Objective: Ethical guidelines are designed to ensure benefits, protection and respect of participants in clinical research. Clinical trials must now be registered on open-access databases and provide details on ethical considerations. This systematic survey aimed to determine the extent to which recently registered clinical trials report the use of standard of care and post-trial obligations in trial registries, and whether trial characteristics vary according to setting. Methods: We selected global randomized trials registered on http://www.clinicaltrials.gov and http://www.controlled-trials.com. We searched for intervention (...) trials of HIV/AIDS, malaria, and tuberculosis from 9 October 2004, the date of the most recent version of the Helsinki Declaration, to 10 April 2007. Results: We collected data from 312 trials. Fifty-eight percent (58%, 95% CI = 53 to 64) of trial protocols report informed consent. Fifty-eight percent (58%, 95% CI = 53 to 64) of trials report active controls. Almost no trials (1%, 95% CI = 0.5 to 3) mention post-trial provisions. Most trials measure surrogate outcomes. Twenty percent (20%, 95% CI = 16 to 25) of trials measure patient-important outcomes, such as death; and the odds that these outcomes are in a low income country are five times greater than for a developed country (odds ratio (OR) 5.03, 95% CI = 2.70 to 9.35, p = < 0.001). Pharmaceutical companies are involved in 28% (CI = 23 to 33) of trials and measure surrogate outcomes more often than nonpharmaceutical companies (OR 2.45, 95% CI = 1.18 to 5.09, p = 0.31). Conclusion: We found a large discrepancy in the quality of reporting and approaches used in trials in developing settings compared to wealthier settings. (shrink)
It can happen that a single surface S, viewed in normal conditions, looks pure blue (“true blue”) to observer John but looks blue tinged with green to a second observer, Jane, even though both are normal in the sense that they pass the standard psychophysical tests for color vision. Tye (2006a) finds this situation prima facie puzzling, and then offers two different “solutions” to the puzzle.1 The first is that at least one observer misrepresents S’s color because, though normal in (...) the sense explained, she is not a Normal color observer: her color detection system is not operating in the current condition in the way that Mother Nature intended it to operate. His second solution involves the idea that Mother Nature designed our color detection systems to be reliable with respect to the detection of coarse-grained colors (e.g., blue, green, yellow, orange), but our capacity to represent the fine-grained colors (e.g., true blue, blue tinged with green) is an undesigned spandrel. On this second solution, it is consistent with the variation between John and Jane that both represent the color of S in a way that complies with Mother Nature’s intentions: both represent S as exemplifying the coarse-grained color blue, and since (we may assume) S is in fact blue, both represent it veridically. Of course, they also represent fine-grained colors of S, and, according to Tye, at most one of these representations is veridical (Tye says that only God knows which). But at the level of representation for which Mother Nature designed our color detection systems, both John and Jane (qua Normal observers) are reliable detectors. (shrink)
In “The Location Problem for Color Subjectivism,” Peter Ross argues against what he calls subjectivism — the view that “colors are not describable in physical terms, ... [but are] mental processes or events of visual states” (2),1 and in favor of physicalism — a view according to which colors are “physical properties of physical objects, such as reflectance properties” (10). He rejects an argument that has been offered in support of subjectivism, and argues that, since no form of subjectivism is (...) able to account for our perception of color, we are better off adopting physicalism. (shrink)
o (2000), 243). In particular, the idea is that binding interactions between the relevant expressions and natural lan- guage quantifiers are best explained by the hypothesis that those expressions harbor hidden but bindable variables. Recently, however, Herman Cappelen and Ernie Lepore have rejected such binding arguments for the presence of hid- den variables on the grounds that they overgeneralize — that, if sound, such arguments would establish the presence of hidden variables in all sorts of ex- pressions where it is (...) implausible that they exist (Cappelen and Lepore (2005), Cappelen and Lepore (2002)).1 In what follows we respond to Cappelen’s and Lepore’s attempted reductio by bringing out crucial disanalogies between cases where the binding argument is successful and cases where it is not. But we have a deeper purpose than merely to respond to Cappelen and Lepore: we think the attempted reductio goes wrong by not taking sufficiently seriously the nature of the binding relation that holds between quantifiers and arguments/variables, and that our criticism will serve to highlight the nature and importance of this relation. (shrink)
This commentary makes two rejoinders to O'Regan & Noë. It clarifies the status of visual representations in their account, and argues that their explanation of the (according to them, illusory) appeal of <span class='Hi'>qualia</span> is unsatisfying.
A is for Alice and astronomers arguing about acceleration -- B is for Bernard's body-exchange machine -- C is for the Catholic cannibal -- D is for Maxwell's demon -- E is for evolution (and an embarrassing problem with it) -- F is for the forms lost forever to the prisoners of the cave -- G is for Galileo's gravitational balls -- H is for Hume's shades -- I is for the identity of indiscernibles -- J is for Henri Poincaré (...) and alternative geometries -- K is for the Kritik and Kant's kind of thought experiments -- L is for Lucretius' spear -- M is for Mach's motionless chain -- N is for Newton's bucket -- O is for Olbers' paradox -- P is for Parfit's person -- Q is for the questions raised by thought experiments quotidiennes -- R is for the rule-ruled room -- S is for Salvatius' ship, sailing along its own space-time line -- T is for the time-travelling twins -- U is for the universe, and Einstein's attempts to understand it -- V is for the vexed case of the violinist -- W is for Wittgenstein's beetle -- X is for xenophanes and thinking by examples -- Y is for counterfactuals and a backwards approach to history -- Z is for Zeno and the mysteries of infinity. (shrink)
Although O'Regan & Noë (O&N) claim that the world may serve as the viewers' external visual memory, findings from the field of memory research have demonstrated the existence of internal visual representations. These representations are stored in the viewer's brain, contain information regarding visual objects and their relations, guide subsequent exploration of the visual world and promote change detection.
Levinas seamlessly unites philosophy and religion via ethics. By doing so he satisfies philosophy's quest for justification by finding it neither in epistemology nor aesthetics (nor in an escapist "fundamentalism") but in the responsibility of each person for each other and for all others. That is to say, the "ground" of meaning emerges neither in intellect nor imagination but in the moral responsibilities one person has for another and, beyond these already infinite obligations, in the justice - law and equality (...) - that such responsibilities require and engender. All of this is at the same time a consistent expression, indeed a profoundly mature expression of the ethical monotheist vision of traditional rabbinic Judaism and of non-mythological religious consciousness more generally. /// O pensamento de Emmanuel Levinas induz uma união perfeita entre Filosofia e Religião mediante a Ética. Nesta medida, o filósofo dá resposta à pergunta da Filosofia pela sua própria justificação, justificação essa que ele não encontra nem na epistemologia nem na estética (nem em qualquer forma de escapismo fundamentalista), mas na responsabilidade de cada pessoa por cada um e por todos. Or a isto equivale a dizerque o "fundamento" para o sentido não emerge nem do intelecto nem da imaginação, mas sim da responsabilidade moral que nos obriga a cada um diante dos outros e, para lá destas obrigações infinitas, nos compromete com a justiça - representada no princípio da legalidade e da equidade - requerida e engendrada por essas mesmas responsabilidades. Tudo isto, para o autor, é ao mesmo tempo expressão consistente, de facto, uma expressão profundamente madura da visão ética monoteísta do Judaísmo rabínico e, de uma forma mais geral, de toda a forma de consciência religiosa não mitológica. (shrink)
Professor Cohen, 'Jerry' to very many, has been Chichele Professor of Social and Political Theory, All Souls College, Oxford. He has been both a worthy successor to Isaiah Berlin in the chair and also his own man. Born into a Jewish family in Montral, Cohen was educated at McGill University and then in Oxford under Berlin and Gilbert Ryle. He taught philosophy vigorously at University College London and became known as the first proponent of analytical Marxism. His resolute (...) book illustrative of that way of thinking is Karl Marx's Theory of History: A Defence . Cohen has not been imprisoned by it, as his subsequent writings make clear -- Self-Ownership, Freedom, and Equality and If You're An Egalitarian, How Come You're So Rich? The article below, which appeared in Anthony O'Hear (ed.), Political Philosophy , Royal Institute of Philosophy Lectures (Cambridge University Press), has also been reprinted in Stephen Law (ed.), Israel, Palestine and Terror (Continuum). (shrink)
Aim of this article is to suggest that Contemporary Jewish Philosophy take step from Ethics to a focus on Ethics and Law. In a commentary manner, this essay explores the thought of Hermann Cohen, Franz Rosenzweig and Emmanuel Levinas, to see how their dialogical ethics becomes an exploration of the relation of commandments and laws. The dialogical relation is not lost, but remains a central aspect in theories of law. Moreover, the key aspect of the inquiry revolves around the (...) temporality in both the face-to-face relation of ethics and the relation to justice through laws. /// O autor do presente artigo sugere que a Filosofia Judaica Contemporânea focalizar a sua atenção não tanto na Ética, mas sobretudo na relação entre Ética e Lei. Procedendo a modo de um comentário, o autor explora o pensamento de autores tais como Hermann Cohen, Franz Rosenzweig e Emmanuel Levinas em ordem a demonstrar até que ponto a sua respectiva ética dialógica se transforma numa exploração da relação entre mandamentos e leis. Com efeito, segundo o autor, a relação dialógica não se perde, mas permanece um aspecto central nas respectivas teorias sobre a Lei. Além disso, o presente estudo desenrola-se também em torno da questão da temporalidade tanto na relação face-a-face própria da ética como na relação de justiça cuja mediação é a Lei. (shrink)
An ordering ( $\leq_K$ ) on maximal almost disjoint (MAD) families closely related to destructibility of MAD families by forcing is introduced and studied. It is shown that the order has antichains of size c and decreasing chains of length $\mathfrak{c}^+$ bellow every element. Assuming $\mathfrak{t} = \mathfrak{c}$ a MAD family equivalent to all of its restrictions is constructed. It is also shown here that the Continuum Hypothesis implies that for every $\omega^\omega-bounding$ forcing P of size c there is a (...)Cohen-destructible, $\mathbb{P}-indestructible$ MAD family. Finally, two other orderings on MAD families are suggested and an old construction of $Mr\acute{o}wka$ is revisited. (shrink)
A focus on the lawmaking process, I submit, permits us to explore a particular dimension of justice, namely the relationship between law and liberty. Laws that reflect the arbitrary whims of the lawmaker are presumptively unjust, because they constrain liberty for no good reason. A strategy for making arbitrary laws less likely involves recognizing checks on the lawmaker's powers and grounding those checks in processes that allow the governed to express their disapproval. The system of checks and balances employed in (...) the U.S. Constitution embodies this strategy, although reasonable people can debate its efficacy. As A.O. Hirschman observed, regimes that permit free movement of persons and property similarly restrict the force of arbitrary rules by allowing exit from unwanted restrictions. I want to inquire into the role of checks in international lawmaking. At first blush, it might appear that the fundamental principle of state consent provides all the checking that international lawmaking needs. This principle maintains that a state (and by extension, its subjects) can be bound by a rule of international law only if that state manifests its consent to the rule. As long as states have a real choice, itself subject to internal checks on official decisionmaking, the adoption of the rule should meet basic criteria of procedural justice. Indeed, the correlate of this principle—that each state has a veto over the adoption of international law, at least as applied to itself and its subjects—suggests that international lawmaking poses less of a threat to liberty than do conventional municipal lawmaking processes based on majority rule. One might think that, as a result of this principle, no rule will attain the status of international law unless its adoption makes some states better off and no state worse off. This first impression, however, is wrong. First, international lawyers argue for the existence of jus cogens norms that apply regardless of state consent. Second, the concept of state consent is artful, and opportunistic decisionmakers have some freedom to construe consent in ways that circumvent conventional checking processes. Third, political and economic coercion can reduce state consent to a meaningless formality. I discuss each of these points in turn. Once state consent ceases to constrain international lawmaking, the question role of alternative checks to protect liberty looms. Under what circumstances does the international lawmaking process as currently constituted present a threat of arbitrary force? What kinds of resistance to the results of international lawmaking can process values justify? I address these questions in three steps. First, I explore whether international law does carry a threat of coercion. If not, concerns about arbitrary restrictions of liberty are misplaced. Second, I discuss the problems arising from delegations of lawmaking authority to international institutions, with specific reference to the Rome Statute and the International Criminal Court. Third, I discuss the process-value issues associated with judicial lawmaking. None of these concerns justifies blanket opposition to international lawmaking. Rather, those interested in making and enforcing international rules need to grapple with these issues and provide another layer of justification for their efforts. a Footnotesa I am indebted to Ken Abbott, Jean Cohen, Larry Helfer, Robert Hockett, Sean Murphy, Phil Nichols, Ed Swaine, Joel Trachtman, the other contributors to this volume, and participants in a workshop at the University of Virginia School of Law for comments and criticism. Shortcomings are mine alone. (shrink)
Cette étude a pour but de situer la discussion sur l'égalité économique dans le contexte existentiel qui lui est approprié. Interprétant le système économique non seulement comme un système de production et de distribution, mais aussi comme un lieu où s'opère une certaine forme de « colmatage existentiel » individuel, nous étudions les rouages enfouis du système économique qui pourraient expliquer pourquoi les arguments classiques d'incitation, souvent invoqués par la théorie économique égalitariste, peuvent cacher des obstacles puissants à l'égalité. Nous (...) mettons en question les approches des incitations développées par G. A. Cohen et Philippe Van Parijs et nous avançons une approche existentielle inspirée notamment de Norman O. Brown et de Ernest Becker, selon qui l'économie peut aisément devenir le lieu du déni de la corporéité et de la mortalité. L'égalité économique, dès lors, ne peut être atteinte pleinement qu'en couplant la philosophie politique avec l'analyse existentielle et spirituelle des conditions d'assumption individuelle du corps mortel. This study seeks to locate the discussion on economic equality within an appropriate existential context. Seeing the economic system not only as a system of production and distribution, but also as the locus where a certain form of individual « existential containment » is taking place, we study those buried underpinnings of the economic system which could explain why classical incentive arguments often used by economists might hide powerful obstacles to equality. The approaches to incentives proposed by G. A. Cohen and Philippe Van Parijs are discussed and questioned, and an alternative approach is suggested, inspired partially by Norman O. Brown and Ernest Becker, for whom the economy can easily become the locus of a denial of corporeity and mortality. Thus, economic equality can be fully attained only by coupling political philosophy with the existential and spiritual analysis of the conditions under which individuals can accept their mortal body. (shrink)
Machine generated contents note: List of illustrations * Notes On Contributors * Introduction: B.Biebuyck, G.Buelens, O.de Graef, D.Hoens, S.Jttkandt * Who or What Decides: For Derrida: A Catastrophic Theory of Decision--J.Hillis Miller * Catastrophic Narratives and Why the Catastrophe to Catastrophe Might Have Already Happened--E.Vogt * Breath of Relief: Sloterdijk and the Politics of the Intimate--S.van Tuinen * Man is a swarm animal--J.Clemens * Notes on the Bird War: Biopolitics of the Visible (in the Era of Climate Change)--T.Cohen * (...) Dialectical Catastrophe: Hegels Allegory of Physiognomy and the Ethics of Survival--P.Moll * Catastrophe, Citationality and the Limits of Responsibility in Disgrace--G.Buelens * Unpredictable Inevitability and the Boundaries of Psychic Life; D.Nobus * Who is Nietzsche?--A.Badiou * Is Pleasure a Rotten Idea?--A.Schuster * Nationalist Ext(im)asy: Maurice Barrs and the Roots of Fascist Enjoyment--G.Chaitin * Topography of the Border: Derrida Rewriting Transcendental Aesthetics--J.Hodge * Index List of illustrations * Notes On Contributors * Introduction: B.Biebuyck, G.Buelens, O.de Graef, D.Hoens, S.Jttkandt * Who or What Decides: For Derrida: A Catastrophic Theory of Decision--J.Hillis Miller * Catastrophic Narratives and Why the Catastrophe to Catastrophe Might Have Already Happened--E.Vogt * Breath of Relief: Sloterdijk and the Politics of the Intimate--S.van Tuinen * Man is a swarm animal--J.Clemens * Notes on the Bird War: Biopolitics of the Visible (in the Era of Climate Change)--T.Cohen * Dialectical Catastrophe: Hegels Allegory of Physiognomy and the Ethics of Survival--P.Moll * Catastrophe, Citationality and the Limits of Responsibility in Disgrace--G.Buelens * Unpredictable Inevitability and the Boundaries of Psychic Life; D.Nobus * Who is Nietzsche?--A.Badiou * Is Pleasure a Rotten Idea?--A.Schuster * Nationalist Ext(im)asy: Maurice Barrs and the Roots of Fascist Enjoyment--G.Chaitin * Topography of the Border: Derrida Rewriting Transcendental Aesthetics--J.Hodge * Index. (shrink)
The collection of branches (maximal linearly ordered sets of nodes) of the tree $^{ (ordered by inclusion) forms an almost disjoint family (of sets of nodes). This family is not maximal--for example, any level of the tree is almost disjoint from all of the branches. How many sets must be added to the family of branches to make it maximal? This question leads to a series of definitions and results: a set of nodes is off-branch if it is almost disjoint (...) from every branch in the tree; an off-branch family is an almost disjoint family of off-branch sets; and o is the minimum cardinality of a maximal off-branch family. Results concerning o include: (in ZFC) a ≤ p, and (consistent with ZFC) o is not equal to any of the standard small cardinal invariants b,a,d, or c = 2 ω . Most of these consistency results use standard forcing notions--for example, $\mathfrak{b = a in the Cohen model. Many interesting open questions remain, though--for example, whether d ≤ o. (shrink)
Neste artigo interpreta-se a Rechtslehre kantiana enquanto uma doutrina jurídica crítica, compreensível à luz do projeto crítico – iniciado em Kritik der reinen Vernunft e adaptado ao campo prático em Kritik der praktischen Vernunft . Em particular, objetiva-se destacar, além da aprioridade, do caráter sistemático e da busca pela completude dos princípios jurídicos, o emprego da teoria de solubilidade de problemas da razáo em geral nos "prolegômenos" da Rechtslehre . O estudo desta parte introdutória se justifica por apresentar a divisáo (...) suprema do sistema segundo princípios, donde se deriva uma divisáo da doutrina do direito, que determina o objeto ( Gegenstand ) e, por conseguinte, o campo dessa ciência particular e a discussáo do procedimento de pesquisa. Tal moldura a priori da doutrina do direito é o fundamento da sequente teoria kantiana do direito privado e do direito público. Num quadro maior, esse artigo pode ser compreendido enquanto uma renúncia à leitura de que a Rechtslehr e kantiana náo cumpre com as exigências da filosofia crítica – formulada por Hermann Cohen ( Ethik des reinen Willens , 1904) e detalhada por Christian Ritter ( Der Rechtsgedanke Kants nach den frühen Quellen , 1971). (shrink)
G.A. Cohen, and J. Raz object that Constructivism is incoherent because it crucially deploys unconstructed elements in the structure of justification. This paper offers a reply on behalf of constructivism, by reassessing the role of such unconstructed elements. First, it shows that a shared conception of rational agency works as a starting point for the justification, but it does not play a foundational role. Second, it accounts for the unconstructed norm that constrains the activity of construction as constitutive. Finally, (...) on this basis, it draws a contrast between constructivism and foundational methods of ethics, such as deontology and teleology. -/- . (shrink)
