Cet ouvrage rassemble les oeuvres philosophiques de François Hemsterhuis, l'un des représentants les plus importants du mouvement d'idées appelé le siècle des lumières. Ses écrits portent sur des sujets variés tels que l'esthétique, l'éthique, la métaphysique, etc. Ils sont accompagnés d'une préface de Friedrich Heinrich Jacobi, autre figure marquante du mouvement. Cet ouvrage est un témoignage passionnant de la philosophie du XVIIIe siècle. This work has been selected by scholars as being culturally important, and is part of the knowledge base (...) of civilization as we know it. This work is in the "public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant. (shrink)

""Catching Ourselves in the Act" is no less than an attempt to explain intelligence. Delightful how the author dismantles traditional views in.

This festschrift collects a number of insightful essays by a group of accomplished Christian scholars, all of who have either worked with or studied under Hendrik Hart during his 35-year tenure as Senior Member in Systematic Philosophy at the Institute for Christian Studies, Toronto, Canada.

An intercultural framework for servanthood was explored in three Christian community projects. The framework consists of six basic principles, as defined by Duane Elmer, namely openness, acceptance, trust, learning, understanding and serving. This framework is brought into conversation with Miroslav Volf's metaphor of an embrace. In all of this koinonia and diaconia play a pivotal role - especially in the relationship between the two modi. With this hermeneutical framework as point of departure, an empirical study was undertaken to discern the (...) processes and structures within intercultural Christian community projects; and to evaluate the transformation in relationships and the sustainability of the development projects. (shrink)

How does faith-based social involvement within a cultural diverse society express itself? Is the focus pure social outreach, that is, the rendering of services, or should the focus include meaningful interaction between the so called 'outreacher' and those being supported by the outreach? This article looks at the relationship between koinonia and diaconia in the creation of an intercultural space where individuals from different contexts are welcomed and supported in a mutual way. Through an interdisciplinary approach this article reflects on (...) the experience of koinonia and diaconia in the mission of the church by bringing it into an interdisciplinary conversation with Sociology. God's reign become visible if koinonia and diaconia can dance together! (shrink)

BACKGROUND -/- The need for detailed description and modeling of cells drives the continuous generation of large and diverse datasets. Unfortunately, there exists no systematic and comprehensive way to organize these datasets and their information. CELDA (Cell: Expression, Localization, Development, Anatomy) is a novel ontology for the association of primary experimental data and derived knowledge to various types of cells of organisms. -/- RESULTS -/- CELDA is a structure that can help to categorize cell types based on species, anatomical localization, (...) subcellular structures, developmental stages and origin. It targets cells in vitro as well as in vivo. Instead of developing a novel ontology from scratch, we carefully designed CELDA in such a way that existing ontologies were integrated as much as possible, and only minimal extensions were performed to cover those classes and areas not present in any existing model. Currently, ten existing ontologies and models are linked to CELDA through the top-level ontology BioTop. Together with 15.439 newly created classes, CELDA contains more than 196.000 classes and 233.670 relationship axioms. CELDA is primarily used as a representational framework for modeling, analyzing and comparing cells within and across species in CellFinder, a web based data repository on cells (http://cellfinder.org). -/- CONCLUSIONS -/- CELDA can semantically link diverse types of information about cell types. It has been integrated within the research platform CellFinder, where it exemplarily relates cell types from liver and kidney during development on the one hand and anatomical locations in humans on the other, integrating information on all spatial and temporal stages. CELDA is available from the CellFinder website: http://cellfinder.org/about/ontology. (shrink)

This book explores the dynamics of the commentary and textbook traditions in Aristotelian natural philosophy under the headings of doctrine, method, and scientific and social status. It enquires what the evolution of the Aristotelian commentary tradition can tell us about the character of natural philosophy as a pedagogical tool, as a scientific enterprise, and as a background to modern scientific thought. In a unique attempt to cut old-fashioned historiographic divisions, it brings together scholars of ancient, medieval, Renaissance and seventeenth-century philosophy. (...) The book covers a remarkably broad range of topics: it starts with the first Greek commentators and ends with Leibniz. (shrink)

The means by which social environmental exposures influence risk of mental disorders is a persistent and still open question. A key candidate mechanism for the biologic mediation of environmental effects involves epigenetic factors, which regulate gene function without altering underlying DNA sequence. Recent work has shown that environmental exposures such as childhood abuse, family history of mental disorder, and low socioeconomic status (SES) associate with differential DNA methylation (5mC) – a relatively stable, but modifiable, epigenetic factor. However, the longitudinal relation (...) among SES, 5mC, brain function, and risk of depression remains to be elucidated. Here, we briefly review literature relevant to these associations and discuss recent findings that, for the first time, prospectively demonstrate sequential links between low SES, changes in 5mC, changes in brain function, and risk of depression in a cohort of adolescents. (shrink)

In order to strengthen RI in the private sector, it is imperative to understand how companies organise this process, where it takes place, and what considerations and motivations are central in the innovation process. In this chapter, the questions of whether and where normative considerations play a role in the innovation process, and whether dimensions of RI are present in the innovation process, are addressed. In order answer these research questions, a theoretical framework is developed based on Jones’s theory of (...) ethical decision making and Cooper’s stagegate model of innovation management. In order to answer the research questions, a specific case of innovations that contribute to public health is explored, namely, that of food companies that participate in a Front-of-Pack logo for healthier food. As the use of healthy food logos does not necessarily have a positive impact on sales and profits, it is expected that in the decision-making process, as part of their innovation process, companies make several trade-offs between economic, technical and moral factors. As the social-ethical values at stake in corporate innovation processes have remained to a large extent unexplored in research on innovation management, the aim of this chapter is to identify the motivations and barriers for companies embracing and continuing a FoP logo for healthier food, and to assess whether ethical considerations play a role in this innovation process. From the findings in this research, it will become clear that although the studied companies participated in a programme for healthy food and thus are responsive to the needs of society, and although the companies feel responsible for public health, ethical considerations do not play a central role in the operational innovation process. Instead, technical and economic considerations seem to prevail in the operational innovation process. Furthermore, none of the procedural dimensions of RI seems to be present at this level in the innovation trajectory. It is argued that this may be an indication that the ethical decision-making process for RI is not located at the level of the operational innovation process itself, but is something that might be located on a higher strategic level in the company. It is at this level that the moral decision is taken to adopt the FoP logo and to engage in the RI process. The findings cast a new light on the discourse on RI in general, and in the private sector in particular. (shrink)

For academic administrators, the management of research remains a matter more of hope than expectation. It has proved particularly difficult to measure quality. Managers typically view research as an ‹asset’. This essay argues that it is more useful to view research and its management as ‹process’, and explores the implications of doing so for managers and researchers alike.

About one third of patients with epilepsy have seizures refractory to the medical treatment. Electrical stimulation mapping is the gold standard for the identification of “eloquent” areas prior to resection of epileptogenic tissue. However, it is time-consuming and may cause undesired side effects. Broadband gamma activity recorded with extraoperative electrocorticography during cognitive tasks may be an alternative to ESM but until now has not proven of definitive clinical value. Considering their role in cognition, the alpha and beta bands could further (...) improve the identification of eloquent cortex. We compared gamma, alpha and beta activity, and their combinations for the identification of eloquent cortical areas defined by ESM. Ten patients with intractable focal epilepsy participated in a delayed-match-to-sample task, where syllable sounds were compared to visually presented letters. We used a generalized linear model approach to find the optimal weighting of each band for predicting ESM-defined categories and estimated the diagnostic ability by calculating the area under the receiver operating characteristic curve. Gamma activity increased more in eloquent than in non-eloquent areas, whereas alpha and beta power decreased more in eloquent areas. Diagnostic ability of each band was close to 0.7 for all bands but depended on multiple factors including the time period of the cognitive task, the location of the electrodes and the patient’s degree of attention to the stimulus. We show that diagnostic ability can be increased by 3–5% by combining gamma and alpha and by 7.5–11% when gamma and beta were combined. We then show how ECoG power modulation from cognitive testing can be used to map the probability of eloquence in individual patients and how this probability map can be used in clinical settings to optimize ESM planning. We conclude that the combination of gamma and beta power modulation during cognitive testing can contribute to the identification of eloquent areas prior to ESM in patients with refractory focal epilepsy. (shrink)

Brieven van de Nederlandse filosoof (1898-1955) uit de periode 1917-1927 aan een vriend.

Translation:Hendrik Josephus POS, „Phénoménologie et linguistique.“ In: Keur uit de verspreide geschrift en van Dr. H. J. Pos. Vol. I. Assen: Van Loghum Slaterus 1957, p. 131–141.

This chapter explores the opportunities and limitations of the ideal of transparency in responsible innovation, by consulting the virtual case of "The Circle", a company which appears in Dave Eggers' novel The Circle. The Circle is a high-tech company with the main purpose of being responsive to societal needs. They want to eradicate unethical behaviour in society, enhance public health and make a positive impact on the environment. The ultimate goal of The Circle is to reach 100% full transparency in (...) the world, which is impossible without any societal desirability. In first instance, it is free choice of people to accept and embrace the products and services of The Circle, who invest resources in keeping customers happy and in raising awareness about the dangers of privacy. The chapter concludes that The Circle meets the requirements regarding the outcomes of responsible innovation, at least to a certain extent, while at the same time, one feels unease about certain activities they undertake. (shrink)

This piece looks into the atmospheric and catastrophic environments that punctuate H of H: storms, ice-breaks, volcanic eruptions, and nuclear explosions that give the tragic narrative an electrifying edge. It draws attention to a “chemical” poetics at the heart of Carson’s translation technique and thinking about Euripides’ play. This mannerism, also found in Euripides’s “combustible mixture of realism and extremism” (Grief Lessons, blurb), is not exclusive to H of H. It can be detected across Carson’s oeuvre – a tendency to (...) combust the reader’s mind in ways that become a philosophy for re-reading Euripides and, more ambitiously, Carson’s own sense of the tragic. (shrink)

Carbon monoxide intoxication leads to acute and chronic neurological deficits, but little is known about the specific noxious mechanisms. 1 H magnetic resonance spectroscopy may allow insight into the pathophysiology of CO poisoning by monitoring neurochemical disturbances, yet only limited information is available to date on the use of this protocol in determining the neurological effects of CO poisoning. To further examine the short-term and long-term effects of CO on the central nervous system, we have studied seven patients with CO (...) poisoning assessed by gray and white matter MRS, magnetic resonance imaging and neuropsychological testing. Five patients suffered from acute high-dose CO intoxication and were in coma for 1–6 days. In these patients, MRI revealed hyperintensities of the white matter and globus pallidus and also showed increased choline and decreased N -acetyl aspartate ratios to creatine, predominantly in the white matter. Lactate peaks were detected in two patients during the early phase of high-dose CO poisoning. Two patients with chronic low-dose CO exposure and without loss of consciousness had normal MRI and MRS scans. On follow-up. five of our seven patients had long-lasting intellectual impairment, including one individual with low-dose CO exposure. The MRS results showed persisting biochemical alterations despite the MRI scan showing normalization of morphological changes. In conclusion, the MRS was normal in patients suffering from chronic low-dose CO exposure; in contrast, patients with high-dose exposure showed abnormal gray and white matter levels of NAA/Cr, Cho/Cr and lactate, as detected by 1 H MRS, suggesting disturbances of neuronal function, membrane metabolism and anaerobic energy metabolism, respectively. Early increases in Cho/Cr and decreases of NAA/Cr may be related to a poor long-term outcome, but confirmation by future studies is needed. (shrink)

This essay serves as an introduction to Anne Carson’s Euripides. It discusses Carson’s ongoing engagement with the tragedian, from Grief Lessons to her latest experimental H of H Playbook and The Trojan Women: A Comic, drawing attention to Carson’s cross-pollinating approach to Euripidean tragedy and antiquity more broadly, as well as the characteristic blending of academic and artistic styles that inform her translation poetics. The introduction includes details of the themes explored in the special issue, together with summaries of the (...) eight ‘takes’ that make up the collection. (shrink)

Diese Studie widmet sich der Grundfrage der Politischen Philosophie nach der richtigen Beschaffenheit der grundlegenden gesellschaftlichen und politischen Institutionen, ihre methodische Problemstellung besteht in der Verbindung von philosophischen und ökonomischen Theorieperspektiven. Das Buch vollzieht eine kritische Analyse der wichtigsten klassischen und modernen Ansätze dazu und überführt diese Kritik in einen konstruktiven Entwurf, der wesentlich auf die Theorie der Grundbefähigungen zurückgreift. Dieses auf Amartya Sen und Martha Nussbaum zurückgehende Konzept knüpft die Legitimation eines Staatswesens an die Bedingung, dass es jedem seiner (...) Bürger ein bestimmtes Minimum an realen Lebensmöglichkeiten garantiert oder zumindest um dessen Garantierung bemüht ist. Die Hauptthese des Buches lässt sich so zusammenfassen, dass die Frage »Equality of what?« für den modernen Sozialstaat weder mit dem Konzept eines für alle garantierten Nutzenminimums noch mit dem Konzept eines für alle garantierten Mindesteinkommens beantwortet werden kann, sondern mit dem Konzept eines garantierten Minimums an Grundbefähigungen, d. h. an realen Lebensoptionen, über die ein Individuum verfügen kann. (shrink)

With the calls to decolonize the Philosophy curriculum, and the University more generally, which have seen a series of intellectual interventions in South Africa, the paper takes its cue from Nyoka’s (2020) recommendation when he suggests moving beyond merely thinking about decolonization. In reflecting on processes of decolonising the curriculum, the paper considers the successes and failures of a course taught during a global pandemic, wherein pedagogic strategies were constrained. Reflecting on a module taught in the first semester of 2021, (...) the paper thinks through the fundamental question that underpins the course, primarily:—how to develop a contextually responsive philosophical approach on the southernmost tip of the African continent. Using two primary texts, Kumalo’s Decolonization as Democratization (2021) and Jansen’s Decolonization in Universities (2019), the module analysed this question by juxtaposing, respectively, a philosophical and educational text. In this pedagogic autocritique, I reflect on ‘what obligation do intellectuals owe their students’ in a decolonising context. (shrink)

Dr. Jansen's paper raises three main issues. The one with which he himself is most concerned is the question of which methods of abortion are ethically right, and whether methods which risk the birth of a damaged baby are wrong. But there are two others: first, how the (originally unintended) birth of a live but damaged child alters the moral situation, and secondly, whether the overcoming of sterility by inducing a multiple pregnancy in which some of the fetuses have (...) to be killed in order for any of them to survive is at all morally acceptable. (shrink)

What, if anything remains of religion after the demise of traditional theism and the theologies based upon it? What are the consequences of so-called Post-theism for the modern scholarly study of religion (in Religionswissenschaft and philosophical theology or church dogmatics, in the philosophy of religion as well as in the more recent phenomenon of comparitive religious studies)? This volume collects some thirty articles written in honor of Professor Hendrik Johan Adriaanse whose intellectual trajectory, recounted here in extensive personal reflections, has (...) lead to an incisive inquiry into the possibilities of thinking and experiencing "After Theism" (the title of a fundamental article reprinted here). Post-theism : Refraiming the Judeo-Christian Tradition raises this question from three different perspectives : first, by spelling out the historical and intellectual backgrounds that have led to the supposed end of theism as it had been known through the ages; secondly, by discussing the systematic relationship between the disciplines of theology and competing concepts of rationality; and, thirdly, by sketching out the contours of a philosophical thought that ventures beyond the most tenacious classical and modern presuppositions of theism. Along the way, the contributors explore a variety of ways in which the concepts and arguments, imagery and rhetoric of the Judeo-Christian traditions are in need and in the process of being constantly displaced. Henri Krop, Arie L. Molendijk and Hent de Vries teach Philosophy, the history of Christianity, and Metaphysics, respectively, at the Erasmus University, The University of Groningen, and the University of Amsterdam. (shrink)

Casper Hendrik Rautenbach: 'Deeds, more than ideas, make life meaningful'Professor Casper Hendrik Rautenbach was born on 6th of March 1902 in Zeerust in the Western Transvaal, RSA, where he matriculated at the Zeerust Public School at the end of 1918. In June 1923 he was awarded the MA degree in Philosophy and at the end of the same year the BD degree in Theology. In 1932 he completed his thesis, titled 'Sedelike Keuring '. After serving as clergyman in the Nederduitsch (...) Hervormde Kerk van Afrika, and as lecturer in Philosophy and Christian Ethics, he was promoted to Rector of the University of Pretoria, an office which he held from the 9th of April 1948 until the 30th of June 1970. Professor Rautenbach is respected as an outstanding academic and leading churchman. He achieved outstanding results in the educational field especially by playing an active role in the formulation of the Education Policy Act. (shrink)

Heterotrimeric G proteins, consisting of α, β, and γ subunits, couple ligand-bound seven transmembrane domain receptors to the regulation of effector proteins and production of intracellular second messengers. G protein signaling mediates the perception of environmental cues in all higher eukaryotic organisms, including yeast, Dictyostelium, plants, and animals. The nematode Caenorhabditis elegans is the first animal to have complete descriptions of its cellular anatomy, cell lineage, neuronal wiring diagram, and genomic sequence. In a recent paper, Jansen et al.(1) used (...) sequence searches of the C. elegans genome database to identify all heterotrimeric G protein genes (20 Gα, 2 Gβ, 2 Gγ). C. elegans encodes one ortholog of each of the four Gα classes found in metazoans and 16 new Gα genes. The orthologous genes are widely expressed, whereas 14 of the divergent Gα genes are almost exclusively expressed in sensory neurons where they may regulate perception and chemotaxis.BioEssays 21:713–717, 1999. © 1999 John Wiley & Sons, Inc. (shrink)

In this interview with Jan Hendrik van den Berg, the Dutch phenomenologist and psychiatrist addresses the origins of his work, his most significant influences, and the purpose of metabletic phenomenology in the modern age. In the course of the interview. Dr. Van den Berg provides a basic overview of his work, and highlights the central finding of his metabletic analyses: a loss of wonder before nature, which results from the more fundamental loss of genuine spirituality in the modern world.