According to Russo and Williamson (Int Stud Philos Sci 21(2):157–170, 2007, Hist Philos Life Sci 33:389–396, 2011a, Philos Sci 1(1):47–69, 2011b), in order to establish a causal claim of the form, ‘C is a cause of E’, one typically needs evidence that there is an underlying mechanism between C and E as well as evidence that C makes a difference to E. This thesis has been used to argue that hierarchies of evidence, as championed by evidence-based movements, tend to (...) give primacy to evidence of difference making over evidence of mechanisms and are flawed because the two sorts of evidence are required and they should be treated on a par. An alternative approach gives primacy to evidence of mechanism over evidence of difference making. In this paper, we argue that this alternative approach is equally flawed, again because both sorts of evidence need to be treated on a par. As an illustration of this parity, we explain how scientists working in the ‘EnviroGenomarkers’ project constantly make use of the two evidential components in a dynamic and intertwined way. We argue that such an interplay is needed not only for causal assessment but also for policy purposes. (shrink)
Philosophy of medicine: between clinical trials and mechanisms Content Type Journal Article Category Book Review Pages 1-4 DOI 10.1007/s11016-011-9630-5 Authors Federica Russo, Philosophy-SECL, University of Kent, Canterbury, CT2 7NF UK Journal Metascience Online ISSN 1467-9981 Print ISSN 0815-0796.
Tobacco, divine, rare superexcellent tobacco, which goes far beyond all panaceas, potable gold and philosopher's stones, a sovereign remedy to all diseases.Although most of the toxicity, including cancerogenicity, of tobacco is related to a mix of components other than nicotine present in cigarettes (U.S. Surgeon General 2010), it is indeed nicotine that causes addiction to smoking (Benowitz 2010; Russo et al. 2011).In 1988, the U.S. Surgeon General's Report concluded that cigarettes and other forms of tobacco are addictive as a (...) result of their nicotine content, and that the processes determining tobacco addiction "are similar to those that determine addiction to drugs such as heroin and cocaine." Previously, in .. (shrink)
The concept of corporate social responsibility (CSR) has been widely investigated, but a generally accepted theoretical framework does not yet exist. This paper argues that the idiosyncrasies of large firms and SMEs explains the different approaches to CSR, and that the notion of social capital is a more useful way of understanding the CSR approach of SMEs, whereas stakeholder theory more closely addresses the CSR approach of large firms. Based on the extant literature, we present a comparison of large firm (...) and SME idiosyncrasies suggesting that both consolidated and emerging strategic orientations toward responsible behaviours exist. Idiosyncrasies of large firms and SMEs are also discussed to provide an assessment of the firm’s strategic CSR orientation, suggesting the key drivers upon which CSR strategies must be based. A twofold consideration emerges. First, the CSR–SME relationship could be better explained if the notion of social capital is taken into account, but this should also be accompanied by a stakeholder view of the SME; second, social capital and stakeholder theory should be taken as alternative ways of explaining CSR in both large firms and SMEs. (shrink)
While corporate social responsibility (CSR) is becoming a mainstream issue for many organizations, most of the research to date addresses CSR in large businesses rather than in small- and medium-sized enterprises (SMEs), because it is too often considered a prerogative of large businesses only. The role of SMEs in an increasingly dynamic context is now being questioned, including what factors might affect their socially responsible behaviour. The goal of this paper is to make a comparison of SME and large firm (...) CSR strategies. Furthermore, size of the firm is analyzed as a factor that influences specific choices in the CSR field, and studied by means of a sample of 3,680 Italian firms. Based on a multi-stakeholder framework, the analysis provides evidence that large firms are more likely to identify relevant stakeholders and meet their requirements through specific and formal CSR strategies. (shrink)
The anti-causal prophecies of last century have been disproved. Causality is neither a ‘relic of a bygone’ nor ‘another fetish of modern science’; it still occupies a large part of the current debate in philosophy and the sciences. This investigation into causal modelling presents the rationale of causality, i.e. the notion that guides causal reasoning in causal modelling. It is argued that causal models are regimented by a rationale of variation, nor of regularity neither invariance, thus breaking down the dominant (...) Human paradigm. The notion of variation is shown to be embedded in the scheme of reasoning behind various causal models: e.g. Rubin’s model, contingency tables, and multilevel analysis. It is also shown to be latent – yet fundamental – in many philosophical accounts. Moreover, it has significant consequences for methodological issues: the warranty of the causal interpretation of causal models, the levels of causation, the characterisation of mechanisms, and the interpretation of probability. This book offers a novel philosophical and methodological approach to causal reasoning in causal modelling and provides the reader with the tools to be up to date about various issues causality rises in social science. "Dr. Federica... more on http://springer.com/978-1-4020-8816-2.. (shrink)
The Agency and the Manipulability theory of causation, in spite of significant differences, share at least three claims. First, that manipulation – roughly, that by manipulating causes we bring about effects – is a central notion for causation; second, that such a notion of manipulation allows a reductive – i.e. general and comprehensive – account of causation; third, that this view has its forefathers in the works of Collingwood, Gasking and von Wright. This paper mainly challenges the third claim and (...) argues that the misreading of those authors leads to a more dangerous consequence: a confusion between epistemological, metaphysical and methodological issues about causation. (shrink)
Recent research on corporate social responsibility (CSR) suggests the need for further exploration into the relationship between small and medium-sized enterprises (SMEs) and CSR. SMEs rarely use the language of CSR to describe their activities, but informal CSR strategies play a large part in them. The goal of this article is to investigate whether differences exist between the formal and informal CSR strategies through which firms manage relations with and the claims of their stakeholders. In this context, formal CSR strategies (...) seem to characterize large firms while informal CSR strategies prevail among micro, small, and medium-sized enterprises. We use a sample of 3,626 Italian firms to investigate our research questions. Based on a multistakeholder framework, the analysis provides evidence that small businesses* use of CSR, involving strategies with an important impact on the bottom line, reflects an attempt to secure their license to operate in the communities; while large firms rarely make attempts to integrate their CSR strategies into explicit management systems. (shrink)
We argue that the health sciences make causal claims on the basis of evidence both of physical mechanisms, and of probabilistic dependencies. Consequently, an analysis of causality solely in terms of physical mechanisms or solely in terms of probabilistic relationships, does not do justice to the causal claims of these sciences. Yet there seems to be a single relation of cause in these sciences - pluralism about causality will not do either. Instead, we maintain, the health sciences require a theory (...) of causality that unifies its mechanistic and probabilistic aspects. We argue that the epistemic theory of causality provides the required unification. (shrink)
For four decades, research on the role and responsibilities of business in society has centered on the business case for corporate social responsibility (CSR) and an increasing number of studies on the corporate social performance (CSP)—corporate financial performance (CFP) link emerged leading to controversial results. Heeding the call for a deeper understanding of the mechanisms linking certain CSR efforts to certain performance outcomes, this study provides a stakeholder-based organizing framework rooted in an extensive review of existing literature on the link (...) between CSP and CFP. In so doing, we aim at guiding research and practice toward less simplistic understandings of the CSP–CFP connection, thus advancing the debate over the consequences of voluntary integrating CSR into business operations and into relationships with stakeholders. By disentangling specific drivers and outcomes of the CSP–CFP link, we underline the importance of setting clear boundaries and specifying levels of analysis to generate comparable results. (shrink)
A careful analysis of Salmon’s Theoretical Realism and van Fraassen’s Constructive Empiricism shows that both share a common origin: the requirement of literal construal of theories inherited by the Standard View. However, despite this common starting point, Salmon and van Fraassen strongly disagree on the existence of unobservable entities. I argue that their different ontological commitment towards the existence of unobservables traces back to their different views on the interpretation of probability via different conceptions of induction. In fact, inferences to (...) statements claiming the existence of unobservable entities are inferences to probabilistic statements, whence the crucial importance of the interpretation of probability. (shrink)
Causal analysis in the social sciences takes advantage of a variety of methods and of a multi-fold source of information and evidence. This pluralistic methodology and source of information raises the question of whether we should accordingly have a pluralistic metaphysics and epistemology. This paper focuses on epistemology and argues that a pluralistic methodology and evidence dont entail a pluralistic epistemology. It will be shown that causal models employ a single rationale of testing, based on the notion of variation. Further, (...) I shall argue that this monistic epistemology is also involved in alternative philosophical theories of causation. (shrink)
The paper examines definitions of ‘cause’ in the epidemiological literature. Those definitions all describe causes as factors that make a difference to the distribution of disease or to individual health status. In the philosophical jargon, causes in epidemiology are difference-makers. Two claims are defended. First, it is argued that those definitions underpin an epistemology and a methodology that hinge upon the notion of variation, contra the dominant Humean paradigm according to which we infer causality from regularity. Second, despite the fact (...) that causes be defined in terms of ‘difference-making’, this cannot fixes the causal metaphysics. Causality in epidemiology ought to be interpreted according to the epistemic theory. In this approach relations are deemed causal depending on the evidence and on the available methods. Indeed, evidence to establish causal claims requires difference-making considerations; furthermore, those definitions of cause reflect the ‘variational’ epistemology and methodology of epidemiology. (shrink)
We give in this paper indications about the dynamical impact (as phenotypic changes) coming from the main sources of perturbation in biological regulatory networks. First, we define the boundary of the interaction graph expressing the regulations between the main elements of the network (genes, proteins, metabolites, ...). Then, we search what changes in the state values on the boundary could cause some changes of states in the core of the system (robustness to boundary conditions). After, we analyse the role of (...) the mode of updating (sequential, block sequential or parallel) on the asymptotics of the network, essentially on the occurrence of limit cycles (robustness to updating methods). Finally, we show the influence of some topological changes (e.g. suppression or addition of interactions) on the dynamical behaviour of the system (robustness to topology perturbations). (shrink)
This paper deals with causal analysis in the social sciences. We first present a conceptual framework according to which causal analysis is based on a rationale of variation and invariance, and not only on regularity. We then develop a formal framework for causal analysis by means of structural modelling. Within this framework we approach causality in terms of exogeneity in a structural conditional model based which is based on (i) congruence with background knowledge, (ii) invariance under a large variety of (...) environmental changes, and (iii) model fit. We also tackle the issue of confounding and show how latent confounders can play havoc with exogeneity. This framework avoids making untestable metaphysical claims about causal relations and yet remains useful for cognitive and action-oriented goals. (shrink)
The Recursive Bayesian Net (RBN) formalism was originally developed for modelling nested causal relationships. In this paper we argue that the formalism can also be applied to modelling the hierarchical structure of mechanisms. The resulting network contains quantitative information about probabilities, as well as qualitative information about mechanistic structure and causal relations. Since information about probabilities, mechanisms and causal relations is vital for prediction, explanation and control respectively, an RBN can be applied to all these tasks. We show in particular (...) how a simple two-level RBN can be used tomodel a mechanism in cancer science. The higher level of our model contains variables at the clinical level, while the lower level maps the structure of the cell’s mechanism for apoptosis. (shrink)
The paper addresses the question of how different types of evidence ought to inform public health policy. By analysing case studies on obesity, the paper draws lessons about the different roles that different types of evidence play in setting up public health policies. More specifically, it is argued that evidence of difference-making supports considerations about ‘what works for whom in what circumstances’, and that evidence of mechanisms provides information about the ‘causal pathways’ to intervene upon.
We investigate the semantics of the logical systems obtained by introducing the modalities and into the family of substructural implication logics (including relevant, linear and intuitionistic implication). Then, in the spirit of the LDS (Labelled Deductive Systems) methodology, we "import" this semantics into the classical proof system KE. This leads to the formulation of a uniform labelled refutation system for the new logics which is a natural extension of a system for substructural implication developed by the first two authors in (...) a previous paper. (shrink)
In social science, one objection to causal analysis is that the assumption of the closure of the system makes the analysis too narrow in scope, that is, it considers only 'closed' and 'hermetic' systems thus neglecting many other external influences. On the contrary, system analysis deals with complex structures where every element is interrelated with everything else in the system. The question arises as to whether the two approaches can be compatible and whether causal analysis can be integrated into the (...) broader framework of system analysis. This article attempts a negative answer on the grounds of fundamental differences in their assumptions and suggests using system analysis as a post-hoc comparative tool. (shrink)
According to mental model theory, illusory inferences are a class of deductions in which individuals systematically go wrong. Mental model theory explains them invoking the principle of truth, which is a tendency not to represent models that falsify the premises. In this paper we focus on the illusory problems based on conditional sentences. In three experiments, we show that: (a) rather than not representing models that falsify the conditionals, participants have a different understanding of what falsifies a conditional (Experiment I); (...) (b) specifically, participants think that a conditional with an impossible antecedent or consequent is false (Experiment 2); (c) if the domain of the conditionals in the illusory problems are expanded to show that their antecedents and consequents are possible, the participants find it easy to reach the correct conclusions (Experiment 3). According to our results, the illusory inferences based on conditional premises, differently from those based on disjunctive premises, are caused by a difference between the understanding of natural language factual conditionals and the truth table of the factual implication; the principle of truth is not necessary to explain them. (shrink)
The empirical data do not unequivocally support a consistent fixed capacity of four chunks. We propose an alternative account whereby capacity is limited by the precision of specifying the temporal and spatial context in which items appear, that similar psychophysical constraints limit number estimation, and that short term memory (STM) is continuous with long term memory (LTM).
In celebration of the centenary of the Italian philosopher Cornelio Fabro’s birth (1911–1995), this paper investigates the essential theoretical traits that undergird the framework of Fabro’s 1941 texts, by comparing them with Franz Brentano’s (1838–1817) project of renewing Thomism through a new understanding of Aristotle. The secondary literature concerning the comparison of both these authors is almost nonexistent. Our goal is to clarify some of the central issues regarding the relation between Fabro and Brentano through direct textual analysis of unpublished (...) letters exchanged between Fabro and Agostino Gemelli about Brentano and his pupil Carl Stumpf. (shrink)
Harry Frankfurt has argued that Descartes’s madness doubt in the First Meditation is importantly different from his dreaming doubt. The madness doubt does not provide a reason for doubting the senses since were the meditator to suppose he was mad his ability to successfully complete the philosophical investigation he sets for himself in the first few pages of the Meditations would be undermined. I argue that Frankfurt’s interpretation of Descartes’s madness doubt is mistaken and that it should be understood as (...) playing the same role as his more famous dreaming doubt. I focus my discussion around four questions: (Q1) What does the meditator have in mind when speaking of madness?, (Q2) Why does the meditator so quickly dismiss the madness doubt but take seriously the dreaming doubt?, (Q3) Does the madness doubt have the same scope as the dreaming doubt?, and (Q4) Why does the meditator bring up the madness doubt at all? (shrink)
Building a meaningful model of biological regulatory network is usually done by specifying the components (e.g. the genes) and their interactions, by guessing the values of parameters, by comparing the predicted behaviors to the observed ones, and by modifying in a trial-error process both architecture and parameters in order to reach an optimal fitness. We propose here a different approach to construct and analyze biological models avoiding the trial-error part, where structure and dynamics are represented as formal constraints. We apply (...) the method to Hopfield-like networks, a formalism often used in both neural and regulatory networks modeling. The aim is to characterize automatically the set of all models consistent with all the available knowledge (about structure and behavior). The available knowledge is formalized into formal constraints. The latter are compiled into Boolean formula in conjunctive normal form and then submitted to a Boolean satisfiability solver. This approach allows to formulate a wide range of queries, expressed in a high level language, and possibly integrating formalized intuitions. In order to explore its potential, we use it to find cycles for 3-nodes networks and to determine the flower morphogenesis regulatory network of Arabidopsis thaliana . Applications of this technique are numerous and concern the building of models from data as well as the design of biological networks possessing specified behaviors. (shrink)
Globalization is a natural process. It has a number of advantages & disadvantages, causes many questions and problems, which can hardly sometimes be solved by countries independently. These problems can only be solved by the world community. One of these problems is to maintain the concrete communities identity. Is it possible to keep the unique culture of different ethnos, language, traditions in the globalizing world? Or as some researchers consider, there is a tendency to the formation of the so called (...) super ethnos? In such conditions tolerance takes on special significance as a certain means of activity, as social behavior model, as a norm of behavior for each member of the society. Tolerance as a behavior model on one hand should be worked out by a state legislative body, from the other it should be a norm of behavior for each member of the society. The basis of the tolerant behavior is the principle of mutual understanding.It can be considered to be a moral imperative for the resolution of conflict situations. The relevance & importance of tolerance & creating tolerant relations is a characteristic feature of the democratic personality. (shrink)
This article describes different positions of very specific human behavior features in Evolutionary Ethics and their correspondence with the Modern scientific paradigm.
The paper analyzes the role of epistemology in contemporary science study. According to the representatives of cultural approach to scientific cognition the latter should be considered regardless of the issues of falsity or truth, which excludes epistemology from the sphere of science investigation. The paper argues, that though the inquiry of science as an aspect of human culture is quite possible, this sort of analysis is insufficient. In order to understand the nature of scientific cognition one has to supplement it (...) by the results of epistemological consideration. (shrink)
There is a need for integrated thinking about causality, probability and mechanisms in scientific methodology. Causality and probability are long-established central concepts in the sciences, with a corresponding philosophical literature examining their problems. On the other hand, the philosophical literature examining mechanisms is not long-established, and there is no clear idea of how mechanisms relate to causality and probability. But we need some idea if we are to understand causal inference in the sciences: a panoply of disciplines, ranging from epidemiology (...) to biology, from econometrics to physics, routinely make use of probability, statistics, theory and mechanisms to infer causal relationships. -/- These disciplines have developed very different methods, where causality and probability often seem to have different understandings, and where the mechanisms involved often look very different. This variegated situation raises the question of whether the different sciences are really using different concepts, or whether progress in understanding the tools of causal inference in some sciences can lead to progress in other sciences. The book tackles these questions as well as others concerning the use of causality in the sciences. (shrink)
Recent research on corporate social responsibility (CSR) is suggesting the need for filling the knowledge gap in the relationship between small and mediumsized enterprises (SMEs) and CSR. SMEs rarely use the language of CSR to describe what they are doing, but informal CSR strategies deeply characterize their businesses. The goal of this paper is to investigate whether a distinction exists between formal and informal CSR strategies, whereas formal CSR strategies should be a prerogative by large firms and informal CSR strategies (...) should be a condition of micro, small, and medium-sized enterprises. A sample of 3,626 Italian firms is used to investigate the research questions. Based on a multi-stakeholder framework, the analysis provides evidence that small businesses reveal their aptitude towards CSR through strategies with an important impact on the bottom line as an attempt to strengthen their license to operate in the communities; large firms are far away from integrating their CSR strategies with explicit management systems. (shrink)
This short paper is a "quick and dirty" introduction for non-philosophers (with some background in propositional logic) to Jaegwon Kim's famous supervenience argument against non-reductive physicalism (also known as the exclusion problem). It motivates the problem of mental causation, introduces Kim's formulation of the issue centered around mind-body supervenience, presents the argument in deductive form, and makes explicit why Kim concludes that vindicating mental causation demands a reduction of mind.
This paper investigates the influence of the increasingly sustainable sourcing policies of many multinational companies on suppliers located in developing countries. Our research was conducted in Viet Nam and involved 25 Vietnamese enterprises. The results reveal, on the one hand, how CSR makes business sense even in a developing country and, on the other hand, the difficulties of maintaining sustainability as products move from northern consumers to Vietnamese suppliers. In more detail, we highlight the unsustainable process through which corporate responsibility (...) is being imposed on Vietnamese suppliers and how CSR might eventually turn into a new form of protectionism. Therefore, this process calls for more collaborative models of governance among the companies along the supply chain, local authorities, international players, and civil society at large. (shrink)
Russo and Williamson claim that establishing causal claims requires mechanistic and difference-making evidence. In this article, I will argue that Russo and Williamson's formulation of their thesis is multiply ambiguous. I will make three distinctions: mechanistic evidence as type vs object of evidence; what mechanism or mechanisms we want evidence of; and how much evidence of a mechanism we require. I will feed these more precise meanings back into the Russo?Williamson thesis and argue that it is both (...) true and false: two weaker versions of the thesis are worth supporting, while the stronger versions are not. Further, my distinctions are of wider concern because they allow us to make more precise claims about what kinds of evidence are required in particular cases. (shrink)
In this paper I offer an anti-Humean critique to Williamson and Russo’s approach to medical mechanisms. I focus on one of the specific claims made by Williamson and Russo, namely the claim that micro-structural ‘mechanisms’ provide evidence for the stability across populations of causal relationships ascertained at the (macro-) level of (test) populations. This claim is grounded in the epistemic account of causality developed by Williamson, an account which—while not relying exclusively on mechanistic evidence for justifying causal judgements—appeals (...) nevertheless to mechanisms, and rejects their anti-Humean interpretation in terms of capacities, powers, potencies, etc. By using (and expanding on) Cartwright’s basic critique against Humean mechanisms, I suggest that, in order to move beyond the level of plausibility, Williamson and Russo’s position is in need of a clarification as to the occurent reading of the components, functioning and interferences of mechanisms. Relatedly, as concerns Williamson’s epistemic account of causation, I argue that this account is in need of a more straightforward answer as to what truth-makers its causal claims should have. (shrink)
In this thesis, I give a metascientific account of causality in medicine. I begin with two historical cases of causal discovery. These are the discovery of the causation of Burkitt’s lymphoma by the Epstein-Barr virus, and of the various viral causes suggested for cervical cancer. These historical cases then support a philosophical discussion of causality in medicine. This begins with an introduction to the Russo- Williamson thesis (RWT), and discussion of a range of counter-arguments against it. Despite these, I (...) argue that the RWT is historically workable, given a small number of modifications. I then expand Russo and Williamson’s account. I first develop their suggestion that causal relationships in medicine require some kind of evidence of mechanism. I begin with a number of accounts of mechanisms and produce a range of consensus features of them. I then develop this consensus position by reference to the two historical case studies with an eye to their operational competence. In particular, I suggest that it is mechanistic models and their representations which we are concerned with in medicine, rather than the mechanism as it exists in the world. -/- I then employ these mechanistic models to give an account of the sorts of evidence used in formulating and evaluating causal claims. Again, I use the two human viral oncogenesis cases to give this account. I characterise and distinguish evidence of mechanism from evidence of difference-making, and relate this to mechanistic models. I then suggest the relationship between types of evidence presents us with a means of tackling the reference-class problem. This sets the scene for the final chapter. Here, I suggest the manner in which these two different classes of evidence become integrated is also reflected in the way that developing research programmes change as their associated causal claims develop. (shrink)
