Search results for 'Human gene libraries' (try it on Scholar)

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  1.  1
    Human Gene (2009). Ond ecember. In Vardit Ravitsky, Autumn Fiester & Arthur L. Caplan (eds.), The Penn Center Guide to Bioethics. Springer Publishing Company 383.
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  2.  13
    Margaret Sleeboom-Faulkner (ed.) (2009). Human Genetic Biobanks in Asia: Politics of Trust and Scientific Advancement. Routledge.
    This volume investigates human genetic biobanking and its regulation in various Asian countries and areas, including Japan, Mainland China, Taiwan, Hong Kong, ...
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  3.  26
    Veikko Launis (2002). Human Gene Therapy and the Slippery Slope Argument. Medicine, Health Care and Philosophy 5 (2):169-179.
    The article investigates the validity of two different versions of the slippery slope argument construed in relation to human gene therapy: the empirical and the conceptual argument. The empirical version holds that our accepting somatic cell therapy will eventually cause our accepting eugenic medical goals. The conceptual version holds that we are logically committed to accepting such goals once we have accepted somatic cell therapy. It is argued that neither the empirical nor the conceptual version of the argument (...)
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  4. Z. Bankowski, Alexander Morgan Capron, Council for International Organizations of Medical Sciences, Nihon Gakujutsu Kaigi & Unesco (1991). Genetics, Ethics and Human Values Human Genome Mapping, Genetic Screening and Gene Therapy : Proceedings of the Xxivth Cioms Conference, Tokyo and Inuyama City, Japan, 22-27 July 1990. [REVIEW]
     
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  5.  16
    Nils Holtug (1993). Human Gene Therapy: Down the Slippery Slope? Bioethics 7 (5):402-419.
    The strength of a slippery slope argument is a matter of some dispute. Some see it as a reasonable argument pointing out what probably or inevitably follows from adopting some practice, others see it as essentially a fallacious argument. However, there seems to be a tendency emerging to say that in many cases, the argument is not actually fallacious, although it may be unsubstantiated. I shall not try to settle this general discussion, but merely seek to assess the strength of (...)
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  6.  50
    T. McGleenan (1995). Human Gene Therapy and Slippery Slope Arguments. Journal of Medical Ethics 21 (6):350-355.
    Any suggestion of altering the genetic makeup of human beings through gene therapy is quite likely to provoke a response involving some reference to a 'slippery slope'. In this article the author examines the topography of two different types of slippery slope argument, the logical slippery slope and the rhetorical slippery slope argument. The logical form of the argument suggests that if we permit somatic cell gene therapy then we are committed to accepting germ line gene (...)
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  7.  71
    W. French Anderson (1989). Human Gene Therapy: Why Draw a Line? Journal of Medicine and Philosophy 14 (6):681-693.
    Despite widespread agreement that it would be ethical to use somatic cell gene therapy to correct serious diseases, there is still uneasiness on the part of the public about this procedure. The basis for this concern lies less with the procedure's clinical risks than with fear that genetic engineering could lead to changes in human nature. Legitimate concerns about the potential for misuse of gene transfer technology justify drawing a moral line that includes corrective germline therapy but (...)
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  8.  17
    John C. Fletcher (1985). Ethical Issues in and Beyond Prospective Clinical Trials of Human Gene Therapy. Journal of Medicine and Philosophy 10 (3):293-310.
    As the potential for the first human trials of somatic cell gene therapy nears, two ethical issues are examined: (1) problems of moral choice for members of institutional review boards who consider the first protocols, for parents, and for the clinical researchers, and the special protections that may be required for the infants and children to be involved, and (2) ethical objections to somatic cell therapy made by those concerned about a putative inevitable progression of genetic knowledge from (...)
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  9. W. French Anderson (1985). Human Gene Therapy: Scientific and Ethical Considerations. Journal of Medicine and Philosophy 10 (3):275-292.
    types of application of genetic engineering for the insertion of genes into humans. The scientific requirements and the ethical issues associated with each type are discussed. Somatic cell gene therapy is technically the simplest and ethically the least controversial. The first clinical trials will probably be undertaken within the next year. Germ line gene therapy will require major advances in our present knowledge and it raises ethical issues that are now being debated. In order to provide guidelines for (...)
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  10.  20
    Nils Holtug (1997). Altering Humans—The Case For and Against Human Gene Therapy. Cambridge Quarterly of Healthcare Ethics 6 (2):157-174.
    The case in favor of gene therapy is quite simple. Gene therapy is likely to improve the health and well-being of some people that are among the worst off in society, namely patients with painful and life-threatening diseases. However, two types of objection have been raised.
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  11.  36
    David B. Resnik (1997). The Morality of Human Gene Patents. Kennedy Institute of Ethics Journal 7 (1):43-61.
    : This paper discusses the morality of patenting human genes and genetic technologies. After examining arguments on different sides of the issue, the paper concludes that there are, at present, no compelling reasons to prohibit the extension of current patent laws to the realm of human genetics. However, since advances in genetics are likely to have profound social implications, the most prudent course of action demands a continual reexamination of genetics laws and policies in light of ongoing developments (...)
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  12.  15
    J. Manuel Torres (1997). On the Limits of Enhancement in Human Gene Transfer: Drawing the Line. Journal of Medicine and Philosophy 22 (1):43-53.
    Enhancement-line human genetic engineering has recurrently been targeted for bioethical discussion and is usually (if not always) illustrated by examples alluding to a genetic technology that is far beyond our current possibilities. By discussing an ambitious project related to solid tumor cancers – multidrug resistance (MDR) – the present paper places the question on a more realistic plane and draws bioethical conclusions to serve as guidelines in the field. The paper also establishes the inadequacy of the prevalent concept of (...)
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  13.  9
    Rogeer Hoedemaekers (2001). Human Gene Patents: Core Issues in a Multi-Layered Debate. [REVIEW] Medicine, Health Care and Philosophy 4 (2):211-221.
    After ten years of debate Directive 98/44/EG on the legal protection of biotechnological inventions was adopted in 1998. This directive takes decisions on some controversial bioethical and legal issues and offers the European biotech industries more space to develop their inventions, but leaves a number of philosophical and moral issues unresolved. This paper distinguishes between different layers in the debate and maps its modes of argumentation. Major philosophical, ethical and conceptual issues are located. It is argued that further analysis of (...)
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  14.  1
    Juan Manuel Torres (1997). On the Limits of Enhancement in Human Gene Transfer: Drawing the Line. Journal of Medicine and Philosophy 22 (1):43-53.
    Enhancement-line human genetic engineering has recurrently been targeted for bioethical discussion and is usually illustrated by examples alluding to a genetic technology that is far beyond our current possibilities. By discussing an ambitious project related to solid tumor cancers – multidrug resistance – the present paper places the question on a more realistic plane and draws bioethical conclusions to serve as guidelines in the field. The paper also establishes the inadequacy of the prevalent concept of genetic medicine as one (...)
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  15.  63
    David Resnik (1994). Debunking the Slippery Slope Argument Against Human Germ-Line Gene Therapy. Journal of Medicine and Philosophy 19 (1):23-40.
    This paper attempts to debunk the slippery-slope argument against human germ-line gene therapy by showing that the downside of the slope – genetic enhancement – need not be as unethical or unjust as some people have supposed. It argues that if genetic enhancement is governed by proper regulations and is accompanied by adequate education, then it need not violate recognized principles of morality or social justice. Keywords: germ-line therapy, slippery slope argument, future generations, social justice CiteULike Connotea Del.icio.us (...)
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  16.  4
    Y. Du, X. Chen, X. Wei, K. R. Bales, D. T. Berg, S. M. Paul, M. R. Farlow, B. Maloney, Y. W. Ge & D. K. Lahiri (2005). NF-B Mediates Amyloid Beta Peptide-Stimulated Activity of the Human Apolipoprotein E Gene Promoter in Human Astroglial Cells. Brain Res Mol Brain Res 136:177-88.
    The apolipoprotein E gene plays an important role in the pathogenesis of Alzheimer's disease , and amyloid plaque comprised mostly of the amyloid-beta peptide ) is one of the major hallmarks of AD. However, the relationship between these two important molecules is poorly understood. We examined how A treatment affects APOE expression in cultured cells and tested the role of the transcription factor NF-B in APOE gene regulation. To delineate NF-B's role, we have characterized a 1098 nucleotide segment (...)
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  17.  25
    Maurizio Salvi (2001). Shaping Individuality: Human Inheritable Germ Line Gene Modification. Theoretical Medicine and Bioethics 22 (6):527-542.
    In this paper I deal with ethical factors surrounding germline gene therapy. Such implications include intergenerational responsibility, human dignity, moral status of embryos and so on. I will explore the relevance of the above mentioned issues to discuss the ethical implication of human germline gene therapy (HGLT). We will see that most of arguments claimed by bioethicists do not provide valid reason to oppose HGLT. I will propose an alternative view, based on personal identity issues, to (...)
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  18.  10
    LeRoy Walters (2000). The Oversight of Human Gene Transfer Research. Kennedy Institute of Ethics Journal 10 (2):171-174.
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  19.  94
    R. P. Hamilton (1997). The Ethics of Human Gene Therapy. Journal of Medical Ethics 23 (6):386-387.
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  20.  18
    Ray Moseley, Lee Crandall & Marvin Dewar (1991). Ethical Implications of a Complete Human Gene Map for Insurance. Business and Professional Ethics Journal 10 (4):69-82.
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  21.  13
    Ulrich Dettweiler & Perikles Simon (2001). Points to Consider for Ethics Committees in Human Gene Therapy Trials. Bioethics 15 (5-6):491-500.
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  22.  12
    Marvin Dewar (1991). Ethical Implications of a Complete Human Gene Map for Insurance. Business and Professional Ethics Journal 10 (4):69-82.
  23.  26
    Kathleen Cranley Glass (1999). LeRoy Walters and Julie Gage Palmer, the Ethics of Human Gene Therapy. Theoretical Medicine and Bioethics 20 (5):489-490.
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  24.  19
    Nancy S. Jecker & Andrea E. Glassberg (1997). The Ethics of Human Gene Therapy, by LeRoy Walters and Julie Gage Palmer. New York: Oxford University Press, 1997. 209 Pp. [REVIEW] Cambridge Quarterly of Healthcare Ethics 6 (4):494.
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  25.  4
    Manuel A. F. V. Gonçalves (2005). A Concise Peer Into the Background, Initial Thoughts and Practices of Human Gene Therapy. Bioessays 27 (5):506-517.
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  26.  4
    Johann S. Ach, Susanne Ackerman, F. Terrence, Allan Adelman & Howard See Adelman (2003). Agich, George J., and Bethan J. Spielman. Ethics Expert Testimony: Against the Skeptics 22, 381. Agich, George J., and Royce P. Jones. The Logical Status of Brain Death Criteria 10, 387. Allison, David, and Mark D. Roberts. On Constructing the Disorder of Hysteria 19, 239. Anderson, W. French. Human Gene Therapy: Scientific and Ethical Considerations 10, 275. [REVIEW] Journal of Medicine and Philosophy 360:5310.
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  27.  1
    Diego Gracia (2001). Ethics, Genetics, and Human Gene Therapy. In H. Ten Have & Bert Gordijn (eds.), Bioethics in a European Perspective. Kluwer Academic Publishers 309--338.
  28.  2
    Leroy Walters (1990). Ethical Issues in Human Gene Therapy. Journal of Clinical Ethics 2 (4):267-74.
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  29.  1
    Mary Carrington Coutts (1994). Human Gene Therapy. Kennedy Institute of Ethics Journal 4 (1):63-83.
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  30. Juan Manuel Torres (1994). The Importance of Microevolutionary Tenets in the Debate on Germ-Line Human Gene Theraphy. Ludus Vitalis 2 (3):137-150.
     
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  31. W. F. Anderson (forthcoming). Human Gene Therapy: Scientific Considerations'. Beauchamp, T. And Walters, L.: Contemporary Issues in Bioethics, Belmont, California: Wadsworth.
     
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  32. Julian T. Forton & Dominic P. Kwiatkowski (2006). Searching for the Regulators of Human Gene Expression. Bioessays 28 (10):968-972.
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  33. Mike Fortun (2003). Stephen Hall.Invisible Frontiers: The Race to Synthesize a Human Gene. Foreword by James Watson. Xiii + 334 Pp., Index. New York: Oxford University Press, 2002. $15.95. [REVIEW] Isis 94 (1):193-194.
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  34. E. D. Garber (1994). Human Gene Mutation By David N. Cooper and Michael Krawczak. Perspectives in Biology and Medicine 37 (4):609-610.
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  35. Ray Moseley, Lee Crandall & Marvin Dewar (1991). Ethical Implications of a Complete Human Gene Map for Insurance. Business and Professional Ethics Journal 10 (4):69-82.
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  36. Stephanie H. To (2015). Human Gene Patents and Human Dignity. The National Catholic Bioethics Quarterly 15 (2):265-285.
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  37.  10
    Wentian Li (2012). Menzerath's Law at the Gene‐Exon Level in the Human Genome. Complexity 17 (4):49-53.
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  38.  13
    Monkol Lek, Kate Gr Quinlan & Kathryn N. North (2010). The Evolution of Skeletal Muscle Performance: Gene Duplication and Divergence of Human Sarcomeric Α‐Actinins. Bioessays 32 (1):17-25.
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  39.  20
    Maciej Chudek & Joseph Henrich (2011). Culture–Gene Coevolution, Norm-Psychology and the Emergence of Human Prosociality. Trends in Cognitive Sciences 15 (5):218-226.
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  40.  72
    Sara Goering (2000). Gene Therapies and the Pursuit of a Better Human. Cambridge Quarterly of Healthcare Ethics 9 (3):330-341.
    As a philosopher interested in biomedical ethics, I find recent advances in genetic technologies both fascinating and frightening. Future technologies for genetic therapies and elimination of clearly deleterious genes offer us the ability to get rid of the cause of much human suffering, seemingly at its physiological root. But memories of past eugenics programs gone horribly awry must make cautious our initial optimism for these generally well-intentioned programs. Most often the scientist proceeds in research with the best of intentions, (...)
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  41.  1
    Hugh V. McLachlan (2005). Unique Persons and the Replicable Gene-Sets of Their Reproducible Bodies: A Defence of Human Cloning. Human Reproduction and Genetic Ethics 11 (2).
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  42. Martine Hoogman, Tulio Guadalupe, Marcel P. Zwiers, Patricia Klarenbeek, Clyde Francks & Simon E. Fisher (2014). Assessing the Effects of Common Variation in the FOXP2 Gene on Human Brain Structure. Frontiers in Human Neuroscience 8.
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  43.  83
    Adam D. Moore (2000). Owning Genetic Information and Gene Enhancement Techniques: Why Privacy and Property Rights May Undermine Social Control of the Human Genome. Bioethics 14 (2):97–119.
  44.  6
    Norman K. Swazo (2015). CRISPR/Cas9-Mediated Editing of Human Β-Globin Gene in Human Cells: A Commentary on the Research Ethics. Bangladesh Journal of Bioethics 6 (1):22.
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  45.  1
    Celeste Michelle Condit (1999). The Meanings of the Gene: Public Debates About Human Heredity. University of Wisconsin Press.
    The work of scientists and doctors in advancing genetic research and its applications has been accompanied by plenty of discussion in the popular press—from Good Housekeeping and Forbes to Ms. and the Congressional Record—about such ...
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  46.  5
    Michael W. Nestor, Elena Artimovich & Richard L. Wilson (2014). The Ethics of Gene Editing Technologies in Human Stem Cells. Ethics in Biology, Engineering and Medicine: An International Journal 5 (4):323-338.
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  47.  2
    Guido Van Steendam, András Dinnyés, Jacques Mallet, Rolando Meloni, Carlos Romeo Casabona, Jorge Guerra González, Josef Kure, Eörs Szathmáry, Jan Vorstenbosch & Péter Molnár (2006). The Budapest Meeting 2005 Intensified Networking on Ethics of Science: The Case of Reproductive Cloning, Germline Gene Therapy and Human Dignity. Science and Engineering Ethics 12 (4):731-793.
    For more information about the authors and the participants in the Budapest Meeting, see pp. 419–420.
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  48.  49
    N. Holtug (2001). Human Germline Gene Therapy: Scientific, Moral and Political Issues: David B Resnik, Holly B Steinkraus and Pamela J Langer, Austin, Texas, R G Landes Company, 1999, 189 Pages, US$99.00 (Hb). [REVIEW] Journal of Medical Ethics 27 (1):67-a-68.
  49.  27
    Erik Parens (2000). David B. Resnik, Holly B. Steinkraus, and Pamela J. Langer, Human Germline Gene Therapy: Scientific, Moral and Political Issues. [REVIEW] Theoretical Medicine and Bioethics 21 (4):399-403.
  50.  8
    Erika Crispo, Jean‐Sébastien Moore, Julie A. Lee‐Yaw, Suzanne M. Gray & Benjamin C. Haller (2011). Broken Barriers: Human‐Induced Changes to Gene Flow and Introgression in Animals. Bioessays 33 (7):508-518.
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