Search results for 'Central Dogma' (try it on Scholar)

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  1. Víctor de Lorenzo (2014). From Theselfish Genetoselfish Metabolism: Revisiting the Central Dogma. Bioessays 36 (3):226-235.score: 75.0
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  2. Marcel Weber (2006). The Central Dogma as a Thesis of Causal Specificity. History and Philosophy of the Life Sciences 28 (4):595-610.score: 60.0
    I present a reconstruction of F.H.C. Crick's two 1957 hypotheses "Sequence Hypothesis" and "Central Dogma" in terms of a contemporary philosophical theory of causation. Analyzing in particular the experimental evidence that Crick cited, I argue that these hypotheses can be understood as claims about the actual difference-making cause in protein synthesis. As these hypotheses are only true if restricted to certain nucleic acids in certain organisms, I then examine the concept of causal specificity and its potential to counter (...)
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  3. E. M. (1999). The Prion Challenge to the `Central Dogma' of Molecular Biology, 1965-1991 - Part I: Prelude to Prions. Studies in History and Philosophy of Science Part C 30 (1):1-19.score: 60.0
    Since the 1930s, scientists studying the neurological disease scrapie had assumed that the infectious agent was a virus. By the mid 1960s, however, several unconventional properties had arisen that were difficult to reconcile with the standard viral model. Evidence for nucleic acid within the pathogen was lacking, and some researchers considered the possibility that the infectious agent consisted solely of protein. In 1982, Stanley Prusiner coined the term `prion' to emphasize the agent's proteinaceous nature. This infectious protein hypothesis was denounced (...)
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  4. Predrag Sustar (2007). Crick's Notion of Genetic Information and the ‘Central Dogma’ of Molecular Biology. British Journal for the Philosophy of Science 58 (1):13-24.score: 60.0
    An assessment is offered of the recent debate on information in the philosophy of biology, and an analysis is provided of the notion of information as applied in scientific practice in molecular genetics. In particular, this paper deals with the dependence of basic generalizations of molecular biology, above all the ‘central dogma’, on the so-called ‘informational talk’ (Maynard Smith [2000a]). It is argued that talk of information in the ‘central dogma’ can be reduced to causal claims. (...)
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  5. Predrag Šustar (2007). Crick's Notion of Genetic Information and the 'Central Dogma' of Molecular Biology. British Journal for the Philosophy of Science 58 (1):13 - 24.score: 60.0
    An assessment is offered of the recent debate on information in the philosophy of biology, and an analysis is provided of the notion of information as applied in scientific practice in molecular genetics. In particular, this paper deals with the dependence of basic generalizations of molecular biology, above all the 'central dogma', on the socalled 'informational talk' (Maynard Smith [2000a]). It is argued that talk of information in the 'central dogma' can be reduced to causal claims. (...)
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  6. Alex Rosenberg (2006). Is Epigenetic Inheritance a Counterexample to the Central Dogma? History and Philosophy of the Life Sciences 28 (4):549 - 565.score: 60.0
    This paper argues that nothing that has been discovered in the increasingly complex delails of gene regulation has provided any grounds to retract or qualify Crick's version of the central dogma. In particular it defends the role of the genes as the sole bearers of information, and argues that the mechanism of epigenetic modification of the DNA is but another vindication of Crick's version of the central dogma. The paper shows that arguments of C.K. Waters for (...)
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  7. Karola Stotz (2006). Molecular Epigenesis: Distributed Specificity as a Break in the Central Dogma. History and Philosophy of the Life Sciences 28 (4):533 - 548.score: 60.0
    The paper argues against the central dogma and its interpretation by C. Kenneth Waters and Alex Rosenberg. I argue that certain phenomena in the regulation of gene expression provide a break with the central dogma, according to which sequence specificity for a gene product must be template derived. My thesis of 'molecular epigenesis' with its three classes of phenomena, sequence 'activation', 'selection', and 'creation', is exemplified by processes such as transcriptional activation, alternative cis- and trans-splicing, and (...)
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  8. Michel Morange (2006). The Protein Side of the Central Dogma: Permanence and Change. History and Philosophy of the Life Sciences 28 (4):513 - 524.score: 60.0
    There are two facets to the central dogma proposed by Francis Crick in 1957. One concerns the relation between the sequence of nucleotides and the sequence of amino acids, the second is devoted to the relation between the sequence of amino acids and the native three-dimensional structure of proteins. 'Folding is simply a function of the order of the amino acids,' i.e. no information is required for the proper folding of a protein other than the information contained in (...)
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  9. John S. Wilkins, Ian Musgrave & Clem Stanyon (2012). Selection Without Replicators: The Origin of Genes, and the Replicator/Interactor Distinction in Etiobiology. Biology and Philosophy 27 (2):215-239.score: 45.0
    Genes are thought to have evolved from long-lived and multiply-interactive molecules in the early stages of the origins of life. However, at that stage there were no replicators, and the distinction between interactors and replicators did not yet apply. Nevertheless, the process of evolution that proceeded from initial autocatalytic hypercycles to full organisms was a Darwinian process of selection of favourable variants. We distinguish therefore between Neo-Darwinian evolution and the related Weismannian and Central Dogma divisions, on the one (...)
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  10. Martha E. Keyes (1999). The Prion Challenge to the `Central Dogma' of Molecular Biology, 1965–1991. Studies in History and Philosophy of Science Part C 30 (2):181-218.score: 45.0
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  11. Susie Fisher (2010). Not Beyond Reasonable Doubt: Howard Temin's Provirus Hypothesis Revisited. [REVIEW] Journal of the History of Biology 43 (4):661 - 696.score: 45.0
    During the 1960s, Howard M. Temin (1934-1994), dared to advocate a "heretical" hypothesis that appeared to be at variance with the central dogma of molecular biology, understood by many to imply that information transfer in nature occurred only from DNA to RNA. Temin's provirus hypothesis offered a simple explanation of both virus replication and viral-induced cancer and stated that Rous sarcoma virus, an RNA virus, is replicated via a DNA intermediate. Popular accounts of this scientific episode, written after (...)
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  12. Alexis De Tiège, Koen Tanghe, Johan Braeckman & Yves Van de Peer (2014). From DNA- to NA-Centrism and the Conditions for Gene-Centrism Revisited. Biology and Philosophy 29 (1):55-69.score: 45.0
    First the ‘Weismann barrier’ and later on Francis Crick’s ‘central dogma’ of molecular biology nourished the gene-centric paradigm of life, i.e., the conception of the gene/genome as a ‘central source’ from which hereditary specificity unidirectionally flows or radiates into cellular biochemistry and development. Today, due to advances in molecular genetics and epigenetics, such as the discovery of complex post-genomic and epigenetic processes in which genes are causally integrated, many theorists argue that a gene-centric conception of the organism (...)
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  13. Bruno J. Strasser (2006). A World in One Dimension: Linus Pauling, Francis Crick and the Central Dogma of Molecular Biology. History and Philosophy of the Life Sciences 28 (4):491 - 512.score: 45.0
    In 1957, Francis Crick outlined a startling vision of life in which the great diversity of forms and shapes of macromolecules was encoded in the one-dimensional sequence of nucleic acids. This paper situates Crick's new vision in the debates of the 1950s about protein synthesis and gene action. After exploring the reception of Crick's ideas, it shows how they differed radically from a different model of protein synthesis which enjoyed wide currency in that decade. In this alternative model, advocated by (...)
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  14. Jesper Hoffmeyer (2002). The Central Dogma: A Joke That Became Real. Semiotica 2002 (138):1-13.score: 45.0
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  15. James Silverberg & J. Patrick Gray (1986). What is Sociobiology's Central Dogma? Behavioral and Brain Sciences 9 (1):206.score: 45.0
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  16. J. M. Torres (1999). On the Falsification of the Central Dogma and the de Novo Synthesis of Molecular Species: A Methodological Analysis. Philosophia Naturalis 36 (1):1-18.score: 45.0
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  17. Vitor B. Pinheiro, David Loakes & Philipp Holliger (2013). Synthetic Polymers and Their Potential as Genetic Materials. Bioessays 35 (2):113-122.score: 30.0
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  18. James Marcum (2002). From Heresy to Dogma in Accounts of Opposition to Howard Temin's DNA Provirus Hypothesis. History and Philosophy of the Life Sciences 24 (2):165 - 192.score: 24.0
    In 1964 the Wisconsin virologist Howard Temin proposed the DNA provirus hypothesis to explain the mechanism by which a cancer-producing virus containing only RNA infects and transforms cells. His hypothesis reversed the flow of genetic information, as ordained by the central dogma of molecular biology. Although there was initial opposition to his hypothesis it was widely accepted, after the discovery of reverse transcriptase in 1970. Most accounts of Temin's hypothesis after the discovery portray the hypothesis as heretical, because (...)
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  19. John S. Mattick (2003). Challenging the Dogma: The Hidden Layer of Non-Protein-Coding RNAs in Complex Organisms. Bioessays 25 (10):930-939.score: 24.0
    The central dogma of biology holds that genetic information normally flows from DNA to RNA to protein. As a consequence it has been generally assumed that genes generally code for proteins, and that proteins fulfil not only most structural and catalytic but also most regulatory functions, in all cells, from microbes to mammals. However, the latter may not be the case in complex organisms. A number of startling observations about the extent of non-protein-coding RNA (ncRNA) transcription in the (...)
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  20. Irene Appelbaum (1999). The Dogma of Isomorphism: A Case Study From Speech Perception. Philosophy of Science 66 (3):S250-S259.score: 21.0
    In this paper I provide a metatheoretical analysis of speech perception research. I argue that the central turning point in the history of speech perception research has not been well understood. While it is widely thought to mark a decisive break with what I call "the alphabetic conception of speech," I argue that it instead marks the entrenchment of this conception of speech. In addition, I argue that the alphabetic conception of speech continues to underwrite speech perception research today (...)
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  21. John H. Zammito (2012). The Last Dogma of Positivism: Historicist Naturalism and the Fact/Value Dichotomy. Journal of the Philosophy of History 6 (3):305-338.score: 21.0
    Has the emergence of post-positivism in philosophy of science changed the terms of the “is/ought” dichotomy? If it has demonstrated convincingly that there are no “facts” apart from the theoretical frames and evaluative standards constructing them, can such a cordon sanitaire really be upheld between “facts” and values? The point I wish to stress is that philosophy of science has had a central role in constituting and imposing the fact/value dichotomy and a revolution in the philosophy of science should (...)
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  22. Jawid Mojaddedi (2012). Beyond Dogma: Rumi's Teachings on Friendship with God and Early Sufi Theories. Oup Usa.score: 21.0
    Beyond Dogma examines Rumi's central teaching about friendship with God (walaya) in light of earlier Sufi discourse on this topic and its reception by Muslim theologians and jurists. It provides a nuanced and historically contextualized appreciation of Rumi's place in Islam.
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  23. Thomas M. Besch (2012). Political Liberalism, the Internal Conception, and the Problem of Public Dogma. Philosophy and Public Issues 2 (1):153-177.score: 18.0
    According to the “internal” conception (Quong), political liberalism aims to be publicly justifiable only to people who are reasonable in a special sense specified and advocated by political liberalism itself. One advantage of the internal conception allegedly is that it enables liberalism to avoid perfectionism. The paper takes issue with this view. It argues that once the internal conception is duly pitched at its fundamental, metatheoretical level and placed in its proper discursive context, it emerges that it comes at the (...)
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  24. Mindaugas Broga, Goran Mijaljica, Marcin Waligora, Aime Keis & Ana Marusic (2013). Publication Ethics in Biomedical Journals From Countries in Central and Eastern Europe. Science and Engineering Ethics (1):1-11.score: 18.0
    Publication ethics is an important aspect of both the research and publication enterprises. It is particularly important in the field of biomedical science because published data may directly affect human health. In this article, we examine publication ethics policies in biomedical journals published in Central and Eastern Europe. We were interested in possible differences between East European countries that are members of the European Union (Eastern EU) and South-East European countries (South-East Europe) that are not members of the European (...)
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  25. Michael K. Cundall (2006). Rethinking the Divide: Modules and Central Systems. Philosophia 34 (4):379-393.score: 18.0
    In this paper I argue that the cognitive system is best viewed as a continuum of cognitive processing from modules to central systems rather than having these as discrete and wholly different modes of cognitive processing. I rely on recent evidence on the development of theory of mind (ToM) abilities and the developmental disorder of autism. I then turn to the phenomenology of modular processes. I show that modular outputs have a stronger force than non-modular or central system (...)
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  26. Krzysztof Brzechczyn (2009). The Distinctiveness of Central Europe in Light of the Cascadeness of the Historical Process. Poznan Studies in the Philosophy of the Sciences and the Humanities 97 (1):231-268.score: 18.0
    The author interprets the emergence of the manorial-serf economy in Central Europe on the basis of the concept of the cascadeness of historical process. The course of development in the XVIth century Central Europe relied on many insignificant factors which their joint influence gradually outweighed the impact of developmental regularities according to which societies in Central and Western Europe evolved from the XIth to circa the XVIth centuries. Factors that appear in the cascade of European differentiation are (...)
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  27. Carolyn Erdener (2011). Business Ethics as a Field of Teaching, Training, and Research in Central Asia. Journal of Business Ethics 104 (S1):7-18.score: 18.0
    Central Asia presents a unique configuration of historical experience and societal responses that have been interacting and evolving for thousands of years. The current era of economic, political, and societal transformation in Central Asia began with the peaceful devolution of the Soviet Union and transition to the Commonwealth of Independent States in December 1991. Expectations about the natural social order based on western beliefs and experience may not apply in this part of the world, for—like all transitional and (...)
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  28. L. S. F. Olavo (2004). Foundations of Quantum Mechanics: The Connection Between QM and the Central Limit Theorem. [REVIEW] Foundations of Physics 34 (6):891-935.score: 18.0
    In this paper we unravel the connection between the quantum mechanical formalism and the Central limit theorem (CLT). We proceed to connect the results coming from this theorem with the derivations of the Schrödinger equation from the Liouville equation, presented by ourselves in other papers. In those papers we had used the concept of an infinitesimal parameter δx that raised some controversy. The status of this infinitesimal parameter is then elucidated in the framework of the CLT. Finally, we use (...)
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  29. Valentin Riedl Anselm Doll, Christian Sorg, Andrei Manoliu, Andreas Wöller, Chun Meng, Hans Förstl, Claus Zimmer, Afra M. Wohlschläger (2013). Shifted Intrinsic Connectivity of Central Executive and Salience Network in Borderline Personality Disorder. Frontiers in Human Neuroscience 7.score: 18.0
    Borderline personality disorder (BPD) is characterized by “stable instability” of emotions and behavior and their regulation. This emotional and behavioral instability corresponds with a neurocognitive triple network model of psychopathology, which suggests that aberrant emotional saliency and cognitive control is associated with aberrant interaction across three intrinsic connectivity networks (ICN) (i.e. the salience, default mode, and central executive network, SN, DMN, CEN). The objective of the current study was to investigate whether and how such triple network intrinsic functional connectivity (...)
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  30. Krzysztof Brzechczyn (2000). The Notion of Central Europe in Historiography. Periphery. Journal of Polish Affairs 6:4-9.score: 18.0
    The aim of this paper is analyse the notion of Central Europe used in historiography. The author reconstructs different meanings of this term used in the works of George Schopflin, Peter Burke, Oskar Halecki, Piotr Wandycz. This notion has not only geographic but also social and historical meaning.
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  31. Dr Pedro Iwashita Cssp (2011). A relação entre experiência E dogma Mariano – sensus fidelium E psicologia da profundidade. Revista de Teologia (Reveleteo). Issn 2177-952x 5 (8):04-16.score: 18.0
    A pesquisa sobre o dogma mariano mostra que, no seu desenvolvimento, a experiência, mas, sobretudo, a fé vivida, precedeu as proclamações dogmáticas oficiais, de modo que é importante que o dogma mantenha contato com a fé viva da Igreja, pois é nesse contato, que aquilo que está ainda implícito se torne sempre mais explícito sem que haja mudança no seu conteúdo formal, porque não se trata de adição de verdades, e sim de clarificação da verdade. Esse estudo mostra (...)
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  32. Hillary N. Fouts, Barry S. Hewlett & Michael E. Lamb (2001). Weaning and the Nature of Early Childhood Interactions Among Bofi Foragers in Central Africa. Human Nature 12 (1):27-46.score: 18.0
    Western scholarly literature suggests that (1) weaning is initiated by mothers; (2) weaning takes place within a few days once mothers decide to stop nursing; (3) mothers employ specific techniques to terminate nursing; (4) semi-solid foods (gruels and mashed foods) are essential when weaning; (5) weaning is traumatic for children (it leads to temper tantrums, aggression, etc.); (6) developmental stages in relationships with mothers and others can be demarcated by weaning; and (7) weaning is a process that involves mothers and (...)
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  33. Marek Kwiek (2003). The University, Globalization, Central Europe. Frankfurt and New York: Peter Lang.score: 18.0
    Book synopsis This book is devoted to the condition of the university under the pressures of globalization, with particular reference to Central Europe. It is intended as a companion volume for all those who combine their academic and disciplinary research with wider interests in the functioning of higher education institutions under the new pressures affecting Central Europe. Drawing on its interdisciplinary nature and the wide range of scholars involved, it intends to outline a useful map of new, often (...)
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  34. Maria Pantea (2010). Sandu Frunzã, Nicu Gavrilutã and Michael S. Jones (Eds.) The Challenges of Multiculturalism in Central and Eastern Europe. Journal for the Study of Religions and Ideologies 4 (10):248-249.score: 18.0
    Sandu Frunzã, Nicu Gavrilutã and Michael S. Jones (Eds.) The Challenges of Multiculturalism in Central and Eastern Europe. Provopress, Cluj Napoca, 2005.
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  35. R. Thomas (2011). Developments in Ethics in British Central Government. Ramon Llull Journal of Applied Ethics 1 (2):57.score: 18.0
    This Paper identifies seven positive elements of an _ethics system_, or framework, for public officials - namely, (1) the culture and values prevailing in a country; (2) codes and laws and their enforcement; (3) new institutions to uphold ethics in public life; (4) audit, public accountability and openness; (5) guiding principles and motivation to encourage good conduct; (6) external and internal education and training for public life; and (7) the views of the public in regard to their call for greater (...)
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  36. Daniel C. Dennett, Altruists, Chumps, and Inconstant Pluralists.score: 15.0
    Anybody interested in evolutionary explanations of social phenomena (and every philosopher should be) will learn a lot from Unto Others. In addition to its cornucopia of fascinating empirical findings from biology and psychology, it is chock full of arresting perspectives, ingenious thought experiments, and clear expositions of difficult-indeed, treacherous-concepts that should be in every philosopher's kit. What philosophers will not learn, however, is the status of group selection in current evolutionary theory, because while Sober and Wilson (hereafter S&W) strive intelligently (...)
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  37. Maurice Blondel (1964/1994). The Letter on Apologetics, and, History and Dogma. W.B. Eerdmans Pub. Co..score: 15.0
    'The Letter on Apologetics' is a key statement on the possibility and meaning of Christian philosophy.
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  38. Christopher Hoyt (2007). Wittgenstein and Religious Dogma. International Journal for Philosophy of Religion 61 (1):39 - 49.score: 15.0
    It is well understood that Wittgenstein defends religious faith against positivistic criticisms on the grounds of its logical independence. But exactly how are we to understand the nature of that independence? Most scholars take Wittgenstein to equate language-games with belief-systems, and thus to assert that religions are logical schemes founded on their own basic beliefs and principles of inference. By contrast, I argue that on Wittgenstein’s view, to have religious faith is to hold fast to a certain picture of the (...)
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  39. Brant Pridmore (2008). Review of Genes in Development: Re-Reading the Molecular Paradigm. [REVIEW] Biology and Philosophy 23 (4):579-586.score: 15.0
    Genes in Development is a collection of 13 stimulating essays on "post genomic" approaches to the concept of the gene. At the risk of caricaturing some complex balances, the contributors tend to be skeptical about genetic determinism, the central dogma of molecular biology, reductionism, genes as programs and the concept of the gene as a DNA sequence. They tend to like emergent properties, complexity theory, the parity thesis for developmental resources, developmental systems theory, and membranes. But within this (...)
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  40. Walton Padelford & Darin W. White (2010). The Influence of Historical Socialism and Communism on the Shaping of a Society's Economic Ethos: An Exploratory Study of Central and Eastern Europe. [REVIEW] Journal of Business Ethics 97 (1):109 - 117.score: 15.0
    This study utilizes an exploratory research design to investigate the influence of historical socialism and communism on the shaping of a society's economic ethos. The discussion of ethics and economics has a very long history across multiple disciplines including the founder of modern economics, Adam Smith. However, with the growth of economic science, academic consideration has shifted toward positive analysis while normative analysis has been left mainly to philosophers. By utilizing the newly developed Morality of Profit-Making (MPM) scale, the authors (...)
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  41. Karola Stotz, 2001 and All That: A Tale of a Third Science.score: 15.0
    The paper describes the change from molecular genetics to postgenomic biology. It focuses on phenomena in the regulation of gene expression that provide a break with the central dogma, according to which sequence specificity for a gene product must be template derived. In its place we find what is called here ‘constitutive molecular epigenesis’. Its three classes of phenomena, which I call sequence ‘activation’, ‘selection’ and ‘creation’, are exemplified by processes such as transcriptional activation, alternative cis- and trans-splicing, (...)
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  42. Jacob Feldman (2013). Tuning Your Priors to the World. Topics in Cognitive Science 5 (1):13-34.score: 15.0
    The idea that perceptual and cognitive systems must incorporate knowledge about the structure of the environment has become a central dogma of cognitive theory. In a Bayesian context, this idea is often realized in terms of “tuning the prior”—widely assumed to mean adjusting prior probabilities so that they match the frequencies of events in the world. This kind of “ecological” tuning has often been held up as an ideal of inference, in fact defining an “ideal observer.” But widespread (...)
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  43. David B. Resnik (1992). Discussion: Leo Buss's the Evolution of Individuality. Biology and Philosophy 7 (4):453-460.score: 15.0
    In his book The Evolution of Individuality, Leo Buss attacks a central dogma of the neo-Darwinian (or synthetic) theory of evolution, the idea that the individual is the sole unit of selection, by arguing that individuals themselves emerged as the result of selective forces that regulated the replication of cell lineages for the benefit of the whole organism. Buss also argues that metazoan developmental patterns and life cycles are the products of selection operating on different units of selection, (...)
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  44. Pierre Effa, Achille Massougbodji, Francine Ntoumi, François Hirsch, Henri Debois, Marissa Vicari, Assetou Derme, Jacques Ndemanga-kamoune, Joseph Nguembo, Benido Impouma, Jean-paul Akué, Armand Ehouman, Alioune Dieye & Wen Kilama (2007). Ethics Committees in Western and Central Africa: Concrete Foundations. Developing World Bioethics 7 (3):136–142.score: 15.0
    The involvement of developing countries in international clinical trials is necessary for the development of appropriate medicines fo.
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  45. Marek Kwiek (2014). Changing Higher Education and Welfare States in Postcommunist Central Europe: New Contexts Leading to New Typologies? Human Affairs 24 (1):48-67.score: 15.0
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  46. Carol H. Ammons & Joseph Weitz (1951). Central and Peripheral Factors in the Phi Phenomenon. Journal of Experimental Psychology 42 (5):327.score: 15.0
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  47. Andreas Bågenholm (2013). The Electoral Fate and Policy Impact of “Anti-Corruption Parties” in Central and Eastern Europe. Human Affairs 23 (2):174-195.score: 15.0
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  48. George E. Briggs & James M. Swanson (1970). Encoding, Decoding, and Central Functions in Human Information Processing. Journal of Experimental Psychology 86 (2):296.score: 15.0
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  49. Soniia David & Louise Sperling (1999). Improving Technology Delivery Mechanisms: Lessons From Bean Seed Systems Research in Eastern and Central Africa. [REVIEW] Agriculture and Human Values 16 (4):381-388.score: 15.0
    This article addresses concerns of technology dissemination for small farmers, specifically focusing on the diffusion of new varieties of a self-pollinating crop. Based on bean seed systems research in Uganda, Rwanda, Burundi, and the Democratic Republic of Congo, it shows four commonly-held basic assumptions to be false, namely that: first, small-scale farmers do not buy bean seed; they mainly rely on their own stocks or obtain seed from other farmers; second, that small-scale farmers cannot afford to buy seed of newly (...)
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