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Profile: Bartlomiej Swiatczak (University of Science and Technology of China)
  1. Bartlomiej Swiatczak (2013). Immune Balance: The Development of the Idea and its Applications. [REVIEW] Journal of the History of Biology:1-32.
    It has long been taken for granted that the immune system’s capacity to protect an individual from infection and disease depends on the power of the system to distinguish between self and nonself. However, accumulating data have undermined this fundamental concept. Evidence against the self/nonself discrimination model left researchers in need of a new overarching framework able to capture the immune system’s reactivity. Here, I highlight that along with the self/nonself model, another powerful representation of the immune system’s reactivity has (...)
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  2. Bartlomiej Swiatczak (2012). Immune System, Immune Self. Introduction. Avant 3 (1):12-18.
    The idea that the immune system distinguishes between self and non-self was one of the central assumptions of immunology in the second half of 20th century. This idea influenced experimental design and data interpretation. However, in the face of new evidence there is a need for a new conceptual framework in immunology.
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  3. Bartlomiej Swiatczak (2012). System odpornościowy, ja immunologiczne. Wprowadzenie. Avant 3 (1).
    [Przekład] Pogląd głoszący, że układ odpornościowy rozróżnia to, co swoje, od tego, co obce, był jednym z centralnych założeń immunologii w drugiej połowie XX wieku. Pogląd ten miał wpływ na projekty eksperymentalne i interpretowanie danych. Jednakże w obliczu nowych dowodów empirycznych konieczny jest w immunologii nowy aparat konceptualny.
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  4. Bartlomiej Swiatczak & Maria Rescigno (2012). How the Interplay Between Antigen Presenting Cells and Microbiota Tunes Host Immune Responses in the Gut. Seminars in Immunology 24 (1):43-49.
    Coordination of immune responses in the gut is a complex task. In order to fight pathogens and maintain a defined population of commensal microbes, the mucosal immune system has to coordinate information from the external (luminal) and internal (abluminal) environment and respond accordingly. Dendritic cells (DCs) are crucial cell types involved in this process as they integrate these signals and direct immunogenic or tolerogenic responses. Here, we review how various functions of DCs depend on microbial stimuli and how these stimuli (...)
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  5. Bartlomiej Swiatczak (2011). Conscious Representations: An Intractable Problem for the Computational Theory of Mind. [REVIEW] Minds and Machines 21 (1):19-32.
    Advocates of the computational theory of mind claim that the mind is a computer whose operations can be implemented by various computational systems. According to these philosophers, the mind is multiply realisable because—as they claim—thinking involves the manipulation of syntactically structured mental representations. Since syntactically structured representations can be made of different kinds of material while performing the same calculation, mental processes can also be implemented by different kinds of material. From this perspective, consciousness plays a minor role in mental (...)
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  6. Bartlomiej Swiatczak (2011). Indeterminism in the Immune System: The Case of Somatic Hypermutation. Paradigmi 1:49-65.
    One of the fundamental questions of life sciences is one of whether there are genuinely random biological processes. An affirmative or negative answer to this question may have important methodological consequences. It appears that a number of biological processes are explicitly classified as random. One of them is the so-called somatic hypermutation. However, closer analysis of somatic hypermutation reveals that it is not a genuinely random process. Somatic hypermutation is called random because the exact outcome of this process is difficult (...)
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  7. Bartlomiej Swiatczak, Maria Rescigno & Irun Cohen (2011). Systemic Features of Immune Recognition in the Gut. Microbes and Infection 13:983-991.
    The immune system, to protect the body, must discriminate between the pathogenic and non-pathogenic microbes and respond to them in different ways. How the mucosal immune system manages to make this distinction is poorly understood. We suggest here that the distinction between pathogenic and non-pathogenic microbes is made by an integrated system rather than by single types of cells or single types of receptors; a systems biology approach is needed to understand immune recognition.
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