There have been many efforts to infer causation from association byusing statistical models. Algorithms for automating this processare a more recent innovation. In Humphreys and Freedman[(1996) British Journal for the Philosophy of Science 47, 113–123] we showed that one such approach, by Spirtes et al., was fatally flawed. Here we put our arguments in a broader context and reply to Korb and Wallace [(1997) British Journal for thePhilosophy of Science 48, 543–553] and to Spirtes et al.[(1997) British Journal for (...) the Philosophy of Science 48, 555–568]. Their arguments leave our position unchanged: claims to have developed a rigorous engine for inferring causation from association are premature at best, the theorems have no implications for samples of any realistic size, and the examples used to illustrate the algorithms are indicative of failure rather than success. The gap between association and causation has yet to be bridged. (shrink)
: This essay explores the epistemological significance of the kinds of beliefs that grow out of traumatic experiences, such as the rape survivor's belief that she is never safe. On current theories of justification, beliefs like this one are generally dismissed due to either insufficient evidence or insufficient propositional content. Here, Freedman distinguishes two discrete sides of the aftermath of psychic trauma, the shattered self and the shattered worldview. This move enables us to see these beliefs as beliefs; in (...) other words, as having cognitive content. Freedman argues that what we then need is a theory of justification that allows us to handpick reliable sources of information on sexual violence, and give credibility where deemed appropriate. She advances a mix of reliabilism and coherentism that privileges feminism. On this account, the evidence for the class of beliefs in question will depend on an act of sexual violence (or testimony, or statistics) to the extent that the act is a reliable indication of the prevalence of sexual violence against women. (shrink)
In previous work, I defended Larry Laudan against the criticism that the axiological component of his normative naturalism lacks a naturalistic justification. I argued that this criticism depends on an equivocation over the term 'naturalism' and that it begs the question against what we are entitled to include in our concept of nature. In this paper, I generalize that argument and explore its implications for Laudan and other proponents of epistemic naturalism. Here, I argue that a commitment to naturalism in (...) the methods and aims of science inevitably entails a kind of epistemic relativism. However, I argue that this should not be interpreted as a reductio of naturalism, since the admission of contextually based standards and aims of science does not result in quietism when it comes to important questions concerning scientific rationality. (shrink)
Doppelt (1986,1990), Siegel (1990), and Rosenberg (1996) argue that the pivotal feature of Laudan's normative naturalism, namely his axiology, lacks a naturalistic foundation. In this paper I show that this objection turns on a misunderstanding of Laudan's use of the term 'naturalism'. Specifically, I argue that there are two important senses of naturalism running through Laudan's work. Once these two strands are made explicit, the objection raised by Doppelt and others simply disappears.
After sketching the conflict between objectivists and subjectivists on the foundations of statistics, this paper discusses an issue facing statisticians of both schools, namely, model validation. Statistical models originate in the study of games of chance, and have been successfully applied in the physical and life sciences. However, there are basic problems in applying the models to social phenomena; some of the difficulties will be pointed out. Hooke's law will be contrasted with regression models for salary discrimination, the latter being (...) a fairly typical application in the social sciences. (shrink)
Helen Longino argues that the way to ensure scientific knowledge is objective is to have a diversity of scientific investigators. This is the best example of recent feminist arguments which hold that the real value of diversity is epistemic, and not political, but it only partly succeeds. In the end, Longino's objectivity amounts to intersubjective agreement about contextually based standards, and while her account gives us a good reason for wanting diversity in our scientific communities, this reason turns out to (...) be political. (shrink)
Born in China in 551 B.C., Confucius rose from poverty to the heights of his country's ruling class. But then he quit his high post for the life of an itinerant philosopher. "The Analects" collects his teachings on education and government, the definition of nobility, the equality of man, and the right way and purpose of living - ideas that eventually spread to the West and influenced the great thinkers of the Enlightenment. And five centuries before Christ, Confucius set forth (...) his own Golden Rule: "Do not impose on others what you do not wish for yourself.". (shrink)
The authors find it more useful to payattention to relationships than to boundaries.By focusing attention on bounded, individualpsychological issues, the metaphor ofboundaries can distract helping professionalsfrom thinking about inequities of power. Itoversimplifies a complex issue, inviting us toignore discourses around gender, race, class,culture, and the like that support injustice,abuse, and exploitation. Making boundaries acentral metaphor for ethical practice can keepus from critically examining the effects ofdistance, withdrawal, and non-participation.The authors describe how it is possible toexamine the practical, moral, and ethicaleffects (...) of our participation in relationshipsby focusing on just relationships rather thanon boundaries. They give illustrations andclinical examples of relationally-focusedethical practices that derive from a narrativeapproach to therapy. (shrink)
Monogenesis of language is widely accepted, but the conventional argument seems to be mistaken; a simple probabilistic model shows that polygenesis is likely. Other prehistoric inventions are discussed, as are problems in tracing linguistic lineages. Language is a system of representations; within such a system, words can evoke complex and systematic responses. Along with its social functions, language is important to humans as a mental instrument. Indeed, the invention of language,that is the accumulation of symbols to represent emotions, objects, and (...) acts may be the most important event in human evolution, because so many developments follow from it. For example, Edward Sapir speculated that some embryonic form of language must have been available to early man to help him fashion tools from stone (Sapir,1921). Sophisticated biface stone tools date to early Homo erectus some 1.5 million years ago, suggesting a similar age for language. This paper considers whether the invention of language occurred at only one pre-historic site or at several sites. In other words, did language emerge by monogenesis or polygenesis? Early thinkers believed in monogenesis, against a background of divine creation. Perhaps the best known account is the biblical story of Adam giving names to plants and animals in the Garden of Eden. Similar legends are found among many peoples. Modern linguists too assume monogenesis, but on probabilistic grounds (see, for instance, Southworth and Daswani, 1974, p.314). The argument seems to be that the invention of language is an extremely unlikely event, because symbolization involves abstraction and requires synchronized insight by several individuals; therefore, the probability of occurrence at more than one site must be vanishingly small. We have found no explicit quantitative treatment of this question in the literature, but the underlying logic has to be the multiplication of probabilities. If p is small at one site,then p.p for two sites is smaller still, and so on. This reasoning is false, as we show here. The fallacy lies in the focus on two particular sites rather than consideration of all pairs of sites. (shrink)
A common difficulty with the application of theories of justice to the allocation of medical resources is the assumption that one perspective is primary, whether that privileged perspective be that of the practitioner, on the one hand, or policy analyst on the other. By a discussion of three theories — those of Ramsey, Childress, and Joseph Fletcher — I attempt to show that these perspectives must be treated as related. As a result, values and ethics expressed in micro-allocation should be (...) uniform with those of macro-allocation. This point has implications for such issues as substance and procedure in just decision, the role of the political process in medical allocation, and the definition of health and health services. (shrink)
Duty and Healing positions ethical issues commonly encountered in clinical situations within Jewish law. The concept of duty is significant in exploring bioethical issues, and this book presents an authentic and non-parochial Jewish approach to bioethics, while it includes critiques of both current secular and Jewish literatures. Among the issues the book explores are the role of family in medical decision-making, the question of informed consent as a personal religious duty, and the responsibilities of caretakers. The exploration of contemporary ethical (...) problems in healthcare through the lens of traditional sources in Jewish law is an indispensable guide of moral knowledge. (shrink)
The old literature on whether medical confidentiality may be breached to warn a spouse of a risk of contracting syphilis from his/her partner — a deep and rich literature — has become relevant once again in the context of HIV infection and AIDS. This paper examines the reasoning and method employed in: the Catholic approach centered around the patient's (property) right to the secret; a (generic) model of justice, utilizing minimal principles of non-aggression and restitution; and an approach involving the (...) elimination of unstable alternatives: the view that public health officials, but not the spouse, may/must be notified; and, that maintaining that the physician is at liberty to disclose but is not obliged to do so. The theory and method behind confidentiality turns out to be deeper than you might have anticipated. (shrink)
A series of studies investigated the capacity of children between the ages of 7 and 12 to give free and informed consent to participation in psychological research. Children were reasonably accurate in describing the purpose of studies, but many did not understand the possible benefits or especially the possible risks of participating. In several studies children's consent was not affected by the knowledge that their parents had given their permission or by the parents saying that they would not be upset (...) if the children refused. In contrast, other studies found that children were much more likely to stop their participation if the experimenter said explicitly that she would not be upset if they stopped. We suggest that experimenters should pay more attention to describing the possible risks and benefits of participation in research, and that they should also make it clearer to children that they are free to stop once they have begun. (shrink)
In summary, the usual elements of a typical health care ethics consultation note might reasonably accommodate the needs and expectations of relevant parties, and would therefore include: 1. identification of the relevant ethical issues, questions, or dilemmas; 2. reference to any relevant facts--medical, nursing, social, psychological, spiritual, legal, political, etc.; 3. a prioritized list of recommendations to improve coordinated care; 4. a clear and concise articulation of relevant arguments, wtih specific reference to the list of recommendations as well as to (...) the institution's overall ethos; 5. a contextual statement, identifying the perceived degree of consensus or support for the recommendations and conclusions, as well as any inherent agendas. (shrink)
This experiment investigated the effect of format (line vs. bar), viewers’ familiarity with variables, and viewers’ graphicacy (graphical literacy) skills on the comprehension of multivariate (three variable) data presented in graphs. Fifty-five undergraduates provided written descriptions of data for a set of 14 line or bar graphs, half of which depicted variables familiar to the population and half of which depicted variables unfamiliar to the population. Participants then took a test of graphicacy skills. As predicted, the format influenced viewers’ interpretations (...) of data. Specifically, viewers were more likely to describe x–y interactions when viewing line graphs than when viewing bar graphs, and they were more likely to describe main effects and “z–y” (the variable in the legend) interactions when viewing bar graphs than when viewing line graphs. Familiarity of data presented and individuals’ graphicacy skills interacted with the influence of graph format. Specifically, viewers were most likely to generate inferences only when they had high graphicacy skills, the data were familiar and thus the information inferred was expected, and the format supported those inferences. Implications for multivariate data display are discussed. (shrink)
In contrast to attempts that have been made to measure the clarity of reporting of the methods of clinical trials in journal articles, we report here an attempt to measure the accuracy of methods reporting. We focus in this article on eligibility criteria as a test case for the reporting of clinical trial methods. We examined the reporting of eligibility criteria in the protocol, methods paper (if applicable), journal article, and Clinical Alert for articles appearing in print between January 1988 (...) and September 1994 for which a Clinical Alert had been issued. Eligibility criteria were further classified into five categories in order to examine the content of information loss, if any. On average, 82% of protocol eligibility criteria were reported in methods papers. Journal articles and Clinical Alerts fared somewhat worse: 63% of criteria were reported in journal articles, 19% in Clinical Alerts. In all three categories of medical communication, the reporting of criteria that defined the study disease tended to be complete; reporting of criteria relating to trial precision, patient safety, legal and ethical concerns, and administrative considerations, was not complete. We found that criteria for clinical trial eligibility are frequently under-reported in medical communications. Moreover, some of the criteria omitted are of considerable clinical importance. We suggest that in the design phase of clinical trials, proposed eligibility criteria be scrutinized closely. Those criteria that survive this scrutiny and that have clinical import must be reported upon fully and accurately when communicating trial results. (shrink)
OBJECTIVE: To investigate whether eligibility criteria that exclude the elderly, persons with psychiatric disease, and persons with substance abuse problems from participation in randomized controlled trials (RCTs) are subjective and hence a source of variability in enrolment decisions and investigator uncertainty. DESIGN: Survey questionnaire. PARTICIPANTS: Cancer investigators from the United States and Canada. INTERVENTIONS: Investigators were presented with clinical vignettes from 3 patient categories--eligible, ineligible and uncertain--for each of 5 eligibility criteria--3 subjective and 2 objective--and were asked whether they would (...) enrol the patient in a trial and how sure they were of this decision. Demographic characteristics of the investigators were also collected. OUTCOME MEASURES: The difference in enrolment decisions between subjective and objective criteria, and the difference in the certainty associated with these decisions. RESULTS: Of 365 questionnaires sent out, 224 usable ones were returned. Compared with the objective criteria, the subjective criteria were associated with more variable enrolment decisions (p = 0.07 for the "eligible" scenario and p = 0.0001 for the "ineligible" and "uncertain" scenarios), and investigators were less sure about the decisions they made (p = 0.0001 for all scenarios). Demographic characteristics of the investigators failed to explain the observed differences. CONCLUSIONS: Subjective eligibility criteria may interfere with the conduct and interpretation of RCTs and, therefore, their use ought to be justified explicitly in the study protocol. RCT designers, funding agencies and research ethics boards have an important role in reviewing eligibility criteria for their necessity. (shrink)
OBJECTIVE: Pilot study to characterize treatment differences between patients treated in clinical trials and those treated in a clinical setting. Previous studies have shown higher survival rates for participants in trials of cancer therapy. This difference is observed even after rates are adjusted for important covariates such as age and stage of disease. DESIGN: Retrospective chart review. SETTING: Oncology outpatient department in a tertiary care hospital. PATIENTS: Ninety women 18 to 70 years of age with early-stage breast cancer who were (...) diagnosed in 1990. Fifty-one of the women were treated through clinical trials and 39 were treated outside of clinical trials. OUTCOME MEASURES: Number of blood tests, telephone calls, clinic visits and imaging procedures as well as intensity of chemotherapy and use of radiation therapy. The age of the patient and the stage of disease were important covariates. RESULTS: After the analysis was controlled for patient age and stage of disease, patients treated through a clinical trial were more likely to receive standard-dose chemotherapy (p = 0.020, 95% confidence interval 1.20 to 200.73) and more frequent blood tests (p < 0.001, 95% confidence interval 1.02 to 1.13) than other patients treated in the clinic. CONCLUSIONS: Our results provide a plausible mechanism for the observed survival advantage for participants in clinical trials in oncology. Further study is called for. If these results are confirmed, they have important implications for informed consent to participate in clinical trials and for clinical practice. (shrink)
We studied changes in eligibility criteria--the largest impediment to patient accrual--in two samples of clinical trials. Trials from the NSABP (National Surgical Adjuvant Breast and Bowel Program) and POG (Pediatric Oncology Group) were analyzed. After eliminating duplications, the criteria in each protocol were enumerated and classified according to a novel schema. NSABP trials contained significantly more criteria than POG trials, and added precision criteria (making study populations homogeneous) at a faster rate than POG studies. The difference between NSABP studies (explanatory (...) trials) and POG studies (pragmatic trials) suggest that large numbers of eligibility criteria are not necessary for quality studies. We recommend that: (1) the inclusion/exclusion criteria distinction be abandoned; (2) eligibility criteria be explicitly justified; (3) the need for each criterion be assessed when new trials are planned; (4) criteria in phase III trials restricting patient accrual be minimized; and (5) further research be done to assess the impact of criteria on generalizability. (shrink)
This research concerns accountability by the U.S. electric utility industry for the financial impacts of cap-and-trade emissions allowance activity. We report findings from an extensive examination of disclosure practices for more than 100 facilities that were required to curb pollutant discharges and participate in a government-mandated program of emission allowance distribution and trading.
Part of Keynes? 'struggle of escape from habitual modes of thought and expression' (Keynes 1960: viii) involves an implicit attempt to break with the methodology as well as the theory of the past. Unfortunately the rhetorical strategy Keynes adopted in The General Theoryblurred this attempt. As a result, it is only by examining both the methodology and rhetoric embedded in this work that it becomes possible to understand the book as a coherent whole. This paper demonstrates the validity of taking (...) such an approach. (shrink)
This paper is an attempt to achieve a moral understanding of recombinant DNA technology through an examination of the Biblical ban on the cross-breeding of species, as that ban was understood by traditional Jewish commentators. By paying close attention to the concept of natural law which some of those commentators employed in this connection, a nuanced response to the modern moral problem can be developed, which is immune to the standard arguments employed against those who rely upon natural law.
It is often claimed that a clinical investigator may ethically participate (e.g., enroll patients) in a trial only if she is in equipoise (if she has no way to ground a preference for one arm of the study). But this is a serious problem, for as data accumulate, it can be expected that there will be a discernible trend favoring one of the treatments prior to the point where we achieve the trial's objective. In this paper, I critically evaluate Benjamin (...)Freedman's 'clinical equipoise' solution to this dilemma. I argue that Freedman actually puts forth at least two distinct contrasts - one in terms of community vs. individual equipoise, and another concerning clinical vs. theoretical equipoise - and that neither of them resolves the dilemma. I then make a proposal for a more adequate account of how to think about the circumstances under which entering subjects in trials would be justified - a 'sliding-scale equipoise' that arises out of a discussion of patients' values. (shrink)
After describing the philosophical background of Kerry?s work, an account is given of the way Kerry proposed to supplement Bolzano?s conception of logic with a psychological account of the mental acts underlying mathematical judgements.In his writings Kerry criticized Frege?s work and Kerry?s views were then attacked by Frege.The following two issues were central to this controversy: (a) the relation between the content of a concept and the object of a concept; (b) the logical roles of the (...) definite article.Not only did Frege in 1892 offer an unconvincing solution to Kerry?s puzzle concerning ?the concept horse? but he also overlooked the many criticisms levelled by Kerry against the notion of an (indefinite) extension on which his own definition of number was based. (shrink)
During the first months of 1887, while completing the drafts of his Mitteilungen zur Lehre vom Transfiniten, Georg Cantor maintained a continuous correspondence with Benno Kerry. Their exchange essentially concerned two main topics in the philosophy of mathematics, namely, (a) the concept of natural number and (b) the infinitesimals. Cantor's and Kerry's positions turned out to be irreconcilable, mostly because of Kerry's irremediably psychologistic outlook, according to Cantor at least. In this study, I will examine and reconstruct (...) the main points in the discussion around (a) and (b) and stress some interesting aspects of the philosophical and mathematical thought of Benno Kerry. (shrink)
Certainly I am in no way opposed to philosophy, or metaphysics in the sense that Wm. James defined it as a particularly intense effort to think clearly. Indeed, Klein would like to say that what I am talking about is nothing but metaphysics. But the kind of philosophy/metaphysics that is needed here is of a particular kind: a kind that does not separate philosophy/metaphysics and physics into two disjoint realms. It is of the kind that seeks to construct useful testable (...) physical theories that are adequately connected to what we can know. (shrink)
When Benno Kerry (1858?89) died at the age of 30 he was already well?known for his competent and thoroughgoing philosophical criticism of Cantor?s set theory and Frege?s early philosophy of mathematics.Before his death he was working on a theory of limits (Grenzbegriffe) which was an elaboration of his Habilitationsschrift of 1884 and of which only a first part was published posthumously.This paper gives a survey of Kerry?s basic biographical data, and a first description of his Habilitationsschrift which had (...) been missing for a long time but was found by chance in the Nachlass of the German philosopher Leonard Nelson. (shrink)
In Causation, Prediction, and Search (Spirtes, Glymour, and Scheines 1993), we undertook a three part project. (Henceforth we will refer to Causation, Prediction, and Search as CPS.) First, we characterized when causal models are indistinguishable by population conditional independence relations under several different assumptions relating causality to probability. Second, we proposed a number of algorithms that take sample data and optional background knowledge as input, and output a class of causal models compatible with the data and the background knowledge; the (...) algorithms (with the exception of the heuristic algorithm described in Chapter 11) were accompanied by proofs of their correctness given assumptions that were clearly stated in CPS, and that we will restate below. Finally, we offered a theory of how to predict the effects of interventions in causal structures, given only partial knowledge of causal structure. Freedman's objections are all directed against the causal inference algorithms we proposed. We do not have room here to discuss all of his criticisms, but we have answered his major points. With regard to the points we do not have room to discuss, the reader should be warned that Freedman is an unreliable interpreter of what we have written. For convenience, we have divided Freedman's objections into the following categories. 1.) Freedman questions some of the assumptions on which our correctness theorems are based. Some of his criticisms are based on covariance matrices that he constructed. None of the examples he constructed in sections 11.2, 11.3, or 12.3 are counterexamples to any theorem that we stated, nor are they even germane to the question of how probable are the assumptions we make. His examples only illustrate points discussed in detail in our book (particularly in the chapter on indistinguishability), in which we give similar examples. 2.) The most serious charge that Freedman makes is that the algorithms do not compute what we say they do.. (shrink)
While results from statistical modelling too often receive blind acceptance, we question whether there is any real alternative to use of modelling. This does not diminish the main point of Professor Freedman, which is that healthy scepticism towards models is needed. While agreeing with many of Professor Freedman's points concerning the objectivist debate, we argue that there is a Bayesian school of objectivists that possesses considerable advantages over the classical objectivist school. At the least, the debate needs to (...) be enlarged to include this school. (shrink)
After presenting the ordinary and the Fregean formulations of the ancestral, I raise the question of what is their relationship, the natural candidate being that the Fregean version is an analysans intended to improve upon, and replace, the common notion of ancestral (the analysandum). Next, two types of circles that arise in connection with the Fregean ancestral are presented, and it is claimed that one of the circles makes it impossible to maintain the just described (“replacement”) interpretation. A reference is (...) made to Kerry, who was the first to point out a circularity in Frege’s ancestral. Some of Frege’s remarks are examined in order to tentatively sketch, an answer to the issue of the relationship between ordinary and Fregean ancestral; the latter, if not as an analysans replacing the common notion, can still be seen as a profound enrichment of the former. (shrink)
Managers seeking to respect local norms when operating in cross-cultural settings may encounter ethical dilemmas when faced with values that potentially conflict with their own. The question of whose ethics or values should be applied or whether a set of universal eth- ical norms should be developed often confronts managers in their international business dealings. This article explores the findings from a qualitative research study that examines critical ethical dilemmas confronting Australian managers in their international business operations and their responses (...) to those dilemmas. For Australians managers in this study, bribery emerged as the major ethical dilemma confronting them in their international operations. (shrink)
