Objective: Ethical guidelines are designed to ensure benefits, protection and respect of participants in clinical research. Clinical trials must now be registered on open-access databases and provide details on ethical considerations. This systematic survey aimed to determine the extent to which recently registered clinical trials report the use of standard of care and post-trial obligations in trial registries, and whether trial characteristics vary according to setting. Methods: We selected global randomized trials registered on http://www.clinicaltrials.gov and http://www.controlled-trials.com. We searched for intervention (...) trials of HIV/AIDS, malaria, and tuberculosis from 9 October 2004, the date of the most recent version of the Helsinki Declaration, to 10 April 2007. Results: We collected data from 312 trials. Fifty-eight percent (58%, 95% CI = 53 to 64) of trial protocols report informed consent. Fifty-eight percent (58%, 95% CI = 53 to 64) of trials report active controls. Almost no trials (1%, 95% CI = 0.5 to 3) mention post-trial provisions. Most trials measure surrogate outcomes. Twenty percent (20%, 95% CI = 16 to 25) of trials measure patient-important outcomes, such as death; and the odds that these outcomes are in a low income country are five times greater than for a developed country (odds ratio (OR) 5.03, 95% CI = 2.70 to 9.35, p = < 0.001). Pharmaceutical companies are involved in 28% (CI = 23 to 33) of trials and measure surrogate outcomes more often than nonpharmaceutical companies (OR 2.45, 95% CI = 1.18 to 5.09, p = 0.31). Conclusion: We found a large discrepancy in the quality of reporting and approaches used in trials in developing settings compared to wealthier settings. (shrink)
It is impossible to imagine contemporary critical theory without the work of Michel Foucault. His radical reworkings of the concepts of power, knowledge, discourse and identity have influenced the widest possible range of theories and impacted upon disciplinary fields from literary studies to anthropology. Aimed at students approaching Foucault's texts for the first time, this volume offers: * an examination of Foucault's contexts * a guide to his key ideas * an overview of responses to his work * practical hints (...) on 'using Foucault' * an annotated guide to his most influential works * suggestions for further reading. Challenging not just what we think but how we think, Foucault's work remains the subject of heated debate. Sara Mills' Michel Foucault offers an introduction to both the ideas and the debate, fully equipping student readers for an encounter with this most influential of thinkers. (shrink)
Sara Mills offers a trenchant analysis of the complexities of social relations--including notions of class, nationality and gender--and spatial relations, landscape, topography and travel, in post-colonial contexts.
Stephanie Mills presented the following as the keynote address at the 2007 Annual Meeting of the International Association for Environmental Philosophy in Chicago. Mills addresses the readers of this journal in her role as a bioregional author and social critic. Adopting a narrative style rather than the typical format of the “philosophical essay,” she raises questions that are always and still at the core of our philosophical dialogue: What is nature? How do we humans perceive our relationship with (...) nature? And how may the blind spots of academic philosophy be discerned in traditional approaches to issues such as “nature versus humans,” the wilderness debate, and the possibility and limits of technology? (shrink)
Presents an analysis of Jonathan Edwards' theological position. This book includes a study of his life and the intellectual issues in the America of his time, and examines the problem of free will in connection with Leibniz, Locke, and Hume.
The framing question of Mills' important and thought-provoking paper is whether there is reason for political progressives and radicals to employ the notion of a social contract for either descriptive or normative purposes. In contrast to the common response that the social contract is a piece of "bourgeois mystification" he argues instead that a reformulated conception of the contract, one which he calls the..
Edward Shils presented his book Tradition (1981) as the first extensive study of the subject. This article casts light on Shils' multifaceted understanding of tradition, comprising pragmatic, Burkean, veridical, and evolutionist perspectives. His typology of traditions is noted, and his view of institutional bearers of tradition described. In assessing Shils' theory, however, we find that it overreaches, collapsing differences that exist between traditions, transmissions, and the traditional. Key Words: tradition • transmission • rationalization • antitradition • science.
Classical and quantum field theory provide not only realistic examples of extant notions of empirical equivalence, but also new notions of empirical equivalence, both modal and occurrent. A simple but modern gravitational case goes back to the 1890s, but there has been apparently total neglect of the simplest relativistic analog, with the result that an erroneous claim has taken root that Special Relativity could not have accommodated gravity even if there were no bending of light. The fairly recent acceptance of (...) nonzero neutrino masses shows that widely neglected possibilities for nonzero particle masses have sometimes been vindicated. In the electromagnetic case, there is permanent underdetermination at the classical and quantum levels between Maxwell's theory and the one-parameter family of Proca's electromagnetisms with massive photons, which approximate Maxwell's theory in the limit of zero photon mass. While Yang–Mills theories display similar approximate equivalence classically, quantization typically breaks this equivalence. A possible exception, including unified electroweak theory, might permit a mass term for the photons but not the Yang–Mills vector bosons. Underdetermination between massive and massless (Einstein) gravity even at the classical level is subject to contemporary controversy. (shrink)
The elucidation of the gauge principle ``is the most pressing problem in current philosophy of physics" Redhead. This paper argues two points that contribute to this elucidation in the context of Yang-Mills theories. 1) Yang-Mills theories, including quantum electrodynamics, form a class. They should be interpreted together. To focus on electrodynamics is a mistake. 2) The essential role of gauge and BRST surplus is to provide a local theory that can be quantized and would be equivalent to the (...) quantization of the non-local reduced theory. (shrink)
One way to do socially relevant investigations of science is through conceptual analysis of scientific terms used in special-interest science (SIS). SIS is science having welfare-related consequences and funded by special interests, e.g., tobacco companies, in order to establish predetermined conclusions. For instance, because the chemical industry seeks deregulation of toxic emissions and avoiding costly cleanups, it funds SIS that supports the concept of “hormesis” (according to which low doses of toxins/carcinogens have beneficial effects). Analyzing the hormesis concept of its (...) main defender, chemical-industry-funded Edward Calabrese, the paper shows Calabrese and others fail to distinguish three different hormesis concepts, H, HG, and HD. H requires toxin-induced, short-term beneficial effects for only one biological endpoint, while HG requires toxin-induced, net-beneficial effects for all endpoints/responses/subjects/ages/conditions. HD requires using the risk-assessment/ regulatory default rule that all low-dose toxic exposures are net-beneficial, thus allowable. Clarifying these concepts, the paper argues for five main claims. (1) Claims positing H are trivially true but irrelevant to regulations. (2) Claims positing HG are relevant to regulation but scientifically false. (3) Claims positing HD are relevant to regulation but ethically/scientifically questionable. (4) Although no hormesis concept (H, HG, or HD) has both scientific validity and regulatory relevance, Calabrese and others obscure this fact through repeated equivocation, begging the question, and data-trimming. Consequently (5) their errors provide some undeserved rhetorical plausibility for deregulating low-dose toxins. (shrink)
Edward Said's mode of intellectual thinking cannot be categorized in terms of concepts such as liberal, socialist or anarchist. In this sense, Said remained all his life, through his work and his action, an "outsider. " This "outsiderhood" created in him an acute awareness of the world and a critical sense of resistance to all forms of political and intellectual domination. In consequence, Said detects a particularly revealing relationship between a deep-seated commitment to the secular principles of humanism andoutsiderhood (...) as the ideal ontological position for the intellectual. (shrink)
This book provides a distinctive account of Edward Said's critique of modern culture by highlighting the religion-secularism distinction on which it is predicated. This distinction is both literal and figurative. It refers, on the one hand, to religious traditions and to secular traditions and, on the other hand, to tropes that extend the meaning and reference of religion and secularism in indeterminate ways. The author takes these tropes as the best way of organizing Said's heterogeneous corpus - from Joseph (...) Conrad and the Fiction of Autobiography, his first book, to Orientalism, his most influential book, to his recent writings on the Palestinian question. The religion-secularism distinction, as an act of imagination and narrative continuity, lies behind Said's cultural criticism, his notion of intellectual responsibility, and his public controversy with Michael Walzer about the meaning and the uses of the Exodus story and about the question of Palestine. (shrink)
This volume examines the role and influence of multiculturalism in general theories of international law; in the composition and functioning of international ...
István Hargittai: Judging Edward Teller: A closer look at one of the most influential scientists of the twentieth century Content Type Journal Article Category Book Review Pages 1-3 DOI 10.1007/s10698-011-9133-x Authors George B. Kauffman, Department of Chemistry, California State University, Fresno, Fresno, CA 93740-8034, USA Journal Foundations of Chemistry Online ISSN 1572-8463 Print ISSN 1386-4238.
In this essay, the author employs Edward S. Casey’s philosophy of place in order to perform a reading of Dave Eggers’ recent biographical novel, What is the What (2007). This reading is dependant upon certain concepts that Casey articulates in Getting Back Into Place (1993) and Remembering (2000), particularly the concepts of displacement, desolation, and homesteading. After an exegesis of these concepts, the author employs them in order to better understand the life of Valentino Achak Deng, one of the (...) so-called ‘Lost Boys’ from southern Sudan. Since his life is largely a narrative of displacements, Deng’s story provides us with an exceptionally rich opportunity to implement Casey’s articulation of place. (shrink)
Edward R. Murrow's reputation began and grew with World War II. This analysis, focused on his radio reporting, concerns two reports filed after he accompanied a bombing mission over Germany. The two reports provide a unique analytic opportunity because their foundation is in a singular experience. It is an analysis of the decision process, with ethical questions central to the development of the story, it is an application of classical ethical theory to a historical object for the purposes of (...) creating an understanding of media heritage and the application of moral philosophy. (shrink)
During the course of his lengthy career, Edward Schillebeeckx has developed a series of epistemological frameworks which inform his theology. Using the metaphor of “circle” to describe these frameworks, the article will argue that Schillebeeckx in his earlier theology describes experience and knowledge within the framework of an ontological circle of subject and object. In his later work, Schillebeeckx develops a second, hermeneutical circle and finally a critical circle of theory and praxis. Later developments in his thought both depend (...) upon and radically re-interpret the earlier circles of epistemology. Since all theological language and practice must originate within the boundaries of human knowledge and experience, only by this reinterpretation of epistemology, Schillebeeckx argues, can Christian theology begin to meet the challenge of the understanding of faith in the modern and postmodern world. (shrink)
This article brings together the Sartrean concept of bad faith and Edward Upward's novel, Journey to the Border , first published in 1938. The aim is to provide an overtly political reading that challenges the surreal obscurity of Upward's psychological narrative, while at the same time showing the continuing relevance of Sartre's understanding of the psychological tensions and existential dilemmas of the modern condition. Upward's novel has been the focus of much critical debate as to the meaning of the (...) story - the descent of the main character towards madness in the context of the 1930s threat of fascism and war - as well as the generic characterisation of the text in terms of satire, fable, fantasy or political parable. The article argues in contrast a more unequivocally ideological reading of the series of existential choices, both personal and political, of the main character as a struggle for individual freedom and authenticity through a radical commitment to socialism and responsibility for the Other. (shrink)
This article recounts the history of the composition, publication and dissemination of Edward Pococke's translation into Arabic of Grotius, De Veritate , the motivation for making it alleged both by Grotius and by Pococke, and the changes in the text which were introduced by Pococke. An Appendix provides, for the two chapters which are most different from Grotius's original, the Arabic text, a literal translation, Grotius's Latin, and details of the sources of Grotius and Pococke for their accusations against (...) the Muslims in those chapters. (shrink)
Numinous spaces in British literature from William Wordsworth to Samuel Beckett -- Jesus figures in American literature from Ralph Waldo Emerson to Edward Albee -- Using Bakhtin's definitions to discover ethical voices in Solzhenitsyn and Tolstoy -- René Girard's categories of scapegoats in literature of the American South -- Hopkins's metaphysics of nature as sacred disclosure -- The book of job as mirrored in Hopkins's metaphysics -- Beckett's mythos of the absence of God.
This is a collection of fifty essays featured in Edward R. Murrow's 1950s This I Believe radio series. It includes such celebrities of the twentieth century as Pearl Buck, Norman Cousins, Margaret Mead, James Michener, Jackie Robinson, and Harry Truman. With an introduction by Edward R. Murrow and a foreword by Dan Gediman, executive producer of the contemporary This I Believe radio broadcasts, heard weekly on public radio.
'Critical Management Studies', or 'CMS', has emerged over the last ten years as the term to describe a diverse group of work that has adopted a critical or questioning approach to the traditional concerns of Management Studies. In this time, CMS has come to exert an increasing influence in Management and Management Studies, and while it has prompted fierce debate about its validity and use, there is no doubt that the rapidly growing interest in CMS has produced a vibrant and (...) exciting body of work. -/- Christopher Grey and Hugh Willmott, leading authorities in this area, have collected together seventeen readings which reflect these developments, and show why CMS has become an important field of research. The book is divided into four sections, 'Anticipating CMS', looking at some of the roots of CMS, 'Studying Management Critically', 'Critical Studies of Management', and 'Assessing CMS', examining some of the internal and external critical discussions of CMS. -/- Each reading and its significance is introduced by the editors, and in their introduction to the Reader, they reflect more broadly on the history of CMS. In particular, they consider its institutionalization, both in terms of its becoming an identifiable body of work or approach, and its institutional context within business schools, and indeed what it means to produce a Reader of critical work. -/- As an assessment of CMS, the Reader will be of interest to academics, researchers, and students of Management Studies. As an introduction to CMS, the book will prove invaluable to students taking courses requiring familiarity with the CMS literature. -/- Includes work by: -/- Paul S. Adler, Mats Alvesson, P. D. Anthony, James R. Barker, Loren Baritz, Stewart Clegg, Bill Cooke, Stanley Deetz, David Dunkerley, Christopher Grey, Heather Hopfl, David Knights, Richard Marsden, C Wright Mills, Martin Parker, Rosemary Pringle, Paul Thompson, Barbara Townley, Hugh Willmott, and Edward Wray-Bliss. (shrink)
Newman’s dramatic poem, “The Dream of Gerontius” (1865), was set to music by Edward Elgar (1857-1934) in 1900. This essay brings out the sympathy of mind and heart between poet and composer, and perhaps between them both and the listener of today, as well as the universality and depth of the human stake in some kind of personal and peopled life after death.
Michael Polanyi and Edward Shils shared a great many views, and in their long mutual relationship influenced one another. This memorial note examines the relationship and some of the respects in which Shils presented a Polanyian social theory organized around the notion of tradition.
How should we live? What really exists? And how do we know for sure? In this lively and engaging study, Edward Craig argues that learning philosophy is merely a matter of broadening and deepening what most of us do already. But he also shows that philosophy is no mere intellectual pastime: thinkers such as Plato, the Buddhist sages, Descartes, Hobbes, Hume, Hegel, Darwin, Mill, and de Beauvoir responded to real needs and events—and many of their concerns shape our daily (...) lives. (shrink)
I want to explore strategic expressions of ignorance against the background of Charles W. Mills's account of epistemologies of ignorance in The Racial Contract (1997). My project has two interrelated goals. I want to show how Mills's discussion is restricted by his decision to frame ignorance within the language and logic of social contract theory. And, I want to explain why Maria Lugones's work on purity is useful in reframing ignorance in ways that both expand our understandings of (...) ignorance and reveal its strategic uses. I begin with Mills's account of the Racial Contract, and explain how it prescribes for its signatories an epistemology of ignorance, which Mills characterizes as an inverted epistemology. I briefly outline his program for undoing white ignorance and indicate that retooling white ignorance is more complex than his characterization suggests. Making this argument requires an abrupt shift from the white-created frameworks of social contract theory to Lugones's system of thinking rooted in the lives of people of color. So, the next section outlines Lugones's distinction between the logic of purity and the logic of curdling and explains its usefulness in addressing ignorance. With both accounts firmly in place the third section demonstrates how the Racial Contract produces at least two expressions of ignorance and explains how the logic of purity underlying the Contract shapes each expression in ways that limit possibilities for resistance. I don't mean to suggest that the social contract theory's love of purity invalidates Mills's work, only that this framework limits prospects for long-term change by neglecting the relationship between white ignorance and non-white resistance. The final sections explain how people of color use ignorance strategically to their advantage , and argue that examining ignorance through a curdled lens not only makes strategic ignorance visible, but also points to alternatives for retooling white ignorance. (shrink)
The dialogue between internalists who maintain a belief is a case of knowledge when that which justifies the belief is within the agent's first-person perspective and externalists who maintain epistemic justification can be in part, or entirely, outside the agent's first-person perspective has been part of the epistemological literature for some time with one side usually attempting to show how the other side is mistaken. Edward Craig argues the internalist/externalist debate is flawed from the outset. Specifically, both internalism and (...) externalism should be incorporated into the correct analysis of knowledge once we revamp that project. The epistemological project, according to Craig, is a practical explication of what both our epistemological practices and the concept of knowledge do for us. My purpose here is to evaluate this proposal, as well as Ram Neta's attempt to generalize this proposal to cover all epistemic appraisals, in light of the internalism/externalism debate. I argue the Craig/Neta proposal does not actually 'solve' the internalism/externalism debate, but rather pushes it back a level or assumes that one side is correct; hence, the Craig/Neta proposal is not an adequate 'solution' to the internalism/externalism debate. (shrink)
The question as to the appropriate method of epistemic analysis has always been an issue for epistemologists. In recent years, the traditional method utilized in epistemology - conceptual analysis - has come under attack from various perspectives. Yet, often no replacement method is given in its place. In two works, "A Practical Explication of Knowledge" and Knowledge and the State of Nature, Edward Craig proposes a new way of doing epistemology. Craig's epistemic method eschews traditional conceptual analysis in favor (...) of what he calls "conceptual synthesis". He proposes we start not from the finding of necessary and sufficient conditions that match our intuitions; rather we start from considerations on what the concept of knowledge does for us. Though there is much to discuss in Craig proposal, in this paper I explore one aspect - the good informant. It is this aspect that is central to Craig's epistemic method and perhaps most problematic. In this essay, I evaluate this concept by first articulating three initial worries that some have had about the concept. I show that each of the initial worries can be quelled by looking deeper into the features of what Craig's proposal is. I then assess Craig's proposal on its own terms. Instead of looking to counterexamples for possible problems, I look at the concept of a good informant in light of the criteria for an adequate explication. What I hope to show is that while there is much to be sympathetic with in Craig's proposal, there are some open questions that need to be solved in order to say that an adequate explication has been reached. (shrink)
Essay review of Gauging What’s Real: The Conceptual Foundations of Contemporary Gauge Theories R. Healey. Oxford University Press (2007). To be published in the Studies in History and Philosophy of Modern Physics, 39(3):687-693, 2008.
In this chapter we shall examine the characteristic properties of a construction wide-spread in the world’s languages, the passive. In section 1 below we discuss defining characteristics of passives, contrasting them with other foregrounding and backgrounding constructions. In section 2 we present the common syntactic and semantic properties of the most wide-spread types of passives, and in section 3 we consider passives which differ in one or more ways from these. In section 4, we survey a variety of constructions that (...) resemble passive constructions in one way or another. In section 5, we briefly consider differences between languages with regard to the roles passives play in their grammars. Specifically, we show that passives are a more essential part of the grammars of some languages than of others. (shrink)
