Search results for 'Human embryonic stem cells' (try it on Scholar)

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  1. Frederic Bretzner, Frederic Gilbert, Françoise Baylis & Robert M. Brownstone (2011). Target Populations for First-In-Human Embryonic Stem Cell Research in Spinal Cord Injury. Cell Stem Cell 8 (5):468-475.score: 1368.0
    Geron recently announced that it had begun enrolling patients in the world's first-in-human clinical trial involving cells derived from human embryonic stem cells (hESCs). This trial raises important questions regarding the future of hESC-based therapies, especially in spinal cord injury (SCI) patients. We address some safety and efficacy concerns with this research, as well as the ethics of fair subject selection. We consider other populations that might be better for this research: chronic complete SCI (...)
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  2. Roman J. Krawetz, Xiangyun Li & Derrick E. Rancourt (2009). Human Embryonic Stem Cells: Caught Between a ROCK Inhibitor and a Hard Place. Bioessays 31 (3):336-343.score: 1312.0
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  3. Demetrio Neri (2011). The Race Toward 'Ethically Universally Acceptable' Human Pluripotent (Embryonic-Like) Stem Cells: Only a Problem of Sources? Bioethics 25 (5):260-266.score: 1240.0
    Over the past few years, several proposals aimed at procuring human pluripotent (embryonic-like) stem cells without involving the destruction of a human embryo have been proposed and widely discussed. This article focuses on a basic aspect of the debate, namely the plausibility of one or more of these new proposals being able to meet the ethical requirements that those who regard the human embryo as sacred have tried to impose on stem cells (...)
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  4. David B. Resnik (2007). Embryonic Stem Cell Patents and Human Dignity. Health Care Analysis 15 (3):211-222.score: 1211.0
    This article examines the assertion that human embryonic stem cells patents are immoral because they violate human dignity. After analyzing the concept of human dignity and its role in bioethics debates, this article argues that patents on human embryos or totipotent embryonic stem cells violate human dignity, but that patents on pluripotent or multipotent stem cells do not. Since patents on pluripotent or multipotent stem cells (...)
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  5. Audrey R. Chapman & Courtney C. Scala (2012). Evaluating the First-in-Human Clinical Trial of a Human Embryonic Stem Cell-Based Therapy. Kennedy Institute of Ethics Journal 22 (3):243-261.score: 1032.0
    The transition of novel and potentially promising medical therapies into their initial human clinical trials can engender conflicting pressures. On the one side, because Phase I trials raise greater ethical and human protection challenges than later stage clinical trials, there is a need to proceed cautiously. This is particularly the case for Phase I trials with a novel therapy being tested in humans for the first time, usually termed first-in-human (FIH) trials, especially if the FIH trial involves (...)
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  6. G. Badura-Lotter (2001). Ethical, Biological and Legal Aspects in the Use of Human Embryonic Stem Cells in Germany. Human Reproduction and Genetic Ethics 7 (2):38.score: 1032.0
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  7. Michel Revel (2010). Research on Human Embryonic Stem Cells and Cloning for Stem Cells. Human Reproduction and Genetic Ethics 14 (1):4-14.score: 1032.0
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  8. Erica Haimes & Ken Taylor (2011). The Contributions of Empirical Evidence to Socio-Ethical Debates on Fresh Embryo Donation for Human Embryonic Stem Cell Research. Bioethics 25 (6):334-341.score: 1024.0
    This article is a response to McLeod and Baylis (2007) who speculate on the dangers of requesting fresh ‘spare’ embryos from IVF patients for human embryonic stem cell (hESC) research, particularly when those embryos are good enough to be transferred back to the woman. They argue that these embryos should be frozen instead. We explore what is meant by ‘spare’ embryos. We then provide empirical evidence, from a study of embryo donation and of embryo donors' views, to (...)
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  9. Audrey R. Chapman (2009). The Ethics of Patenting Human Embryonic Stem Cells. Kennedy Institute of Ethics Journal 19 (3):pp. 261-288.score: 1020.0
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  10. William B. Hurlbut (2005). Altered Nuclear Transfer as a Morally Acceptable Means for the Procurement of Human Embryonic Stem Cells. Perspectives in Biology and Medicine 48 (2):211-228.score: 1020.0
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  11. Geron Ethics Advisory Board (forthcoming). Research with Human Embryonic Stem Cells: Ethical Considerations. Hastings Center Report.score: 1020.0
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  12. J. R. Meyer (2000). Human Embryonic Stem Cells and Respect for Life. Journal of Medical Ethics 26 (3):166-170.score: 1020.0
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  13. Karen Lebacqz, Michael M. Mendiola, Ted Peters, Ernlé W. D. Young & Laurie Zoloth‐Dorfman (1999). Research with Human Embryonic Stem Cells: Ethical Considerations. Hastings Center Report 29 (2):31-36.score: 1020.0
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  14. M. M. Mendiola, T. Peters, E. W. Young & L. Zoloth-Dorfman (1999). Research with Human Embryonic Stem Cells: Ethical Considerations. By Geron Ethics Advisory Board. Hastings Center Report 29 (2):31.score: 1020.0
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  15. Christine Mummery (2007). Cardiomyocytes From Human Embryonic Stem Cells: More Than Heart Repair Alone. Bioessays 29 (6):572-579.score: 1020.0
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  16. Mi-Kyung Kim (2009). Oversight Framework Over Oocyte Procurement for Somatic Cell Nuclear Transfer: Comparative Analysis of the Hwang Woo Suk Case Under South Korean Bioethics Law and U.S. Guidelines for Human Embryonic Stem Cell Research. Theoretical Medicine and Bioethics 30 (5):367-384.score: 1012.0
    We examine whether the current regulatory regime instituted in South Korea and the United States would have prevented Hwang’s potential transgressions in oocyte procurement for somatic cell nuclear transfer, we compare the general aspects and oversight framework of the Bioethics and Biosafety Act in South Korea and the US National Academies’ Guidelines for Human Embryonic Stem Cell Research, and apply the relevant provisions and recommendations to each transgression. We conclude that the Act would institute centralized oversight under (...)
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  17. David B. Resnik (2002). The Commercialization of Human Stem Cells: Ethical and Policy Issues. [REVIEW] Health Care Analysis 10 (2):127-154.score: 1005.0
    The first stage of the human embryonic stem(ES) cell research debate revolved aroundfundamental questions, such as whether theresearch should be done at all, what types ofresearch may be done, who should do theresearch, and how the research should befunded. Now that some of these questions arebeing answered, we are beginning to see thenext stage of the debate: the battle forproperty rights relating to human ES cells. The reason why property rights will be a keyissue in (...)
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  18. Maureen L. Condic & Edward J. Furton (2007). Harvesting Embryonic Stem Cells From Deceased Human Embryos. The National Catholic Bioethics Quarterly 7 (3):507-526.score: 1005.0
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  19. Yves Maury, Morgane Gauthier, Marc Peschanski & Cécile Martinat (2012). Human Pluripotent Stem Cells for Disease Modelling and Drug Screening. Bioessays 34 (1):61-71.score: 993.0
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  20. Divya Rajamohan, Elena Matsa, Spandan Kalra, James Crutchley, Asha Patel, Vinoj George & Chris Denning (2013). Current Status of Drug Screening and Disease Modelling in Human Pluripotent Stem Cells. Bioessays 35 (3):281-298.score: 993.0
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  21. Mark Moller (2009). Human Embryonic Stem Cell Research and the Discarded Embryo Argument. Theoretical Medicine and Bioethics 30 (2):131-145.score: 984.0
    Many who believe that human embryos have moral status are convinced that their use in human embryonic stem cell (hESC) research can be morally justified as long as they are discarded embryos left over from fertility treatments. This is one reason why this view about discarded embryos has played such a prominent role in the debate over publicly funding hESC research in the United States and other countries. Many believe that this view offers the best chance (...)
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  22. Matthew Herder (2006). Proliferating Patent Problems with Human Embryonic Stem Cell Research? Journal of Bioethical Inquiry 3 (1-2):69-79.score: 984.0
    The scientific challenges and ethical controversies facing human embryonic stem cell (hESC) research continue to command attention. The issues posed by patenting hESC technologies have, however, largely failed to penetrate the discourse, much less result in political action. This paper examines U.S. and European patent systems, illustrating discrepancies in the patentability of hESC technologies and identifying potential negative consequences associated with efforts to make available hESC research tools for basic research purposes while at same time strengthening the (...)
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  23. Søren Holm (2006). Who Should Control the Use of Human Embryonic Stem Cell Lines: A Defence of the Donors' Ability to Control. [REVIEW] Journal of Bioethical Inquiry 3 (1-2):55-68.score: 984.0
    In this paper I analyse who should be able to control the use of human embryonic stem cell lines. I distinguish between different kinds of control and analyse a set of arguments that purport to show that the donors of gametes and embryos should not be able to control the use of stem cell lines derived from their embryos. I show these arguments to be either deficient or of so general a scope that they apply not (...)
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  24. Ronald K. F. Fung & Ian H. Kerridge (2013). Uncertain Translation, Uncertain Benefit and Uncertain Risk: Ethical Challenges Facing First-in-Human Trials of Induced Pluripotent Stem (Ips) Cells. Bioethics 27 (2):89-96.score: 962.0
    The discovery of induced pluripotent stem (iPS) cells in 2006 was heralded as a major breakthrough in stem cell research. Since then, progress in iPS cell technology has paved the way towards clinical application, particularly cell replacement therapy, which has refueled debate on the ethics of stem cell research. However, much of the discourse has focused on questions of moral status and potentiality, overlooking the ethical issues which are introduced by the clinical testing of iPS cell (...)
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  25. Philip J. Nickel (2008). Ethical Issues in Human Embryonic Stem Cell Research. In Kristen Renwick Monroe, Ronald B. Miller & Jerome Tobis (eds.), Fundamentals of the Stem Cell Debate: The Scientific, Religious, Ethical & Political Issues. University of California Press.score: 960.0
    As a moral philosopher, the perspective I will take in this chapter is one of argumentation and informed judgment about two main questions: whether individuals should ever choose to conduct human embryonic stem cell research, and whether the law should permit this type of research. I will also touch upon a secondary question, that of whether the government ought to pay for this type of research. I will discuss some of the main arguments at stake, and explain (...)
     
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  26. Jan P. Beckmann (2004). On the German Debate on Human Embryonic Stem Cell Research. Journal of Medicine and Philosophy 29 (5):603 – 621.score: 934.0
    Germany since 1990 has one of the strictest human embryo protection laws, yet according to the Stem Cell Act of 2002 allows, under strict conditions, the import and use of human embryonic stem cells (hESC) for high priority research goals. The author tries to show how this is taken to be coherent by the parliamentary majority (though not necessarily by the general public) in Germany. In doing so, he firstly looks into the chronicle of (...)
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  27. Laurie Zoloth (2002). Reasonable Magic and the Nature of Alchemy: Jewish Reflections on Human Embryonic Stem Cell Research. Kennedy Institute of Ethics Journal 12 (1):65-93.score: 934.0
    : The controversy about research on human embryonic stem cells both divides and defines us, raising fundamental ethical and religious questions about the nature of the self and the limits of science. This article uses Jewish sources to articulate fundamental concerns about the forbiddenness of knowledge in general and of knowledge thought of as magical creation. Alchemy, and the turning of elements into gold and into substances for longevity, and magic used for the creation of living (...)
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  28. Suzanne Holland, Karen Lebacqz & Laurie Zoloth (eds.) (2001). The Human Embryonic Stem Cell Debate: Science, Ethics, and Public Policy. The Mit Press.score: 934.0
    Discusses the ethical issues involved in the use of human embryonic stem cells in regenerative medicine.
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  29. LeRoy Walters (2004). Human Embryonic Stem Cell Research: An Intercultural Perspective. Kennedy Institute of Ethics Journal 14 (1):3-38.score: 932.0
    : In 1998, researchers discovered that embryonic stem cells could be derived from early human embryos. This discovery has raised a series of ethical and public-policy questions that are now being confronted by multiple international organizations, nations, cultures, and religious traditions. This essay surveys policies for human embryonic stem cell research in four regions of the world, reports on the recent debate at the United Nations about one type of such research, and reviews (...)
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  30. Bishop Thomas (2013). Human Embryonic Stem Cell Research: Its Importance in the Culture Wars. Christian Bioethics 19 (1):60-71.score: 932.0
    The debate surrounding human embryonic stem cell research plays a crucial role in the culture wars. Those who embrace post-traditional morality not only see no ethical problem with the destruction of human embryos for research and therapies, but press for their use despite the greater potential for risk from the totipotent cells that are harvested from the destruction of human embryos as opposed to other kinds of stem cells. Indeed, there have been (...)
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  31. S. Matthew Liao (2005). Rescuing Human Embryonic Stem Cell Research: The Blastocyst Transfer Method. American Journal of Bioethics 5 (6):8 – 16.score: 931.0
    Despite the therapeutic potential of human embryonic stem (HES) cells, many people believe that HES cell research should be banned. The reason is that the present method of extracting HES cells involves the destruction of the embryo, which for many is the beginning of a person. This paper examines a number of compromise solutions such as parthenogenesis, the use of defective embryos, genetically creating a "pseudo embryo" that can never form a placenta, and determining embryo (...)
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  32. Bertha Manninen (2008). Are Human Embryos Kantian Persons?: Kantian Considerations in Favor of Embryonic Stem Cell Research. Philosophy, Ethics, and Humanities in Medicine 3 (1):4.score: 921.0
    One argument used by detractors of human embryonic stem cell research (hESCR) invokes Kant's formula of humanity, which proscribes treating persons solely as a means to an end, rather than as ends in themselves. According to Fuat S. Oduncu, for example, adhering to this imperative entails that human embryos should not be disaggregated to obtain pluripotent stem cells for hESCR. Given that human embryos are Kantian persons from the time of their conception, killing (...)
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  33. Don Marquis (2007). The Moral-Principle Objection to Human Embryonic Stem Cell Research. Metaphilosophy 38 (2-3):190–206.score: 885.5
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  34. Patrick Foong (2011). Human Embryonic Stem Cell (HESC) Research in Malaysia: Multi-Faith Perspectives. Asian Bioethics Review 3 (3):182-206.score: 885.5
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  35. Patrick L. Taylor (2005). The Gap Between Law and Ethics in Human Embryonic Stem Cell Research: Overcoming the Effect of U.S. Federal Policy on Research Advances and Public Benefit. Science and Engineering Ethics 11 (4):589-616.score: 864.0
    Key ethical issues arise in association with the conduct of stem cell research by research institutions in the United States. These ethical issues, summarized in detail, receive no adequate translation into federal laws or regulations, also described in this article. U.S. Federal policy takes a passive approach to these ethical issues, translating them simply into limitations on taxpayer funding, and foregoes scientific and ethical leadership while protecting intellectual property interests through a laissez faire approach to stem cell patents (...)
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  36. Brooke Ellison & Jaymie Meliker (2011). Assessing the Risk of Ovarian Hyperstimulation Syndrome in Egg Donation: Implications for Human Embryonic Stem Cell Research. American Journal of Bioethics 11 (9):22-30.score: 847.0
    Stem cell research has important implications for medicine. The source of stem cells influences their therapeutic potential, with stem cells derived from early-stage embryos remaining the most versatile. Somatic cell nuclear transfer (SCNT), a source of embryonic stem cells, allows for understandings about disease development and, more importantly, the ability to yield embryonic stem cell lines that are genetically matched to the somatic cell donor. However, SCNT requires women to donate (...)
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  37. Godfrey B. Tangwa (2007). Moral Status of Embryonic Stem Cells: Perspective of an African Villager. Bioethics 21 (8):449–457.score: 813.0
  38. Françoise Baylis (2009). For Love or Money? The Saga of Korean Women Who Provided Eggs for Embryonic Stem Cell Research. Theoretical Medicine and Bioethics 30 (5):385-396.score: 808.0
    In 2004 and 2005, Woo-Suk Hwang achieved international stardom with publications in Science reporting on successful research involving the creation of stem cells from cloned human embryos. The wonder and success all began to unravel, however, when serious ethical concerns were raised about the source of the eggs for this research. When the egg scandal had completely unfolded, it turned out that many of the women who provided eggs for stem cell research had not provided valid (...)
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  39. Anders Persson, Sven Hemlin & Stellan Welin (2007). Profitable Exchanges for Scientists: The Case of Swedish Human Embryonic Stem Cell Research. [REVIEW] Health Care Analysis 15 (4):291-304.score: 776.5
    In this article two inter-related issues concerning the ongoing commercialisation of biomedical research are analyzed. One aim is to explain how scientists and clinicians at Swedish public institutions can make profits, both commercially and scientifically, by controlling rare human biological material, like embryos and embryonic stem cell lines. This control in no way presupposes legal ownership or other property rights as an initial condition. We show how ethically sensitive material (embryos and stem cell lines) have been (...)
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  40. Robert Streiffer (2005). At the Edge of Humanity: Human Stem Cells, Chimeras, and Moral Status. Kennedy Institute of Ethics Journal 15 (4):347-370.score: 768.0
    : Experiments involving the transplantation of human stem cells and their derivatives into early fetal or embryonic nonhuman animals raise novel ethical issues due to their possible implications for enhancing the moral status of the chimeric individual. Although status-enhancing research is not necessarily objectionable from the perspective of the chimeric individual, there are grounds for objecting to it in the conditions in which it is likely to occur. Translating this ethical conclusion into a policy recommendation, however, (...)
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  41. Katrien Devolder & Christopher M. Ward (2007). Rescuing Human Embryonic Stem Cell Research: The Possibility of Embryo Reconstitution After Stem Cell Derivation. Metaphilosophy 38 (2-3):245–263.score: 764.5
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  42. Ben Zhang, Roman Krawetz & Derrick E. Rancourt (2013). Would the Real Human Embryonic Stem Cell Please Stand Up? Bioessays 35 (7):632-638.score: 764.5
  43. Jason P. Lott & Julian Savulescu (2007). Towards a Global Human Embryonic Stem Cell Bank. American Journal of Bioethics 7 (8):37 – 44.score: 759.0
    An increasingly unbridgeable gap exists between the supply and demand of transplantable organs. Human embryonic stem cell technology could solve the organ shortage problem by restoring diseased or damaged tissue across a range of common conditions. However, such technology faces several largely ignored immunological challenges in delivering cell lines to large populations. We address some of these challenges and argue in favor of encouraging contribution or intentional creation of embryos from which widely immunocompatible stem cell lines (...)
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  44. Kathryn Ehrich, Clare Williams & Bobbie Farsides (2010). Consenting Futures: Professional Views on Social, Clinical and Ethical Aspects of Information Feedback to Embryo Donors in Human Embryonic Stem Cell Research. Clinical Ethics 5 (2):77-85.score: 759.0
    This paper reports from an ongoing multidisciplinary, ethnographic study that is exploring the views, values and practices (the ethical frameworks) drawn on by professional staff in assisted conception units and stem cell laboratories in relation to embryo donation for research purposes, particularly human embryonic stem cell (hESC) research, in the UK. We focus here on the connection between possible incidental findings and the circumstances in which embryos are donated for hESC research, and report some of the (...)
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  45. S. Napier (2009). A Regulatory Argument Against Human Embryonic Stem Cell Research. Journal of Medicine and Philosophy 34 (5):496-508.score: 756.5
    This article explores the plausibility of an argument against embryonic stem cell research based on what the regulations already say about research on pregnant women and fetuses. The center of the argument is the notion of vulnerability and whether such a concept is applicable to human embryos. It is argued that such an argument can be made plausible. The article concludes by responding to several important objections.
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  46. Nicolae Ovidiu Grad, Ionel Ciprian Pop & Ion Aurel Mironiuc (2012). Stem Cells Therapy and Research. Benefits and Ethical Challences. Journal for the Study of Religions and Ideologies 11 (32):190-205.score: 748.0
    The research on stem cell-based therapies has greatly expanded in recent years. Our text attempts to seek those religious and ethical challenges that stem cell therapy and research bring into debate. Our thesis is that bioethics can defend its principle without a religious background. We will develop our argumentation on three major points: firstly, a comparison between secular ethics and religious views will clarify why stem cell therapy and research are important from a scientific point of view, (...)
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  47. Lawrence Burns (2009). “You Are Our Only Hope”: Trading Metaphorical “Magic Bullets” for Stem Cell “Superheroes”. Theoretical Medicine and Bioethics 30 (6):427-442.score: 742.0
    In the wake of two recent developments in stem cell research, it is a fitting time to reassess the claim that stem cells will radically transform the concept and function of medicine. The first is the U.S. Food and Drug Administration’s decision in January 2009 to approve Geron Corporation’s Phase I clinical trial using human embryonic stem cells for patients with spinal cord injuries. The second is the National Institutes of Health’s decision to (...)
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  48. A. -K. M. Andersson (2011). Embryonic Stem Cells and Property Rights. Journal of Medicine and Philosophy 36 (3):221-242.score: 731.0
    This article contributes to the current debate on human embryonic stem cell researchers’ possible complicity in the destruction of human embryos and the relevance of such complicity for the issue of commodification of human embryos. I will discuss if, and to what extent, researchers who destroy human embryos, and researchers who merely use human embryos destroyed by others, have moral use rights, and/or moral property rights, in these embryos. I argue that the moral (...)
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  49. Tuija Takala & Matti Häyry (2007). Benefiting From Past Wrongdoing, Human Embryonic Stem Cell Lines, and the Fragility of the German Legal Position. Bioethics 21 (3):150–159.score: 704.5
    This paper examines the logic and morality of the German Stem Cell Act of 2002. After a brief description of the law’s scope and intent, its ethical dimensions are analysed in terms of symbolic threats, indirect consequences, and the encouragement of immorality. The conclusions are twofold. For those who want to accept the law, the arguments for its rationality and morality can be sound. For others, the emphasis on the uniqueness of the German experience, the combination of absolute and (...)
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  50. N. Espinoza & M. Peterson (2012). How to Depolarise the Ethical Debate Over Human Embryonic Stem Cell Research (and Other Ethical Debates Too!). Journal of Medical Ethics 38 (8):496-500.score: 698.5
    The contention of this paper is that the current ethical debate over embryonic stem cell research is polarised to an extent that is not warranted by the underlying ethical conflict. It is argued that the ethical debate can be rendered more nuanced, and less polarised, by introducing non-binary notions of moral rightness and wrongness. According to the view proposed, embryonic stem cell research—and possibly other controversial activities too—can be considered ‘a little bit right and a little (...)
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