With progress in genetic research advancing as it is, a host of novel theoretical and practical challenges are thereby being raised. From a bioethical perspective, it is easy to get the feeling that, because of this rapid progress, many fundamental concepts that should be in place arent yet in place. This lack may be felt especially in relation to human gene modification. with the Human Genome Projects potential to yield innumerable applications, one of the things that should be in place (...) is a set of fundamental conceptual guidelines demarcating the kinds of genetic modifications that should count as ethically acceptable and legally permissible. In this paper, my goal is to articulate such guidelines, specifically for the set of all possible human germline modifications. (shrink)

The three themes of perception, expression, and history proved to be significant and consistent concerns of Merleau-Ponty from his earliest to his latest writings. In turn, Merleau-Ponty was concerned to discover and show how meaning emerged within the context of each of these themes. My main goal in this essay will be to trace ways that Merleau-Ponty conceived of this emergence, and to how his conceptions underwent increasing sophistication from his earlier to later writings. In section I, I show how (...) a kind of perceptual meaning arises out of an exchange between subject and object, perceived and perceived, and the visible and invisible. In section II, I show how expressive meaning arises out of an exchange between the spoken and speaking word, and the synchronic and diachronic registers of language. In these sections, I also point out that what starts roughly as binary dialogue (characterized by consummate reciprocity) between these matrices of meaning evolves into a more ambiguous interplay (characterized by such later ontological notions as invisibility, reversibility, and the flesh). In section III, I show how meaning arises in history out of an ambiguous interplay between past and present, ideas and institutions, the collective and individual, and the pre-determined and the free; and I suggest ways Merleau-Ponty might have integrated earlier scattered thoughts about meaning's emergence in history with his later ontology, had his work in these directions not been cut short. (shrink)