Search results for 'Molecular biology Philosophy' (try it on Scholar)

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  1. Sahotra Sarkar (1996). Philosophy, History, and Molecular Biology—Introduction. In , The Philosophy and History of Molecular Biology: New Perspectives. Kluwer Academic. 1--13.score: 522.0
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  2. Sahotra Sarkar (ed.) (1996). The Philosophy and History of Molecular Biology: New Perspectives. Kluwer Academic.score: 519.0
  3. Paul Edmund Griffiths, The Philosophy of Molecular and Developmental Biology.score: 486.0
    Philosophical discussion of molecular and developmental biology began in the late 1960s with the use of genetics as a test case for models of theory reduction. With this exception, the theory of natural selection remained the main focus of philosophy of biology until the late 1970s. It was controversies in evolutionary theory over punctuated equilibrium and adaptationism that first led philosophers to examine the concept of developmental constraint. Developmental biology also gained in prominence in the (...)
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  4. Robin Holliday (1999). The Incompatibility of Popper's Philosophy of Science with Genetics and Molecular Biology. Bioessays 21 (10):890-891.score: 435.0
  5. Alexander Rosenberg (2006). Darwinian Reductionism, or, How to Stop Worrying and Love Molecular Biology. University of Chicago Press.score: 432.0
    After the discovery of the structure of DNA in 1953, scientists working in molecular biology embraced reductionism—the theory that all complex systems can be understood in terms of their components. Reductionism, however, has been widely resisted by both nonmolecular biologists and scientists working outside the field of biology. Many of these antireductionists, nevertheless, embrace the notion of physicalism—the idea that all biological processes are physical in nature. How, Alexander Rosenberg asks, can these self-proclaimed physicalists also be antireductionists? (...)
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  6. Manfred D. Laubichier & Kenneth F. Schaffner (2000). Philosophy of Biology, Psychology, and Neuroscience-The Organism in Philosophical Focus-Behavior at the Organismal and Molecular Levels: The Case of C. Elegans. Philosophy of Science 67 (3).score: 414.0
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  7. Sahotra Sarkar & Anya Plutynski (eds.) (2008). A Companion to the Philosophy of Biology. Blackwell Pub..score: 348.0
    Comprised of essays by top scholars in the field, this volume offers concise overviews of philosophical issues raised by biology. Brings together a team of eminent scholars to explore the philosophical issues raised by biology Addresses traditional and emerging topics, spanning molecular biology and genetics, evolution, developmental biology, immunology, ecology, mind and behaviour, neuroscience, and experimentation Begins with a thorough introduction to the field Goes beyond previous treatments that focused only on evolution to give equal (...)
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  8. Alexander Powell, Maureen A. O'Malley, Staffan Mueller-Wille, Jane Calvert & John Dupré (2007). Disciplinary Baptisms: A Comparison of the Naming Stories of Genetics, Molecular Biology, Genomics and Systems Biology. History and Philosophy of the Life Sciences 29 (1):5-32.score: 345.0
    Understanding how scientific activities use naming stories to achieve disciplinary status is important not only for insight into the past, but for evaluating current claims that new disciplines are emerging. In order to gain a historical understanding of how new disciplines develop in relation to these baptismal narratives, we compare two recently formed disciplines, systems biology and genomics, with two earlier related life sciences, genetics and molecular biology. These four disciplines span the twentieth century, a period in (...)
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  9. John Dupré (2012). Processes of Life: Essays in the Philosophy of Biology. OUP Oxford.score: 306.0
    John Dupré explores recent revolutionary developments in biology and considers their relevance for our understanding of human nature and human society. Epigenetics and related areas of molecular biology have eroded the exceptional status of the gene and presented the genome as fully interactive with the rest of the cell. Developmental systems theory provides a space for a vision of evolution that takes full account of the fundamental importance of developmental processes. Dupré shows the importance of microbiology for (...)
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  10. Predrag Sustar (2007). Crick's Notion of Genetic Information and the ‘Central Dogma’ of Molecular Biology. British Journal for the Philosophy of Science 58 (1):13-24.score: 306.0
    An assessment is offered of the recent debate on information in the philosophy of biology, and an analysis is provided of the notion of information as applied in scientific practice in molecular genetics. In particular, this paper deals with the dependence of basic generalizations of molecular biology, above all the ‘central dogma’, on the so-called ‘informational talk’ (Maynard Smith [2000a]). It is argued that talk of information in the ‘central dogma’ can be reduced to causal (...)
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  11. Richard M. Burian (2007). On MicroRNA and the Need for Exploratory Experimentation in Post-Genomic Molecular Biology. History and Philosophy of the Life Sciences 29 (3):285 - 311.score: 306.0
    This paper is devoted to an examination of the discovery, characterization, and analysis of the functions of microRNAs, which also serves as a vehicle for demonstrating the importance of exploratory experimentation in current (post-genomic) molecular biology. The material on microRNAs is important in its own right: it provides important insight into the extreme complexity of regulatory networks involving components made of DNA, RNA, and protein. These networks play a central role in regulating development of multicellular organisms and illustrate (...)
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  12. Kenneth F. Schaffner (1974). The Peripherality of Reductionism in the Development of Molecular Biology. Journal of the History of Biology 7 (1):111 - 139.score: 306.0
    I have not attempted to provide here an analysis of the methodology of molecular biology or molecular genetics which would demonstrate at what specific points a more reductionist aim would make sense as a research strategy. This, I believe, would require a much deeper analysis of scientific growth than philosophy of science has been able to provide thus far. What I have tried to show is that a straightforward reductionist strategy cannot be said to be follwed (...)
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  13. Predrag Šustar (2007). Crick's Notion of Genetic Information and the 'Central Dogma' of Molecular Biology. British Journal for the Philosophy of Science 58 (1):13 - 24.score: 306.0
    An assessment is offered of the recent debate on information in the philosophy of biology, and an analysis is provided of the notion of information as applied in scientific practice in molecular genetics. In particular, this paper deals with the dependence of basic generalizations of molecular biology, above all the 'central dogma', on the socalled 'informational talk' (Maynard Smith [2000a]). It is argued that talk of information in the 'central dogma' can be reduced to causal (...)
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  14. Manfred D. Laubichler & Günter P. Wagner (2001). How Molecular is Molecular Developmental Biology? A Reply to Alex Rosenberg's Reductionism Redux: Computing the Embryo. [REVIEW] Biology and Philosophy 16 (1):53-68.score: 297.0
    This paper argues in defense of theanti-reductionist consensus in the philosophy ofbiology. More specifically, it takes issues with AlexRosenberg's recent challenge of this position. Weargue that the results of modern developmentalgenetics rather than eliminating the need forfunctional kinds in explanations of developmentactually reinforce their importance.
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  15. F. Ayala & T. Dobzhansky (eds.) (1974). Studies in the Philosophy of Biology. University of California Press.score: 297.0
    Should the philosophy of biology deal with organismic, or with molecular aspects , or with both ? We are, of course, not the first to appreciate the ...
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  16. Michel Morange (2010). How Evolutionary Biology Presently Pervades Cell and Molecular Biology. Journal for General Philosophy of Science / Zeitschrift für Allgemeine Wissenschaftstheorie 41 (1):113 - 120.score: 279.0
    The increasing place of evolutionary scenarios in functional biology is one of the major indicators of the present encounter between evolutionary biology and functional biology (such as physiology, biochemistry and molecular biology), the two branches of biology which remained separated throughout the twentieth century. Evolutionary scenarios were not absent from functional biology, but their places were limited, and they did not generate research programs. I compare two examples of these past scenarios with two (...)
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  17. Paul Griffiths, Philosophy of Biology. Stanford Encyclopedia of Philosophy.score: 270.0
    The philosophy of biology has existed as a distinct sub-discipline within the philosophy of science for about thirty years. The rapid growth of the field has mirrored that of the biological sciences in the same period. Today the discipline is well represented in the leading journals in philosophy of science, as well as in several specialist journals. There have been two generations of textbooks (see conclusion) and the subject is regularly taught at undergraduate as well as (...)
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  18. Ingo Brigandt (2006). A Theory of Conceptual Advance: Explaining Conceptual Change in Evolutionary, Molecular, and Evolutionary Developmental Biology. Dissertation, University of Pittsburghscore: 267.0
    The theory of concepts advanced in the dissertation aims at accounting for a) how a concept makes successful practice possible, and b) how a scientific concept can be subject to rational change in the course of history. Traditional accounts in the philosophy of science have usually studied concepts in terms only of their reference; their concern is to establish a stability of reference in order to address the incommensurability problem. My discussion, in contrast, suggests that each scientific concept consists (...)
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  19. Gregory J. Morgan (2001). Bacteriophage Biology and Kenneth Schaffner's Rendition of Developmentalism. Biology and Philosophy 16 (1):85-92.score: 264.0
    In this paper I consider Kenneth Schaffner''s(1998) rendition of ''''developmentalism'''' from the point of viewof bacteriophage biology. I argue that the fact that a viablephage can be produced from purified DNA and host cellularcomponents lends some support to the anti-developmentalist, ifthey first show that one can draw a principled distinctionbetween genetic and environmental effects. The existence ofhost-controlled phage host range restriction supports thedevelopmentalist''s insistence on the parity of DNA andenvironment. However, in the case of bacteriophage, thedevelopmentalist stands on less (...)
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  20. Sylvia Culp & Philip Kitcher (1989). Theory Structure and Theory Change in Contemporary Molecular Biology. British Journal for the Philosophy of Science 40 (4):459-483.score: 261.0
    Traditional approaches to theory structure and theory change in science do not fare well when confronted with the practice of certain fields of science. We offer an account of contemporary practice in molecular biology designed to address two questions: Is theory change in this area of science gradual or saltatory? What is the relation between molecular biology and the fields of traditional biology? Our main focus is a recent episode in molecular biology, the (...)
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  21. E. M. (1999). The Prion Challenge to the `Central Dogma' of Molecular Biology, 1965-1991 - Part I: Prelude to Prions. Studies in History and Philosophy of Science Part C 30 (1):1-19.score: 261.0
    Since the 1930s, scientists studying the neurological disease scrapie had assumed that the infectious agent was a virus. By the mid 1960s, however, several unconventional properties had arisen that were difficult to reconcile with the standard viral model. Evidence for nucleic acid within the pathogen was lacking, and some researchers considered the possibility that the infectious agent consisted solely of protein. In 1982, Stanley Prusiner coined the term `prion' to emphasize the agent's proteinaceous nature. This infectious protein hypothesis was denounced (...)
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  22. Harold Kincaid (1990). Molecular Biology and the Unity of Science. Philosophy of Science 57 (4):575-593.score: 261.0
    Advances in molecular biology have generally been taken to support the claim that biology is reducible to chemistry. I argue against that claim by looking in detail at a number of central results from molecular biology and showing that none of them supports reduction because (1) their basic predicates have multiple realizations, (2) their chemical realization is context-sensitive and (3) their explanations often presuppose biological facts rather than eliminate them. I then consider the heuristic and (...)
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  23. Steven Orla Kimbrough (1979). On the Reduction of Genetics to Molecular Biology. Philosophy of Science 46 (3):389-406.score: 261.0
    The applicability of Nagel's concept of theory reduction, and related concepts of reduction, to the reduction of genetics to molecular biology is examined using the lactose operon in Escherichia coli as an example. Geneticists have produced the complete nucleotide sequence of two of the genes which compose this operon. If any example of reduction in genetics should fit Nagel's analysis, the lactose operon should. Nevertheless, Nagel's formal conditions of theory reduction are inapplicable in this case. Instead, it is (...)
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  24. Michel Morange (1997). The Transformation of Molecular Biology on Contact with Higher Organisms, 1960-1980: From a Molecular Description to a Molecular Explanation. [REVIEW] History and Philosophy of the Life Sciences 19 (3):369 - 393.score: 261.0
    The convergence of developmental biology — embryology — and molecular biology was one of the major scientific events of the last decades of the twentieth century. The transformation of developmental biology by the concepts and methods of molecular biology has already been described. Less has been told on the reciprocal transformation of molecular biology on contact with higher organisms. The transformation of molecular biology occurred at the end of a deep (...)
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  25. Joseph D. Robinson (1992). Aims and Achievements of the Reductionist Approach in Biochemistry/Molecular Biology/Cell Biology: A Response to Kincaid. Philosophy of Science 59 (3):465-470.score: 261.0
    Kincaid argues that molecular biology provides little support for the reductionist program, that biochemistry does not reveal common mechanisms, indeed that biochemical theory obstructs discovery. These assertions clash with biologists' stated advocacy of reductionist programs and their claims about the consequent unity of experimental biology. This striking disagreement goes beyond differences in meaning granted to the terms. More significant is Kincaid's misunderstanding of what biochemists do, for a closer look at scientific practice-- and one of Kincaid's examples--reveals (...)
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  26. Kenneth F. Schaffner (1994). Interactions Among Theory, Experiment, and Technology in Molecular Biology. PSA: Proceedings of the Biennial Meeting of the Philosophy of Science Association 1994:192 - 205.score: 261.0
    This article examines how a molecular "solution" to an important biological problem-how is antibody diversity generated? was obtained in the 1970s. After the primarily biological clonal selection theory (CST) was accepted by 1967, immunologists developed several different contrasting theories to complete the SCST. To choose among these theories, immunology had to turn to the new molecular biology, first to nucleic acid hybridization and then to recombinant DNA technology. The research programs of Tonegawa and Leder that led to (...)
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  27. J. M. (2002). National Politics and International Trends: EMBO and the Making of Molecular Biology in Spain (1960-1975). Studies in History and Philosophy of Science Part C 33 (3):473-487.score: 261.0
    From the mid-1960s onwards, a set of Spanish molecular biology research groups emerged in Spain. The factors contributing to this included: the return of a group of molecular biologists from their postdoctoral period abroad, the negotiations for the return of Spanish-born Nobel prize winner Severo Ochoa from New York, the negotiations for Spanish membership in the European Conference of Molecular Biology, and national policy towards university reform. As a result, the early molecular biologists' research (...)
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  28. S. Chadarevian (2002). Reconstructing Life. Molecular Biology in Postwar Britain. Studies in History and Philosophy of Science Part C 33 (3):431-448.score: 261.0
    The Medical Research Council Laboratory of Molecular Biology (formerly the Medical Research Council Unit for the Study of Molecular Structure of Biological Systems) in Cambridge (England) played a key role in the postwar history of molecular biology. The paper, focussing on the early history of the institution, aims to show that the creation of the laboratory and the making of molecular biology were part of a new scientific culture set in place after World (...)
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  29. U. Deichmann (2002). Emigration, Isolation and the Slow Start of Molecular Biology in Germany. Studies in History and Philosophy of Science Part C 33 (3):449-471.score: 261.0
    Until the 1930s Germany had been the international leader in biochemistry, chemistry, and areas of biology. After WWII, however, molecular biology as a new interdisciplinary scientific enterprise was scarcely represented in Germany for almost 20 years. Three major reasons for the low performance of molecular biology are discussed: first, the forced emigration of Jewish scientists after 1933, which not only led to the expulsion of future distinguished molecular biologists, but also to a strong decline (...)
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  30. Michel Morange (2008). The Death of Molecular Biology? History and Philosophy of the Life Sciences 30 (1):31 - 42.score: 261.0
    In recent decades the expression "molecular biology" has progressively disappeared from journals, and no longer designates new chairs or departments. This begs the question: does it mean that molecular biology is dead, and has been displaced by new emerging disciplines such as systems biology and synthetic biology? Maybe its reductionist approach to living phenomena has been substituted by one that is more holistic. The situation, undoubtedly, is far less simple. To appreciate better what has (...)
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  31. J. B. (2002). Institutionalizing Molecular Biology in Post-War Europe: A Comparative Study. Studies in History and Philosophy of Science Part C 33 (3):515-546.score: 261.0
    The intellectual origins of molecular biology are usually traced back to the 1930s. By contrast, molecular biology acquired a social reality only around 1960. To understand how it came to designate a community of researchers and a professional identity, I examine the creation of the first institutes of molecular biology, which took place around 1960, in four European countries: Germany, the United Kingdom, France, and Switzerland. This paper shows how the creation of these institutes (...)
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  32. Philip Kitcher (1999). The Hegemony of Molecular Biology. Biology and Philosophy 14 (2):195-210.score: 246.0
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  33. Jérôme Pierrel (2012). An RNA Phage Lab: MS2 in Walter Fiers' Laboratory of Molecular Biology in Ghent, From Genetic Code to Gene and Genome, 1963-1976. [REVIEW] Journal of the History of Biology 45 (1):109 - 138.score: 230.0
    The importance of viruses as model organisms is well-established in molecular biology and Max Delbrück's phage group set standards in the DNA phage field. In this paper, I argue that RNA phages, discovered in the 1960s, were also instrumental in the making of molecular biology. As part of experimental systems, RNA phages stood for messenger RNA (mRNA), genes and genome. RNA was thought to mediate information transfers between DNA and proteins. Furthermore, RNA was more manageable at (...)
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  34. Lindley Darden & Michael Cook (1994). Reasoning Strategies in Molecular Biology: Abstractions, Scans and Anomalies. PSA: Proceedings of the Biennial Meeting of the Philosophy of Science Association 1994:179 - 191.score: 228.0
    Molecular biologists use different kinds of reasoning strategies for different tasks, such as hypothesis formation, experimental design, and anomaly resolution. More specifically, the reasoning strategies discussed in this paper may be characterized as (1) abstraction-instantiation, in which an abstract skeletal model is instantiated to produce an experimental system; (2) the systematic scan, in which alternative hypotheses are systematically generated; and (3) modular anomaly resolution, in which components of a model are stated explicitly and methodically changed to generate alternative changes (...)
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  35. Raphael Falk (2013). On the Nature of the Gene (Reviewing P.R. Sloan, B. Fogel (Eds.), Creating a Physical Biology: The Three-Man Paper and Early Molecular Biology). [REVIEW] Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 44 (4):623-625.score: 228.0
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  36. Angela N. H. Creager (2009). Phosphorus-32 in the Phage Group: Radioisotopes as Historical Tracers of Molecular Biology. Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 40 (1):29-42.score: 228.0
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  37. Steven P. R. Rose (1987). Molecules and Minds: Essays on Biology and the Social Order. Open University Press.score: 225.0
  38. Stefan Artmann (2002). Three Types of Semiotic Indeterminacy in Monod's Philosophy of Modern Biology. Sign Systems Studies 30 (1):149-160.score: 222.0
    Synthesizing important research traditions in information theory, structuralist semiotics, and generative linguistics, at least three main types of semiotic indeterminacy must be distinguished: Kolmogorov’s notion of randomness defined as sequential incompressibility, de Saussure’s principle of contingency of sign which ensures the possibility of translation between different sign systems, and Chomsky’s idea of indefiniteness in generative mechanisms as a requirement for the explanation of semiotic creativity. These types of semiotic indeterminacy form an abstract system useful for the description of concrete sign (...)
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  39. H. Atlan (1986). Molecular Versus Biological Evolution and Programming in The Kaleidoscope of Science. The Israel Colloquium: Studies in History, Philosophy, and Sociology of Science. Volume I. [REVIEW] Boston Studies in the Philosophy of Science 94:137-145.score: 222.0
     
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  40. John A. Winnie (2000). Information and Structure in Molecular Biology: Comments on Maynard Smith. Philosophy of Science 67 (3):517-526.score: 219.0
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  41. Hans-Jörg Rheinberger (2009). Recent Science and its Exploration: The Case of Molecular Biology. Studies in History and Philosophy of Science Part C 40 (1):6-12.score: 219.0
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  42. Jean-Paul Gaudillière (2009). New Wine in Old Bottles? The Biotechnology Problem in the History of Molecular Biology. Studies in History and Philosophy of Science Part C 40 (1):20-28.score: 219.0
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  43. David Berlinski (1972). Philosophical Aspects of Molecular Biology. Journal of Philosophy 64 (12):319-335.score: 219.0
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  44. Martha E. Keyes (1999). The Prion Challenge to the `Central Dogma' of Molecular Biology, 1965–1991. Studies in History and Philosophy of Science Part C 30 (2):181-218.score: 219.0
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  45. Phillip R. Sloan (2012). How Was Teleology Eliminated in Early Molecular Biology? Studies in History and Philosophy of Science Part C 43 (1):140-151.score: 219.0
  46. Bruno J. Strasser (2002). Institutionalizing Molecular Biology in Post-War Europe: A Comparative Study. Studies in History and Philosophy of Science Part C 33 (3):515-546.score: 219.0
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  47. Emily Grosholz (2011). Studying Populations Without Molecular Biology: Aster Models and a New Argument Against Reductionism. Studies in History and Philosophy of Science Part C 42 (2):246-251.score: 219.0
  48. Soraya de Chadarevian & Bruno Strasser (2002). Molecular Biology in Postwar Europe: Towards a 'Glocal' Picture. Studies in History and Philosophy of Science Part C 33 (3):361-365.score: 219.0
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  49. Donald Livingston (2001). Book Review: Nazis, Women and Molecular Biology, Memoirs of a Lucky Self-Hater, by Gunther S. STENT. [REVIEW] Journal of Medicine and Philosophy 26 (1):119 – 122.score: 219.0
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  50. María Jesús Santesmases (2002). National Politics and International Trends: EMBO and the Making of Molecular Biology in Spain (1960–1975). Studies in History and Philosophy of Science Part C 33 (3):473-487.score: 219.0
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