New concepts may prove necessary to profit from the avalanche of sequence data on the genome, transcriptome, proteome and interactome and to relate this information to cell physiology. Here, we focus on the concept of large activity-based structures, or hyperstructures, in which a variety of types of molecules are brought together to perform a function. We review the evidence for the existence of hyperstructures responsible for the initiation of DNA replication, the sequestration of newly replicated origins of replication, cell division (...) and for metabolism. The processes responsible for hyperstructure formation include changes in enzyme affinities due to metabolite-induction, lipid-protein affinities, elevated local concentrations of proteins and their binding sites on DNA and RNA, and transertion. Experimental techniques exist that can be used to study hyperstructures and we review some of the ones less familiar to biologists. Finally, we speculate on how a variety of in silico approaches involving cellular automata and multi-agent systems could be combined to develop new concepts in the form of an Integrated cell (I-cell) which would undergo selection for growth and survival in a world of artificial microbiology. (shrink)
Many linguists and philosophers of language explain linguistic meaning in terms of truth conditions. This book focuses on the meanings of expressions that escape such truth-conditional treatment, in particular the concessives: but , even if , and although . Corinne Iten proposes semantic analyses of these expressions based on the cognitive framework of relevance theory. A thoroughly cognitive approach to linguistic meaning is presented in which linguistic forms are seen as mapping onto mental entities, rather than individuals and properties (...) in the real world. Researchers and advanced students in pragmatics will find this account lucid, clear and accessible. (shrink)
This article explores how the diversity of board resources and the number of women on boards affect firms’ corporate social responsibility (CSR) ratings, and how, in turn, CSR influences corporate reputation. In addition, this article examines whether CSR ratings mediate the relationships among board resource diversity, gender composition, and corporate reputation. The OLS regression results using lagged data for independent and control variables were statistically significant for the gender composition hypotheses, but not for the resource diversity-based hypotheses. CSR ratings had (...) a positive impact on reputation and mediated the relationship between the number of women on the board and corporate reputation. (shrink)
In this article we present (1) a close paraphrase--virtually a translation--of Heidegger's Sein und Zeit, §74, "Die Grundverfassung der Geschichtlichkeit," pp. 382-387, together with an analytical outline found in the Appendix; and (2) a brief commentary on the text. What Heidegger says about his own translation of Aristotle's Physics B 1 applies here as well: "The ‘translation' is already the interpretation proper. Thereafter only an explanation of the ‘translation' is called for.".
The context of economic globalization has contributed to the emergence of a new form of social action which has spread into the economic sphere in the form of the new social economic movements. The emblematic figure of this new generation of social movements is fair trade, which influences the economy towards political or social ends. Having emerged from multiple alternative trade practices, fair trade has gradually become institutionalized since the professionalization of World Shops, the arrival of fair trade products in (...) the food industry, and the establishment of an official "fair trade" label. With the strength that this institutionalization has generated, fair trade can now be considered a real trade system that questions, as much as it renews, the traditional economic system. In parallel, this transformation has exacerbated the tensions within the movement, which can be characterized as a clash between a "radical, militant" pole and a "softer, more commercial" one. However, it is not the actual institutionalization of fair trade which is being debated among fair trade actors on either side of the fence, but rather the challenges inherent in finding an economic institutionalization acceptable to social economic movements. Therefore the institutionalization process of fair trade should not be seen as mere degradation of social action, but rather as typical of the institutionalization process of new social economic movements. If we need to worry about the highjacking and alteration of the fair trade movement by the dominant economic system, the opposite is no less likely, as new social economic movements contribute to an ethical restructuring of markets. (shrink)
This paper discusses possible correspondences between neuroscientific findings and phenomenologically informed methodologies in the investigation of kinesthetic empathy in watching dance. Interest in phenomenology has recently increased in cognitive science (Gallagher and Zahavi 2008 ) and dance scholars have recently contributed important new insights into the use of phenomenology in dance studies (e.g. Legrand and Ravn (Phenomenology and the Cognitive Sciences 8(3):389–408, 2009 ); Parviainen (Dance Research Journal 34(1):11–26, 2002 ); Rothfield (Topoi 24:43–53, 2005 )). In vision research, coherent neural (...) mechanisms for perceptual phenomena were uncovered, thus supporting correlation of phenomenology and neurophysiology Spillmann (Vision Research 49(12):1507–1521, 2009 ). Correspondingly, correlating subjects’ neurophysiological data with qualitative responses has been proposed as a means to research the human brain in the study of consciousness (Gallagher and Zahavi 2008 ), with similar issues in clinical psychology Mishara (Current Opinion in Psychiatry 20(6):559–569, 2007 ) and biology Kosslyn et al. (American Psychologist 57:341–351, 2002 ). Yet the relationship between neuroscience and qualitative research informed by phenomenology remains problematic. How qualitative research normally handles subjective experiences is difficult to reconcile with standard statistical analysis of objective data. Recent technological developments in cognitive neuroscience have inspired a number of researchers to use more naturalistic stimuli, outside the laboratory environment, such as dance, thereby perhaps helping to open up the cognitive sciences to more phenomenologically informed approaches. A question central to our research, addressed here, is how the phenomenal experiences of a dance audience member, as accessed by qualitative research methods, can be related to underlying neurophysiological events. We outline below some methodological challenges encountered in relating audiences’ first-person accounts of watching live dance performance to neurophysiological evidence of their experiences. (shrink)
In this paper I provide a compelling argument against the thesis that Aristotle’s understanding of the relation between the soul and the body can be construed asfunctionalist, despite some passages that would seem to support such an interpretation. Toward this end, in section I of the essay I offer an interpretation of Aristotle’s account of the soul-body relation that emphasizes the non-contingent nature of the connection between the soul and a specific kind of body, arguing that Aristotle’s account of the (...) soul as the “form” and “actuality” of the living thing, and of the organic body as its “matter” and “potentiality,” shows their necessary relation with one another. In section II, I present the functionalist account of mind, placing especial emphasis on its post-Cartesian genesis, which takes seriously the “problematic” status of the relation between mind and body. I then attempt to show, in section III, how because functionalism holds that psychic capacities can be realized within a number of different material bases, including physical and artificial systems, it is incompatible with Aristotle’s conception of the necessary soul-body relation, and thus that Aristotle’s account of psuche is not best construed as functionalist. (shrink)
One of the major roadblocks in conducting Environmental Corporate Social Responsibility (ECSR) research is operationalization of the construct. Existing ECSR measurement tools either require primary data gathering or special subscriptions to proprietary databases that have limited replicability. We address this deficiency by developing a transparent ECSR measure, with an explicit coding scheme, that strictly relies on publicly available data. Our ECSR measure tests favorably for internal consistency and inter-rater reliability, as well as convergent and discriminant validity.
The pressure on companies to practice corporate social responsibility (CSR) has gained momentum in recent times as a means of sustaining competitive advantage in business. The pharmaceutical industry has been acutely affected by this trend. While pharmaceutical product recalls have become rampant and increased dramatically in recent years, no comprehensive study has been conducted to study the effects of announcements of recalls on the shareholder returns of pharmaceutical companies. As product recalls could significantly damage a company's reputation, profitability and brand (...) integrity, this paper investigates the effect on shareholder wealth and the extent to which the adoption of CSR practices by pharmaceutical companies in the United Kingdom (U.K.) and the United States (U.S.), the two largest markets for pharmaceutical products in the world, affected market reactions surrounding product recall announcements. The analysis of product recall announcements from 1998 to 2004 compiled from The Pharmaceutical Journal and U.S. Food and Drug Administration enforcement reports revealed marked differences in the way market participants in the two countries responded to news of product recalls. U.S. investors penalised firms according to the severity of product defects while U.K. investors were indifferent. While U.K. investors rewarded product recalls by firms which were not usually CSR-active, U.S. investors punished non-CSR active firms that performed recalls. These observations could pose strategic challenges to pharmaceutical firms operating in both countries. (shrink)
One new tradition that has emerged from early research on autonomous robots is embodied cognitive science. This paper describes the relationship between embodied cognitive science and a related tradition, synthetic psychology. It is argued that while both are synthetic, embodied cognitive science is antirepresentational while synthetic psychology still appeals to representations. It is further argued that modern connectionism offers a medium for conducting synthetic psychology, provided that researchers analyze the internal representations that their networks develop. The paper then provides a (...) detailed example of the synthetic approach by showing how the construction (and subsequent analysis) of a connectionist network can be used to contribute to a theory of how humans solve Piaget's classic balance scale task. (shrink)
Reviewed: The Philosophy of Husserl, by Burt C. Hopkins. Mc-Gill-Queen’s University Press, 2010. 290 pp., pb. $22.95, ISBN-13: 9780773538238; hb. $95, ISBN-13: 978-0773538221. Burt Hopkins’s The Philosophy of Husserl presents a challenging and thoughtful elucidation of Husserl’s phenomenology that pays special attention to important methodological aspects of Husserl’s philosophy, and, thereby, to Husserl’s characterization of phenomenology as a pure and transcendental philosophy. Unlike other texts that attempt to elucidate Husserl’s philosophy, Hopkins carries out his project in an unusual fashion, by (...) beginning with a consideration of the conflict between Plato and Aristotle regarding the meaning and status of the eide, and ending with a systematic critique of two of Husserl’s most fierce opponents, Heidegger and Derrida. This review essay gives an overview of Hopkins’s book and offers some critical remarks. (shrink)
Consider sentences like (1): 1. Null Complement Containing Sentences a. Aryn followed b. Marie-Odile promised c. Corinne left d. Samir found out at midnight e. I applied f. They already know g. He volunteered h. Abdiwahid insisted i. I suppose j. Paul gave to Amnesty International These illustrate the phenomenon of null complements -- also called ‘pragmatically controlled zero anaphora’, ‘understood arguments’, and ‘linguistically unrealized arguments’. In each case, a complement is (phonologically) omitted, yet (a) the sentence is well-formed (...) and (b) the meaning effect is as if a complement were present. This contrasts on the one hand with structures that lack complements, but are ill-formed as a result – e.g., (2a-c) – and, on the other hand, with structures that lack overt complements, are well-formed, but do not exhibit the meaning effect of a complement – e.g., sentences (3a-b). 2. Contrast with Ill-formed Structures.. (shrink)
In the last three decades, the consideration of whether non-human animals should be ascribed any moral status, and if so in what way it ought to be ascribed to them, has become of central philosophical, political and economic importance. Thus, given thecontemporary significance of what may be called (jar simplicity’s sake) the “animal issue,” it is worthwhile to examine in what way Ancient Greek philosophy might contribute to our understanding of the issue and to our philosophical response to it. With (...) this in mind,in this essay I examine the issue of the moral status of animals from a “critical” Aristotelian perspective, on the basis of which I shall attempt: (§I) to show how, unlike the Cartesian view of animal nature, Aristotle’s conception of the non-moral status of animals stillinforms the prevailing contemporary view of the animal, and (§II) to establish that Aristotle’s failure to ascribe moral status to animals should be rejected (a) given his admission that animals are, by nature, capable of suffering while they are unable to engage in rational deliberation, and (b) given his understanding of the connection between moral blameworthiness, natural disposition, and various kinds of acts, particularly un-chosen and chosen willing acts. In this way, we shall show that although the prevailing contemporary view of the animal’s moral status represents a slightly more “elevated” view than Aristotle’s, insofar as (typically) we do not explicitly claim, as Aristotle did, that animals are due no moral consideration, by critically appropriating the relevant Aristotelian texts, we nonetheless findrich philosophical evidence that permits us to further elevate our conception of the moral status of animals such that we are prepared to grant them genuine moral significance, not just in theory but also in practice. (shrink)
In three experiments we tested hypotheses derived from the goal specificity literature using a real-world physics task. In the balance-scale paradigm participants predict the state of the apparatus based on a configuration of weights at various distances from the fulcrum. Non-specific goals (NSG) have been shown to encourage hypothesis testing, which facilitates rule discovery, whereas specific goals (SG) do not. We showed that this goal specificity effect depends on task difficulty. The NSG strategy led to rule induction among some participants. (...) Among non-discoverers, SG participants were faster and more accurate on difficult problems than NSG participants. The use of misleading exemplars (scale configurations that obscured the rule governing outcomes) led to fixation on inappropriate hypotheses for NSG but not SG participants. When more diagnostic learning exemplars were used, NSG non-discoverers still performed worse than SG participants on difficult problems. SG participants also outperformed NSG participants on a post-test of difficult problems. These findings qualify the generality of goal specificity effects. (shrink)
In this essay I argue that the Stranger’s interest in keeping the philosopher and the sophist distinct is connected, primarily, to his assessment of the charges ofsophistry advanced against Socrates, which compels him to defend Socrates from these unduly advanced accusations. On this basis, I establish that the Stranger’s task in the Sophist, namely to keep philosophy distinct from sophistry, is intimately tied to the project of securing justice and is therefore not merely of theoretical importance but is also—and essentially—of (...) political and ethical significance. (shrink)
Combining philosophical and historical scholarship, the articles in this volume focus on scientific concepts, rather than theories, as units of analysis. They thereby contribute to a growing literature about the role of concepts in scientific research. The authors are particularly interested in exploring the dynamics of research; they investigate the ways in which scientists form and use concepts, rather than in what the concepts themselves represent. The fields treated range from mathematics to virology and genetics, from nuclear physics to psychology, (...) from technology to present-day neural engineering. The volume contains articles by Vassi Kindi, Miles MacLeod, Ingo Brigandt, Friedrich Steinle, Dirk Schlimm, Theodore Arabatzis, Uljana Feest, Corinne Bloch, Mieke Boon, Nancy Nersessian, and Hanne Andersen. (shrink)
Teaching business ethics and corporate social responsibility should neither be misconstrued as a plea for moral rectitude, nor as a limited utilitarian recipe for managing public interest issues or stakeholders — as it too often is. Rather, teaching CSR should allow students to recognize corporations as social institutions so that they can gauge their impact on a social scale and better weigh the values that inform them.However, this vision of CSR training has not found many supporters in North American schools (...) of management, even as the demand for ethics education continues to increase. Our paper endeavours to clarify the bipolar origins of the rising concern around ethics in the business world and how demand for more ethical corporate management is impacting demand for ethics education in management programs. We have noted that despite the intensity of demand, there is a great deal of skepticism and strong resistance to the integration of ethics and social responsibility into the education of management students. Therefore, while providing a preliminary assessment of ethical training in North American schools of management, we raise questions regarding current objectives and those that could be pursued. With these factors in mind, teaching choices that inspired the development of a new course in economic and social ethics can be presented and justified. (shrink)
