Search results for 'Clinical Protocols' (try it on Scholar)

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  1.  2
    Akoh Walter Ebile, Jerome Ateudjieu, Martin Ndinakie Yakum, Marceline Ngounoue Djuidje & Pierre Watcho (2015). Assessing the Detection, Reporting and Investigation of Adverse Events in Clinical Trial Protocols Implemented in Cameroon: A Documentary Review of Clinical Trial Protocols. BMC Medical Ethics 16 (1):1-9.
    BackgroundInternational guidelines recommend ethical and scientific quality standards for managing and reporting adverse events occurring during clinical trials to competent research ethics committees and regulatory authorities. The purpose of this study was to determine whether clinical trial protocols in Cameroon are developed in line with national requirements and international guidelines as far as detecting, reporting and investigating of adverse events is concerned.MethodsIt was a documentary review of all approved clinical trial protocols that were submitted at (...)
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  2.  61
    R. Dal-Re, J. Espada & R. Ortega (1999). Performance of Research Ethics Committees in Spain. A Prospective Study of 100 Applications for Clinical Trial Protocols on Medicines. Journal of Medical Ethics 25 (3):268-273.
    OBJECTIVES: To review the characteristics and performance of research ethics committees in Spain in the evaluation of multicentre clinical trial drug protocols. DESIGN: A prospective study of 100 applications. SETTING: Forty-one committees reviewing clinical trial protocols, involving 50 hospitals in 25 cities. MAIN MEASURES: Protocol-related features, characteristics of research ethics committees and evaluation dynamics. RESULTS: The 100 applications involved 15 protocols (of which 12 were multinational) with 12 drugs. Committees met monthly (except one). They had (...)
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  3.  20
    M. A. Sanchez-Gonzalez, B. Herreros, V. R. Ramnath, M. D. Martin, E. Pintor & L. Bishop (2014). Clinical Ethics Protocols in the Clinical Ethics Committees of Madrid. Journal of Medical Ethics 40 (3):205-208.
    Introduction Currently, The nature and scope of Clinical Ethics Protocols in Madrid are not well understood.Objectives The main objective is to describe the features of ‘guideline/recommendation’ type CEPs that have been or are being developed by existing Clinical Ethics Committees in Madrid. Secondary objectives include characterisation of those CECs that have been the most prolific in reference to CEP creation and implementation and identification of any trends in future CEP development.Methods We collected CEPs produced and in process (...)
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  4. Daniel W. Fitzgerald, Angela Wasunna & Jean William Pape (forthcoming). Ten Questions Institutional Review Boards Should Ask When Reviewing International Clinical Research Protocols. IRB: Ethics & Human Research.
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  5.  3
    Frederick Grinnell (forthcoming). Endings of Clinical Research Protocols: Distinguishing Therapy From Research. IRB: Ethics & Human Research.
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  6.  2
    Núria Homedes & Antonio Ugalde (2015). The Evaluation of Complex Clinical Trial Protocols: Resources Available to Research Ethics Committees and the Use of Clinical Trial Registries—a Case Study. Journal of Medical Ethics 41 (6):464-469.
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  7.  8
    Brian Hurwitz (1995). Clinical Guidelines and the Law: Advice, Guidance or Regulation? Journal of Evaluation in Clinical Practice 1 (1):49-60.
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  8.  11
    Anna C. Mastroianni, Ruth R. Faden & Daniel D. Federman (eds.) (1994). Women and Health Research: Ethical and Legal Issues of Including Women in Clinical Studies. National Academy Press.
    Executive Summary There is a general perception that biomedical research has not given the same attention to the health problems of women that it has given ...
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  9.  5
    E. A. Waters (1997). Improving Clinical Effectiveness: A Practical Approach. Journal of Evaluation in Clinical Practice 3 (4):255-264.
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  10.  20
    Laura Vargas-Parada, Simon Kawa, Alberto Salazar, Juan Jose Mazon & Ana Flisser (2006). Informed Consent in Clinical Research at a General Hospital in Mexico: Opinions of the Investigators. Developing World Bioethics 6 (1):41-51.
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  11.  2
    Jill A. Fisher (2008). Institutional Mistrust in the Organization of Pharmaceutical Clinical Trials. Medicine, Health Care and Philosophy 11 (4):403-413.
    In this paper I explore the politics of trust in the clinical testing of pharmaceuticals in the US. Specifically, I analyze trust in terms of its institutional manifestations in the pharmaceutical clinical trials industry. In the process of testing new drugs, pharmaceutical companies must (1) protect their proprietary information from the clinicians who conduct their studies, and (2) find a way to ensure human subjects’ compliance to study protocols. Concern with these two critical issues leads drug companies (...)
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  12.  5
    Martine C. de Vries, Mirjam Houtlosser, Jan M. Wit, Dirk P. Engberts, Dorine Bresters, Gertjan Jl Kaspers & Evert van Leeuwen (2011). Ethical Issues at the Interface of Clinical Care and Research Practice in Pediatric Oncology: A Narrative Review of Parents' and Physicians' Experiences. BMC Medical Ethics 12 (1):18.
    BackgroundPediatric oncology has a strong research culture. Most pediatric oncologists are investigators, involved in clinical care as well as research. As a result, a remarkable proportion of children with cancer enrolls in a trial during treatment. This paper discusses the ethical consequences of the unprecedented integration of research and care in pediatric oncology from the perspective of parents and physicians.MethodologyAn empirical ethical approach, combining a narrative review of qualitative studies on parents' and physicians' experiences of the pediatric oncology research (...)
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  13.  12
    Spencer Phillips Hey (2015). Ethics and Epistemology of Accurate Prediction in Clinical Research. Journal of Medical Ethics 41 (7):559-562.
    All major research ethics policies assert that the ethical review of clinical trial protocols should include a systematic assessment of risks and benefits. But despite this policy, protocols do not typically contain explicit probability statements about the likely risks or benefits involved in the proposed research. In this essay, I articulate a range of ethical and epistemic advantages that explicit forecasting would offer to the health research enterprise. I then consider how some particular confidence levels may come (...)
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  14.  11
    Adnan A. Hyder & Salman A. Wali (2006). Informed Consent and Collaborative Research: Perspectives From the Developing World. Developing World Bioethics 6 (1):33–40.
    203 surveys were considered complete and were included in the analysis. Written consent was not used by nearly 40% of the researchers.
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  15.  13
    Sarah Chan, Ying-Kiat Zee, Gordon Jayson & John Harris (2011). 'Risky' Research and Participants' Interests: The Ethics of Phase 2C Clinical Trials. Clinical Ethics 6 (2):91-96.
    Biomedical research involving human participants is highly regulated and subject to stringent ethical requirements. Clinical research ethics, regulation and policy have tended to focus almost exclusively on the protection of participants' interests against harms that might result from taking part in research. Less consideration, however, has been given to the interests that patients may themselves have in research participation, even in trials that may be beyond the bounds of current clinical research practice. In this paper, we consider the (...)
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  16.  1
    A. Stroustrup, S. Kornetsky & S. Joffe (2007). Knowledge of Regulations Governing Pediatric Research: A Pilot Study. IRB: Ethics & Human Research 30 (5):1-7.
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  17.  3
    D. J. Opel, B. S. Wilfond, D. Brownstein, D. S. Diekema & R. A. Pearlman (2009). Characterisation of Organisational Issues in Paediatric Clinical Ethics Consultation: A Qualitative Study. Journal of Medical Ethics 35 (8):477-482.
    Background: The traditional approach to resolving ethics concerns may not address underlying organisational issues involved in the evolution of these concerns. This represents a missed opportunity to improve quality of care “upstream”. The purpose of this study was to understand better which organisational issues may contribute to ethics concerns. Methods: Directed content analysis was used to review ethics consultation notes from an academic children’s hospital from 1996 to 2006 (N = 71). The analysis utilised 18 categories of organisational issues derived (...)
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  18.  6
    B. Pignatelli (2005). Authorship Ignorance: Views of Researchers in French Clinical Settings. Journal of Medical Ethics 31 (10):578-581.
    Objectives: To assess the knowledge and behaviour of researchers regarding criteria for authorship, and the practices of ghost and gift authorship. Design: Semidirective interviews of senior clinical researchers. Setting: University hospital. Participants: Thirty-nine main investigators of clinical research programmes. Main measurements: Awareness and use of International Committee of Medical Journal Editors (ICMJE) criteria for authorship, and perceptions about ghost and gift authorship. Results: A total of 48 protocols submitted by 42 principal investigators between 1994 and 1996 were (...)
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  19.  5
    H. M. Evans (2004). Should Patients Be Allowed to Veto Their Participation in Clinical Research? Journal of Medical Ethics 30 (2):198-203.
    Patients participating in the shared benefits of publicly funded health care enjoy the benefits of treatments tested on previous patients. Future patients similarly depend on treatments tested on present patients. Since properly designed research assumes that the treatments being studied are—so far as is known at the outset—equivalent in therapeutic value, no one is clinically disadvantaged merely by taking part in research, provided the research involves administering active treatments to all participants. This paper argues that, because no other practical or (...)
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  20.  6
    A. Blumle, G. Antes, M. Schumacher, H. Just & E. von Elm (2008). Clinical Research Projects at a German Medical Faculty: Follow-Up From Ethical Approval to Publication and Citation by Others. Journal of Medical Ethics 34 (9):e20-e20.
    Background: Only data of published study results are available to the scientific community for further use such as informing future research and synthesis of available evidence. If study results are reported selectively, reporting bias and distortion of summarised estimates of effect or harm of treatments can occur. The publication and citation of results of clinical research conducted in Germany was studied.Methods: The protocols of clinical research projects submitted to the research ethics committee of the University of Freiburg (...)
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  21.  6
    T. Meulenbergs (2005). The Current State of Clinical Ethics and Healthcare Ethics Committees in Belgium. Journal of Medical Ethics 31 (6):318-321.
    Ethics committees are the most important practical instrument of clinical ethics in Belgium and fulfil three tasks: the ethical review of experimental protocols, advising on the ethical aspects of healthcare practice, and ethics consultation. In this article the authors examine the current situation of ethics committees in Belgium from the perspective of clinical ethics. Firstly, the most important steps which thus far have been taken in Belgium are examined. Secondly, recent opinion by the Belgian Advisory Committee on (...)
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  22.  8
    David Wendler & Rebecca Johnson (2016). When Clinical Care is Like Research: The Need for Review and Consent. Theoretical Medicine and Bioethics 37 (3):193-209.
    The prevailing “segregated model” for understanding clinical research sharply separates it from clinical care and subjects it to extensive regulations and guidelines. This approach is based on the fact that clinical research relies on procedures and methods—research biopsies, blinding, randomization, fixed treatment protocols, placebos—that pose risks and burdens to participants in order to collect data that might benefit all patients. Reliance on these methods raises the potential for exploitation and unfairness, and thus points to the need (...)
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  23.  62
    J. M. Barton, M. S. Macmillan & L. Sawyer (1995). The Compensation of Patients Injured in Clinical Trials. Journal of Medical Ethics 21 (3):166-169.
    The problem of 'no fault' compensation for patients who suffer adverse effects as a result of their participation in clinical trials is discussed in the light of the guidelines issued by the Association of the British Pharmaceutical Industry (ABPI) and our recent experiences in reviewing protocols submitted to the local ethics of surgical research sub-committee. We have found a variety of qualifications being applied by pharmaceutical firms which are not in the spirit of the guidelines, let alone the (...)
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  24.  2
    Kirstin Borgerson (2016). An Argument for Fewer Clinical Trials. Hastings Center Report 46 (6):25-35.
    The volume of clinical research is increasing exponentially—far beyond our ability to process and absorb the results. Given this situation, it may be beneficial to consider reducing the flow at its source. In what follows, I will motivate and critically evaluate the following proposal: researchers should conduct fewer clinical trials. More specifically, I c onsider whether researchers should be permitted to conduct only clinical research of very high quality and, in turn, whether research ethics committees should prohibit (...)
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  25.  16
    Evelyne Decullier, Véronique Lhéritier & François Chapuis (2005). The Activity of French Research Ethics Committees and Characteristics of Biomedical Research Protocols Involving Humans: A Retrospective Cohort Study. [REVIEW] BMC Medical Ethics 6 (1):1-10.
    Background Clinical trials throughout the world must be evaluated by research ethics committees. No one has yet attempted to clearly quantify at the national level the activity of ethics committees and describe the characteristics of the protocols submitted. The objectives of this study were to describe 1) the workload and the activity of Research Ethics Committees in France, and 2) the characteristics of protocols approved on a nation-wide basis. Methods Retrospective cohort of 976 protocols approved by (...)
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  26.  6
    G. Paul (2008). The Remote Prayer Delusion: Clinical Trials That Attempt to Detect Supernatural Intervention Are as Futile as They Are Unethical. Journal of Medical Ethics 34 (9):e18-e18.
    Extreme rates of premature death prior to the advent of modern medicine, very low rates of premature death in First World nations with low rates of prayer, and the least flawed of a large series of clinical trials indicate that remote prayer is not efficacious in treating illness. Mass contamination of sample cohorts renders such clinical studies inherently ineffectual. The required supernatural and paranormal mechanisms render them implausible. The possibility that the latter are not benign, and the potentially (...)
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  27.  11
    Udo Schüklenk & Carlton Hogan (1996). Patient Access to Experimental Drugs and AIDS Clinical Trial Designs: Ethical Issues. Cambridge Quarterly of Healthcare Ethics 5 (3):400.
    Today's clinical AIDS research is in trouble. Principal investigators are confronted with young and frequently highly knowledgeable patients. Many of these people with AIDS are often unwilling to adhere to the trial protocols. These PWAs believe they are ethically justified in breaching trial protocols because they do not consider themselves true volunteers in such trials. PWAs argue that they do not really volunteer because existing legislation prevents them from buying and using experimental drugs or from testing alternative (...)
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  28.  1
    Maximilian Schochow, Giovanni Rubeis & Florian Steger (forthcoming). The Application of Standards and Recommendations to Clinical Ethics Consultation in Practice: An Evaluation at German Hospitals. Science and Engineering Ethics:1-7.
    The executive board of the Academy for Ethics in Medicine and two AEM working groups formulated standards and recommendations for clinical ethics consultation in 2010, 2011, and 2013. These guidelines comply with the international standards like those set by the American Society for Bioethics and Humanities. There is no empirical data available yet that could indicate whether these standards and recommendations have been implemented in German hospitals. This desideratum is addressed in the present study. We contacted 1.858 German hospitals (...)
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  29.  20
    H. C. M. L. Rodrigues & P. P. van den Berg (2014). Randomized Controlled Trials of Maternal‐Fetal Surgery: A Challenge to Clinical Equipoise. Bioethics 28 (8):405-413.
    This article focuses on maternal-fetal surgery (MFS) and on the concept of clinical equipoise that is a widely accepted requirement for conducting randomized controlled trials (RCT). There are at least three reasons why equipoise is unsuitable for MFS. First, the concept is based on a misconception about the nature of clinical research and the status of research subjects. Second, given that it is not clear who the research subject/s in MFS is/are, if clinical equipoise is to be (...)
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  30.  11
    Susan Sherwin (1994). Women in Clinical Studies: A Feminist View. Cambridge Quarterly of Healthcare Ethics 3 (4):533.
    There is significant evidence that the health needs of women and minorities have been neglected by a medical research community whose agendas and protocols tend to focus on more advantaged segments of society. In response, the National Institutes of Health and Food and Drug Administration in the United States have recently issued new policies aimed at increasing the utilization of women in clinical studies. As well, the U.S. Congress passed the NIH Revitalization Act of 1993, which specifically mandates (...)
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  31.  2
    I. H. Kunkler (1997). Variations in the Management of Cancer in the NHS: A Legitimate Cause for Concern? Journal of Evaluation in Clinical Practice 3 (3):173-177.
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  32.  18
    John C. Fletcher (1985). Ethical Issues in and Beyond Prospective Clinical Trials of Human Gene Therapy. Journal of Medicine and Philosophy 10 (3):293-310.
    As the potential for the first human trials of somatic cell gene therapy nears, two ethical issues are examined: (1) problems of moral choice for members of institutional review boards who consider the first protocols, for parents, and for the clinical researchers, and the special protections that may be required for the infants and children to be involved, and (2) ethical objections to somatic cell therapy made by those concerned about a putative inevitable progression of genetic knowledge from (...)
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  33.  11
    M. I. Zia, R. Heslegrave & G. E. Newton (2011). Post-Trial Period Surveillance for Randomised Controlled Cardiovascular Studies: Submitted Protocols, Consent Forms and the Role of the Ethics Board. Journal of Medical Ethics 37 (12):762-765.
    Background The post-trial period is the time period after the end of study drug administration. It is unclear whether post-trial arrangements for patient surveillance are routinely included in study protocols and consents, and whether research ethics boards (REB) consider the post-trial period. Objectives The objective was to determine whether trial protocols and consent forms reviewed by the REB describe procedures for post-trial period surveillance. Methods An observational study of protocols of randomised trials of chronic therapies for cardiac (...)
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  34.  8
    Laura Weiss Roberts, Teddy D. Warner, Laura B. Dunn, Janet L. Brody, Katherine Green Hammond & Brian B. Roberts (2007). Shaping Medical Students' Attitudes Toward Ethically Important Aspects of Clinical Research: Results of a Randomized, Controlled Educational Intervention. Ethics and Behavior 17 (1):19 – 50.
    The effects of research ethics training on medical students' attitudes about clinical research are examined. A preliminary randomized controlled trial evaluated 2 didactic approaches to ethics training compared to a no-intervention control. The participant-oriented intervention emphasized subjective experiences of research participants (empathy focused). The criteria-oriented intervention emphasized specific ethical criteria for analyzing protocols (analytic focused). Compared to controls, those in the participant-oriented intervention group exhibited greater attunement to research participants' attitudes related to altruism, trust, quality of relationships with (...)
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  35.  4
    T. Lysaght, B. J. Capps, A. V. Campbell, M. Subramaniam & S. -A. Chong (2012). Intervening in Clinical Research to Prevent the Onset of Psychoses: Conflicts and Obligations. Journal of Medical Ethics 38 (5):319-321.
    A prevailing issue in clinical research is the duty clinicians have to treat or prevent the progression of disease during a study that they are conducting. While all clinical researchers have a duty of care for the patients who participate in clinical research, intervening at the onset or progression of disease may skew results and have a negative impact on the scientific validity of a study. Extreme examples of failures to intervene can be found in the Tuskegee (...)
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  36.  3
    G. Benhamou-Jantelet (2001). Nurses' Ethical Perceptions of Health Care and of Medical Clinical Research: An Audit in a French University Teaching Hospital. Nursing Ethics 8 (2):114-122.
    Very few data exist in France on: (1) nurses’ knowledge and behaviour concerning ethical decisions in clinical practice; and (2) their knowledge of ethical rules in clinical research. This questionnaire-based audit tried mainly to assess these questions in a large French university teaching hospital. Of the 257 questionnaires distributed to nurses in 23 clinical units of the hospital, 206 were returned (80% response rate). When responding to the vignette describing a clinical situation requiring an ethical decision (...)
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  37.  1
    A. Miles, P. Bentley, J. Grey & A. Polychronis (1995). Purchasing Quality in Clinical Practice: What on Earth Do We Mean? Journal of Evaluation in Clinical Practice 1 (2):87-95.
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  38.  14
    Elizabeth Bogdan-Lovis, Leonard Fleck & Henry C. Barry (2012). It's Not Fair! Or is It? The Promise and the Tyranny of Evidence-Based Performance Assessment. Theoretical Medicine and Bioethics 33 (4):293-311.
    Evidence-based medicine (EBM), by its ability to decrease irrational variations in health care, was expected to improve healthcare quality and outcomes. The utility of EBM principles evolved from individual clinical decision-making to wider foundational clinical practice guideline applications, cost containment measures, and clinical quality performance measures. At this evolutionary juncture one can ask the following questions. Given the time-limited exigencies of daily clinical practice, is it tenable for clinicians to follow guidelines? Whose or what interests are (...)
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  39.  20
    A. Nyika, W. Kilama, R. Chilengi, G. Tangwa, P. Tindana, P. Ndebele & J. Ikingura (2009). Composition, Training Needs and Independence of Ethics Review Committees Across Africa: Are the Gate-Keepers Rising to the Emerging Challenges? Journal of Medical Ethics 35 (3):189-193.
    Background: The high disease burden of Africa, the emergence of new diseases and efforts to address the 10/90 gap have led to an unprecedented increase in health research activities in Africa. Consequently, there is an increase in the volume and complexity of protocols that ethics review committees in Africa have to review. Methods: With a grant from the Bill and Melinda Gates Foundation, the African Malaria Network Trust (AMANET) undertook a survey of 31 ethics review committees (ERCs) across sub-Saharan (...)
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  40.  31
    Norbert Steinkamp & Bert Gordijn (2003). Ethical Case Deliberation on the Ward. A Comparison of Four Methods. Medicine, Health Care and Philosophy 6 (3):235-246.
    The objective of this article is to analyse and compare four methods of ethical case deliberation. These include Clinical Pragmatism, The Nijmegen Method of ethical case deliberation, Hermeneutic dialogue, and Socratic dialogue. The origin of each method will be briefly sketched. Furthermore, the methods as well as the related protocols will be presented. Each method will then be evaluated against the background of those situations in which it is being used. The article aims to show that there is (...)
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  41.  15
    Paul J. Ford (2007). Neurosurgical Implants: Clinical Protocol Considerations. Cambridge Quarterly of Healthcare Ethics 16 (3):308-311.
    As neural implants transition from engineering design and testing into human subjects research, careful consideration must be paid to the ethical elements in developing research protocols. Although these ethical aspects may be framed by the design choices of the engineering, a number of challenging choices arise. In spite of many ethical considerations for neural implant technologies being shared with generic research ethics questions, there are subsets needing special attention. Even in considerations requiring increased attention, substantial overlap can be found (...)
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  42.  26
    Linda Farber Post (2007). Handbook for Health Care Ethics Committees. Johns Hopkins University Press.
    The Joint Commission on the Accreditation of Healthcare Organizations (JCAHO) requires as a condition of accreditation that every health care institution -- hospital, nursing home, or home care agency -- have a standing mechanism to address ethical issues. Most organizations have chosen to fulfill this requirement with an interdisciplinary ethics committee. The best of these committees are knowledgeable, creative, and effective resources in their institutions. Many are wellmeaning but lack the information, experience, and skills to negotiate adequately the complex ethical (...)
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  43.  4
    Lorena Charrier, Maria Cristina Allochis, Maria Rita Cavallo, Dario Gregori, Franco Cavallo & Carla Maria Zotti (2008). Integrated Audit as a Means to Implement Unit Protocols: A Randomized and Controlled Study. Journal of Evaluation in Clinical Practice 14 (5):847-853.
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  44.  14
    Sharon Kaur & Sujata Balan (2015). Towards a Balanced Approach to Identifying Conflicts of Interest Faced by Institutional Review Boards. Theoretical Medicine and Bioethics 36 (5):341-361.
    The welfare and protection of human subjects is critical to the integrity of clinical investigation and research. Institutional review boards were thus set up to be impartial reviewers of research protocols in clinical research. Their main role is to stand between the investigator and her human subjects in order to ensure that the welfare of human subjects are protected. While there is much literature on the conflicts of interest faced by investigators and researchers in clinical investigations, (...)
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  45.  25
    Emma R. M. Cohen, Jennifer M. O'neill, Michel Joffres, Ross E. G. Upshur & Edward Mills (2009). Reporting of Informed Consent, Standard of Care and Post-Trial Obligations in Global Randomized Intervention Trials: A Systematic Survey of Registered Trials. Developing World Bioethics 9 (2):74-80.
    Objective: Ethical guidelines are designed to ensure benefits, protection and respect of participants in clinical research. Clinical trials must now be registered on open-access databases and provide details on ethical considerations. This systematic survey aimed to determine the extent to which recently registered clinical trials report the use of standard of care and post-trial obligations in trial registries, and whether trial characteristics vary according to setting. Methods: We selected global randomized trials registered on http://www.clinicaltrials.gov and http://www.controlled-trials.com. We (...)
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  46.  4
    Charles Weijer, Stanley Shapiro, Abraham Fuks, Kathleen Cranley Glass & Myriam Skrutkowska, Monitoring Clinical Research: An Obligation Unfulfilled.
    The revelation that data obtained for the US-based National Surgical Adjuvant Breast and Bowel Project (NSABP) from subjects enrolled at Hôpital Saint-Luc in Montreal was falsified has eroded public trust in research. Institutions can educate researchers and help prevent unethical research practices by establishing procedures to monitor research involving human subjects. Research monitoring encompasses four categories of activity: annual reviews of continuing research, monitoring of informed consent, monitoring of adherence to approved protocols and monitoring of the integrity of data. (...)
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  47.  13
    Doris Wilborn, Ruud Halfens & Theo Dassen (2006). Pressure Ulcer: Prevention Protocols and Prevalence. Journal of Evaluation in Clinical Practice 12 (6):630-638.
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  48.  8
    Rebecca D. Pentz & Anita F. Khayat (2004). The Poster Child for the Need for Central Review of Research Protocols: The Children's Oncology Group. Cambridge Quarterly of Healthcare Ethics 13 (4):359-365.
    Multiple groups, including the National Bioethics Advisory Commission, the American Society of Clinical Oncology, the National Coalition of Comprehensive Cancer Centers, Workgroup 6 of the Summit Series on Cancer, PRIM&R, the Bell Report, and prominent ethicists have called for replacing the current system of local institutional review with central review for multisite national trials. We argue that this need is particularly acute in pediatric oncology, as shown by the experience of the Children's Oncology Group.
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  49.  7
    Lara Huber (2008). Imaging the Brain: Visualising “Pathological Entities”? Searching for Reliable Protocols Within Psychiatry and Their Impact on the Understanding of Psychiatric Diseases. [REVIEW] Poiesis and Praxis 6 (1-2):27-41.
    Given that visualisations via medical imaging have tremendously increased over the last decades, the overall presence of colour-coded brain slices generated on the basis of functional imaging, i.e. neuroimaging techniques, have led to the assumption of so-called kinds of brains or cognitive profiles that might be especially related to non-healthy humans affected by neurological, neuropsychological or psychiatric syndromes or disorders. In clinical contexts especially, one must consider that visualisations through medical imaging are suggestive in a twofold way. Imaging data (...)
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  50.  4
    Faiz Khan (2008). An Islamic Appraisal of Minding the Gap. Journal of Religious Ethics 36 (1):77-96.
    The neglect of psycho-spiritual needs of patients as they traverse the modern healthcare system has been a featured theme in medical literature over the past decade. This literature, which often highlights in-patient palliative care, as well as acute and critical care settings, influences practice guidelines and protocols of doctors and nurses. In this essay, I review some of the pertinent issues raised in the literature and examine the validity of placing an ethical perspective on this issue. I also compare (...)
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