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  1. Ute Deichmann, Michel Morange & Anthony S. Travis (2013). Editors' Introduction to Special Issue. Perspectives in Biology and Medicine 55 (4):470-472.
    In this second decade of the 21st century, we find the pervasive influence of synthetic biology everywhere, not only in research laboratories, but also in the discourses of politicians and ethicists. Despite its ubiquity, the precise meaning of the notions of "synthetic biology" and "synthetic life," as well as their history, potential, and risks, remain obscure not only to the layperson, but also to most biologists.The aim of this special issue is twofold. First, it is intended to help the reader (...)
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  2. Michel Morange (2013). Comparison Between the Work of Synthetic Biologists and the Action of Evolution: Engineering Versus Tinkering. Biological Theory 8 (4):318-323.
    The comparison between natural evolution and the action of a tinkerer has become highly popular since its reintroduction by François Jacob at the end of the 1970s. It has been used as a weapon against the existence of an “intelligent design” as well as a way for synthetic biologists to promote their ambitious projects. I will describe the complex history of this metaphor, and examine its pertinence. Whereas Darwin considered it as a way to describe how evolution proceeded, Jacob linked (...)
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  3. Michel Morange (2013). Synthetic Biology: A Challenge to Mechanical Explanations in Biology? Perspectives in Biology and Medicine 55 (4):543-553.
    The construction of synthetic life might appear to be the natural objective of the emerging discipline of synthetic biology. The situation, though, is not that simple. Plans to synthesize life appeared quite early, at the beginning of the 20th century (Bensaude-Vincent 2009; Deichmann 2009; Fox Keller 2002; Pereto and Catala 2007). Nor can synthetic biology be identified with work on the origin of life. Nevertheless, it is remarkable that a new, more integrated approach to the origin of life appeared exactly (...)
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  4. Rony Armon, Ulrich Charpa, Eric Davidson, Ute Deichmann, Raphael Falk, John Glass, Shimon Glick, Manfred Laubichler, Michel Morange, Isaac, Addy Pross, Siegfried Roth & Varda Shoshan-Barmatz (2012). Final Discussion: Issues and Challenges for the Future. Perspectives in Biology and Medicine 55 (4):608-611.
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  5. Rony Armon, Ulrich Charpa, Eric Davidson, Ute Deichmann, Raphael Falk, John Glass, Shimon Glick, Manfred Laubichler, Michel Morange & Isaac Yanni Nevo (2012). Final Discussion: Issues and Challenges for the Future. Perspectives in Biology and Medicine 55 (4):608-611.
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  6. Michel Morange (2012). From Experimental Systems to Evolutionary Biology: An Impossible Journey? History and Philosophy of the Life Sciences 35 (1):27-32.
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  7. Michel Morange (2012). What Might Be a New “View of Evolution”? Studies in History and Philosophy of Science Part C 43 (2):578-581.
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  8. Michel Morange (2011). Commentaire sur Delisle. Les philosophies du néo-darwinisme. Philosophiques 38 (1):281-284.
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  9. Michel Morange (2011). Development and Aging. Biological Theory 6 (1):59-64.
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  10. Michel Morange (2011). Review of 'A Matter of Wonder–What Biology Reveals About Us, Our World and Our Dreams'. [REVIEW] Bioessays 33 (12):966-967.
  11. Michel Morange (2011). Recent Opportunities for an Increasing Role for Physical Explanations in Biology. Studies in History and Philosophy of Science Part C 42 (2):139-144.
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  12. Michel Morange (2011). What Will Result From the Interaction Between Functional and Evolutionary Biology? Studies in History and Philosophy of Science Part C 42 (1):69-74.
  13. Thomas Pradeu, Lucie Laplane, Michel Morange, Antonine Nicoglou & Michel Vervoort (2011). The Boundaries of Development. Biological Theory 6 (1):1 - 3.
    This special issue of Biological Theory is focused on development; it raises the problem of the temporal and spatial boundaries of development. From a temporal point of view, when does development start and stop? From a spatial point of view, what is it exactly that "develops", and is it possible to delineate clearly the developing entity? This issue explores the possible answers to these questions, and thus sheds light on the definition of development itself.
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  14. Jean Gayon, Christophe Malaterre, Michel Morange, Florence Raulin-Cerceau & Stéphane Tirard, Defining Life.
    This Special Issue of Origins of Life and Evolution of Biospheres contains papers based on the contributions presented at the Conference "Defining Life" held in Paris (France) on 4-5 February, 2008. The main objective of this Conference was to confront speakers from several disciplines--chemists, biochemists, biologists, exo/astrobiologists, computer scientists, philosophers and historians of science--on the topic of the definition of life. Different viewpoints of the problem approached from different perspectives have been expounded and, as a result, common grounds as well (...)
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  15. Michel Morange (2010). How Evolutionary Biology Presently Pervades Cell and Molecular Biology. Journal for General Philosophy of Science / Zeitschrift für Allgemeine Wissenschaftstheorie 41 (1):113 - 120.
    The increasing place of evolutionary scenarios in functional biology is one of the major indicators of the present encounter between evolutionary biology and functional biology (such as physiology, biochemistry and molecular biology), the two branches of biology which remained separated throughout the twentieth century. Evolutionary scenarios were not absent from functional biology, but their places were limited, and they did not generate research programs. I compare two examples of these past scenarios with two present-day ones. At least three characteristics distinguish (...)
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  16. Anouk Barberousse, Michel Morange & Thomas Pradeu (2009). Mapping the Future of Biology: Evolving Concepts and Theories Vol. 266. Springer.
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  17. Michel Morange (2009). A Critical Perspective on Synthetic Biology. Hyle 15 (1):21 - 30.
    Synthetic biology emerged around 2000 as a new biological discipline. It shares with systems biology the same modular vision of organisms, but is more concerned with applications than with a better understanding of the functioning of organisms. A herald of this new discipline is Craig Venter who aims to create an artificial microorganism with the minimal genome compatible with life and to implement into it different 'functional modules' to generate new micro-organisms adapted to specific tasks. Synthetic biology is based on (...)
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  18. Michel Morange (2009). Coming to Cologne: Molecular Biology and the Organisation of Research. [REVIEW] Metascience 18 (2):339-342.
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  19. Michel Morange (2009). Synthetic Biology: A Bridge Between Functional and Evolutionary Biology. Biological Theory 4 (4):368-377.
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  20. Michel Morange (2008). Life Explained. Yale University Press.
    In this accessible and fascinating book, Michel Morange draws on recent advances in molecular genetics, evolutionary biology, astrobiology, and other disciplines to find today’s answers to the question of life.
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  21. Michel Morange (2008). The Death of Molecular Biology? History and Philosophy of the Life Sciences 30 (1):31 - 42.
    In recent decades the expression "molecular biology" has progressively disappeared from journals, and no longer designates new chairs or departments. This begs the question: does it mean that molecular biology is dead, and has been displaced by new emerging disciplines such as systems biology and synthetic biology? Maybe its reductionist approach to living phenomena has been substituted by one that is more holistic. The situation, undoubtedly, is far less simple. To appreciate better what has happened it is necessary to acknowledge (...)
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  22. Michel Morange (2006). Jacob. In L. Kritzman (ed.), The Columbia History of Twentieth Century French Thought. Columbia Univ Pr. 549--551.
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  23. Michel Morange (2006). Monod. In L. Kritzman (ed.), The Columbia History of Twentieth Century French Thought. Columbia Univ Pr. 622--624.
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  24. Michel Morange (2006). Post-Genomics, Between Reduction and Emergence. Synthese 151 (3):355 - 360.
    It is frequently said that biology is emerging from a long phase of reductionism. It would be certainly more correct to say that biologists are abandoning a certain form of reductionism. We describe this past form, and the experiments which challenged the previous vision. To face the difficulties which were met, biologists use a series of concepts and metaphors - pleiotropy, tinkering, epigenetics - the ambiguity of which masks the difficulties, instead of solving them. In a similar way, the word (...)
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  25. Michel Morange (2006). The Protein Side of the Central Dogma: Permanence and Change. History and Philosophy of the Life Sciences 28 (4):513 - 524.
    There are two facets to the central dogma proposed by Francis Crick in 1957. One concerns the relation between the sequence of nucleotides and the sequence of amino acids, the second is devoted to the relation between the sequence of amino acids and the native three-dimensional structure of proteins. 'Folding is simply a function of the order of the amino acids,' i.e. no information is required for the proper folding of a protein other than the information contained in its sequence. (...)
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  26. Michel Morange (2005). Les Secrets du Vivant: Contre la Pensée Unique En Biologie. Editions la Découverte.
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  27. Michel Morange, What is Life? A New Look at an Old Question.
    For molecular biologists, the question What is Life?" disappeared in the 1960s to reemerge recently. The reasons for this reemergence will be analysed: they tell us much about the recent transformations of biology, and its present state. This question can be considered as a thermometer, which measures the balance between reductionist vs. holist explanations in biology: when the question disappears, reductionist approaches are dominant; when the question reappears, the reductionist vision is challenged.
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  28. Michel Morange (2004). L'énigme de la vie. Revue Philosophique de la France Et de l'Etranger 194 (3):285 - 289.
    Il y a trente ans, Georges Canguilhem montrait que la question « Qu'est-ce que la vie ? » avait eu une histoire, qui semblait s'être arrêtée avec l'avènement de la biologie moléculaire. Nous montrons que la question a réémergé ces dernières années. Nous analysons les raisons de cette renaissance, et la nature des réponses qui lui sont aujourd'hui apportées. 30 years ago, Georges Canguilhem showed that the question « What's life ? » had its own story, which seemed to have (...)
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  29. Michel Morange (2003). Archaeology in the Capital of Molecular Biology. Metascience 12 (2):195-197.
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  30. Michel Morange (2001). On the Relations Between History and Philosophy of the Life Sciences and Biology. History and Philosophy of the Life Sciences 23 (1):65 - 74.
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  31. Michel Morange (2000). François Jacob's Lab in the Seventies: The T-Complex and the Mouse Developmental Genetic Program. History and Philosophy of the Life Sciences 22 (3):397 - 411.
    The existence of a genetic program of development was proposed by molecular biologists in the nineteen-sixties. Historians and philosophers of science have since thoroughly criticized this notion. To fully appreciate its significance, it is interesting to consider the research which was pursued during this period by molecular biologists who proposed this notion. This study focuses on François Jacob's work and on the model of development supported by his lab in the early seventies, the T-complex model. This episode of Jacob's scientific (...)
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  32. Michel Morange (2000). Georges Canguilhem Et la Biologie du XXe Siècle/Georges Canguilhem and Twentieth-Century Biology. Revue d'Histoire des Sciences 53 (1):83-106.
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  33. Michel Morange (2000). Le Complexe? De la Souris: Un Mirage Riche d'Enseignements/The Complex of the Mouse: An Instructive Mirage. Revue d'Histoire des Sciences 53 (3):521-554.
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  34. Michel Morange (2000). The T Complex of the Mouse: An Instructive Mirage. Revue d'Histoire des Sciences 53 (3-4):521-554.
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  35. William C. Summers & Michel Morange (2000). Book Reviews-Felix d'Herelle and the Origins of Molecular Biology. History and Philosophy of the Life Sciences 22 (3):441-441.
     
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  36. Bruno J. Strasser, Michel Morange & Matthew Cobb (1999). Molecular Biology, Macroscopic HistoryA History of Molecular Biology. BioScience 49 (11):929.
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  37. Michel Morange (1997). From the Regulatory Vision of Cancer to the Oncogene Paradigm, 1975-1985. Journal of the History of Biology 30 (1):1 - 29.
  38. Michel Morange (1997). The Transformation of Molecular Biology on Contact with Higher Organisms, 1960-1980: From a Molecular Description to a Molecular Explanation. [REVIEW] History and Philosophy of the Life Sciences 19 (3):369 - 393.
    The convergence of developmental biology — embryology — and molecular biology was one of the major scientific events of the last decades of the twentieth century. The transformation of developmental biology by the concepts and methods of molecular biology has already been described. Less has been told on the reciprocal transformation of molecular biology on contact with higher organisms. The transformation of molecular biology occurred at the end of a deep crisis which affected this discipline in the sixties and seventies (...)
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  39. Michel Morange (1993). The Discovery of Cellular Oncogenes. History and Philosophy of the Life Sciences 15 (1):45 - 58.
    Between 1975 and 1985 a series of experiments demonstrated that cancer, whatever its causative agent, is due to the activation, by modification or overexpression, of a family of genes highly conserved during evolution, called the cellular oncogenes. These genes participate in the control of cell division in every living cell. Their products belong to the regulatory network relaying external signals from the membranes towards the nucleus and allowing cells to adapt their division rate to the demand of the organism. These (...)
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