Online research in philosophy

We have synthesized a 582,970-base pair Mycoplasma genitalium genome. This synthetic genome, named M. genitalium JCVI-1.0, contains all the genes of wild-type M. genitalium (...) class='Hi'> G37 except MG408, which was disrupted by an antibiotic marker to block pathogenicity and to allow for selection. To identify the genome as synthetic, we inserted "watermarks" at intergenic sites known to tolerate transposon insertions. Overlapping "cassettes" of 5 to 7 kilobases (kb), assembled from chemically synthesized oligonucleotides, were joined by in vitro recombination to produce intermediate assemblies of approximately 24 kb, 72 kb ("1/8 genome"), and 144 kb ("1/4 genome"), which were all cloned as bacterial artificial chromosomes in Escherichia coli. Most of these intermediate clones were sequenced, and clones of all four 1/4 genomes with the correct sequence were identified. The complete synthetic genome was assembled by transformation-associated recombination cloning in the yeast Saccharomyces cerevisiae, then isolated and sequenced. A clone with the correct sequence was identified. The methods described here will be generally useful for constructing large DNA molecules from chemically synthesized pieces and also from combinations of natural and synthetic DNA segments. 10.1126/science.1151721. (shrink)

Spade 1988 sugges t s tha t t he r e are ac tua l l y two theo r i e s t o address t (...) h i s ques t i o n t o , an ear l y one and a l a t e r one . 2 Most o f the presen t pape r i s a deve l o pmen t o f t h i s i dea . I sugges t tha t ear l y work by Sherwood and o the r s was a s tudy o f quan t i f i e r s : the i r semant i c s and t he e f f e c t s o f con t e x t on i n f e r e n ce s t ha t can be made f r om quan t i f i e d te rms . La te r , i n the hands o f Bur l e y and o the r s , i t changed i n t o a s tudy o f someth i n g e l se , a s tudy o f what I ca l l g loba l quan t i f i c a t i o n a l e f f e c t . In sec t i o n 1 , I exp l a i n what these two op t i o n s are. (shrink)

Verbin, N., Divinely abused: a philosophical perspective on Job and his kin Content Type Journal Article DOI 10.1007/s11153-010-9262-5 Authors A. K. Anderson, Department of (...) class='Hi'> Religion, Wofford College, 429 N. Church St., Spartanburg, SC 29303, USA Journal International Journal for Philosophy of Religion Online ISSN 1572-8684 Print ISSN 0020-7047. (shrink)

. In the XIXth century there was a persistent opposition to Aristotelian logic. Nicolai A. Vasiliev (1880–1940) noted this opposition and stressed that the way for the (...) novel – non-Aristotelian – logic was already paved. He made an attempt to construct non-Aristotelian logic (1910) within, so to speak, the form (but not in the spirit) of the Aristotelian paradigm (mode of reasoning). What reasons forced him to reassess the status of particular propositions and to replace the square of opposition by the triangle of opposition? What arguments did Vasiliev use for the introduction of new classes of propositions and statement of existence of various levels in logic? What was the meaning and role of the “method of Lobachevsky” which was implemented in construction of imaginary logic? Why did psychologism in the case of Vasiliev happen to be an important factor in the composition of the new ‘imaginary’ logic, as he called it? (shrink)

We can learn about human ethics from machines. We discuss the design of a working machine for making ethical decisions, the N-Reasons platform, applied to the (...) class='Hi'>ethics of robots. This N-Reasons platform builds on web based surveys and experiments, to enable participants to make better ethical decisions. Their decisions are better than our existing surveys in three ways. First, they are social decisions supported by reasons. Second, these results are based on weaker premises, as no exogenous expertise (aside from that provided by the participants) is needed to seed the survey. Third, N-Reasons is designed to support experiments so we can learn how to improve the platform. We sketch experimental results that show the platform is a success as well as pointing to ways it can be improved. (shrink)

H. Wittman, A. Desmarais, and N. Wiebe (eds.): Food Sovereignty: Reconnecting Food, Nature and Community Content Type Journal Article Category Review Paper Pages 1-3 DOI 10.1007 (...) class='Hi'>/s10806-012-9375-1 Authors Charles Francis, Department of Agronomy and Horticulture, UNL, 279 Plant Science, Lincoln, NE 68583-0915, USA Journal Journal of Agricultural and Environmental Ethics Online ISSN 1573-322X Print ISSN 1187-7863. (shrink)

Hume’s view of reason is notoriously hard to pin down, not least because of the apparently contradictory positions which he appears to adopt in different places. (...) class='Hi'>The problem is perhaps most clear in his writings concerning induction - in his famous argument of Treatise I iii 6 and Enquiry IV, on the one hand, he seems to conclude that “probable inference” has no rational basis, while elsewhere, for example in much of his writing on natural theology, he seems happy to acknowledge that such inference is not only reasonable, but is even a paradigm of reasoning against which the theistic arguments must be judged. In the face of this apparent contradiction, many recent commentators have proferred “non-sceptical” interpretations of Hume’s argument concerning induction, but in this paper I sketch an alternative and perhaps less radical method of resolving the problem, by identifying a major threefold ambiguity in Hume’s use of the word “reason”. On this interpretation, Hume indeed sees induction as a paradigm of reasonableness in what is arguably the most important sense, but he nevertheless believes induction to be entirely non-reasonable in another sense, which though less important in common life is nevertheless very significant philosophically. A comparison with Locke can help to illuminate Hume’s position, which though indeed not entirely sceptical about induction, is by no means entirely non-sceptical either. (shrink)

In this paper, we develop a duality for the varieties of a Łukasiewicz n + 1-valued modal System. This duality is an extension of Stone duality for (...) modal algebras. Some logical consequences (such as completeness results, correspondence theory...) are then derived and we propose some ideas for future research. (shrink)

Despite all that has been written about Russian historiography and how it profoundly changed after the Bolsheviks seized power in 1917, very little is known about the (...) historical tradition immediately before the Soviet era. This article attempts to begin to address this issue by examining the major forces that shaped the historical and sociological thought of Nikolai Alesandrovich Rozhkov (1868–1927). It argues that as Kliuchevskii’s successor and as the first professional historian to eventually present a Marxist analysis of Russian history, Rozhkov was not only the most important historian at that time but one whose work best represented the most significant transition in Russia’s historical tradition. The article concludes that an examination of Rozhkov’s historical methodology offers a new interpretation of the origins of Soviet historiography. (shrink)

Several philosophical problems are based on an analogy between a real situation and a probabilistic model. Such problems are based on urn analogies. The present dissertation aims (...) to describe and implement a methodology oriented towards the resolution of philosophical problems based on an urn analogy. This methodology is based on the use of the n-universes. To this end, I describe first the n-universes in a detailed way. I also discuss the difficulties of the theory of n-universes related to the demultiplication of the criteria and to the relation one/many between the objects and a given criterion. On the one hand, I present an application of the framework of n-universes to the Doomsday argument and to the problems recently appeared in the literature in keeping with the Doomsday argument. My concern is also with showing how the application of the framework of n-universes to several problems and thought experiments related to the Doomsday argument helps clarifying the problem data and making disappear the associated ambiguity. I present then an analysis of the following problems related to the Doomsday argument: the two urn case, God's Coin Toss, the Sleeping Beauty Problem, the Presumptuous Philosopher, Lazy Adam, and the Shooting-Room Paradox. I present lastly a solution to the Doomsday argument, based on a third route, by contrast to two types of solutions classically described. On the other hand, I present an application of the framework of n-universes to Goodman's paradox. I replace first Goodman's statement in the framework of n-universes. I propose then a solution to the paradox, based on a distinction between two different modelizations of Goodman's statement in two structurally different n-universes. (shrink)

I describe in this paper the basic elements of the n-universes, a methodological tool originally introduced in Franceschi (2001) in the context of the study of (...) class='Hi'>Goodman's paradox. As the n-universes can be used in wide-ranging applications, such as thought experiments, I describe them from an essentially pragmatic standpoint, i.e. by describing accurately the step-by-step process which leads to a given modelisation. (shrink)

This review summarises why it is difficult for Darwinian evolutionary theory to explain the existence and function of consciousness. It then evaluates whether Humphrey's book Soul (...) class='Hi'>Dust overcomes these problems. According to Humphrey, consciousness is an illusion constructed by the brain to enhance reproductive fitness by motivating creatures that have it to stay alive. Although the review entirely accepts that consciousness gives a first-person meaning to existence, it concludes that Humphrey does not give a convincing account of how this can arise from random variations in the genome. Nor does he demonstrate how first-person experiences might enter into or be reducable to third-person functioning. The review concludes that Humphrey's case is unconvincing, and goes on to suggest that an entirely different, non-reductive approach may be required to understand consciousness. (shrink)

You might think a simple “No” would suffice as an answer. But there are features of Kant’s ethics that appear to be strikingly similar to virtue (...) class='Hi'>oriented views, so striking that some Kantians themselves have argued that Kant’s ethics in fact shares these features with virtue ethics. In what follows, I will argue against this view, though along the way I will acknowledge the features of Kant’s view that make it appear more like a kind of virtue ethics than it really is. (shrink)

: This response to Nikolaus Knoepffler's paper in the same issue of the Journal agrees that if the arguments supporting the first two of the eight human (...) embryonic stem cell research policy options discussed are unsound, as Knoepffler argues, then it seems natural to move to the increasingly permissive options. If the arguments are sound, however, then the more permissive options should be rejected. It is argued that three of the rejected arguments, taken together, constitute very good reasons to hold that a human embryo is endowed with dignity from fertilization onward. Thus, countries that want their public policies to match the moral imperative of respect for human beings should refrain from allowing destructive human embryo research and should devote considerable energy and public funds to research and clinical trials using non-embryonic ("adult") stem cells. (shrink)

In this short paper, I compare and contrast the kind of symmetric treatment of negation favoured in different ways by Huw Price (in “Why ‘Not’?”) and by (...) me (in “Multiple Conclusions”) with Robert Brandom’s analysis of scorekeeping in terms of commitment, entitlement and incompatibility. Both kinds of account are what Brandom calls a normative pragmatics. They are both semantic anti-realist accounts of meaning in the significance of vocabulary is explained in terms of our rule-governed (normative) practice (pragmatics). These accounts differ from intuitionist semantic anti-realism by providing a way to distinguish the inferential significance of “A” and “A is warranted.” Although proof plays a central role, in neither accont is verification the primary bearer of meaning. Our accounts make these distinctions in terms of a subtle analysis of our practices. On the one hand according to Price and me, we assert as well as deny; on the other, Brandom distingushes downstream commitments from upstream entitlements and the notion of incompatibility definable in terms of these. In this paper I will examine a number connections between these different approaches, and end with a discussion of the kind of account of proof that might emerge from these considerations. (shrink)