Abstract Human rights education is an essential part of preparation for participation in a pluralistic democracy. As Europe aspires to be a continent of democratic states accepting human rights as their basic principles, a human rights ethic should be a feature of all schools within Europe. Human rights education provides an ethical and moral framework for living in community. Moreover, this ethical position is backed in Europe by the powerful legal framework of the European Convention on Human Rights. This paper (...) describes the features of two teachers? human rights education courses based on a structure proposed by Richardson. Both explore the relationship between moral and legal aspects of human rights teaching. The Council of Europe Recommendation on ?Teaching and Learning about Human Rights in Schools? identifies three broad dimensions of human rights education, namely: skills, knowledge and feelings. The latter affective dimension, as well as facts and pedagogy, is critical to successful teacher education in human rights. (shrink)
This volume examines the influence that Epicureanism and Stoicism, two philosophies of nature and human nature articulated during classical times, exerted on the development of European thought to the Enlightenment. Although the influence of these philosophies has often been noted in certain areas, such as the influence of Stoicism on the development of Christian thought and the influence of Epicureanism on modern materialism, the chapters in this volume forward a new awareness of the degree to which these philosophies and their (...) continued interaction informed European intellectual life well into early modern times. The influence of the Epicurean and Stoic philosophies in the areas of literature, philosophy, theology, and science are considered. Many thinkers continue to perceive these philosophies as significant alternatives for understanding the human and natural worlds. Having become incorporated into the canon of philosophical alternatives, Epicureanism and Stoicism continued to exert identifiable influences on scientific and philosphical thought at least until the middle of the eighteenth century. (shrink)
INTRODUCTORY REMARKS It is my lot, if not my duty, in presenting these opening remarks at our conference, to take the title of our meeting seriously. ...
The logical empiricists often appear as a foil for feminist theories. Their emphasis on the individualistic nature of knowledge and on the value-neutrality of science seems directly opposed to most feminist concerns. However, several recent works have highlighted aspects of Carnap's views that make him seem like much less of a straightforwardly positivist thinker. Certain of these aspects lend themselves to feminist concerns much more than the stereotypical picture would imply.
This book is about the influence of varying theological conceptions of contingency and necessity on two versions of the mechanical philosophy in the seventeenth century. Pierre Gassendi (1592-1655) and Rene; Descartes (1596-1650) both believed that all natural phenomena could be explained in terms of matter and motion alone. They disagreed about the details of their mechanical accounts of the world, in particular about their theories of matter and their approaches to scientific method. This book traces their differences back to theological (...) presuppositions they inherited from the Middle Ages. Theological ideas were transformed into philosophical and scientific ideas which led to the emergence of different styles of science in the second half of the seventeenth century. (shrink)
Writing about the history of science and the history of philosophy involves assumptions about the role of context and about the relationships between past and present ideas. Some historians emphasize the context, concentrating on the intellectual, personal, and social factors that affect the way earlier thinkers have approached their subject. Analytic philosophers take a critical approach, considering the logic and merit of the arguments of past thinkers almost as though they are engaging in contemporary debates. Some philosophers use the ideas (...) of historical figures to support their own philosophical agendas. Scholarly studies of the French natural philosopher Pierre Gassendi (1592–1655) exemplify many of these .. (shrink)
Professor Margaret Jo Osler of the University of Calgary, an historian of early modern science and philosophy (and a member of the Board of Directors of the Journal of the History of Philosophy since 2002) died on September 15, 2010. Born on November 27, 1942, she proudly proclaimed herself to be a "red diaper baby" and particularly delighted in telling her right-wing friends how her middle name was her parents' homage to Stalin. An energetic scholar with a vibrant and (...) positive personality, Maggie, as everyone who worked with her came to call her, never considered retirement and was actively working right up to her diagnosis with pancreatic cancer in early July, 2010.After graduating from Swarthmore College in .. (shrink)
This essay reviews some of the issues associated with the challenge of integrating the concepts of medical professionalism into the socialization and identity formation of the undergraduate medical student. A narrative-based approach to the integration of professionalism in medical education proposed by Coulehan (Acad Med 80(10):892–898, 2005) offers an appealing method to accomplish the task in a less didactic format and in a way that promotes more personal growth. In this essay, I review how the Osler Student Societies of (...) the University of Texas Medical Branch developed and how they offer a convenient vehicle to carry out this narrative-based approach to professionalism. Through mentor-modeled professional behavior, opportunities for student self-reflection, the development of narrative skills through reflection on great literature, and opportunities for community service, the Osler Student Societies provide a ready-made narrative-based approach to medical professionalism education. (shrink)
Globalization, a process characterized by the growing interdependence of the world's people, impacts health systems and the social determinants of health in ways that are detrimental to health equity. In a world in which there are few countervailing normative and policy approaches to the dominant neoliberal regime underpinning globalization, the human rights paradigm constitutes a widely shared foundation for challenging globalization's effects. The substantive rights enumerated in human rights instruments include the right to the highest attainable level of physical and (...) mental health and others that are relevant to the determinants of health. The rights stipulated in these documents impose extensive legal obligations on states that have ratified these documents and confer health entitlements on their residents. Human rights norms have also inspired civil society efforts to improve access to essential medicines and medical services, particularly for HIV/AIDS. Nevertheless, many factors reduce the potential counterweight human rights might exert, including and specifically the nature of the human rights approach, weak political commitments to promoting and protecting health rights on the part of some states and their lack of institutional and economic resources to do so. Global economic markets and the relative power of global economic institutions are also shrinking national policy space. This article reviews the potential contributions and limitations of human rights to achieving greater equity in shaping the social determinants of health. (shrink)
There are two general questions which many views in the philosophy of mathematics can be seen as addressing: what are mathematical objects, and how do we have knowledge of them? Naturally, the answers given to these questions are linked, since whatever account we give of how we have knowledge of mathematical objects surely has to take into account what sorts of things we claim they are; conversely, whatever account we give of the nature of mathematical objects must be accompanied by (...) a corresponding account of how it is that we acquire knowledge of those objects. The connection between these problems results in what is often called “Benacerraf’s Problem”, which is a dilemma that many philosophical views about mathematical objects face. It will be my goal here to present a view, attributed to Richard Dedekind, which approaches the initial questions in a different way than many other philosophical views do, and in doing so, avoids the dilemma given by Benacerraf’s problem. (shrink)
van Bentham et al. (Merging frameworks for interaction: DEL and ETL, 2007) provides a framework for generating the models of Epistemic Temporal Logic ( ETL : Fagin et al., Reasoning about knowledge, 1995; Parikh and Ramanujam, Journal of Logic, Language, and Information, 2003) from the models of Dynamic Epistemic Logic ( DEL : Baltag et al., in: Gilboa (ed.) Tark 1998, 1998; Gerbrandy, Bisimulations on Planet Kripke, 1999). We consider the logic TDEL on the merged semantic framework, and its extension (...) with the labeled past-operator “ P ϵ ” (“The event ϵ has happened before which. . .”). To axiomatize the extension, we introduce a method for transforming a given model into a normal form in a suitable sense. These logics suggest further applications of DEL in the theory of agency, the theory of learning, etc. (shrink)
It is a commonly held view that Dedekind’s construction of the real numbers is impredicative. This naturally raises the question of whether this impredicativity is justified by some kind of Platonism about sets. But when we look more closely at Dedekind’s philosophical views, his ontology does not look Platonist at all. So how is his construction justified? There are two aspects of the solution: one is to look more closely at his methodological views, and in particular, the places in which (...) predicativity restrictions ought to be applied; another is to take seriously his remarks about the reals as things created by the cuts, instead of considering them to be the cuts themselves. This can lead us to make finer-grained distinctions about the extent to which impredicative definitions are problematic, since we find that Dedekind’s use of impredicative definitions in analysis can be justified by his (non-Platonist) philosophical views. (shrink)
Any study of the 'Scientific Revolution' and particularly Descartes' role in the debates surrounding the conception of nature (atoms and the void v. plenum theory, the role of mathematics and experiment in natural knowledge, the status and derivation of the laws of nature, the eternality and necessity of eternal truths, etc.) should be placed in the philosophical, scientific, theological, and sociological context of its time. Seventeenth-century debates concerning the nature of the eternal truths such as '2 + 2 = 4' (...) or the law of inertia turn on the question of whether these truths were created along with nature, or were uncreated and subsisting in God's mind. One's answer to that question has direct consequences for conceptions of the necessity/contingency of mathematical and natural knowledge, how knowledge of such truths is accomplished by humans, and what grounds these truths. In this paper, I review the positions of four successors to Descartes' philosophy on the question of the eternal truths to illustrate how in specific ways that question with its theological, metaphysical, modal, and epistemological dimensions concerned the objectivity and certainty of the discoveries of the new science. Author Recommends: Clarke, Desmond. Descartes' Philosophy of Science . University Park, Penn State Press, 1982. This work provides an account of Descartes as a practicing scientist whose rationalism is mitigated by reliance on experiment and experience. Author re-examines Descartes' philosophical and scientific works in this new light. Dear, Peter. Revolutionizing the Sciences: European Knowledge and its Ambitions, 1500–1700 . Princeton, Princeton University Press, 2001. This work provides a useful overview of the issues and thinkers of the Scientific Revolution. Of particular relevance is chapter 8 on Cartesian and Newtonian science. Funkenstein, Amos. Theology and the Scientific Imagination from the Middle Ages to the Seventeenth Century . Princeton, Princeton University Press, 1986. This work is an advanced study of the theological and metaphysical foundations of early modern science. Discussions include questions of God's nature, God's knowledge in relation to human knowledge, providence, the laws of nature, and the truths of mathematics. In particular, chapter 3 discusses Descartes' account of the eternal truths and divine omnipotence. Garber, Daniel. Descartes' Metaphysical Physics . Chicago, University of Chicago Press, 1992. This work examines how Descartes' metaphysical doctrines of God, soul, and body set the groundwork for his physics. It includes a study of God and the grounds for the laws of physics (chapter 9). Henry, John. The Scientific Revolution and the Origins of Modern Science . 3rd ed. New York, Palgrave, Macmillan Press, 2008. This work provides a brief, general, and informative overview of the Scientific Revolution, including the themes of method, magic, religion, and culture. Osler, Margaret J. Divine Will and the Mechanical Philosophy: Gassendi and Descartes on Contingency and Necessity in the Created World . Cambridge, Cambridge University Press, 1994. This work is an examination and comparison of the mechanical philosophies of Gassendi and Descartes. It offers in-depth discussion of the issue of voluntarism and intellectualism in the period and how that related to conceptions of laws of nature and the eternal truths. Shapin, Steven. The Scientific Revolution . Chicago, University of Chicago Press, 1996. This work provides a critical synthesis of as well as a guide to recent scholarship in the history of science for a general readership. Online Materials Dr. Robert A. Hatch's Scientific Revolution Website: http://web.clas.ufl.edu/users/rhatch/pages/03-Sci-Rev/SCI-REV-Home/ A compendium of resources for the study of Scientific Revolution. Early English Books Online: http://eebo.chadwyck.com/home Early English Books Online (EEBO) contains digital facsimile page images of virtually every work printed in England, Ireland, Scotland, Wales and British North America and works in English printed elsewhere from 1473 to 1700. Early Modern Resources: http://www.earlymodernweb.org.uk/emr/ Early Modern Resources is a gateway for all those interested in finding electronic resources relating to the early modern period in history. Gallica, the Digital Library of the Bibliothèque Nationale de France: http://gallica.bnf.fr/ An ever-growing digital library which includes numerous primary and secondary texts of relevance to Descartes and his role in Scientific Revolution. Hatfield, Gary, 'René Descartes', The Stanford Encyclopedia of Philosophy. Spring 2009 ed. Ed. Edward N. Zalta; URL: http://plato.stanford.edu/archives/spr2009/entries/descartes/ Slowik, Edward, 'Descartes' Physics', The Stanford Encyclopedia of Philosophy. Winter 2008 ed. Ed. Edward N. Zalta; URL: http://plato.stanford.edu/archives/win2008/entries/descartes-physics/ Syllabus Sample Syllabus: Cartesian Science The following is five weeks covering Cartesian Science in a course on Descartes or the Scientific Revolution, or 17th-century theories of matter, or related themes on early modern truth and method, especially on the continent. This material is best suited to a graduate level audience, but it could be modified to suit an upper-division undergraduate course, as the readings are basically primary texts whose context and background can be explained in lectures. Week 1: Cartesian Revolution in France • Scientific method • Role of mathematics and experiment • Certainty of scientific knowledge Readings: Hatfield, Gary, 'René Descartes', The Stanford Encyclopedia of Philosophy. Spring 2009 ed. Ed. Edward N. Zalta; URL: http://plato.stanford.edu/archives/spr2009/entries/descartes/ Descartes, Discourse on Method , Parts 1–3 Descartes, Meditations on First Philosophy , First Meditation. Week 2: Descartes' Scientific Treatises • Mechanization and mathematization of nature • Primary–secondary quality distinction Readings: Discourse on Method, Parts 4–6 Selections from Descartes' Scientific Essays: The World or Treatise on Light (ATXI 3–48); Treatise on Man (ATXI 119–202); Optics (ATVI 82–147). Slowik, Edward, 'Descartes' Physics', The Stanford Encyclopedia of Philosophy. Winter 2008 ed. Ed. Edward N. Zalta; URL: http://plato.stanford.edu/archives/win2008/entries/descartes-physics/ Henry, John, 'The Mechanical Philosophy,' chapter 5. The Scientific Revolution and the Origins of Modern Science . 3rd ed. Macmillan, 2008. Week 3: Descartes' Theory of Nature • Descartes' derivation of the law of conservation and the three laws of motion • God's role in the metaphysics and physics of nature Readings: Selections from Principles of Philosophy, Preface (all); Letter to Elizabeth; Part I: 1–8; Part II: 1–45, 55, 64; Part III: 1–4, 15–19, 45–47; Part IV: 187–207. John Henry, 'Religion and Science,' chapter 6. The Scientific Revolution and the Origins of Modern Science . 3rd ed. Macmillan, 2008. Week 4: Post-1650 Cartesian Science: Necessity and Contingency in Nature • Debates on God, Creation, and Causes Readings: Easton, Patricia, 'What is at Stake in the Cartesian Debates on the Eternal Truths?' Philosophy Compass 4.2 (2009): 348–62. Malebranche, Nicolas, 'Elucidation 10', from The Search after Truth (1674). Note: All selections available in Nicolas Malebranche (1992). Philosophical Selections , edited by S. Nadler, Hackett. Gottfried Leibniz (1714) Monadology . Week 5: Causes in Nature and Morals • Theodicy as an explanation of defect and evil in a lawful universe: Malebranche v. Leibniz Readings: Nicolas Malebranche, Elucidation XVI (on occasionalism), and Treatise on Nature and Grace, Discourse One, Part 1. Gottfried Leibniz (1706), Theodicy. Focus Questions Weekly questions can be used to focus the readings. This can be done in a web or e-mail discussion thread, as a weekly assignment, or for in class discussion. I require students to post a short paragraph in response to the question or some posting by a classmate on the question. Students are required to post by 10 a.m. the day before we meet for class on a course website. Week 1: According to Descartes, what role does skepticism play in scientific reasoning? Week 2: Comment on the following: 'But I am supposing this machine to be made by the hands of God, and so I think you may reasonably think it capable of a greater variety of movements than I could possibly imagine in it, and of exhibiting more artistry than I could possibly ascribe to it' [ Treatise on Man ; ATXI 120]. Week 3: What is Descartes' conception of the relation between the metaphysics and physics of nature? Week 4: Critically discuss the positions of Descartes, Malebranche, and Leibniz on what provides the foundation for the certitude of natural knowledge? Week 5: Explain why both Malebranche and Leibniz consider moral sin to be analogous to natural defect? Seminar/Project Idea Hold a debate on the question of the status of the eternal truths. The proposition will be Descartes' position: 'Eternal truths must be both created and necessary if certainty in science is to be possible'. Format: 1. At the beginning of the 5-week module, students will be assigned to one of three roles: Team A, Team B, and judge's panel. Students will be given the debate proposition, but will not be told which team will take the affirmative and which team the negative until the time of the debate. 2. Recommend a variation on the Classic Debate Format to encourage the development of argument: sequence begins with affirmative construction (8 minutes), negative construction (8 minutes), second affirmative construction (8 minutes), second negative construction (8 minutes), first negative rebuttal (4 minutes), first affirmative rebuttal (4 minutes), final negative rebuttal (4 minutes) and final affirmative rebuttal (4 minutes). 3. Judges Panel: will consist of 3–4 judges who will assess the performance of Teams A and B. Judgment should be based on the persuasiveness of the team position. 4. Debate will be held at the end of the fifth week, or semester, whichever makes most sense given the course length and structure. Acknowledgements The author gratefully acknowledges the immensely helpful comments and suggestions by the participants in her graduate seminar on the Scientific Revolution: Benjamin Chicka, Sarah Jacques-Ross, Richard Ross, Marcella Stockstill, and Zohra Wolters. (shrink)
An ad hominem fallacy is committed when an individual employs an irrelevant personal attack against an opponent instead of addressing that opponent’s argument. Many discussions of such fallacies discuss judgments of relevance about such personal attacks, and consider how we might distinguish those that are relevant from those that are not. This paper will argue that the literature on bias and testimony can helpfully contribute to that analysis. This will highlight ways in which biases, particularly unconscious biases, can make ad (...) hominem fallacies seem effective, even when the irrelevance is recognized. (shrink)
Organizational citizenship behaviors (OCBs) are essential for effective organizational functioning. Decisions by employees to engage in these important discretionary behaviors are based on how they make sense of the organizational context. Using fairness heuristic theory, we tested two important OCB predictors: manager trustworthiness and interactional justice. In the process, we control for the effects of dispositional factors (propensity to trust) and for system-based organizational fairness (procedural and distributive justice). Results, based on surveys collected from 120 employee–supervisor dyads, indicate that manager (...) trustworthiness explains variance in OCBs over and above the variance accounted for by interactional fairness. Implications for theory and practice are discussed. (shrink)
Historically, the Vienna Circle and the Dessau Bauhaus were related, with members of each group familiar with the ideas of the other. Peter Galison argues that their projects are related as well, through shared political views and methodological approach. The two main figures that connect the Vienna Circle to the Bauhaus—and the figures upon which Galison focuses—are Rudolf Carnap and Otto Neurath. Yet the connections that Galison develops do not properly capture the common themes between the Bauhaus and Neurath’s philosophical (...) projects. We demonstrate this by considering Neurath’s philosophical commitments. We suggest different connections between Neurath’s projects and the Bauhaus, connections that are both substantive and philosophically interesting. (shrink)
The logical empiricists often appear as a foil for feminist theories. Their emphasis on the individualistic nature of knowledge and on the value-neutrality of science seems directly opposed to most feminist concerns. However, several recent works have highlighted aspects of Carnap's views that make him seem like much less of a straightforwardly positivist thinker. Certain of these aspects lend themselves to feminist concerns much more than the stereotypical picture would imply.
The perennial issue of the distinctiveness of the mental health nurse (MHN) is once again to the fore. Previous attempts to resolve this apparent identity crisis in the discipline have included proposals for new models, new research and new educational preparation as well as new alliances, and new ways of practising. Now the politically driven concept of the generic nurse is gaining enough momentum to potentially end the discussion once and for all. This paper takes a postmodernist approach to MHN (...) identity that questions the requirement for MHNs to articulate their distinctiveness, and offers alternative constructions of this identity to those promulgated by policy makers and by other health disciplines. (shrink)
The frequency of earnings restatements has been increasing over the last decade. Restating previous earnings erodes perceived trustworthiness and competence of management, giving firms strong incentives to take actions to enhance perceived credibility of future financial reports [Farber, D. B.: 2005, The Accounting Review 80(2), 539–561.]. Using an experimental case, we examine the ability of post-restatement actions taken by a firm to positively influence non-professional investors’ perceptions of management’s financial reporting credibility. Our examination considers credibility judgments following two types of (...) restatements – those resulting from fraud in which the character, ethics, and values of an organization may be called into question [cf. Copeland, Jr., J. E.: 2005, Accounting Horizons 19(1), 35–43.], and those resulting from non-fraud (i.e., aggressive accounting). Based on the information in the experimental case, non-professional investors take the role of potential equity investors and make a judgment about management’s financial reporting credibility after reviewing a set of post-restatement actions taken by a firm. The possible actions include changes in four corporate governance mechanisms (i.e., internal audit function, external audit firm, board of directors, CFO) and a buyback of company stock. Our results provide an important contribution to the literature by demonstrating that among non-professional investors, perceptions of management’s financial reporting credibility are affected both by the post-restatement action taken and the nature of the restatement. These results offer insight into the formation of a key credibility judgment made by non-professional investors following a trust-destroying event, an earnings restatement. (shrink)
My subject is ambitious, the state of health care globally in 2012. As William Osler's most recent biographer, I'm often asked what Osler, who died in 1919, would say about this or that issue in health care if he were alive today. My usual, and safe, answer is that I don't know. But in some cases I think I do know, and in this case I will attempt a broad answer. Suppose Osler were asked where we are (...) at in the profession and practice of medicine in 2012? What has, say, the last five or six centuries of medical history come down to?First another small thought—about the meaning of history. Historians, as you know, tend to be a skeptical and critical lot. We have an occupational tendency to be particularly skeptical .. (shrink)
Poetry illuminates the work of health care professionals well beyond procedure guidelines, clinic schedules or best practice policy. Poems and commentary from the perspective of a nurse, an emergency medical technician and two physicians are accompanied by an exploration of the meaning of work and the role of medical humanities.
Aristotle’s virtue ethics can teach us about the relationship between our habits and our actions. Throughout his works, Aristotle explains much about how one may develop a virtuous character, and little about how one might change from one character type to another. In recent years criminal law has been concerned with the issue of recidivism and how our system might reform the criminals we return to society more effectively. This paper considers how Aristotle might say a vicious person could change (...) and what a penal system could do to facilitate such a transformation. It discusses how previous attempts to rehabilitate criminals may have failed because they do not address habit in the way that Aristotle advocates. This paper concludes that a rehabilitative model that addresses habit more aggressively than previous methods might be required to soften the hardest criminals. (shrink)
The transition of novel and potentially promising medical therapies into their initial human clinical trials can engender conflicting pressures. On the one side, because Phase I trials raise greater ethical and human protection challenges than later stage clinical trials, there is a need to proceed cautiously. This is particularly the case for Phase I trials with a novel therapy being tested in humans for the first time, usually termed first-in-human (FIH) trials, especially if the FIH trial involves significant risks. On (...) the other side, scientists interested in having their research validated, corporations with a financial interest in the field, and potential patients and patient support groups desirous of having .. (shrink)
Abstract The infantilization of older adults seems morally deplorable whereas very young children are appropriate recipients of such treatment. Children, we argue, are not mentally capable of acting autonomously and reasoning clearly. However, we have difficulty reconciling this justification with the fact that many of the elders whom we respect are mentally deficient in those very same ways. In this paper, I try to make sense of this asymmetry between our justifications for infantilizing the young and our conviction that our (...) elders ought to be respected. I argue that our intuitions against adult infantilization are non-consequentialist (i.e., deontic). I consider several candidates for the deontic factor that might explain the asymmetry of our judgments and practices. I argue that a very specific kind of dignity (one that is socially constructed and reified) grounds our disparate judgments and treatments of very young and very old persons with similar needs. (shrink)
Narratives by survivors of abuse offer compelling entries into the experiences of abuse and its effects on health. Reading such stories can enlarge the clinician's understanding of the complexities of abuse. Furthermore, attention to narrative can enhance the therapeutic options for abuse victims not only in mental health arenas, but also in other medical contexts. In this article we define the genre of survivor narratives, examine one such narrative in particular (Push by Sapphire, 1996), and explore the clinical implications of (...) narrative in abuse victims' clinical care. (shrink)
The term ‘locked-in’ syndrome (LIS) describes a medical condition in which persons concerned are severely paralyzed and at the same time fully conscious and awake. The resulting anarthria makes it impossible for these patients to naturally communicate, which results in diagnostic as well as serious practical and ethical problems. Therefore, developing alternative, muscle-independent communication means is of prime importance. Such communication means can be realized via brain–computer interfaces (BCIs) circumventing the muscular system by using brain signals associated with preserved cognitive, (...) sensory, and emotional brain functions. Primarily, BCIs based on electrophysiological measures have been developed and applied with remarkable success. Recently, also blood flow–based neuroimaging methods, such as functional magnetic resonance imaging (fMRI) and functional near-infrared spectroscopy (fNIRS), have been explored in this context. After reviewing recent literature on the development of especially hemodynamically based BCIs, we introduce a highly reliable and easy-to-apply communication procedure that enables untrained participants to motor-independently and relatively effortlessly answer multiple-choice questions based on intentionally generated single-trial fMRI signals that can be decoded online. Our technique takes advantage of the participants’ capability to voluntarily influence certain spatio-temporal aspects of the blood oxygenation level–dependent (BOLD) signal: source location (by using different mental tasks), signal onset and offset. We show that healthy participants are capable of hemodynamically encoding at least four distinct information units on a single-trial level without extensive pretraining and with little effort. Moreover, realtime data analysis based on simple multi-filter correlations allows for automated answer decoding with a high accuracy (94.9%) demonstrating the robustness of the presented method.. (shrink)
Computational cell models appear as necessary tools for handling the complexity of intracellular cell dynamics, especially calcium dynamics. However, while oscillating intracellular calcium oscillations are well documented and modelled, a simple enough virtual cell taking into account the mechano-chemical coupling between calcium oscillations and cell mechanical properties is still lacking. Considering the spontaneous periodic contraction of isolated cardiac myocytes, we propose here a virtual cardiac cell model in which the cellular contraction is modelled using an hyperelastic description of the cell (...) mechanical behaviour. According to the experimental data, the oscillating cytosolic calcium concentrations trigger the spatio-temporal variation of the anisotropic intracellular stresses. The finite element simulations of the virtual cell deformations are compared to the self-sustained contractions of isolated rat cardiomyocytes recorded by time-lapse video-microscopy. (shrink)
When the atomic theory was revived in the seventeenth century, the atomists faced a problem concerning the status of the laws of nature. On the face of it, the postulation of absolutely hard, rigid, and impenetrable atoms seems to entail the existence of natural necessities and impossibilities: Atoms A and B cannot interpenetrate, so atom A must push atom B when they collide. The properties of compound bodies are to be explained in terms of their “textures” (i.e., the arrangements of (...) their constituent atoms) on the famous lock-and-key model. Once again, it looks as if we have a domain of natural necessities depending on the textures of compound bodies. But the atomists seem to think of the laws of nature as radically contingent, not the sorts of things that could in principle be known a priori. This article seeks to address this tension between what the atomists seem committed to by their matter theory (real necessary connections in nature) and what they in fact say (that all the laws are contingent). In my Atomism (1995) I sought to resolve the tension by appealing to a sharp distinction between the atomists’ metaphysics and their epistemology. On this interpretation, they remain committed to natural necessity, but insist that we can never do Natural Philosophy in the “high priori” manner, by discovering real essences and their necessary connections. Our sciences of nature must remain empirical. Since publication of Atomism, however, this possible solution of the problem has come to seem more doubtful. Reflection on the work of my three “dissenting voices” (Margaret Osler, Peter Anstey and Rae Langton) has forced a radical rethink, focussing on the problematic relation between the intrinsic properties of the atoms and their (dynamic) powers. If there is no discoverable intelligible connection between what the atom is in itself (its intrinsic properties) and what it does (its powers), then my earlier solution will turn out to be untenable. (shrink)
From the fourteenth to the eighteenth centuries, Indian intellectuals produced numerous Sanskrit–Persian bilingual lexicons and Sanskrit grammatical accounts of Persian. However, these language analyses have been largely unexplored in modern scholarship. Select works have occasionally been noticed, but the majority of such texts languish unpublished. Furthermore, these works remain untheorized as a sustained, in-depth response on the part of India’s traditional elite to tremendous political and cultural changes. These bilingual grammars and lexicons are one of the few direct, written ways (...) that Sanskrit intellectuals attempted to make sense of Indo-Persian culture in premodern and early modern India. Here I provide the most comprehensive account to date of the texts that constitute this analytical tradition according to three major categories: general lexicons, full grammars, and specialized glossaries. I further draw out the insights offered by these materials into how early modern thinkers used language analysis to try to understand the growth of Persian on the subcontinent. (shrink)
