1. Hedi Ben Amor, Fabien Corblin, Eric Fanchon, Adrien Elena, Laurent Trilling, Jacques Demongeot & Nicolas Glade (forthcoming). Formal Methods for Hopfield-Like Networks. Acta Biotheoretica.
    Building a meaningful model of biological regulatory network is usually done by specifying the components (e.g. the genes) and their interactions, by guessing the values of parameters, by comparing the predicted behaviors to the observed ones, and by modifying in a trial-error process both architecture and parameters in order to reach an optimal fitness. We propose here a different approach to construct and analyze biological models avoiding the trial-error part, where structure and dynamics are represented as formal constraints. We apply (...)
    Direct download (3 more)  
     
    My bibliography  
     
    Export citation  
  2. Minh-Uyen Dao Thi, Candice Trocmé, Marie-Paule Montmasson, Eric Fanchon, Bertrand Toussaint & Philippe Tracqui (forthcoming). Investigating Metalloproteinases MMP-2 and MMP-9 Mechanosensitivity to Feedback Loops Involved in the Regulation of In Vitro Angiogenesis by Endogenous Mechanical Stresses. [REVIEW] Acta Biotheoretica.
    Abstract Angiogenesis is a complex morphogenetic process regulated by growth factors, but also by the force balance between endothelial cells (EC) traction stresses and extracellular matrix (ECM) viscoelastic resistance. Studies conducted with in vitro angiogenesis assays demonstrated that decreasing ECM stiffness triggers an angiogenic switch that promotes organization of EC into tubular cords or pseudo-capillaries. Thus, mechano-sensitivity of EC with regard to proteases secretion, and notably matrix metalloproteinases (MMPs), should likely play a pivotal role in this switching mechanism. While most (...)
    Translate to English
    | Direct download (3 more)  
     
    My bibliography  
     
    Export citation  
  3. Eric Fanchon & Philippe Tracqui (forthcoming). Proceedings of the XXXIth Seminar of the French-Speaking Society for Theoretical Biology. Acta Biotheoretica.