Search results for 'Genomics' (try it on Scholar)

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  1. Jordan Bartol (2013). Re-Examining the Gene in Personalized Genomics. Science and Education 22 (10):2529-2546.score: 24.0
    Personalized genomics companies (PG; also called ‘direct-to-consumer genetics’) are businesses marketing genetic testing to consumers over the Internet. While much has been written about these new businesses, little attention has been given to their roles in science communication. This paper provides an analysis of the gene concept presented to customers and the relation between the information given and the science behind PG. Two quite different gene concepts are present in company rhetoric, but only one features in the science. To (...)
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  2. Michel Morange (2006). Post-Genomics, Between Reduction and Emergence. Synthese 151 (3):355 - 360.score: 24.0
    It is frequently said that biology is emerging from a long phase of reductionism. It would be certainly more correct to say that biologists are abandoning a certain form of reductionism. We describe this past form, and the experiments which challenged the previous vision. To face the difficulties which were met, biologists use a series of concepts and metaphors - pleiotropy, tinkering, epigenetics - the ambiguity of which masks the difficulties, instead of solving them. In a similar way, the word (...)
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  3. Marko Barendregt & René Van Hezewijk (2005). Adaptive and Genomic Explanations of Human Behaviour: Might Evolutionary Psychology Contribute to Behavioural Genomics? [REVIEW] Biology and Philosophy 20 (1):57-78.score: 24.0
    . Evolutionary psychology and behavioural genomics are both approaches to explain human behaviour from a genetic point of view. Nonetheless, thus far the development of these disciplines is anything but interdependent. This paper examines the question whether evolutionary psychology can contribute to behavioural genomics. Firstly, a possible inconsistency between the two approaches is reviewed, viz. that evolutionary psychology focuses on the universal human nature and disregards the genetic variation studied by behavioural genomics. Secondly, we will discuss the (...)
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  4. Ernesto Schwartz-Marín & Irma Silva-Zolezzi (2010). “The Map of the Mexican’s Genome”: Overlapping National Identity, and Population Genomics. [REVIEW] Identity in the Information Society 3 (3):489-514.score: 24.0
    This paper explores the intersections between national identity and the production of medical/population genomics in Mexico. The ongoing efforts to construct a Haplotype Map of Mexican genetic diversity offers a unique opportunity to illustrate and analyze the exchange between the historic-political narratives of nationalism, and the material culture of genomic science. Haplotypes are central actants in the search for medically significant SNP’s , as well as powerful entities involved in the delimitation of ancestry, temporality and variability . By following (...)
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  5. Gabriele Badano (2012). Genomics and Public Involvement: Giving Justifications Their Due. Studies in Ethics, Law, and Technology 6 (1).score: 24.0
    The involvement of the public in the governance of genomics has become a topic of growing interest among scholars, practitioners and policy-makers. The implementation of public involvement programmes may be quite expensive, and the design and evaluation of public participation is a matter of controversy. Thus, this paper examines the justifications for public participation in the governance of genomic research to help understand whether public involvement is worthwhile and to provide a guide to the design of public participation. I (...)
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  6. Alexander Powell, Maureen A. O'Malley, Staffan Mueller-Wille, Jane Calvert & John Dupré (2007). Disciplinary Baptisms: A Comparison of the Naming Stories of Genetics, Molecular Biology, Genomics and Systems Biology. History and Philosophy of the Life Sciences 29 (1):5-32.score: 24.0
    Understanding how scientific activities use naming stories to achieve disciplinary status is important not only for insight into the past, but for evaluating current claims that new disciplines are emerging. In order to gain a historical understanding of how new disciplines develop in relation to these baptismal narratives, we compare two recently formed disciplines, systems biology and genomics, with two earlier related life sciences, genetics and molecular biology. These four disciplines span the twentieth century, a period in which the (...)
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  7. Lisa Gannett (2013). Projectibility and Group Concepts in Population Genetics and Genomics. Biological Theory 7 (2):130-143.score: 24.0
    Although the category “race” fails as a postulated natural kind, racial, ethnic, national, linguistic, religious, and other group designations might nonetheless be considered projectible insofar as they support inductive inferences in biomedicine. This article investigates what it might mean for group concepts in population genetics and genomics to be projectible and whether the projectibility of such predicates licenses the representation of their corresponding classes as natural kinds according to currently prevailing projectibility-based accounts of natural kinds. The article draws on (...)
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  8. Hub Zwart (2009). From Utopia to Science: Challenges of Personalised Genomics Information for Health Management and Health Enhancement. [REVIEW] Medicine Studies 1 (2):155-166.score: 24.0
    From 1900 onwards, scientists and novelists have explored the contours of a future society based on the use of “anthropotechnologies” (techniques applicable to human beings for the purpose of performance enhancement ranging from training and education to genome-based biotechnologies). Gradually but steadily, the technologies involved migrated from (science) fiction into scholarly publications, and from “utopia” (or “dystopia”) into science. Building on seminal ideas borrowed from Nietzsche, Peter Sloterdijk has outlined the challenges inherent in this development. Since time immemorial, and at (...)
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  9. Hub Zwart (2009). Genomics and Identity: The Bioinformatisation of Human Life. [REVIEW] Medicine, Health Care and Philosophy 12 (2):125-136.score: 24.0
    The genomics “revolution” is spreading. Originating in the molecular life sciences, it initially affected a number of biomedical research fields such as cancer genomics and clinical genetics. Now, however, a new “wave” of genomic bioinformation is transforming a widening array of disciplines, including those that address the social, historical and cultural dimensions of human life. Increasingly, bioinformation is affecting “human sciences” such as psychiatry, psychology, brain research, behavioural research (“behavioural genomics”), but also anthropology and archaeology (“bioarchaeology”). Thus, (...)
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  10. Jantina de Vries, Thomas N. Williams, Kalifa Bojang, Dominic P. Kwiatkowski, Raymond Fitzpatrick & Michael Parker (2014). Knowing Who to Trust: Exploring the Role of 'Ethical Metadata' in Mediating Risk of Harm in Collaborative Genomics Research in Africa. BMC Medical Ethics 15 (1):62.score: 24.0
    The practice of making datasets publicly available for use by the wider scientific community has become firmly integrated in genomic science. One significant gap in literature around data sharing concerns how it impacts on scientists’ ability to preserve values and ethical standards that form an essential component of scientific collaborations. We conducted a qualitative sociological study examining the potential for harm to ethnic groups, and implications of such ethical concerns for data sharing. We focused our empirical work on the MalariaGEN (...)
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  11. Lawrence Fagbemiro & Clement Adebamowo (2014). Knowledge and Attitudes to Personal Genomics Testing for Complex Diseases Among Nigerians. BMC Medical Ethics 15 (1):34.score: 24.0
    The study examined the knowledge and attitudes to personal genomics testing for complex diseases among Nigerians and identified how the knowledge and attitudes vary with gender, age, religion, education and related factors.
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  12. Jeffrey H. Barker (2003). Common-Pool Resources and Population Genomics in Iceland, Estonia, and Tonga. Medicine, Health Care and Philosophy 6 (2):133-144.score: 24.0
    This paper addresses the application of the ethical concept of trust and the legal and political concept of public trust to population genomics projects in Iceland, Estonia, and Tonga. Focusing on trust and public trust, the paper explores analogies between the genomics projects and the treatment of other common-pool resources, making use of the notion of trust as an ethical demand, derived from the works of Emmanuel Levinas and Knud Eljer Lgstrup. The paper discusses the degree to which (...)
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  13. Monika Piotrowska (2009). What Does It Mean to Be 75% Pumpkin? The Units of Comparative Genomics. Philosophy of Science 76 (5):838-850.score: 22.0
    Comparative genomicists seem to be convinced that the unit of measurement employed in their studies is a gene that drives the function of cells and ultimately organisms. As a result, they have come to some substantive conclusions about how similar humans are to other organisms based on the percentage of genetic makeup they share. I argue that the actual unit of measurement employed in the studies corresponds to a structural rather than a functional gene concept, thus rendering many of the (...)
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  14. Hub Zwart (2009). Biotechnology and Naturalness in the Genomics Era: Plotting a Timetable for the Biotechnology Debate. [REVIEW] Journal of Agricultural and Environmental Ethics 22 (6):505-529.score: 21.0
    Debates on the role of biotechnology in food production are beset with notorious ambiguities. This already applies to the term “biotechnology” itself. Does it refer to the use and modification of living organisms in general, or rather to a specific set of technologies developed quite recently in the form of bioengineering and genetic modification? No less ambiguous are discussions concerning the question to what extent biotechnology must be regarded as “unnatural.” In this article it will be argued that, in order (...)
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  15. John Dupré (2004). Understanding Contemporary Genomics. Perspectives on Science 12 (3):320-338.score: 18.0
    : Recent molecular biology has seen the development of genomics as a successor to traditional genetics. This paper offers an overview of the structure, epistemology, and (very briefly) history of contemporary genomics. A particular focus is on the question to what extent the genome contains, or is composed of, anything that corresponds to traditional conceptions of genes. It is concluded that the only interpretation of genes that has much contemporary scientific relevance is what is described as the "developmental (...)
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  16. Lenny Moss (2006). Redundancy, Plasticity, and Detachment: The Implications of Comparative Genomics for Evolutionary Thinking. Philosophy of Science 73 (5):930-946.score: 18.0
    Radically new or unexpected findings in a science demand an openness to new concepts and styles of explanation. The time is more than ripe for asking ourselves what we have learned from the research program of comparative genomics. Where not long ago the human genome was expected to reveal a close association of complexity with the quantitative expansion of the roster of unique genes, more recent findings, especially in relation to comparisons between human and chimp, have raised the bracing (...)
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  17. John I. Glass (2013). Synthetic Genomics and the Construction of a Synthetic Bacterial Cell. Perspectives in Biology and Medicine 55 (4):473-489.score: 18.0
    The topic of synthetic life has long been a subject for science fiction writers, philosophers, and even scientists. With the announcement in 2010 by renowned biologist J. Craig Venter that he and a team of scientists from the J. Craig Venter Institute (JCVI) had created a bacterial cell with chemically synthesized genome, discussions of synthetic life were no longer just conjecture.Humans had assembled nonliving components to make a living cell (Gibson et al. 2010). I was one of the leaders of (...)
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  18. Alex Rosenberg, Emerging Normative Problems of Genomics.score: 18.0
    The administrators of the human genome project were eager to stimulate public discussion, academic debate, legal and legislative deliberation of how individuals and institutions should respond to the revolution in genomics. Paramount among the issues whose discussion they encouraged are three obvious matters: The threat which access to our genetic information poses for heath insurance, employment, and social discrimination the nefarious consequences for scientific advance of turning basic scientific discoveries about genomes into private property The permissibility of prenatal genetic (...)
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  19. S. H. E. Harmon (2008). Ethical Rhetoric: Genomics and the Moral Content of UNESCO's "Universal" Declarations. Journal of Medical Ethics 34 (11):e24-e24.score: 18.0
    Genomic research is an expanding and subversive field, leaking into various others, from environmental protection to food production to healthcare delivery, and in doing so, it is reshaping our relationship with them. The international community has issued various declaratory instruments aimed at the human genome and genomic research. These soft law instruments stress the special nature of genomics and our genetic heritage, and attempt to set limits on our activities with respect to same, as informed by the human rights (...)
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  20. Catherine Kendig, Reconstructing the Concept of Homology for Genomics. Pittsburgh/London Colloquium on Philosophy of Biology and Neuroscience, University of London. Online at PhilSci Archive.score: 18.0
    Homology has been one of, if not the most, fecund concepts which has been used towards the understanding of the genomes of the model organisms. The evidence for this claim can be supported best with an examination of current research in comparative genomics. In comparative genomics, the information of genes or segments of the genome, and their location and sequence, are used to search for genes similar to them, known as 'homologues'. Homologues can be either within that same (...)
     
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  21. Sandra Soo-Jin Lee & LaVera Crawley (2009). Research 2.0: Social Networking and Direct-To-Consumer (DTC) Genomics. American Journal of Bioethics 9 (6):35-44.score: 18.0
    The convergence of increasingly efficient high throughput sequencing technology and ubiquitous Internet use by the public has fueled the proliferation of companies that provide personal genetic information (PGI) direct-to-consumers. Companies such as 23andme (Mountain View, CA) and Navigenics (Foster City, CA) are emblematic of a growing market for PGI that some argue represents a paradigm shift in how the public values this information and incorporates it into how they behave and plan for their futures. This new class of social networking (...)
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  22. Hub Zwart (2010). The Nobel Prize as a Reward Mechanism in the Genomics Era: Anonymous Researchers, Visible Managers and the Ethics of Excellence. [REVIEW] Journal of Bioethical Inquiry 7 (3):299-312.score: 18.0
    The Human Genome Project (HGP) is regarded by many as one of the major scientific achievements in recent science history, a large-scale endeavour that is changing the way in which biomedical research is done and expected, moreover, to yield considerable benefit for society. Thus, since the completion of the human genome sequencing effort, a debate has emerged over the question whether this effort merits to be awarded a Nobel Prize and if so, who should be the one(s) to receive it, (...)
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  23. A. W. Cappelen, O. F. Norheim & B. Tungodden (2008). Genomics and Equal Opportunity Ethics. Journal of Medical Ethics 34 (5):361-364.score: 18.0
    Genomics provides information on genetic susceptibility to diseases and new possibilities for interventions which can fundamentally alter the design of fair health policies. The aim of this paper is to explore implications of genomics from the perspective of equal opportunity ethics. The ideal of equal opportunity requires that individuals are held responsible for some, but not all, factors that affect their health. Informational problems, however, often make it difficult to implement the ideal of equal opportunity in the context (...)
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  24. Ruth Chadwick, Telling the Truth About Genomics.score: 18.0
    Issues about communication in genomics have moved out of the clinic and into the public arena. Scientists other than clinicians are confronted by calls for public engagement. Genomics gives rise to these demands partly because it inevitably raises the three basic questions of philosophy as outlined by Kant: What can I know? What ought I to do? What may I hope? Genomics on its own cannot answer these questions. In relation to what can be known, its answer (...)
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  25. Clarissa Allen, Karine Sénécal & Denise Avard (2014). Defining the Scope of Public Engagement: Examining the “Right Not to Know” in Public Health Genomics. Journal of Law, Medicine and Ethics 42 (1):11-18.score: 18.0
    In this article, we explore the concept of a “right not to know” on a population rather than individual level. We argue that a population level “right not to know” is a useful concept for helping to define the appropriate boundaries of public engagement initiatives in the emerging public health genomics context.
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  26. Robert Streiffer (2005). An Ethical Analysis of Ojibway Objections to Genomics and Genetics Research on Wild Rice. Philosophy in the Contemporary World 12 (2):37-45.score: 18.0
    I analyze Ojibway objections to genomics and genetics research on wild rice. Although key academic and industry participants in this research have dismissed their objections out of hand, my analysis supports the conclusion that the objections merit serious consideration, even by those who do not share the Ojibway’s religious beliefs.
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  27. Anthony M. Cutter (2006). To Clear or to Convict? The Role of Genomics in Criminal Justice. Genomics, Society and Policy 2 (1):1-15.score: 18.0
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  28. Peter Derkx & Harry Kunneman (eds.) (2013). Genomics and Democracy: Towards a 'Lingua Democratica' for the Public Debate on Genomics. Editions Rodopi.score: 18.0
    This book addresses the ethical and political questions flowing from the vastly increased possibilities to manipulate the genetic properties of organisms, including human beings. Due to the great complexity of the scientific fields involved, these questions are framed and answered mostly by scientific experts. But the new technological possibilities and social practices connected with genetic manipulation intrude into domains that for a long time have been the provenance of religious and secular worldviews and touch upon deep-seated convictions and emotions. Moreover (...)
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  29. Gail E. Henderson, Eric T. Juengst, Nancy M. P. King, Kristine Kuczynski & Marsha Michie (2012). What Research Ethics Should Learn From Genomics and Society Research: Lessons From the ELSI Congress of 2011. Journal of Law, Medicine and Ethics 40 (4):1008-1024.score: 18.0
    Research on the ethical, legal, and social implications (ELSI) of human genomics has devoted significant attention to the research ethics issues that arise from genomic science as it moves through the translational process. Given the prominence of these issues in today's debates over the state of research ethics overall, these studies are well positioned to contribute important data, contextual considerations, and policy arguments to the wider research ethics community's deliberations, and ultimately to develop a research ethics that can help (...)
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  30. Hub Zwart (2011). Towards an Eco-Centric View of Human Existence: Implications of Genomics for the Environmental Zone. Genomics, Society and Policy 6 (2):40-55.score: 18.0
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  31. Evelyn Fox Keller (2011). Genes, Genomes, and Genomics. Biological Theory 6 (2):132-140.score: 17.0
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  32. Koffi N. Maglo (2010). Genomics and the Conundrum of Race Some Epistemic and Ethical Considerations. Perspectives in Biology and Medicine 53 (3):357-372.score: 16.0
    The utility of a notion testifies not to its clarity but rather to the philosophic importance of clarifying it. Even mistaken hypotheses and theories are of use in leading to discoveries. This remark is true in all the sciences. The genomic revolution raised hopes that the putative utility of race in biomedicine could be grounded in the view that race has a biological reality and scientific validity (Burchard et al. 2003; Risch et al. 2002). However, the rebuttal of the contention (...)
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  33. Hub Zwart & Bart Penders (2011). Genomics and the Ark An Ecocentric Perspective on Human History. Perspectives in Biology and Medicine 54 (2):217-231.score: 16.0
    In 1990 the Human Genome Project (HGP) was launched as an important historical marker, a pivotal contribution to the time-old quest for human self-knowledge. However, when in 2001 two major publications heralded its completion, it seemed difficult to make out how the desire for self-knowledge had really been furthered by this endeavor (IHGSC 2001; Venter et al. 2001). In various ways mankind seems to stand out from other organisms as a unique type of living entity, developing a critical perspective on (...)
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  34. Peter J. Richersona, Gene-Culture Coevolution in the Age of Genomics.score: 16.0
    The use of socially learned information (culture) is central to human adaptations. We investigate the hypothesis that the process of cultural evolution has played an active, leading role in the evolution of genes. Culture normally evolves more rapidly than genes, creating novel environments that expose genes to new selective pressures. Many human genes that have been shown to be under recent or current selection are changing as a result of new environments created by cultural innovations. Some changed in response to (...)
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  35. Michael S. Barker & Paul G. Wolf (2010). Unfurling Fern Biology in the Genomics Age. BioScience 60 (3):177-185.score: 16.0
    Twenty-first century technology is addressing many of the questions posed by 20th-century biology. Although the new approaches, especially those involving genomic data and bioinformatic tools, were first applied to model organisms, they are now stretching across the tree of life. Here, we review some recent revelations in the ferns. We first examine how DNA sequence data have contributed to our understanding of fern phylogeny. We then address evolution of the fern plastid genome, including reports of high levels of RNA editing. (...)
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  36. Fernando Castro-Chavez (2012). The Rules of Variation Expanded, Implications for the Research on Compatible Genomics. Biosemiotics 5 (1):121-145.score: 16.0
    The main focus of this article is to present the practical aspect of the code rules of variation and the search for a second set of genomic rules, including comparison of sequences to understand how to preserve compatible organisms in danger of extinction and how to generate biodiversity. Three new rules of variation are introduced: 1) homologous recombination, 2) a healthy fertile offspring, and 3) comparison of compatible genomes. The novel search in the natural world for fully compatible genomes capable (...)
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  37. Jantina de Vries, Akin Abayomi, James Brandful, Katherine Littler, Ebony Madden, Patricia Marshall, Odile Ouwe Missi Oukem-Boyer & Janet Seeley (2014). A Perpetual Source of DNA or Something Really Different: Ethical Issues in the Creation of Cell Lines for African Genomics Research. BMC Medical Ethics 15 (1):60.score: 16.0
    The rise of genomic studies in Africa – not least due to projects funded under H3Africa – is associated with the development of a small number of biorepositories across Africa. For the ultimate success of these biorepositories, the creation of cell lines including those from selected H3Africa samples would be beneficial. In this paper, we map ethical challenges in the creation of cell lines.
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  38. Benjamin Ja Dickins (2012). Is Genomics Bad for You? Behavioral and Brain Sciences 35 (5):364-365.score: 16.0
    The plasticity of the genome complicates genetic causation but should be investigated from a functional perspective. Specific adaptive hypotheses are referenced in the target article, but it is also necessary to explain how the integrity of the genome is maintained despite processes that tend towards its diversification and degradation. These include the accumulation of deleterious changes and intragenomic conflict.
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  39. Gail E. Henderson, Susan M. Wolf, Kristine J. Kuczynski, Steven Joffe, Richard R. Sharp, D. Williams Parsons, Bartha M. Knoppers, Joon‐Ho Yu & Paul S. Appelbaum (2014). The Challenge of Informed Consent and Return of Results in Translational Genomics: Empirical Analysis and Recommendations. Journal of Law, Medicine and Ethics 42 (3):344-355.score: 16.0
    As exome and genome sequencing move into clinical application, questions surround how to elicit consent and handle potential return of individual genomic results. This study analyzes nine consent forms used in NIH-funded sequencing studies. Content analysis reveals considerable heterogeneity, including in defining results that may be returned, identifying potential benefits and risks of return, protecting privacy, addressing placement of results in the medical record, and data-sharing. In response to lack of consensus, we offer recommendations.
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  40. M. Ruiz-Canela, J. I. Valle-Mansilla & D. P. Sulmasy (2009). Researchers' Preferences and Attitudes on Ethical Aspects of Genomics Research: A Comparative Study Between the USA and Spain. Journal of Medical Ethics 35 (4):251-257.score: 16.0
    Introduction: The use of human samples in genomic research has increased ethical debate about informed consent (IC) requirements and the information that subjects should receive regarding the results of the research. However, there are no quantitative data regarding researchers’ attitudes about these issues. Methods: We present the results of a survey of 104 US and 100 Spanish researchers who had published genomic epidemiology studies in 61 journals during 2006. Results: Researchers preferred a broader IC than the IC they had actually (...)
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  41. Ann Backus, Richard A. Spinello & Herman T. Tavani (2004). Genomics, Ethics, and ICT. Ethics and Information Technology 6 (1):1-3.score: 15.0
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  42. Alex Rosenberg (2005). Will Genomics Do More for Metaphysics Than Locke>. In P. Achinstein (ed.), Scientific Evidence: Philosophical Theories & Applications. The Johns Hopkins University Press.score: 15.0
  43. Adam Bostanci & Jane Calvert (2008). Invisible Genomes: The Genomics Revolution and Patenting Practice. Studies in History and Philosophy of Science Part C 39 (1):109-119.score: 15.0
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  44. Miriam Bentwich (2012). It's About Scientific Secrecy, Dummy: A Better Equilibrium Among Genomics Patenting, Scientific Research and Health Care. [REVIEW] Science and Engineering Ethics 18 (2):263-284.score: 15.0
    This paper offers a different pragmatic and patent-based approach to concerns regarding the negative effects of genetic-based patenting on advancing scientific research and providing adequate and accessible health care services. At the basis of this approach lies an explication of a mandatory provisional patented paper procedure (PPPA), designed for genetic-based patents and administered by leading scientific journals in the field, while officially acknowledged by the USPTO, and subsequently by other patent offices as well. It is argued that the uniqueness of (...)
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  45. John Dupre (2004). Understanding Contemporary Genomics. Perspectives on Science 12 (3):320-338.score: 15.0
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  46. M. W. Foster, C. D. M. Royal & R. R. Sharp (2006). The Routinisation of Genomics and Genetics: Implications for Ethical Practices. Journal of Medical Ethics 32 (11):635-638.score: 15.0
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  47. David Resnik (2009). Direct-to-Consumer Genomics, Social Networking, and Confidentiality. American Journal of Bioethics 9 (6):45-46.score: 15.0
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  48. Dov Greenbaum (2012). Introducing Personal Genomics to College Athletes: Potentials and Pitfalls. American Journal of Bioethics 12 (4):45-47.score: 15.0
    The American Journal of Bioethics, Volume 12, Issue 4, Page 45-47, April 2012.
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  49. Dov Greenbaum (2013). If You Can't Walk the Walk, Do You Have to Talk the Talk: Ethical Considerations for the Emerging Field of Sports Genomics. American Journal of Bioethics 13 (10):19 - 21.score: 15.0
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