Summary 1. Ecologists and conservation biologists consider many issues when designing a field study, such as the expected value of the data, the interests of the study species, the welfare of individual organisms and the cost of the project. These different issues or values often conflict; however, neither animal ethics nor environmental ethics provides practical guidance on how to assess trade-offs between them. -/- 2. We developed a decision framework for considering trade-offs between values in ecological research, drawing on the (...) field of ecological ethics. We used a case study of the population genetics of three frog species, in which a researcher must choose between four methods of sampling DNA from the study animals. We measured species welfare as the reduction in population growth rate following sampling, and assessed individual welfare using two different definitions: (i) the level of suffering experienced by an animal, and (ii) the level of suffering combined with loss of future life. -/- 3. Tipping the tails of tadpoles ranked as the best sampling method for species welfare, while collecting whole tadpoles and buccal swabbing of adult frogs ranked best for the first and second definitions of individual welfare, respectively. Toe clipping of adult frogs ranked as the worst sampling method for species welfare and the first definition of individual welfare, and equal worst for the second definition of individual welfare. -/- 4. When considering species and individual welfare simultaneously, toe clipping was clearly inferior to the other sampling methods, but no single sampling method was clearly superior to the other three. Buccal swabbing, collecting tadpoles and tail tipping were all preferred options, depending on the definition of individual welfare and the level of precision with which we assessed species welfare. -/- 5.Synthesis and applications. The decision framework we present can be used by ecologists to assess ethical and other trade-offs when planning field studies. A formal decision analysis makes transparent how a researcher might negotiate competing ethical, financial and practical objectives. Defining the components of the decision in this way can help avoid errors associated with human judgement and linguistic uncertainty. (shrink)
This essay treats the idea specific to the French republican culture, where the state does not oppose individual freedom, but rather makes it possible. It tries to assess and defend this idea using philosophical and historical arguments on the nature of democracy and the meaning of freedom. If liberty requires some sort of equality that goes beyond equality of rights, the state is a necessary component for freedom whenever equality is not simply given, but gained in opposition to private and (...) non-private domination. (shrink)
L'article traduit ici parut dans le Contemporary Jewish Record, Review of events and digest of opinion, 7 (Juin 1944), pages 115 à 126. Cette revue, l'une des nombreuses publications de l'American Jewish Committee, vit le jour peu avant la guerre, en septembre 1938, et finit avec elle en juin 1945, ne trouvant plus sa raison d'être, à savoir dénoncer les crimes allemands et travailler à la paix. Figurent aussi dans ce volume sept un article de Hannah Arendt : « Concerning (...) Minorities » et la traduction de la communication de Renan à la Société des Études Juives, le 26 mai 1883 : « Judaïsme et Christianisme ». Sur les thèmes évoqués, on se référera aux textes suivants : — « Judaism and the Modem political Myths », Symbol, Myth and Culture, Yale University Press, 1979, p.233-239. Il s'agit du texte, incomplet, d'une épreuve manuscrite (Cassirer Deposit 162 b), restée inachevée, de l'article traduit ici. — « The Myth of the State », Fortune, vol. 26, n° 6, juin 1944. — « Der mythos als politische Waffe », Die Amerikanische Rundschau, Munich, n° 11. — « Philosophy and Politics », in Symbol, Myth and Culture, Essays and Lectures of E. Cassirer, ed. by D.P. Varene, Yale University Press, 1979. Traduction française : « Philosophie et politique », in E. Cassirer, L'idée de l'Histoire, les inédits de Yale et autres écrits d'exil, Paris, Éditions du Cerf, 1989. — « The Technique of our Modem Political Myths », in Symbol, Myth and Culture, Essays and Lectures of E. Cassirer, ed. by D.P. Varene, Yale University Press, 1979. — The Myth of the State, Yale University Press, 1946. — T. Cassirer, Aus meinem Leben mit Ernst Cassirer, New York, Prìvately issued, 1950, notamment p. 291-296. (shrink)
(2013). The Cube, the Square and the Problem of Existential Import. History and Philosophy of Logic: Vol. 34, No. 2, pp. 101-132. doi: 10.1080/01445340.2013.764962.
Building a meaningful model of biological regulatory network is usually done by specifying the components (e.g. the genes) and their interactions, by guessing the values of parameters, by comparing the predicted behaviors to the observed ones, and by modifying in a trial-error process both architecture and parameters in order to reach an optimal fitness. We propose here a different approach to construct and analyze biological models avoiding the trial-error part, where structure and dynamics are represented as formal constraints. We apply (...) the method to Hopfield-like networks, a formalism often used in both neural and regulatory networks modeling. The aim is to characterize automatically the set of all models consistent with all the available knowledge (about structure and behavior). The available knowledge is formalized into formal constraints. The latter are compiled into Boolean formula in conjunctive normal form and then submitted to a Boolean satisfiability solver. This approach allows to formulate a wide range of queries, expressed in a high level language, and possibly integrating formalized intuitions. In order to explore its potential, we use it to find cycles for 3-nodes networks and to determine the flower morphogenesis regulatory network of Arabidopsis thaliana . Applications of this technique are numerous and concern the building of models from data as well as the design of biological networks possessing specified behaviors. (shrink)
