In the metabolic control theory, the control coefficient is a key parameter in quantifying the sensitivity of the flux towards an infinitesimal variation of enzyme activity. This concept does not apply just as it is for variations of enzyme concentrations whenever there is spatial, energy or resources limitations in the cell. Due to constraint on total enzyme concentration, the variation of concentration of any given enzyme may affect the concentrations of other enzymes. To take into account these correlations between enzyme (...) concentrations, we propose the concept of "combined response coefficient". Its definition is similar to that of the control coefficient, but its mathematical expression is different. Its range of variation is from – + 1, the null value corresponding to optimum enzyme concentration, i.e. to concentrations that maximise the flux, and the negative values to concentrations beyond the optimum value. A summation property could be derived using a simple weighting of the combined response coefficients, the sum of the weighed coefficient being 0. (shrink)
Service-Robotic—mainly defined as “non-industrial robotics”—is identified as the next economical success story to be expected after robots have been ubiquitously implemented into industrial production lines. Under the heading of service-robotic, we found a widespread area of applications reaching from robotics in agriculture and in the public transportation system to service robots applied in private homes. We propose for our interdisciplinary perspective of technology assessment to take the human user/worker as common focus. In some cases, the user/worker is the effective subject (...) acting by means of and in cooperation with a service robot; in other cases, the user/worker might become a pure object of the respective robotic system, for example, as a patient in a hospital. In this paper, we present a comprehensive interdisciplinary framework, which allows us to scrutinize some of the most relevant applications of service robotics; we propose to combine technical, economical, legal, philosophical/ethical, and psychological perspectives in order to design a thorough and comprehensive expert-based technology assessment. This allows us to understand the potentials as well as the limits and even the threats connected with the ongoing and the planned implementation of service robots into human lifeworld—particularly of those technical systems displaying increasing grades of autonomy. (shrink)
In this paper the relations between the almost unknown Spanish mathematician Ventura Reyes Prósper (1863-1922) with Charles S. Peirce and Christine Ladd-Franklin are described. Two brief papers from Reyes Prósper published in El Progreso Matemático 12 (20 December 1891), pp. 297-300, and 18 (15 June 1892) pp. 170-173 on Ladd-Franklin, and on Peirce and Mitchell, respectively, are translated for first time into English and included at the end of the paper.
An important part of making philosophy as a discipline gender equal is to ensure that female authors are not simply wiped out of the history of philosophy. This has implications for teaching as well as research. In this context, I reflect on my experience of teaching a text by medieval philosopher Christine de Pizan as part of an introductory history of philosophy course taught to Turkish students in law, political science, and international relations. I describe the challenges I encountered, (...) the ways in which I dealt with them, and draw some conclusions based on my observations and feedback obtained at the end of the course. (shrink)
In response to Arroyo, I explain my position on the concept of ‘‘natural goodness’’ and how my use of that concept compares to that of Geach and Foot. An Aristotelian or functional notion of goodness provides the material for Kantian endorsement in a theory of value that avoids a metaphysical commitment to intrinsic values. In response to Cummiskey, I review reasons for thinking Kantianism and consequentialism incompatible, especially those objections to aggregation that arise from the notion of the natural good (...) previously described. In response to Moland, I explain why I think Hegelian worries about the supposed emptiness of the Kantian self do not apply to my account. And in response to both Moland and Bird-Pollan, I argue that, contrary to the view of some Hegelians, the intersubjective normativity of reason is not something developed through actual social relations; rather, it is something essential to an individual’s relations with himself or herself. (shrink)
Christine Delphy is a major architect of materialist feminism, a radical feminist perspective which she developed in the context of the French women's movement in the late 1960s and early 1970s. She has always been controversial and continues to make original and challenging contributions to current feminist debates. This informative volume profiles Delphy and discusses topics including her opposition to the idea that femininity and masculinity are natural phenomena. Her insistence that women and men are social categories, defined by (...) the hierarchical relationship between them rather than by biology, typifies the materialist school within French feminism. In this lucid introduction to Delphy's work, Stevi Jackson recounts the events in Delphy's life as a feminist activist and the social and political context of her work. This text is essential reading for anyone with an interest in feminism or cultural history, this is a readable and accessible introduction to a key thinker in the modern women's movement. (shrink)
El propósito de este artículo es analizar la vida y la obra de Christine de Pisan (1364-1430), una protofeminista que defendió que las mujeres podían desempeñar un importante papel en la sociedad. Por ello, consideramos que esta escritora puede ser considerada una �figura de la emancipación�.
The idea that there is such an analytic connection will hardly come as news. It amounts to no more and no less than an endorsement of the claim that all reasons are 'internal', as opposed to 'external', to use Bernard Williams's terms (Williams 1980). Or, to put things in the way Christine Korsgaard favours, it amounts to an endorsement of the 'internalism requirement' on reasons (Korsgaard 1986). But how exactly is the internalism requirement to be understood? What does it (...) tell us about the nature of reasons? And where-in lies its appeal? My aim in this paper is to answer these ques- tions. (shrink)
According to the "recognitional" view of practical reason, rational practical reasoning consists in trying to figure out which of the available options are good things to do, and then choosing accordingly. According to the rival "constructivist" view, rational practical reasoning consists in complying with certain conditions of purely formal coherence or procedural rationality. Christine Korsgaard objects that recognitional views cannot answer the "normative question". But constructivist views are vulnerable to the same objection. One version of the recognitional view is (...) immune to this objection, and can also be defended against David Velleman's charge that it is empty and without content. (shrink)
Taking Ourselves Seriously and Getting It Right is written in a manner that is accessible to all. Frankfurt’s arguments are, as usual, clear and persuasive. Korsgaard’s, Bratman’s, and Dan-Cohen’s comments are thought provoking. There are, however, two main areas in which Frankfurt’s arguments need clarification (the notion of wholehearted identification, and the concept of ambivalence), and there are misunderstandings of Frankfurt at work in Korsgaard’s (relationship between the self and the will, and concept of the will for Frankfurt) and Bratman’s (...) (meaning of "necessity" for Frankfurt) comments. (shrink)
Some concepts, such as colour concepts or value concepts, seem to bear traces of the mind's own make-up. For instance, the character of perceptually-determined colour concepts seems in some sense derivative from the character of the visual system. Thus, it has seemed plausible to claim that the corresponding colour properties are dispositions to elicit certain visual experiences in normal observers under suitable conditions. Much the same has been suggested for value concepts. An extreme position would be that colours and values (...) therefore are not in the world at all, they instead are mere projections that tell us more about the users of response-dependent concepts than about the world they inhabit. But even setting aside such extreme views, a number of important philosophical and psychological questions remain open. What exactly is response-dependence, and does any concept have this feature? What is the appropriate metaphysics for properties represented by response-dependent concepts, and for these concepts themselves? What determines the extension of such properties? How are we to account for knowledge expressed in terms of response-dependent concepts? What mechanisms correctly explain the origins of response-dependent concepts, and their role in representation? This volume brings together a wide range of views on these questions. (shrink)
According to Christine Korsgaard, Kantian hypothetical and categorical imperative principles are constitutive principles of agency. By acting in a way that is guided by these imperatives, an individual makes herself into an agent. There is hence, on her theory, an inextricable link between the nature of agency and the practical issue of why we should be rational and moral. The benefits of such an account would be great: in Korsgaard’s view, an account that bases morality on the nature of (...) agency is the basis for a refutation of any kind of moral skepticism, providing an indubitable and objective foundation for morality. This may seem too good to be true, and it is. Korsgaard could only succeed at offering a foundation for morality at a great cost. The cost is that Korsgaard gives too restrictive an account of agency. Korsgaard does not present a coherent account of irrational or immoral agency, and the inability to offer an account of such agency implies an inability to offer a proper account of responsibility. Korsgaard’s view shares a fundamental flaw with Immanuel Kant’s account of morality in the Groundwork of the Metaphysics of Morals: Korsgaard cannot give a full, adequate account of individual responsibility. In light of the failure of Kant’s and Korsgaard’s accounts, Kantians need to provide a better, more comprehensive characterization of agency. Presenting a proper account of agency will require a rejection of a central tenet of traditional Kantian metaethics, but the rejection of this central tenet does not require a full rejection of Kantianism. (shrink)
Do we need principles of the unification of our agency, our mode of acting? Immanuel Kant and Christine Korsgaard argue that the reflective structure of our mind forces us to have some conception of ourselves, others and the world—including our agency—and that it is through will and reason, and in particular principles of our agency, that we take upon ourselves to unify and test the way(s) in which we make our lives consistent. I argue that the principles suggested—the hypothetical (...) imperative and the categorical imperative—function to unify our understanding of ourselves and others as agents as efficacious and autonomous and that the extent to which those concerned render themselves efficacious and autonomous in cosmopolitan education or elsewhere is due to the extent to which they act in accordance with and are motivated by the suggested principles and in particular the categorical one. I first discuss how the principles function to unify our agency and how the categorical imperative functions as a test of maxims for our actions, how the will is the source of our morality, and how we are forced to have practical identities. I end with some remarks on what it means to acknowledge the mentioned principles in cosmopolitan education. (shrink)