Search results for 'Immunology' (try it on Scholar)

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  1. Thomas Pradeu & Edgardo D. Carosella (2006). The Self Model and the Conception of Biological Identity in Immunology. Biology and Philosophy 21 (2):235-252.score: 18.0
    The self/non-self model, first proposed by F.M. Burnet, has dominated immunology for 60 years now. According to this model, any foreign element will trigger an immune reaction in an organism, whereas endogenous elements will not, in normal circumstances, induce an immune reaction. In this paper we show that the self/non-self model is no longer an appropriate explanation of experimental data in immunology, and that this inadequacy may be rooted in an excessively strong metaphysical conception of biological identity. We (...)
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  2. David L. Hull, Rodney E. Langman & Sigrid S. Glenn (2001). A General Account of Selection: Biology, Immunology, and Behavior. Behavioral and Brain Sciences 24 (3):511-528.score: 18.0
    Authors frequently refer to gene-based selection in biological evolution, the reaction of the immune system to antigens, and operant learning as exemplifying selection processes in the same sense of this term. However, as obvious as this claim may seem on the surface, setting out an account of “selection” that is general enough to incorporate all three of these processes without becoming so general as to be vacuous is far from easy. In this target article, we set out such a general (...)
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  3. Thomas Pradeu (2012). The Limits of the Self: Immunology and Biological Identity. Oxford University Press.score: 15.0
    The Limits of the Self, will be essential reading for anyone interested in the definition of biological individuality and the understanding of the immune system.
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  4. Neeraja Sankaran (2012). The Pluripotent History of Immunology. A Review. [REVIEW] Avant 3 (1).score: 12.0
    The historiography of immunology since 1999 is reviewed, in part as a response to claims by historians such as Thomas Söderqvist the field was still immature at the time (Söderqvist & Stillwell 1999). First addressed are the difficulties, past and present, surrounding the disciplinary definition of immunology, which is followed by a commentary on the recent scholarship devoted to the concept of the immune self. The new literature on broad immunological topics is examined and assessed, and specific charges (...)
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  5. Donald R. Forsdyke (2012). Immunology (1955-1975): The Natural Selection Theory, the Two Signal Hypothesis and Positive Repertoire Selection. [REVIEW] Journal of the History of Biology 45 (1):139 - 161.score: 12.0
    Observations suggesting the existence of natural antibody prior to exposure of an organism to the corresponding antigen, led to the natural selection theory of antibody formation of Jerne in 1955, and to the two signal hypothesis of Forsdyke in 1968. Aspects of these were not only first discoveries but also foundational discoveries in that they influenced contemporaries in a manner that, from our present vantage point, appears to have been constructive. Jerne's later hypothesis (1971, European Journal of Immunology 1: (...)
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  6. Moira Howes (2008). Conceptualizing the Maternal-Fetal Relationship in Reproductive Immunology. In Kenton Kroker, Jennifer Keelan & Pauline Mazumdar (eds.), Crafting Immunity: Working Histories of Clinical Immunology. Ashgate.score: 12.0
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  7. Ilana Löwy (2008). Immunology in the Clinics: Reductionism, Holism or Both? In Kenton Kroker, Jennifer Keelan & Pauline Mazumdar (eds.), Crafting Immunity: Working Histories of Clinical Immunology. Ashgate. 165--76.score: 12.0
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  8. Warwick Anderson & Ian R. Mackay (2013). Fashioning the Immunological Self: The Biological Individuality of F. Macfarlane Burnet. [REVIEW] Journal of the History of Biology 47 (1):1-29.score: 10.0
    During the 1940s and 1950s, the Australian microbiologist F. Macfarlane Burnet sought a biologically plausible explanation of antibody production. In this essay, we seek to recover the conceptual pathways that Burnet followed in his immunological theorizing. In so doing, we emphasize the influence of speculations on individuality, especially those of philosopher Alfred North Whitehead; the impact of cybernetics and information theory; and the contributions of clinical research into autoimmune disease that took place in Melbourne. We point to the influence of (...)
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  9. Bartlomiej Swiatczak (2012). Immune System, Immune Self. Introduction. Avant 3 (1):12-18.score: 9.0
    The idea that the immune system distinguishes between self and non-self was one of the central assumptions of immunology in the second half of 20th century. This idea influenced experimental design and data interpretation. However, in the face of new evidence there is a need for a new conceptual framework in immunology.
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  10. Henri Atlan (1998). Paradigms in Immunology and Modern, Post-Modern, Post-Post-Modern, _ Philosophy. A Review of Alfred I. Tauber, the Immune Self: Theory or Metaphor? [REVIEW] Biology and Philosophy 13 (1):125-131.score: 9.0
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  11. Amin Turki (2011). On the Normativity of the Immune System. Medicine Studies 3 (1):29-39.score: 9.0
    In the 1940s, Georges Canguilhem has established the concept of biological normativity on the level of the organism in his key work on “ The Normal and the Pathological ”. We would like to present a contemporary analysis of Canguilhem’s work, set it in context with more recent results from the field of complexity and immunology, and evaluate the problematic whether normativity is a genuine capacity of the organism. Based on Canguilhem’s conditions of the definition of biological normativity, we (...)
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  12. Ilana Löwy (1997). Epidemiology, Immunology, and Yellow Fever: The Rockefeller Foundation in Brazil, 1923-1939. [REVIEW] Journal of the History of Biology 30 (3):397 - 417.score: 9.0
  13. Moira Howes (2010). Menstrual Function, Menstrual Suppression, and the Immunology of the Human Female Reproductive Tract. Perspectives in Biology and Medicine 53 (1):16-30.score: 9.0
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  14. Kenneth F. Schaffner (1992). Theory Change in Immunology Part I: Extended Theories and Scientific Progress. Theoretical Medicine and Bioethics 13 (2).score: 9.0
    This two-part article examines the competition between the clonal selection theory and the instructive theory of the immune response from 1957–1967. In Part I the concept of a temporally extended theory is introduced, which requires attention to the hitherto largely ignored issue of theory individuation. Factors which influence the acceptability of such an extended theory at different temporal points are also embedded in a Bayesian framework, which is shown to provide a rational account of belief change in science. In Part (...)
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  15. Kenneth F. Schaffner (1992). Theory Change in Immunology Part II: The Clonal Selection Theory. Theoretical Medicine and Bioethics 13 (2).score: 9.0
    This two-part article examines the competition between the clonal selection theory and the instructive theory of the immune response from 1957–1967. In Part I the concept of a temporally extended theory is introduced, which requires attention to the hitherto largely ignored issue of theory individuation. Factors which influence the acceptability of such an extended theory at different temporal points are also embedded in a Bayesian framework, which is shown to provide a rational account of belief change in science. In Part (...)
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  16. Eileen Crist & Alfred I. Tauber (2000). Selfhood, Immunity, and the Biological Imagination: The Thought of Frank MacFarlane Burnet. [REVIEW] Biology and Philosophy 15 (4):509-533.score: 9.0
    The language of self and nonself has had a prominent place inimmunology. This paper examines Frank Macfarlane Burnet's introductionof the language of selfhood into the science. The distinction betweenself and nonself was an integral part of Burnet's biological outlook– of his interest in the living organism in its totality, itsactivities, and interactions. We show the empirical and conceptualwork of the language of selfhood in the science. The relation betweenself and nonself tied into Burnet's ecological vision of host-parasiteinteraction. The idiom of (...)
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  17. Warwick Anderson, Myles Jackson & Barbara Gutmann Rosenkrantz (1994). Toward an Unnatural History of Immunology. Journal of the History of Biology 27 (3):575 - 594.score: 9.0
  18. Jurrit Bergsma (1994). Illness, the Mind, and the Body: Cancer and Immunology: An Introduction. Theoretical Medicine and Bioethics 15 (4).score: 9.0
    From the sixties on it has become clear how the human physical condition could be influenced by human behavior. Although hypothesis were lacking to understand these connections, nursing research especially proved how systematically introduced patient behavior during illness and hospitalization could induce better recovery results and better prognosis for the patient.Information andattitude proved to be crucial elements in these processes of improved patient expectations. It took less than two decades to get to the insights we have in 1994. Recent research (...)
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  19. Bartlomiej Swiatczak & Maria Rescigno (2012). How the Interplay Between Antigen Presenting Cells and Microbiota Tunes Host Immune Responses in the Gut. Seminars in Immunology 24 (1):43-49.score: 9.0
    Coordination of immune responses in the gut is a complex task. In order to fight pathogens and maintain a defined population of commensal microbes, the mucosal immune system has to coordinate information from the external (luminal) and internal (abluminal) environment and respond accordingly. Dendritic cells (DCs) are crucial cell types involved in this process as they integrate these signals and direct immunogenic or tolerogenic responses. Here, we review how various functions of DCs depend on microbial stimuli and how these stimuli (...)
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  20. Craig R. Stillwell (1994). Thymectomy as an Experimental System in Immunology. Journal of the History of Biology 27 (3):379 - 401.score: 9.0
  21. M. A. O'Malley (2014). Thomas Pradeu the Limits of the Self: Immunology and Biological Identity. British Journal for the Philosophy of Science 65 (1):179-183.score: 9.0
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  22. Alfred I. Tauber (1994). A Typology of Nietzsche's Biology. Biology and Philosophy 9 (1):25-44.score: 9.0
    Friedrich Nietzsche''s will to power, and the philosophical ediface built on this foundation, is formulated on a biologicism that is indebted to a particular post-Darwinian vision of the organism. Of the various models that attempt to formulate a comprehensive organismal biology, Nietzsche unknowingly grasped that of Elie Metchnikoff, who authored the theoretical foundation of modern immunology. Metchnikoff regarded the organism as a disharmonious entity, in constant inner strife between competing cellular activities. Immune functions were responsible for mediating harmonization, which (...)
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  23. Alfred I. Tauber (1998). Conceptual Shifts in Immunology: Comments on the 'Two-Way Paradigm'. [REVIEW] Theoretical Medicine and Bioethics 19 (5):457-473.score: 9.0
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  24. Daniel Bischur (2011). Animated Bodies in Immunological Practices: Craftsmanship, Embodied Knowledge, Emotions and Attitudes Toward Animals. [REVIEW] Human Studies 34 (4):407-429.score: 9.0
    Taking up the body turn in sociology, this paper discusses scientific practices as embodied action from the perspective of Husserl’s phenomenological theory of the “Body”. Based on ethnographic data on a biology laboratory it will discuss the importance of the scientist’s Body for the performance of scientific activities. Successful researchers have to be skilled workers using their embodied knowledge for the process of tinkering towards the material transformation of their objects for data production. The researcher’s body then is an instrument (...)
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  25. Harmke Kamminga (1994). Metchnikoff and the Origins of Immunology: From Metaphor to Theory. Studies in History and Philosophy of Science Part A 25 (1):131-145.score: 9.0
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  26. Tudor M. Baetu (2014). Models and the Mosaic of Scientific Knowledge. The Case of Immunology. Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 45:49-56.score: 9.0
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  27. Melinda B. Fagan (2007). The Search for the Hematopoietic Stem Cell: Social Interaction and Epistemic Success in Immunology. Studies in History and Philosophy of Science Part C 38 (1):217-237.score: 9.0
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  28. Thomas Söderqvist & Craig Stillwell (1999). Review: The Historiography of Immunology Is Still in Its Infancy. [REVIEW] Journal of the History of Biology 32 (1):205 - 215.score: 9.0
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  29. Alfred I. Tauber (2008). Expanding Immunology: Defensive Versus Ecological Perspectives. Perspectives in Biology and Medicine 51 (2):270-284.score: 9.0
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  30. Alfred I. Tauber (2012). From the Immune Self to Moral Agency. Comments. Avant 3 (1):101-105.score: 9.0
    Author comments on the changes in the philosophy of immunology that have occurred since the publication of his book The Immune Self: Theory or Metaphor?, as well as on the dangers, misunderstandings and expectations in this area. Finally, he presents his account of moral agency in the context of his own works discussing this question.
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  31. Alfred I. Tauber (2014). Philosophy as Self-Knowledge. Philosophia 42 (1):1-23.score: 9.0
    An autobiographical account is offered of how the medical study of self (immunology) became a chapter in the philosophical study of human agency (from Nietzsche and Thoreau to Freud by way of Wittgenstein). Whether viewed scientifically or philosophically, several themes converge on the intractable instability of any notion of selfhood—epistemological or moral. How this problematic motivated an extended analysis of selfhood refracts the psychology of the author and his pursuit of philosophy as self‐knowledge.
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  32. Richard W. Dutton (1980). Immunology Methods Selected Methods in Cellular Immunology Barbara B. Mishell Stanley M. Shiigi. Bioscience 30 (11):777-777.score: 9.0
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  33. Melinda Bonnie Fagan (2010). Stems and Standards: Social Interaction in the Search for Blood Stem Cells. Journal of the History of Biology 43 (1):67 - 109.score: 9.0
    This essay examines the role of social interactions in the search for blood stem cells, in a recent episode of biomedical research. Linked to mid-20th century cell biology, genetics and radiation research, the search for blood stem cells coalesced in the 1960s and took a developmental turn in the late 1980s, with significant ramifications for immunology, stem cell and cancer biology. Like much contemporary biomedical research, this line of inquiry exhibits a complex social structure and includes several prominent scientific (...)
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  34. Michelle Jamieson (2010). Imagining 'Reactivity': Allergy Within the History of Immunology. Studies in History and Philosophy of Science Part C 41 (4):356-366.score: 9.0
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  35. Peter Keating & Alberto Cambrosio (1997). Helpers and Suppressors: On Fictional Characters in Immunology. [REVIEW] Journal of the History of Biology 30 (3):381 - 396.score: 9.0
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  36. E. L. Cooper (1985). Introducing Immunology. Bioscience 35 (1):52-52.score: 9.0
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  37. Ulrike Dohrmann (1992). Losing Trk of Progress in Neurotrophic Biology. Current Topics in Microbiology and Immunology 165: Neuronal Growth Factors (1991). Edited by M. Bothwell Springer‐Verlag, Heidelberg. [REVIEW] Bioessays 14 (9):649-650.score: 9.0
  38. Edward S. Golub (1988). Network Theory and the Immune System. Regulatory Idiotopes – Modern Concepts in Immunology. Volume II. By Constantin A. Bona. John Wiley and Sons, 1987. Pp. 279. £57.45/$83.95. [REVIEW] Bioessays 8 (1):45-45.score: 9.0
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  39. Alan S. Perelson (forthcoming). Two Theoretical Problems in Immunology: AIDS and Epitopes. Complexity.score: 9.0
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  40. Alberto Cambrosio, Peter Keating & Alfred I. Tauber (1994). Introduction: Immunology as a Historical Object. [REVIEW] Journal of the History of Biology 27 (3):375-378.score: 9.0
  41. George A. Carlson (1982). A Comprehensive Introduction to Immunology Fundamentals of Immunology Otto G. Bier Wilmar Dias da Silva Dietrich Gotze Ivan Mota. Bioscience 32 (7):626-626.score: 9.0
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  42. B. Cinader (1986). Editorial: Three Goals, Four Revolutions and the Sixth Congress of Immunology. Bioessays 4 (6):243-244.score: 9.0
  43. E. L. Cooper (1985). Introducing Immunology Immunology: An Introduction Ian Tizard. Bioscience 35 (1):52-52.score: 9.0
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  44. J. R. Head & R. E. Billingham (1985). Immunologically Privileged Sites in Transplantation Immunology and Oncology. Perspectives in Biology and Medicine 29 (1).score: 9.0
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  45. Robert Klee (1997). Introduction to the Philosophy of Science: Cutting Nature at its Seams. Oxford University Press.score: 9.0
    Introduction to the Philosophy of Science: Cutting Nature at Its Seams is a clear and lively explanation of key concepts and issues in the philosophy of science. It surveys the field from positivism to social constructivism, focusing on the metaphysical implications of science as a form of knowledge gathering that explains what the world is really like, while simultaneously arguing for the superiority of a holistic model of scientific theories over competing models. An innovative feature is the use of (...) as the central domain of illustration, in contrast to other philosophy of science texts that draw examples predominantly from physics. The text also presents Thomas Kuhn's model of science clearly and accurately, rectifying the notorious and widespread misinterpretations projected upon it in the past. Klee discusses both traditional models of science and alternative interpretations, most notably nonfeminist and feminist models inspired by the work of Kuhn. Richly illustrated and complete with a glossary of over eighty key terms, this book serves as an ideal text for undergraduates, because it presents a highly accessible and contemporary investigation of science as a form of inquiry capable of revealing to us the structure of the world. (shrink)
     
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  46. Ilana Löwy (1994). Experimental Systems and Clinical Practices: Tumor Immunology and Cancer Immunotherapy, 1895-1980. [REVIEW] Journal of the History of Biology 27 (3):403 - 435.score: 9.0
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  47. G. J. Nossal (1986). Turning Points in Cellular Immunology: The Skein Untangled Through a Global Invisible College. Perspectives in Biology and Medicine 29 (3 Pt 2):S166.score: 9.0
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  48. Richard Novak (2004). Human Immunodeficiency Virus: Biology, Immunology and Therapy (Review). Perspectives in Biology and Medicine 47 (2):305-308.score: 9.0
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  49. Neeraja Sankaran (2010). The Bacteriophage, its Role in Immunology: How Macfarlane Burnet's Phage Research Shaped His Scientific Style. Studies in History and Philosophy of Science Part C 41 (4):367-375.score: 9.0
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