Attention-deficit/hyperactivity disorder (ADHD) is currently defined as a cognitive/behavioral developmental disorder where all clinical criteria are behavioral. Inattentiveness, overactivity, and impulsiveness are presently regarded as the main clinical symptoms. The dynamic developmental behavioral theory is based on the hypothesis that altered dopaminergic function plays a pivotal role by failing to modulate nondopaminergic (primarily glutamate and GABA) signal transmission appropriately. A hypofunctioning mesolimbic dopamine branch produces altered reinforcement of behavior and deficient extinction of previously reinforced behavior. This gives rise to delay (...) aversion, development of hyperactivity in novel situations, impulsiveness, deficient sustained attention, increased behavioral variability, and failure to “inhibit” responses (“disinhibition”). A hypofunctioning mesocortical dopamine branch will cause attention response deficiencies (deficient orienting responses, impaired saccadic eye movements, and poorer attention responses toward a target) and poor behavioral planning (poor executive functions). A hypofunctioning nigrostriatal dopamine branch will cause impaired modulation of motor functions and deficient nondeclarative habit learning and memory. These impairments will give rise to apparent developmental delay, clumsiness, neurological “soft signs,” and a “failure to inhibit” responses when quick reactions are required. Hypofunctioning dopamine branches represent the main individual predispositions in the present theory. The theory predicts that behavior and symptoms in ADHD result from the interplay between individual predispositions and the surroundings. The exact ADHD symptoms at a particular time in life will vary and be influenced by factors having positive or negative effects on symptom development. Altered or deficient learning and motor functions will produce special needs for optimal parenting and societal styles. Medication will to some degree normalize the underlying dopamine dysfunction and reduce the special needs of these children. The theory describes how individual predispositions interact with these conditions to produce behavioral, emotional, and cognitive effects that can turn into relatively stable behavioral patterns. Key Words: catecholamine; clumsiness; dopamine; hyperkinesis; hyperkinetic disorder; impulsivity; monoamine; neuromodulator; overactivity; pollutants; reinforcement; reward; verbally governed behavior; soft signs; variability. (shrink)
The dynamic developmental theory (DDT) has benefited from the insights of the commentators, particularly in terms of the implications for the proposed steepened delay gradients in attention-deficit/hyperactivity disorder (ADHD). The introduction of modified memory processes as a basis for the delay gradients improved the links to aspects of ADHD. However, it remains unclear whether the hyperactive-impulsive and inattentive subtypes are separate subgroups or may be explained as different outcomes of the same genetic factors and thus explicable by the same principles. (...) The DDT suggests that altered reinforcement and extinction processes define an endophenotype in ADHD that can be related dimensionally to inattention, hyperactivity, and impulsivity. The relation between the suggested endophenotype, characterized by changes in basic learning mechanisms, and other endophenotypes characterized by delay aversion or response disinhibition, needs to be tested in future studies. (shrink)
Contents: Preface. Johannes BRANDL: Semantic Holism Is Here To Stay. Michael DEVITT: A Critique of the Case for Semantic Holism. Georges REY: The Unavailability of What We Mean: A Reply to Quine, Fodor and LePore. Joseph LEVINE: Intentional Chemistry. Louise ANTHONY: Conceptual Connection and the Observation/Theory Distinction. Gilbert HARMAN: Meaning Holism Defended. Kirk A. LUDWIG: Is Content Holism Incoherent? Anne BEZUIDENHOUT: The Impossibility of Punctate Mental Representations. Takashi YAGISAWA: The Cost of Meaning Solipsism. Alberto PERUZZI: Holism: The Polarized Spectrum. Jonathan (...) BERG: Inferential Roles, Quine, and Mad Holism. Jerry FODOR & Ernest LEPORE: Replies. (shrink)
Author Steven Berg offers an interpretation of this dialogue wherein all the speakers at the banquetwith the exception of Socratesnot only offer their views on ...
Jonathan Berg argues for the Theory of Direct Belief, which treats having a belief about an individual as an unmediated relation between the believer and the individual the belief is about. After a critical review of alternative positions, Berg uses Grice's theory of conversational implicature to provide a detailed pragmatic account of substitution failure in belief ascriptions and goes on to defend this view against objections, including those based on an unwarranted "Inner Speech" Picture of Thought. The work serves as (...) a case study in pragmatic explanation, dealing also with methodological issues about context-sensitivity in language and the relation between semantics and pragmatics. (shrink)
The notion of a capacity ( dunamis ) in the sense of a power to bring about or undergo change plays a key role in Aristotle’s theories about the natural world. However, in Metaphysics Θ Aristotle also extends ‘capacity’, and the corresponding concept of ‘activity’ ( energeia ), to cases where we want to say that something is in capacity, or in activity, such and such but not, or not directly, in virtue of being capable of initiating or undergoing change. (...) This paper seeks to clarify and confirm a certain view of how Aristotle wishes us to see the relationship between the two uses of ‘capacity’ and ‘activity’. To that end, I consider also Aristotle’s employment of the terms in the De Anima , which sheds light on the key examples which direct the discussion in Metaph. Θ. (shrink)
Genetic testing is currently subject to little oversight, despite the significant ethical issues involved. Repeated recommendations for increased regulation of the genetic testing market have led to little progress in the policy arena. A 2005 Internet search identified 13 websites offering health-related genetic testing for direct purchase by the consumer. Further examination of these sites showed that overall, biotech companies are not providing enough information for consumers to make well-informed decisions; they are not consistently offering genetic counseling services; and some (...) sites even offer tests with little evidence of clinical value. This article aims to raise company and consumer awareness about the ethical concerns surrounding the direct-to-consumer marketing of health-related genetic tests. It also suggests ways that biotech companies can bring their services to the public in an ethically responsible manner, without increased regulatory oversight. (shrink)
What is the Timaeus-Critias about? -- The status of the Atlantis story -- The status of Timaeus' account -- Teleology and craftsmanship -- Necessity an teleology -- Space and motion -- Body, soul, and tripartition -- Perception and cosmology -- Dialogue and dialectic.
The physician-patient relationship has changed over the last several decades, requiring a systematic reevaluation of the competing demands of patients, physicians, and families. In the era of genetic testing, using a model of patient care known as the family covenant may prove effective in accounting for these demands. The family covenant articulates the roles of the physician, patient, and the family prior to genetic testing, as the participants consensually define them. The initial agreement defines the boundaries of autonomy and benefit (...) for all participating family members. The physician may then serve as a facilitator in the relationship, working with all parties in resolving potential conflicts regarding genetic information. The family covenant promotes a fuller discussion of the competing ethical claims that may come to bear after genetic test results are received. (shrink)
Jerry Fodor and Ernie LePore argue against inferential role semantics on the grounds that either it relies on an analytic/synthetic distinction vulnerable to Quinean objections, or else it leads to a variety of meaning holism frought with absurd consequences. However, the slide from semantic atomism to meaning holism might be prevented by distinctions not affected by Quine's arguments against analyticity; and the absurd consequences Fodor and LePore attribute to meaning holism obtain only on an implausible construal of inferential roles.
This book makes a valuable contribution to recent debates on redress for historical injustices by offering case studies from nine countries on five continents.
From antiquity on, the status of Critias' account has been the subject of intense debate. Is the Atlantis story 'real history'? The dialogue invites us to raise this question but also to reflect on its terms. In this paper I shall argue that the story should be seen as 'history' only in a special Platonic sense: it is a story which is fabricated about the past in order to reflect a general truth about how ideal citizens would behave in action.
Kant is well known for his restrictive conception of proper science. In the present paper I will try to explain why Kant adopted this conception. I will identify three core conditions which Kant thinks a proper science must satisfy: systematicity, objective grounding, and apodictic certainty. These conditions conform to conditions codified in the Classical Model of Science. Kant’s infamous claim that any proper natural science must be mathematical should be understood on the basis of these conditions. In order to substantiate (...) this reading, I will show that only in this way it can be explained why Kant thought (1) that mathematics has a particular foundational function with respect to the natural sciences and (2) as such secures their scientific status. (shrink)
In this paper the importance of public affairs management in multinational corporations in India will be examined. After briefly discussing the state of the art in international business and society literature, a conceptual framework for public affairs management in multinational corporations will be developed. This framework serves as the theoretical basis for an empirical study among German multinational corporations in India. In the main part of this paper the results of this study will be presented and discussed. The (...) paper ends with a critical assessment and some major implications for future studies. (shrink)
The passage of the Patient Protection and Affordable Care Act on March 23, 2010, significantly changes the health care landscape. But even with the considerable expansion of insurance, many people will still lack coverage. When fully implemented, the act is designed only to cover about thirty-two million of the forty-six million uninsured Americans. Illegal aliens are specifically excluded. For others, implementation is not immediate; the so-called individual mandate, for example, does not take effect until 2014, and there are exceptions for (...) people for whom available policies are still too expensive, or who have religious objections. Once in effect, the mandate has limited penalties, and some people will choose .. (shrink)
In July, the Department of Health and Human Services and the Office of Science and Technology Policy published an advance notice of proposed rulemaking (ANPRM) proposing sweeping changes to the rules governing oversight of research on human subjects—changes aimed at “better protect[ing] human subjects who are involved in research, while facilitating valuable research and reducing burden, delay, and ambiguity for investigators.”1 The process is likely to amend not only the core regulation on human-subjects research (known as the “common rule”), but (...) also regulations governing vulnerable subjects, IRB registration requirements, research regulations of the Food and Drug Administration, and the “privacy rule” of the .. (shrink)
This paper studies Sentence 16 of Porphyry's Pathways to the Intelligible . It is argued that it should be understood against the background of Plotinus' discussions of the similes of the waxen block and the aviary from Plato's Theaetetus . The first part of the paper concentrates on Plotinus' reception of these similes. In the second part of the paper Plotinus' discussions of the two similes are used to shed light on Sentence 16, in particular on the term προχείρισις. Furthermore (...) it is argued that Porphyry does not reject Plotinus' claim that, pace Aristotle, intellection does not require imaging. (shrink)
In this paper we investigate Accardi's claim that the "quantum paradoxes" have their roots in probability theory and that, in particular, they can be evaded by giving up Bayes' rule, concerning the relation between composite and conditional probabilities. We reach the conclusion that, although it may be possible to give up Bayes' rule and define conditional probabilities differently, this contributes nothing to solving the philosophical problems which surround quantum mechanics.
This article examines a social accounting cycle in a Danish savings bank with specific focus on how employees interacted with the cycle. The case study is based on archival material and observations of employee engagement sessions that were a significant part of the cycle. The article exposes the ways in which the cycle can be understood as an initiative that prompts different forms of accountability. The cycle had the potential to bring different forms of accountability together, but the cycle also (...) faced challenges that threatened its relevance from an employee perspective. These challenges might have implications for the way we perceive social accounting and the role of employees. (shrink)
Given free information and unlimited processing power, should decision algorithms use as much information as possible? A formal model of the decision-making environment is developed to address this question and provide conditions under which informationally frugal algorithms, without any information or processing costs whatsoever, are optimal. One cause of compression that allows optimal algorithms to rationally ignore information is inverse movement of payoffs and probabilities (e.g., high payoffs occur with low probably and low payoffs occur with high probability). If inversely (...) related payoffs and probabilities cancel out, then predictors that correlate with payoffs and consequently condition the probabilities associated with different payoffs will drop out of the expected-payoff objective function, severing the link between information and optimal action rules. Stochastic payoff processes in which rational ignoring occurs are referred to as compressed environments, because optimal action depends on a reduced-dimension subset of the environmental parameters. This paper considers benefits and limitations of economic models versus other methods for studying links between environmental structure and the real-world success of simple decision procedures. Different methods converge on the normative proposition of ecological rationality, as opposed to axiomatic rationality based on informational efficiency and internal consistency axioms, as a superior framework for comparing the effectiveness of decision strategies and prescribing decision algorithms in application. (shrink)
The application of semantical concepts such as synonymy and interpretation to actual situations of usage gives rise to perplexing problems. One of the few attempts to tackle these problems has been carried out by Arne Naess. Further advances along this line may become possible after a clarification of the basic concepts employed. The discussion centers around empirical synonymy and certain other notions built on this concept by Naess. Possible ways of making the system coherent are indicated.
This essay considers the potential role of bioethics in disaster response planning and preparedness. Bioethicists can make substantial contributions, by ensuring that decision-making and distribution of resources during crises is carried out in a fair and just manner, as well as by examining the assumptions upon which disaster planning are based. Bioethicists should also be aware of potential pitfalls of overly-hasty engagement with this new field.
This study evaluates the ethical criteria lobbyists consider in their professional activities using Ruth Edgett's model for ethically desirable public relations advocacy. Data were collected from self-administered surveys of 222 registered lobbyists in Oregon. A factor analysis reduced 18 ethical criteria to seven underlying factors describing lobbyists' ethical approaches to their work. Results indicate that lobbyists consider the following factors in their day-to-day professional activities: situation, strategy, argument, procedure, nature of lobbying, priority, and accuracy. This framework, derived from Edgett's 10 (...) criteria, illustrates the importance of context while incorporating ideas from recognized ethical theories. (shrink)
The computer revolution has had an enormous effect on all aspects of the practice of medicine, yet little thought has been given to the role of social media in identifying treatment choices for incompetent patients. We are currently living in the ?Internet age? and many people have integrated social media into all aspects of their lives. As use becomes more prevalent, and as users age, social media are more likely to be viewed as a source of information regarding medical care (...) preferences. This article explores the ethical and legal issues raised by the use of social media in surrogate decision making. (shrink)
Genetic database initiatives have given rise to considerable debate about their potential harms and benefits. The question arises as to whether existing ethical frameworks are sufficient to mediate between the competing interests at stake. One approach is to strengthen mechanisms for obtaining informed consent and for protecting confidentiality. However, there is increasing interest in other ethical frameworks, involving solidarity — participation in research for the common good — and the sharing of the benefits of research.
One method to determine the asymptotics of particular solutions of a difference equation is by solving an associated asymptotic functional equation. Here we study the behaviour of the solutions in an asymptotic neighbourhood of such individual solutions. We identify several types of attraction and repulsion, which range from almost orthogonality to almost parallelness. Necessary and sufficient conditions for these types of behaviour are given.
In his Wissenschaftslehre Bernard Bolzano tried to lay down a logically satisfactory foundation of mathematics and theory of probability. Thereby he became aware of the distinction between the actual thoughts and judgments of human beings, their linguistic expressions and the abstract propositions {Sätze an sich) and their components (Vorstellungen an sich). This ontological distinction is fundamental in Bolzano's thinking paired with a universal world view in the sense that philosophy, mathematics, physics and metaphysics should be build upon the same logical (...) foundations. Bolzano's enterprise is sketched in the light of examples from his logical semantics, proof theory, number theory, theory of truth and his variation logic. (shrink)
