New concepts may prove necessary to profit from the avalanche of sequence data on the genome, transcriptome, proteome and interactome and to relate this information to cell physiology. Here, we focus on the concept of large activity-based structures, or hyperstructures, in which a variety of types of molecules are brought together to perform a function. We review the evidence for the existence of hyperstructures responsible for the initiation of DNA replication, the sequestration of newly replicated origins of replication, cell division (...) and for metabolism. The processes responsible for hyperstructure formation include changes in enzyme affinities due to metabolite-induction, lipid-protein affinities, elevated local concentrations of proteins and their binding sites on DNA and RNA, and transertion. Experimental techniques exist that can be used to study hyperstructures and we review some of the ones less familiar to biologists. Finally, we speculate on how a variety of in silico approaches involving cellular automata and multi-agent systems could be combined to develop new concepts in the form of an Integrated cell (I-cell) which would undergo selection for growth and survival in a world of artificial microbiology. (shrink)
If code is law then standards bodies are governments. This flawed but powerful metaphor suggests the need to examine more closely those standards bodies that are defining standards for the Internet. In this paper we examine the International Telecommunications Union, the Institute for Electrical and Electronics Engineers Standards Association, the Internet Engineering Task Force, and the World Wide Web Consortium. We compare the organizations on the basis of participation, transparency, authority, openness, security and interoperability. We conclude that the IETF and (...) the W3C are becoming increasingly similar. We also conclude that the classical distinction between standards and implementations is decreasingly useful as standards are embodies in code – itself a form of speech or documentation. Recent Internet standards bodies have flourished in part by discarding or modifying the implementation/standards distinction. We illustrate that no single model is superior on all dimensions. The IETF is not effectively scaling, struggling with its explosive growth with the creation of thousands of working groups. The IETF coordinating body, the Internet Society, addressed growth by reorganization that removed democratic oversight. The W3C, initially the most closed, is becoming responsive to criticism and now includes open code participants. The IEEE SA and ITU have institutional controls appropriate for hardware but too constraining for code. Each organization has much to learn from the others. (shrink)
Van Heijenoort’s main contribution to history and philosophy of modern logic was his distinction between two basic views of logic, first, the absolutist, or universalist, view of the founding fathers, Frege, Peano, and Russell, which dominated the first, classical period of history of modern logic, and, second, the relativist, or model-theoretic, view, inherited from Boole, Schröder, and Löwenheim, which has dominated the second, contemporary period of that history. In my paper, I present the man Jean van Heijenoort (Sect. 1); then (...) I describe his way of arguing for the second view (Sect. 2); and finally I come down in favor of the first view (Sect. 3). There, I specify the version of universalism for which I am prepared to argue (Sect. 3, introduction). Choosing ZFC to play the part of universal, logical (in a nowadays forgotten sense) system, I show, through an example, how the usual model theory can be naturally given its proper place, from the universalist point of view, in the logical framework of ZFC; I outline another, not rival but complementary, semantics for admissible extensions of ZFC in the very same logical framework; I propose a way to get universalism out of the predicaments in which universalists themselves believed it to be (Sect. 3.1). Thus, if universalists of the classical period did not, in fact, construct these semantics, it was not that their universalism forbade them, in principle, to do so. The historical defeat of universalism was not technical in character. Neither was it philosophical. Indeed, it was hardly more than the victory of technicism over the very possibility of a philosophical dispute (Sect. 3.2). (shrink)
A colleague’s personal recollections of Jean van Heijenoort’s contributions to the editing of volumes I–III of Gödel’s Collected Works and of his interactions with the other editors.
Jean Hamburger (1909--1992) is considered the founder of the concept of medical intensive care (reanimation medicale) and the first to propose the name Nephrology for the branch of medicine dealing with kidney diseases. One of the first kidney grafts in the world (with short-term success), in 1953, and the first dialysis session in France, in 1955, were performed under his guidance. His achievements as a writer were at least comparable: Hamburger was awarded several important literary prizes, including prix Femina, prix (...) Balzac and the Cino del Duca prize (1979), awarded, among others, to Jorge Luis Borges and Konrad Lorenz.Here we would like to offer a selected reading of a "golden" book, "Conseils aux etudiants en medicine de mon service" ("Advice to the Medical Students in my Service"), the first book dedicated to patient-physician relationship in Nephrology, written when dialysis and transplantation were becoming clinical options (1963). The themes include: the central role of the patient, who should be known by name, profession, life style, and not by disease; the importance of the setting of the care; the need for truth-telling and for leaving hope; the role of research not only in the progression of science, but also in the daily clinical practice. (shrink)
Research in modern biology has largely been developed according to two main ways of inquiry, as they were outlined by Charles Darwin and Claude Bernard. Each stands for a specific approach to the living corresponding to two different methodological rules: the principle of natural selection and the principle of causation.
Jean-Paul Sartre is one of the most famous philosophers of the twentieth century. The principal founder of existentialism, a political thinker and famous novelist and dramatist, his work has exerted enormous influence in philosophy, literature, politics and cultural studies. Jean-Paul Sartre: Basic Writings is the first collection of Sartre's key philosophical writings and provides an indispensable resource for readers of his work. Stephen Priest's clear and helpful introductions make the volume an ideal companion to those coming to Sartre's writing for (...) the first time. (shrink)
Jean-Francois Lyotard is often considered to be the father of postmodernism. Here leading experts in the field of cultural and philosophical studies, including Barry Smart, John O' Neill and Victor J. Seidler, tackle many of the questions still being asked about this controversial figure.
The article analyses the idea that according to the averroist Jean de Jandun, Master of Arts in Paris at the beginning of the 14th century, human beings are composed of a «double form» the separated intellect on the one hand, the cogitative soul on the other hand. After recalling several major accounts of the time, we explore Jean's reading of Averroes' major conceptions concerning the problem. Finally, we challenge the idea according to which we observe in his writings the radical (...) thesis of a sometimes cogitating sometimes thinking «double human being» that makes of the homo intelligens a punctual and exclusive new being, which is accidentally produced while the thinking takes place. (shrink)
Van Heijenoort’s account of the historical development of modern logic was composed in 1974 and first published in 1992 with an introduction by his former student. What follows is a new edition with a revised and expanded introduction and additional notes.
Turing's programme, the idea that intelligence can be modelled computationally, is set in the context of a parallel between certain elements from metamathematics and Popper's schema for the evolution of knowledge. The parallel is developed at both the formal level, where it hinges on the recursive structuring of Popper's schema, and at the contentual level, where a few key issues common to both epistemology and metamathematics are briefly discussed. In light of this connection Popper's principle of transference, akin to Turing's (...) belief in the relevance of the theory of computation for modelling psychological functions, is widened into the extended principle of transference. Thus Turing's programme gains a solid epistemological footing. *I am grateful to Claude Lamontagne and Jean-Pierre Delage for their comments on this paper. (shrink)
This collection of articles illustrates the intimacy between science and literature, pleasure and sense, excess and moderation that Jean Ceard sought to understand and that he instilled in those who collaborated or studied with him.
Jean Starobinski, one of Europe's foremost literary critics, examines the life that led Rousseau, who so passionately sought open, transparent communication with others, to accept and even foster obstacles that permitted him to withdraw into himself. First published in France in 1958, Jean-Jacques Rousseau remains Starobinski's most important achievement and, arguably, the most comprehensive book ever written on Rousseau. The text has been extensively revised for this edition and is published here along with seven essays on Rousseau that appeared between (...) 1962 and 1970. (shrink)
This catalogue essay is based on a series of interviews conducted by the authors with international scholars who were asked to reflect on Guattari's scattered comments concerning animism. Interviewees are: Eduardo Viveiros de Castro (anthropologist, Museu Nacional, Rio de Janeiro), Eric Alliez (philosopher, Paris), Jean Claude Polack (psychoanalyst, Paris), Barbara Glowczewski (anthropologist, Paris), Peter Pál Pelbart (philosopher, São Paolo) Janja Rosangela Araujo (master of Capoeira Angola, and professor, Salvador de Bahia) and Jean Jacques Lebel (artist, Paris). Animism was thought by (...) Guattari in relation to a number of themes and places in excess of religion and ritual but in the context of the shattering of capitalism. (shrink)
This article discusses the ecological and cultural criteria underlying the management practices for protected areas in France. It examines the evolution of French conservation from its roots in the 19th century, when it focused on the protection of scenic landscapes, to current times when the focus is on the protection of biodiversity. However, biodiversity is often socially defined and may not represent an ecologically sound objective for conservation. In particular, we question the current approach to protecting a specific type of (...) biodiversity that is at the basis of traditional landscape but does not value systems that are left to develop naturally (i.e., without significant human intervention). We present several examples of current attempts in France and Europe to managing traditional ecosystems and then discuss the values that exist in systems that develop naturally. We feel the latter systems often have much to offer in terms of biodiversity as well as providing important sites for the study of dynamic ecological communities in an ever-changing world. (shrink)
This article is a critique of: The "Green" and "Gold" Roads to Open Access: The Case for Mixing and Matching Jean-Claude Guédon Serials Review 30(4) 2004 http://dx.doi.org/10.1016/j.serrev.2004.09.005 Open Access (OA) means: free online access to all peer-reviewed journal articles.
The paper shows that in the Art of Thinking (The Port Royal Logic) Arnauld and Nicole introduce a new way to state the truth-conditions for categorical propositions. The definition uses two new ideas: the notion of distributive or, as they call it, universal term, which they abstract from distributive supposition in medieval logic, and their own version of what is now called a conservative quantifier in general quantification theory. Contrary to the interpretation of Jean-Claude Parienté and others, the truth-conditions (...) do not require the introduction of a new concept of ?indefinite? term restriction because the notion of conservative quantifier is formulated in terms of the standard notion of term intersection. The discussion shows the following. Distributive supposition could not be used in an analysis of truth because it is explained in terms of entailment, and entailment in terms of truth. By abstracting from semantic identities that underlie distribution, the new concept of distributive term is definitionally prior to truth and can, therefore, be used in a non-circular way to state truth-conditions. Using only standard restriction, the Logic?s truth-conditions for the categorical propositions are stated solely in terms of (1) universal (distributive) term, (2) conservative quantifier, and (3) affirmative and negative proposition. It is explained why the Cartesian notion of extension as a set of ideas is in this context equivalent to medieval and modern notions of extension. (shrink)
Condillac's claim that all our ideas are derived from sensations leads him to hold against Descartes that they are not on that account obscure and confused. The question is whether and how far he can refute the Cartesian thesis.
La recherche conduite dans le cadre de la thèse de doctorat (CROUZIER 2003) a été focalisée sur l’analyse des liens professionnels tissés entre les dispositifs RASED et les équipes éducatives des écoles primaires. Nous avons co-construit les données nécessaires à leur compréhension et choisi des traitements combinant les avantages du quantitatif et du qualitatif. Nous avons en particulier retenu une approche statistique fondée sur l’analyse statistique textuelle (LEBART SALEM 1994) pour explorer le corpus construit à partir d’entretiens auprès d’un échantillon (...) de professionnels concernés par les aides spécialisées à l’école primaire. Le choix de l’approche statistique s’inscrit dans une conception du raisonnement statistique développée par J.C. Régnier (REGNIER 1998, 2002). L’opérationnalisation du traitement a été rendue possible par le recours à un outil informatique, le logiciel S.P.A.D. (Système Portable de l’Analyse des Données) du CISIA. Cet outil permet de décrypter les corpus obtenus par des méthodes d’analyse factorielle de correspondances multiples. Différentes procédures ont été appliquées aux corpus bruts puis codés. Cette approche “quantiqualitative”, apportant une plus-value interprétative, décrypte de façon singulière la complexité de la collaboration entre acteurs. Abstrac: This PhD dissertation (CROUZIER 2003) focuses on the analysis of the professional relationships between the French institutional comprehensive remedial scheme known as RASED and educational teams in primary schools. We have jointly identified the data relevant to a thorough understanding of such relationships, opting for a method of data processing combining the advantages of both quantitative and qualitative approaches. We have chiefly relied on a specific brand of textual statistics (LEBART SALEM 1994) in order to explore a corpus made up of interviews with the primary school staffs involved in the scheme. The statistical approach accords with the conception of statistical processing developed by JC Regnier (REGNIER 1998, 2002). The processing itself has been engineered thanks to CISIA’s software, known as SPAD (portable data processing system). It has enabled us to decrypt the different types of corpuses through Correspondence Analysis (CA). Both the raw and the coded corpuses have been submitted to different types of processing. The approach, combining quantitative and qualitative elements, opens up on to new powerful interpretative insights and sheds a new light on the intricate network of interaction between the people involved. (shrink)
Current axiomatizations for extensive measurement postulate the existence of infinitely small objects. This assumption is neither necessary nor reasonable. This paper develops this theme and presents a more acceptable axiom system. A representation theorem is stated and proved in detail. This work improves some previous results of the author.
It is well known that, in France, this important movement, which originated in Port-Royal, did not remain exactly on the same basis during its development. In this paper we attempt to show how a new concept (the logical analysis of sentence from phrase) was proposed by Du Marsais (see grammatical articles of the Encyclopédie), Beauzée (1767) and, finally, Letellier (1805, 1811).
Following up on previous results by Falmagne, this paper investigates possible mechanisms explaining how preference relations are created and how they evolve over time. We postulate a preference relation which is initially empty and becomes increasingly intricate under the influence of a random environment delivering discrete tokens of information concerning the alternatives. The framework is that of a class of real-time stochastic processes having interlinked Markov and Poisson components. Specifically, the occurence of the tokens is governed by a Poisson process, (...) while the succession of preference relations is a Markov process. In an example case, the preference relations are the various possible semiorders on the set of alternatives. Asymptotic results are obtained in the form of the limit probabilities of any semiorder. The arguments extend to a much more general situation including interval orders, biorders and partial orders. The results provide (up to a small number of parameters) complete quantitative predictions for panel data of a standard type, in which the same sample of subjects has been asked to compare the alternatives a number of times. (shrink)
I argue that hopes and claims about the liberating power of liberal education are typically exaggerated, naive and wrong. Reflecting upon and borrowing terms from Jim Shelton's essay on "The Subversive Nature of Liberal Education," I use the work of Ivan Illich, Michel Foucault, Pierre Bourdieu and Jean-Claude Passeron to argue that social education—training in efficient and productive consumeristic life—absorbs, muffles and domesticates any radical content liberal arts education may manage to provide. As with virtually all education, liberal education (...) conserves the society from which it emerges. (shrink)
Algebraic theories for extensive measurement are traditionally framed in terms of a binary relation $\lesssim $ and a concatenation (x,y)→ xy. For situations in which the data is "noisy," it is proposed here to consider each expression $y\lesssim x$ as symbolizing an event in a probability space. Denoting P(x,y) the probability of such an event, two theories are discussed corresponding to the two representing relations: p(x,y)=F[m(x)-m(y)], p(x,y)=F[m(x)/m(y)] with m(xy)=m(x)+m(y). Axiomatic analyses are given, and representation theorems are proven in detail.
L’insitution est le cadre, un cadre qui s’adosse toujours à un déjà-là, et il faut encore y faire autorité. Une formation d’enseignants, comme toute formation, requiert que place soit faite à la mémoire: reconstruction, récit qui met en forme et contribue à former. Place aussi à l’écart, au dialogue, à la décision réfléchie. L’inscription de la philosophie permet ces perspectives. L’institution de formation a aussi partie liée avec l’ecole publique: a-t-on pris la mesure de l’exigence étrangère a l’autonomie universitaire, de (...) la laïcité, a-t-on mesuré la difficulte d’assumer la question de la culture comme références communes et expérience singulière? (shrink)
According to Brentano, logic, ethics and aesthetics are practical normative sciences, and they correspond to the three classes of psychic phenomena. But if a judgment or a love may be correct or incorrect, it seems more difficult to speak of a correct representation as this class of phenomena ignores a polarity such as right / wrong or good / bad. Brentano speaks nevertheless from the aesthetical “value” of representations. Aesthetics could in this way be considered as part of a general (...) theory of value; but compared to ethics the specificity of this science tends to vanish. Another way to consider the question is to remember that the distinction among the three classes of psychic phenomena is only formal. It means that one has to question more precisely the very nature of representation and especially its relation to feeling. (shrink)
Taking his critique of totalitarianizing conceptions of community as a starting point, this text examines Jean-Luc Nancy's work of an "ontology of plural singular being" for its political implications. It argues that while at first this ontology seems to advocate a negative or an anti-politics only, it can also be read as a "theory of communicative praxis" that suggests a certain ethos - in the form of a certain use of symbols (which is expressed only inaptly by the word "style") (...) that would render the ontological plurality of singulars perceptible and practically effective. Finally, some recent texts by Nancy even sidestep the ontology of being-with and face the question of what politics, faced with demands of justice, could be and what a democratic politics could provide. Both of these aspects in Nancy's work, however, still remain to be spelled out more politically. (shrink)
Abstract Modern reflection on the ideal of personal autonomy has its Western origin in the philosophy of Jean-Jacques Rousseau, where autonomy, or self-legislation, involves citizens joining together to make laws for themselves that reflect their collective understanding of the common good. Four features of this conception of autonomy continue to be relevant today. First, autonomy, a type of freedom, is introduced into modern philosophy in order to make up for a perceived deficiency, or incompleteness, in merely ?negative? freedom (the right (...) to do as one pleases, unimpeded by others). Second, autonomy is taken to be not merely a complement of negative freedom but a higher, more valuable species of freedom. Third, at its origin personal autonomy is not conceived individualistically; rather, on Rousseau's account, autonomy is achievable only if citizens surrender part of their status as individuals and think of their social membership as essential, not merely accidental, to who they are. Finally, Rousseau's conception of autonomy is distinct from the contemporary ideal of autonomy defined as judging or deciding for oneself (according to one's own reason). Nevertheless, there is an important sense in which autonomy as Rousseau conceives it also requires the developed capacity for independent, self-determined judgment. (shrink)
"[A Commentary on Jean-Paul Sartre's Being and Nothingness] represents, I believe, a very important beginning of a deservingly serious effort to make the whole ...
The seal of the a priori is imprinted on the reception of Kant's philosophy. Piaget's epistemological argumentation seems to ascribe knowledge a more fruitful constructiveness than Kant, seeing the a priori as rooted in unvarying reason. Yet, it seems, he failed to recognize the complexity of Kant's theory, which does not always follow a quid iuris line. Moments of experience, analysis and self-observation played more than a marginal role in his discovery of the a priori. Indeed, Kant himself raises the (...) question of ontogenetic category assimilation in a review which pre-empts Piaget, borrowing the category of `original acquisition' from the doctrine of the laws of natural right. And although Kant should not be elevated to the harbinger of the knowledge on development issues delivered thus far by the history of science and experiments, he did recognize the temporal reference of their categories in principle without resolving their validity in psychogenetic terms. Key Words: a priori • categories • genetic epistemology • Geneva School • neo-Kantianism • original acquisition • Jean Piaget • psychogenesis • self-observation. (shrink)
