What is Life? Decades of research have resulted in the full mapping of the human genome - three billion pairs of code whose functions are only now being understood. The gene's eye view of life, advocated by evolutionary biology, sees living bodies as mere vehicles for the replication of the genetic codes. But for a physiologist, working with the living organism, the view is a very different one. Denis Noble is a world renowned physiologist, and sets out an alternative (...) view to the question - one that becomes deeply significant in terms of the living, breathing organism. The genome is not life itself. Noble argues that far from genes building organisms, they should be seen as prisoners of the organism. The view of life presented in this little, modern, post-genome project reflection on the nature of life, is that of the systems biologist: to understand what life is, we must view it at a variety of different levels, all interacting with each other in a complex web. It is that emergent web, full of feedback between levels, from the gene to the wider environment, that is life. It is a kind of music. Including stories from Noble's own research experience, his work on the heartbeat, musical metaphors, and elements of linguistics and Chinese culture, this very personal and at times deeply lyrical book sets out the systems biology view of life. (shrink)
What is Life? Decades of research have resulted in the full mapping of the human genome - three billion pairs of code whose functions are only now being understood. The gene's eye view of life, advocated by evolutionary biology, sees living bodies as mere vehicles for the replication of the genetic codes. -/- But for a physiologist, working with the living organism, the view is a very different one. Denis Noble is a world renowned physiologist, and sets out an (...) alternative view to the question - one that becomes deeply significant in terms of the living, breathing organism. The genome is not life itself. Noble argues that far from genes building organisms, they should be seen as prisoners of the organism. -/- The view of life presented in this little, modern, post-genome project reflection on the nature of life, is that of the systems biologist: to understand what life is, we must view it at a variety of different levels, all interacting with each other in a complex web. It is that emergent web, full of feedback between levels, from the gene to the wider environment, that is life. It is a kind of music. -/- Including stories from Noble's own research experience, his work on the heartbeat, musical metaphors, and elements of linguistics and Chinese culture, this very personal and at times deeply lyrical book sets out the systems biology view of life. (shrink)
The distinction between personal level explanations and subpersonal ones has been subject to much debate in philosophy. We understand it as one between explanations that focus on an agent’s interaction with its environment, and explanations that focus on the physical or computational enabling conditions of such an interaction. The distinction, understood this way, is necessary for a complete account of any agent, rational or not, biological or artificial. In particular, we review some recent research in Artificial Life that pretends to (...) do completely without the distinction, while using agent-centred concepts all the way. It is argued that the rejection of agent level explanations in favour of mechanistic ones is due to an unmotivated need to choose among representationalism and eliminativism. The dilemma is a false one if the possibility of a radical form of externalism is considered. (shrink)
We give anecdotal accounts from our own experience of scientific theories which have been generally accepted as the ruling opinion long after sufficient evidence has been collected for their disproof. This has led us to the opinion that the normal scientific process, of working hypothesis followed by experimental test aimed at disproof, is being replaced by the ruling opinion followed by experiment aimed at confirmation. The apparently widespread adoption of this procedure may be postulated to arise in part from the (...) need for workers entering a new field of study to obtain grants and to get their results published. (shrink)
The teleological language in the target article is ill-advised, as it obscures the question of whether ecological and cultural inheritances are directed or random. Laland et al. present a very broad palette of explanatory possibilities; evolutionary simulation models could help narrow down the processes important in a particular case. Examples of such models are offered in the areas of language change and the Baldwin effect.
Stimulation of airway myocytes by contractile agents such as acetylcholine (ACh) activates a Ca2+-activated Cl– current (IClCa) which may play a key role in calcium homeostasis of airway myocytes and hence in airway reactivity. The aim of the present study was to model IClCa in airway smooth muscle cells using a computerised model previously designed for simulation of cardiac myocyte functioning. Modelling was based on a simple resistor-battery permeation model combined with multiple binding site activation by calcium. In order to (...) validate the model, a combination of equations, used to mimic [Ca2+]i response to ACh stimulation, were incorporated into the model. The results indicate that the model developed in this article accounts for experimental recordings and electrophysiological characteristics of this current in airway smooth muscle cells, with parameter values consistent with those calculated from experimental data. Such a model may thus be used to predict IClCa functioning, though additional experimental data from airway myocytes would be useful to more accurately determine some parameter values of the model. (shrink)
Nietzsche implicitly endorses a positive value system grounded in his concept of the will to power, a “noble” alternative to the “slavish” and life-denying values that he believes characterize modern European morality. His own power-affirming value system is usually presented amorally: as an alternative to morality, rather than as a competing morality. Most commentators believe this is necessarily so: because Nietzsche founds his values in the affirmation of power, they are incompatible with the concern for the well-being of others (...) that is characteristic of any authentic morality. This paper argues, on the contrary, that Nietzsche’s noble, power-affirming values are fully compatible with morality. It defends this view by rejecting two common misconceptions about Nietzsche’s philosophy: 1) the view that Nietzsche’s concept of the will to power is inseparable from domination, and 2) the view that noble values require and actively promote social hierarchy. (shrink)
With armed conflict in the Persian Gulf now upon us, Harvard archaeologist Steven LeBlanc takes a long-term view of the nature and roots of war, presenting a controversial thesis: The notion of the "noble savage" living in peace with one another and in harmony with nature is a fantasy. In Constant Battles: The Myth of the Peaceful, Noble Savage , LeBlanc contends that warfare and violent conflict have existed throughout human history, and that humans have never lived in (...) ecological balance with nature. The start of the second major U.S. military action in the Persian Gulf, combined with regular headlines about spiraling environmental destruction, would tempt anyone to conclude that humankind is fast approaching a catastrophic end. But as LeBlanc brilliantly argues, the archaeological record shows that the warfare and ecological destruction we find today fit into patterns of human behavior that have gone on for millions of years. Constant Battles surveys human history in terms of social organization-from hunter gatherers, to tribal agriculturalists, to more complex societies. LeBlanc takes the reader on his own digs around the world -- from New Guinea to the Southwestern U.S. to Turkey -- to show how he has come to discover warfare everywhere at every time. His own fieldwork combined with his archaeological, ethnographic, and historical research, presents a riveting account of how, throughout human history, people always have outgrown the carrying capacity of their environment, which has led to war. Ultimately, though, LeBlanc's point of view is reassuring and optimistic. As he explains the roots of warfare in human history, he also demonstrates that warfare today has far less impact than it did in the past. He also argues that, as awareness of these patterns and the advantages of modern technology increase, so does our ability to avoid war in the future. (shrink)
William Hirstein, Brain Fiction -- John Bickle; Susan Blackmore, Consciousness: An Introduction -- Tim Calton; Eric Dietrich and Valerie Gray Hardcastle, Sisyphus's Boulder -- HughNoble; Ted Honderich, On Consciousness -- Paavo Pylkkanen.
William Hirstein, Brain Fiction -- John Bickle; Susan Blackmore, Consciousness: An Introduction -- Tim Calton; Eric Dietrich and Valerie Gray Hardcastle, Sisyphus's Boulder -- HughNoble; Ted Honderich, On Consciousness -- Paavo Pylkkanen.
William Hirstein, Brain Fiction -- John Bickle; Susan Blackmore, Consciousness: An Introduction -- Tim Calton; Eric Dietrich and Valerie Gray Hardcastle, Sisyphus's Boulder -- HughNoble; Ted Honderich, On Consciousness -- Paavo Pylkkanen.
William Hirstein, Brain Fiction -- John Bickle; Susan Blackmore, Consciousness: An Introduction -- Tim Calton; Eric Dietrich and Valerie Gray Hardcastle, Sisyphus's Boulder -- HughNoble; Ted Honderich, On Consciousness -- Paavo Pylkkanen.
Aristotle believes that an agent lacks virtue unless she enjoys the performance of virtuous actions, while Kant claims that the person who does her duty despite contrary inclinations exhibits a moral worth that the person who acts from inclination lacks. Despite these differences, this chapter argues that Aristotle and Kant share a distinctive view of the object of human choice and locus of moral value: that what we choose, and what has moral value, are not mere acts, but actions: acts (...) done for the sake of ends. Morally good actions embody a kind of intrinsic value that inspires us to do them from duty (in Kant) or for the sake of the noble (in Aristotle). The chapter traces the difference in their attitudes about doing one's duty with pleasure to a difference in their attitudes towards pleasure itself: Aristotle sees it as a perception of the good, while Kant thinks of it as mere feeling. (shrink)
Friedrich A. von Hayek influenced many areas of inquiry including economics, psychology and political theory. This article will offer one possible interpretation of the ethical foundation of Hayek’s political and social contributions to libertarianism and free market capitalism by analyzing several of his important non-economic publications, primarily The Road to Serfdom, The Fatal Conceit, The Constitution of Liberty and Law, Legislation and Liberty. While Hayek did not offer a particular ethical foundation for free market capitalism, he argued consistently that free (...) markets are liberating and, for the markets to be truly free and for individuals to participate freely in markets, they should be subject to little control. Beyond some very basic principles, such as the protection of private property, that enable the free market to function properly, individuals are both free to and required to determine their own ethical compass. The central question, then, is what are the ethical principles that underlie Hayek’s view of the successful organization and operation of a free market? If formal rules and regulations must be kept to a minimum, then ethical behavior is an individual choice as well as an important foundation for the self-regulating free market. This article will argue that one possible ethical foundation underlying Hayek’s libertarian justification for free market capitalism are Friedrich Nietzsche’s “will to power” and noble/slave ethics. This article will rely primarily on Nietzsche’s On The Genealogy of Morals, Beyond Good and Evil, Zarathustra, and the Will to Power. (shrink)
The prevailing interpretation of ren (humanness) in the Analects is ethical. One consequence of this interpretation is the one-dimensional image of the Confucian junzi (noble man) as a rigid moralist, a fastidious observer of li (ritual). But there are numerous passages in the Analects that resist such a one-sided representation of the junzi, especially Confucius's remarks related to the (Book of) Songs and music. My basic thesis is that Confucius's concept of junji is aesthetic. This is implied by his (...) notion of junji ru (noble scholar) as opposed to xiaoren ru (common scholar). The noble man is one awakened to the beauty of humanness. It is because of this awareness that he 'sets his mind on the Way, depends on virtue, relies on ren and enjoys the arts.' Confucius included the Songs and music in his curriculum precisely for the purpose of cultivating in his pupils this aesthetic sensibility. (shrink)
According to Buddhism's four noble truths, (1) we find our lives filled with anguished suffering because (2) we habitually crave for life to be other than it is; and (3) this habit of craving will cease (4) only if we cultivate in our lives the Buddha's path of mental discipline, wisdom, and moral conduct. The aim of Buddhist practice is to cure craving. There is a model of the self that can be derived from the recent work of some (...) philosophers in the field of cognitive science, Andy Clark in particular. His writings suggest a model of the self that is spread out or extended. I will argue that the model of the extended self offers contemporary insight for interpreting what craving is in the Buddhist sense and how to cure it. (shrink)
David E. Fisher: Much Ado about (Practically) Nothing. A History of the Noble Gases Content Type Journal Article Pages 1-3 DOI 10.1007/s10698-011-9114-0 Authors Sandra D. Hojniak, Department of Chemistry, Laboratory of Coordination Chemistry, Katholieke Universiteit Leuven, Celestijnenlaan 200F, 3001 Leuven, Belgium Journal Foundations of Chemistry Online ISSN 1572-8463 Print ISSN 1386-4238.
In this bold and innovative new work, Adrian Moore provides a refreshing but challenging new interpretation of Kant's moral philosophy and argues that it can enrich our understanding of a central problem in contemporary ethical debate: the problem of rationality. Noble in Reason, Infinite in Faculty is essential reading for all those interested in Kant, ethics and philosophy of religion.
The Scottish logician Hugh MacColl is well known for his innovative contributions to modal and nonclassical logics. However, until now little biographical information has been available about his academic and cultural background, his personal and professional situation, and his position in the scientific community of the Victorian era. The present article reports on a number of recent findings.
The stereotype of the “ecologically noble savage” is still prevalent in European-American discourses. I examine the empirical justifications offered for this stereotype, concluding that we lack sound empirical grounds for believing in “ecological nobility.” I argue that the stereotype should be abandoned because it has negative consequences for native peoples. Instead of accepting questionable stereotypes, philosophers and others should focus on the lives of particular peoples in order to understand their philosophies as well as the relationships that they maintain (...) with their homelands. (shrink)
The Periodic Table has the column of the noble gas atoms (He, Ne, Ar, Kr, Xe, Rn) as one of its main pillars. Indeed the inert chemical nature of their closed shell structure is so striking that it is sometimes extended to all such structures. Is it true however that any closed shell, say a closed d-subshell will denote a lack of chemical activity? Take the noble metals for instance, so renowned for their catalytic capacity. Platinum has 10 (...) electrons in its valence shell which makes one of its excited states to be a closed 5d10–6s0 state. Surely this state would not be expected to be crucial to the catalytic activity of platinum, or would it? Or take palladium whose ground state is precisely the 4d10–5s0 state, should we expect that an isolated Pd atom at near zero-point temperature would attack a closed-shell hydrogen molecule efficiently? We shall here show that this is precisely the case; the closed-shell excited states of nickel and platinum are indeed crucial, through symmetry avoided crossings, for their reactivity. Other valuable catalysts as ruthenium depend on their excited states with maximal d-shell occupancy for their activity. The most notable confirmation of this new finding; that closed d-shells are vital to the catalytic activity of noble metals however, is the case of palladium whose closed-shell ground state is indeed capable of attacking hydrogen and hydrocarbon molecules even at temperatures well below 10 K as was predicted theoretically and immediately confirmed experimentally. (shrink)
Mendeleev’s failure to represent the periodic system as a continuum may have hidden from him the space for the noble gases. A spiral format might have revealed the significance of the wide gaps in atomic mass between his rows. Tables overemphasize the division of the sequence into ‘periods’ and blocks. Not only do spirals express the continuity; in addition they are more attractive visually. They also facilitate a new placing for hydrogen and the introduction of an ‘element of atomic (...) number zero’. (shrink)
Wheeler, Stark, and Stell have raised many interesting briefly expand on, the proposal I offered in the original points concerning gun control that merit extended treat- paper.' ment. Here, however, I will focus only on two. I wiII then In earlier papers and also in this symposium, Wheeler argues that ov,ming arms is defensible as a means of resisting governmental assaults against indivicluals. If only governments have guns, he argues, then a gover'n- ment gone bad can easily oppress its citizens. (...) An armed citizenry, hov ever, might be able to deflect B governmental assault. Because "governments are among the more serious threats to one's rights,... there is Bt least a p.ima facie right to v hatever means are necessary to deflect threats to rights."' Not only is this a prima I'acie right, he argues, but given the history of governmental oppression, it is an actual right ââ¬â indeecl a right that should be rec ognized by any legitimate government. (shrink)
I examine the implications of stereotyping and its intersections with the political realities facing American Indian communities. Specifically, I examine the typification of Indian as ecologically noble savage, as both employed and refuted by environmentalists, through the lenses of cognitive and social psychological perspectives and then bring it within the context of a broader cultural critique. I argue that the noble savage stereotype, often used to promote the environmentalist agenda is nonetheless immersed in the political and ideological parameters (...) of the modern project. Finally, I reassert the right and, more importantly, the authority of Native American peoples to ultimately define for themselves their respective identities and destinies. (shrink)
I examine the implications of stereotyping and its intersections with the political realities facing American Indian communities. Specifically, I examine the typification of Indian as ecologically noble savage, as both employed and refuted by environmentalists, through the lenses of cognitive and social psychological perspectives and then bring it within the context of a broader cultural critique. I argue that the noble savage stereotype, often used to promote the environmentalist agenda is nonetheless immersed in the political and ideological parameters (...) of the modern project. Finally, I reassert the right and, more importantly, the authority of Native American peoples to ultimately define for themselves their respective identities and destinies. (shrink)
The work of Hugh MacColl (1837?1909) suffered the same fate after his death as before it:despite being vaguely alluded to and in part even commended, on the whole it has remained an unknown quantity. Even worse, those of his ideas which have played a decisive role in the history of logic have been credited to his successors; this is especially the case with the definition of strict implication and the first formal development of formal modal logic. This paper takes (...) an initial step towards a rectification of this unfortunate misrepresentation, presenting a bibliography of MacColl?s most significant publications with particular regard to their reception. (shrink)
The article describes the evolution of Ockham's theory of mental language and its impact on three of his dominican contemporaries at oxford: Hugh Lawton, William Crathorn and Robert Holcot, and its impact at Paris on the works of Gregory of Rimini and Pierre d'Ailly. Hugh Lawton's critical response to Ockham relied on a liar-like paradox to show that mental language would preclude the ability to lie. Crathorn devised an alternative to Ockham's theory in reaction, whereas Holcot defended Ockham's (...) views. At Paris, the debate suggested a solution to the liar paradox to Gregory of Rimini. (shrink)
Born in Saxony in 1096, Hugh became an Augustinian monk and in 1115 moved to the monastery of Saint Victor, Paris, where he spent the remainder of his life, eventually becoming the head of the school there. His writings cover the whole range of arts and sacred science taught in his day. Paul Rorem offers a basic introduction to Hugh's theology, through a comprehensive survey of his works. He argues that Hugh is best understood as a teacher (...) of theology, and that his numerous and varied writings are best appreciated as a comprehensive pedagogical program of theological education and spiritual formation. Drawing his evidence not only from Hugh's own descriptions of his work but from the earliest manuscript traditions of his writings, Rorem organizes and presents his corpus within a tri-part framework. Upon a foundation of training in the liberal arts and history, a structure of doctrine is built up, which is finally adorned with moral formation. Within this scheme of organization, Rorem treats each of Hugh's major works (and many minor ones) in its appropriate place, orienting the reader briefly yet accurately to its contents, as well as its location in Hugh's overarching program of theological pedagogy. (shrink)
This paper draws on Friedrich Nietzsche’s work to defend the (admittedly non-Nietzschean) conclusion that a non-liberal egalitarian society is superior in two ways: first, as a moral ideal, it does not rest on questionable claims about essential human equality and, second, such a society would provide the optimal psychological and political conditions for individual wellbeing, social stability, and cultural achievement. I first explain Nietzsche’s distinction between forms of egalitarianism: noble and slavish. The slavish form promotes equality, defined negatively as (...) the elimination of privilege. It is non-liberal in its prioritization of equality over the interests of the advantaged. Nietzsche rejects both slavish egalitarianism and liberalism for the same reasons: they questionably assume the equal value of all persons, and they harm cultural achievement, sacrificing the potential of those who are most valuable to cultural development to the interests of the majority. Noble egalitarianism, in contrast, exemplifies Nietzsche’s conception of justice as ‘equality among equals’. It demands that individuals of equal worth or power (such as members of an artistic or political elite) treat each other as what they, in fact, are: equals. It avoids asserting essential equality, demanding instead—against both slavish and liberal forms—respect on the basis of shared superiority. And it escapes the charge of harm to cultural development, commanding respect only where equality already exists. Although Nietzsche quickly assumes that ‘noble egalitarianism’ requires the rejection of all forms of universal egalitarianism, concluding that we should ‘never make equal what is unequal’, in fact it only entails the rejection of slavish methods: equalization through harm to the advantaged. However, non-liberal forms of egalitarianism can be ‘noble’, promoting equality without harm to the advantaged—through, for example, unequal distribution of resources, the equalization of economic opportunities, and economic regulation to prevent the creation of substantial wealth disparities. If egalitarianism can ‘make equal’ without slavish methods, then Nietzsche’s demand for ‘equality for equals’ applies to the newly equal, too. More importantly, his moral psychology of power—the view that our source of happiness and incentive to self-development is the feeling of power in relation to equal resistance or ‘opponents who are our equals’ —supports the superiority of a nobly-achieved, non-liberal egalitarian society. For achieved, practical equality of wealth and opportunity would optimize conditions for the feeling of power: a balance of equal, oppositional powers serving as mutual limitation and resistance. Such a society is superior in three ways. First, it maximizes social happiness by promoting and maintaining the feeling of power in all. Liberal and aristocratic societies, in contrast, allow radical inequalities that not only diminish the power of the disadvantaged, but diminish the opportunities of the advantaged to encounter equal resistance, thus undermining the happiness of all. Second, it promotes social stability by preserving a balance of powers that prevents domination and exploitation, in contrast to the inevitable class conflicts of aristocratic and liberal societies. Finally, it promotes cultural achievement, since the feeling of power in relation to proportional resistance is the psychological incentive for self-development and cultural achievement. (shrink)
The late medieval discussion of 'nobility' (= nobilitas, dignitas) defined in philosophical terms (as opposed to other social notions like 'aristocracy'), produced a large number of writings, many of which are still unedited. Nevertheless, modern philosophical historiography (developed throughout the seventeenth century and reaching its first apogee with Hegel) has neglected the conceptual debates on nobility. Perhaps having assumed it to be a dead relic of the 'pre-illuminist' past, historians and philosophers understood 'nobility' as a non-philosophical issue and so it (...) still appears in contemporary scholarship. The first aim of this essay is to draw attention to this issue by presenting a sort of preliminary catalogue of the different types of conceptualizations of 'mobility'. By exploring the meanings and philosophical employment of the expressions 'bene nasci' and 'bene natus', this article also reveals a new aspect of the Aristotelian notion of magnanimity. (shrink)
Discusses the history of animal rights; laws about how animals are treated; moral issues involved in using animals in such fields as medical research and ...
Social relations associated with conventional agricultural exports find their origins in long term associations based on business, family, and class alliances. Working outside these boundaries presents a host of challenges, especially where small producers with little economic or political power are concerned. Yet, in many developing countries, alternative trade organizations (ATOs) based on philosophies of social justice and/or environmental well-being are carving out spaces alongside traditional agricultural export sectors by establishing new channels of trade and marketing. Coffee provides a case (...) in point, with the fair trade and certified organic movements making inroads into the market place. In their own ways, these movements represent a type of economic and social restructuring from below, drawing upon and developing linkages beyond the traditional boundaries of how coffee is produced and traded. An examination of the philosophies of the fair trade and organic coffee movements reveal that the philosophical underpinnings of both certified organic and fair-trade coffee run counter to the historical concerns of coffee production and trade. Associations of small producers involved in these coffees face stiff challenges – both internal and external to their groups. More work, especially in situ fieldwork aimed at uncovering the challenges, benefits, tensions, and successes, is needed to understand better the ways these networks operate in the dynamic agro-food complex. (shrink)
In 1955, an obscure socio-spiritual organization dedicated to the twin aims of individual spiritual realization and social service was formed in the state of Bihar, India. It was named Ānanda Mārga Pracāraka Saṃgha (abbreviated AM), literally translated as "Community for the Propagation of the Path of Bliss." AM stands alongside other New Religious Movements of Indian origin that have captured the imagination and allegiance of a substantial number of followers in both Asia and the West. It is in much the (...) same genre as New Religious Movements such as Transcendental Meditation and the International Society for Kṛṣṇa Consciousness. The founder of AM was a charismatic spiritualist and visionary, Prabhāt Ranjan .. (shrink)
The fact that Oswald T. Avery (1877-1955) did not become a Nobel Laureate for his discovery of DNA as the genetic material has frequently been cited as a prime example of a mistake made in the awarding of the Nobel Prizes. The late Nobel Laureate Arne Tiselius explained the oversight away by saying that Avery "was an old man when he made his discovery" (Litell 1967)—although Avery was actually younger than several others who won the Nobel Prize around the same (...) time. Later, in somewhat of a contradiction, Tiselius said that Avery was the most deserving scientist not to have received the Nobel Prize for his work (Judson 2003).The opening of the Nobel archives 50 years after Avery's name was cited gives insights into .. (shrink)
