Atkinson, Walter Bossert, Francois Bourguignon, John Broome, Satya R. Chakravarty, Rajat Deb, Bhaskar Dutta, James E. Foster, Wulf Gaertner, Indranil K. Ghosh, Peter Hammond, Christopher Handy, Christopher Harris, Satish K. Jain, Isaac Levi, Oliver Linton, S. R. Osmani, Prasanta K. Pattanaik, Edmund S. Phelps, Mozaffar Qizilbash, Martin Ravallion, Kevin Roberts, Ingrid Robeyns, Maurice Salles, Cristina Santos, T. M. Scanlon, Arjun Sengupta, Tae Kun Seo, Anthony Shorrocks , Ron Smith, Joseph E. Stiglitz, S. Subramanian, Kotaro Suzumura, Alain Trannoy, Guanghua Wan, John A. Weymark, and Yongsheng Xu. (shrink)
This paper proposes relative and absolute measures of deprivation using social satisfaction functions. The relative (absolute) measure gives us the amount by which social satisfaction can be increased in proportional (absolute) terms by redistributing incomes equally. We also demonstrate the existence of a relationship between summary indices of deprivation (including the Gini coefficient, the maximin index, the coefficient of variation and their absolute counterparts) and social satisfaction.
Amartya Sen has made deep and lasting contributions to the academic disciplines of economics, philosophy, and the social sciences more broadly. He has engaged in policy dialogue and public debate, advancing the cause of a human development focused policy agenda, and a tolerant and democratic polity. This argumentative Indian has made the case for the poorest of the poor, and for plurality in cultural perspective. It is not surprising that he has won the highest awards, ranging from the Nobel Prize (...) in Economics to the Bharat Ratna, India's highest civilian honor. This public recognition has gone hand in hand with the affection and admiration that Amartya's friends and students hold for him. -/- This volume of essays, written in honor of his 75th birthday by his students and peers, covers the range of contributions that Sen has made to knowledge. They are written by some of the world's leading economists, philosophers and social scientists, and address topics such as ethics, welfare economics, poverty, gender, human development, society and politics. -/- Contributors include: Bina Agarwal, Isher Ahluwalia, Montek S Ahluwalia, Ingela Alger, Sabina Alkire, Paul Anand, Sudhir Anand, Kwame Anthony Appiah, Muhammad Asali, Department of Economics, A. B. Atkinson, Amiya Kumar Bagchi, Pranab Bardhan, Lourdes Benería, Francois Bourguignon, Sugata Bose, Walter Bossert, John Broome, Satya R. Chakravarty, Lincoln C. Chen, Martha Alter Chen, Kanchan Chopra, Rajat Deb, Simon Dietz, Bhaskar Dutta, James E. Foster, Sakiko Fukuda-Parr, Wulf Gaertner, Indranil K. Ghosh, Jonathan Glover, Peter Hammond, Christopher Handy, Christopher Harris, Cameron Hepburn, Jane Humphries, Rizwanul Islam, Satish K. Jain, Ayesha Jalal, Mary Kaldor, Sunil Khilnani, Stephan Klasen, Jocelyn Kynch, Isaac Levi, Oliver Linton, Enrica Chiappero Martinetti, Kirsty McNay, Martha C. Nussbaum, Siddiqur R. Osmani, Elinor Ostrom, Prasanta K. Pattanaik, Edmund S. Phelps, Mozaffar Qizilbash, Gustav Ranis, Martin Ravallion, Sanjay G. Reddy, Kevin Roberts, Ingrid Robeyns, Maurice Salles, Emma Samman, Cristina Santos, Thomas. M. Scanlon, Arjun Sengupta, Tae Kun Seo, Anthony Shorrocks, Ronald Smith, Rehman Sobhan, Robert M. Solow, Nicholas Stern, Frances Stewart, Joseph E. Stiglitz, S. Subramanian, Kotaro Suzumura, Alain Trannoy, Ashutosh Varshney, Sujata Visaria, Guanghua Wan, Jörgen W. Weibull, John A. Weymark, and Yongsheng Xu. (shrink)
