1. Hedi Amor, Fabien Corblin, Eric Fanchon, Adrien Elena & Laurent Trilling (2013). Formal Methods for Hopfield-Like Networks. Acta Biotheoretica 61 (1):21-39.
    Building a meaningful model of biological regulatory network is usually done by specifying the components and their interactions, by guessing the values of parameters, by comparing the predicted behaviors to the observed ones, and by modifying in a trial-error process both architecture and parameters in order to reach an optimal fitness. We propose here a different approach to construct and analyze biological models avoiding the trial-error part, where structure and dynamics are represented as formal constraints. We apply the method to (...)
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  2. Eric Fanchon & Philippe Tracqui (2013). Proceedings of the XXXIth Seminar of the French-Speaking Society for Theoretical Biology. Acta Biotheoretica 61 (1):1-2.
  3. Minh-Uyen Thi, Candice Trocmé, Marie-Paule Montmasson, Eric Fanchon & Bertrand Toussaint (2012). Investigating Metalloproteinases MMP-2 and MMP-9 Mechanosensitivity to Feedback Loops Involved in the Regulation of In Vitro Angiogenesis by Endogenous Mechanical Stresses. [REVIEW] Acta Biotheoretica 60 (1-2):21-40.
    Angiogenesis is a complex morphogenetic process regulated by growth factors, but also by the force balance between endothelial cells traction stresses and extracellular matrix viscoelastic resistance. Studies conducted with in vitro angiogenesis assays demonstrated that decreasing ECM stiffness triggers an angiogenic switch that promotes organization of EC into tubular cords or pseudo-capillaries. Thus, mechano-sensitivity of EC with regard to proteases secretion, and notably matrix metalloproteinases , should likely play a pivotal role in this switching mechanism. While most studies analysing strain (...)
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